Cell Death and Disease - Table of Contents alert Volume 8, June 2017

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TABLE OF CONTENTS Volume 8, June 2017 In this issue News and Commentaries Reviews Original Articles Correspondence Sign up for e-alerts Web feed News and Commentaries Top Genes versus Environment: cytoplasmic BAP1 determines the toxic response to environmental stressors in mesothelioma Ivano Amelio Cell Death Dis 2017 8: e2907; 10.1038/cddis.2017.293 Full Text BH3-only proteins: the thorny end of the ER stress response Jason A Glab, Marcel Doerflinger and Hamsa Puthalakath Cell Death Dis 2017 8: e2889; 10.1038/cddis.2017.283 Full Text Reviews Top MYBL2 (B-Myb): a central regulator of cell proliferation, cell survival and differentiation involved in tumorigenesis Julian Musa, Marie-Ming Aynaud, Olivier Mirabeau, Olivier Delattre and Thomas GP Grünewald Cell Death Dis 2017 8: e2895; 10.1038/cddis.2017.244 Abstract | Full Text Necroptosis in neurodegenerative diseases: a potential therapeutic target Shuo Zhang, Mi-bo Tang, Hai-yang Luo, Chang-he Shi and Yu-ming Xu Cell Death Dis 2017 8: e2905; 10.1038/cddis.2017.286 Abstract | Full Text Original Articles Top Precision medicine for hepatocelluar carcinoma using molecular pattern diagnostics: results from a preclinical pilot study Rahul Agarwal, Yuan Cao, Klaus Hoffmeier, Nicolas Krezdorn, Lukas Jost, Alejandro Rodriguez Meisel, Ruth Jüngling, Francesco Dituri, Serena Mancarella, Björn Rotter, Peter Winter and Gianluigi Giannelli Cell Death Dis 2017 8: e2867; 10.1038/cddis.2017.229 Abstract | Full Text Inefficient differentiation response to cell cycle stress leads to genomic instability and malignant progression of squamous carcinoma cells Pilar Alonso-Lecue, Isabel de Pedro, Vincent Coulon, Rut Molinuevo, Corina Lorz, Carmen Segrelles, Laura Ceballos, Daniel López-Aventín, Ana García-Valtuille, José M Bernal, Francisco Mazorra, Ramón M Pujol, Jesús Paramio, J Ramón Sanz, Ana Freije, Agustí Toll and Alberto Gandarillas Cell Death Dis 2017 8: e2901; 10.1038/cddis.2017.259 Abstract | Full Text The novel hypoxia-inducible factor-1α inhibitor IDF-11774 regulates cancer metabolism, thereby suppressing tumor growth Hyun Seung Ban, Bo-Kyung Kim, Hongsub Lee, Hwan Mook Kim, Dipesh Harmalkar, Miso Nam, Song-Kyu Park, Kiho Lee, Joon-Tae Park, Inhyub Kim, Kyeong Lee, Geum-Sook Hwang and Misun Won Cell Death Dis 2017 8: e2843; 10.1038/cddis.2017.235 Abstract | Full Text Interferon-γ derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity Purnima Bhat, Graham Leggatt, Nigel Waterhouse and Ian H Frazer Cell Death Dis 2017 8: e2836; 10.1038/cddis.2017.67 Abstract | Full Text The role of oligodendrocyte precursor cells expressing the GPR17 receptor in brain remodeling after stroke Elisabetta Bonfanti, Paolo Gelosa, Marta Fumagalli, Leda Dimou, Francesca Viganò, Elena Tremoli, Mauro Cimino, Luigi Sironi and Maria P Abbracchio Cell Death Dis 2017 8: e2871; 10.1038/cddis.2017.256 Abstract | Full Text MicroRNA-29a induces loss of 5-hydroxymethylcytosine and promotes metastasis of hepatocellular carcinoma through a TET–SOCS1–MMP9 signaling axis Qing Chen, Dan Yin, Yong Zhang, Lei Yu, Xue-Dong Li, Zheng-Jun Zhou, Shao-Lai Zhou, Dong-Mei Gao, Jie Hu, Cheng Jin, Zheng Wang, Ying-Hong Shi, Ya Cao, Jia Fan, Zhi Dai and Jian Zhou Cell Death Dis 2017 8: e2906; 10.1038/cddis.2017.142 Abstract | Full Text MicroRNA-195 prevents dendritic degeneration and neuron death in rats following chronic brain hypoperfusion Xin Chen, Xue-Mei Jiang, Lin-Jing Zhao, Lin-Lin Sun, Mei-Ling Yan, You Tian, Shuai Zhang, Ming-Jing Duan, Hong-Mei Zhao, Wen-Rui Li, Yang-Yang Hao, Li-Bo Wang, Qiao-Jie Xiong and Jing Ai Cell Death Dis 2017 8: e2850; 10.1038/cddis.2017.243 Abstract | Full Text The putative tumor suppressor microRNA-30a-5p modulates clear cell renal cell carcinoma aggressiveness through repression of ZEB2 Zhenhua Chen, Jiaxing Zhang, Zhiling Zhang, Zihao Feng, Jinhuan Wei, Jun Lu, Yong Fang, Yanping Liang, Junjie Cen, Yihui Pan, Yong Huang, Fangjian Zhou, Wei Chen and Junhang Luo Cell Death Dis 2017 8: e2859; 10.1038/cddis.2017.252 Abstract | Full Text Human cancer-associated fibroblasts enhance glutathione levels and antagonize drug-induced prostate cancer cell death Emarndeena H Cheteh, Martin Augsten, Helene Rundqvist, Julie Bianchi, Victoria Sarne, Lars Egevad, Vladimir JN Bykov, Arne Östman and Klas G Wiman Cell Death Dis 2017 8: e2848; 10.1038/cddis.2017.225 Abstract | Full Text Nicotine protects rat hypoglossal motoneurons from excitotoxic death via downregulation of connexin 36 Silvia Corsini, Maria Tortora, Rossana Rauti and Andrea Nistri Cell Death Dis 2017 8: e2881; 10.1038/cddis.2017.232 Abstract | Full Text Knockdown of miR-128a induces Lin28a expression and reverts myeloid differentiation blockage in acute myeloid leukemia Luciana De Luca, Stefania Trino, Ilaria Laurenzana, Daniela Tagliaferri, Geppino Falco, Vitina Grieco, Gabriella Bianchino, Filomena Nozza, Valentina Campia, Francesca D'Alessio, Francesco La Rocca, Antonella Caivano, Oreste Villani, Daniela Cilloni, Pellegrino Musto and Luigi Del Vecchio Cell Death Dis 2017 8: e2849; 10.1038/cddis.2017.253 Abstract | Full Text Single-cell time-lapse imaging of intracellular O2 in response to metabolic inhibition and mitochondrial cytochrome-c release Heiko Düssmann, Sergio Perez-Alvarez, Ujval Anilkumar, Dmitri B Papkovsky and Jochen HM Prehn Cell Death Dis 2017 8: e2853; 10.1038/cddis.2017.247 Abstract | Full Text MicroRNA-26a/cyclin-dependent kinase 5 axis controls proliferation, apoptosis and in vivo tumor growth of diffuse large B-cell lymphoma cell lines Floriana Maria Farina, Alessandra Inguscio, Paolo Kunderfranco, Alice Cortesi, Leonardo Elia and Manuela Quintavalle Cell Death Dis 2017 8: e2890; 10.1038/cddis.2017.291 Abstract | Full Text The NF-κB1 is a key regulator of acute but not chronic renal injury Amy Fearn, Gerhard R Situmorang, Christopher Fox, Fiona Oakley, Rachel Howarth, Caroline L Wilson, Agklinta Kiosia, Michael G Robson, Derek A Mann, Anna Moles and Neil S Sheerin Cell Death Dis 2017 8: e2883; 10.1038/cddis.2017.233 Abstract | Full Text A role for TSPO in mitochondrial Ca2+ homeostasis and redox stress signaling Jemma Gatliff, Daniel A East, Aarti Singh, Maria Soledad Alvarez, Michele Frison, Ivana Matic, Caterina Ferraina, Natalie Sampson, Federico Turkheimer and Michelangelo Campanella Cell Death Dis 2017 8: e2896; 10.1038/cddis.2017.186 Abstract | Full Text Brg1-mediated Nrf2/HO-1 pathway activation alleviates hepatic ischemia–reperfusion injury Mian Ge, Weifeng Yao, Dongdong Yuan, Shaoli Zhou, Xi Chen, Yihan Zhang, Haobo Li, Zhengyuan Xia and Ziqing Hei Cell Death Dis 2017 8: e2841; 10.1038/cddis.2017.236 Abstract | Full Text Autophagy fails to prevent glucose deprivation/glucose reintroduction-induced neuronal death due to calpain-mediated lysosomal dysfunction in cortical neurons Cristian Gerónimo-Olvera, Teresa Montiel, Ruth Rincon-Heredia, Susana Castro-Obregón and Lourdes Massieu Cell Death Dis 2017 8: e2911; 10.1038/cddis.2017.299 Abstract | Full Text P7C3 inhibits GSK3β activation to protect dopaminergic neurons against neurotoxin-induced cell death in vitro and in vivo Chao Gu, Yan Zhang, Qingsong Hu, Jiayuan Wu, Haigang Ren, Chun-Feng Liu and Guanghui Wang Cell Death Dis 2017 8: e2858; 10.1038/cddis.2017.250 Abstract | Full Text Titanium particle-induced osteogenic inhibition and bone destruction are mediated by the GSK-3β/β-catenin signal pathway Ye Gu, Zhirong Wang, Jiawei Shi, Liangliang Wang, Zhenyang Hou, Xiaobin Guo, Yunxia Tao, Xiexing Wu, Wei Zhou, Yu Liu, Wen Zhang, Yaozeng Xu, Huilin Yang, Feng Xue and Dechun Geng Cell Death Dis 2017 8: e2878; 10.1038/cddis.2017.275 Abstract | Full Text LISPRO mitigates β-amyloid and associated pathologies in Alzheimer’s mice Ahsan Habib, Darrell Sawmiller, Song Li, Yang Xiang, David Rongo, Jun Tian, Huayan Hou, Jin Zeng, Adam Smith, Shengnuo Fan, Brian Giunta, Takashi Mori, Glenn Currier, Douglas Ronald Shytle and Jun Tan Cell Death Dis 2017 8: e2880; 10.1038/cddis.2017.279 Abstract | Full Text Upconversion nanoparticle-mediated photodynamic therapy induces autophagy and cholesterol efflux of macrophage-derived foam cells via ROS generation Xiaobo B Han, Hongxia X Li, Yueqing Q Jiang, Hao Wang, Xuesong S Li, Jiayuan Y Kou, Yinghong H Zheng, Zhongni N Liu, Hong Li, Jing Li, Dou Dou, You Wang, Ye Tian and Liming M Yang Cell Death Dis 2017 8: e2864; 10.1038/cddis.2017.242 Abstract | Full Text Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells Tinka Haydn, Eric Metzger, Roland Schuele and Simone Fulda Cell Death Dis 2017 8: e2879; 10.1038/cddis.2017.239 Abstract | Full Text Heme oxygenase-1 derived carbon monoxide suppresses Aβ 1–42 toxicity in astrocytes Nishani T Hettiarachchi, John P Boyle, Mark L Dallas, Moza M Al-Owais, Jason L Scragg and Chris Peers Cell Death Dis 2017 8: e2884; 10.1038/cddis.2017.276 Abstract | Full Text Gene knockout of Zmym3 in mice arrests spermatogenesis at meiotic metaphase with defects in spindle assembly checkpoint Xiangjing Hu, Bin Shen, Shangying Liao, Yan Ning, Longfei Ma, Jian Chen, Xiwen Lin, Daoqin Zhang, Zhen Li, Chunwei Zheng, Yanmin Feng, Xingxu Huang and Chunsheng Han Cell Death Dis 2017 8: e2910; 10.1038/cddis.2017.228 Abstract | Full Text Bilirubin neurotoxicity is associated with proteasome inhibition Hongbiao Huang, Mingxing Guo, Ningning Liu, Chong Zhao, Haoyu Chen, Xiaoli Wang, Siyan Liao, Ping Zhou, Yuning Liao, Xin Chen, Xiaoying Lan, Jinghong Chen, Dacai Xu, Xiaofen Li, Xianping Shi, Li Yu, Yuqiang Nie, Xuejun Wang, Chang-E Zhang and Jinbao Liu Cell Death Dis 2017 8: e2877; 10.1038/cddis.2017.274 Abstract | Full Text AQP9-induced cell cycle arrest is associated with RAS activation and improves chemotherapy treatment efficacy in colorectal cancer Dandan Huang, Xingzhi Feng, Yiting Liu, Yanhong Deng, Hao Chen, Daici Chen, Lekun Fang, Yue Cai, Huanliang Liu, Lei Wang, Jianping Wang and Zihuan Yang Cell Death Dis 2017 8: e2894; 10.1038/cddis.2017.282 Abstract | Full Text Voluntary distance running prevents TNF-mediated liver injury in mice through alterations of the intrahepatic immune milieu Yvonne Huber, Nadine Gehrke, Jana Biedenbach, Susanne Helmig, Perikles Simon, Beate K Straub, Ina Bergheim, Tobias Huber, Detlef Schuppan, Peter R Galle, Marcus A Wörns, Marcus Schuchmann and Jörn M Schattenberg Cell Death Dis 2017 8: e2893; 10.1038/cddis.2017.266 Abstract | Full Text In vitro expansion impaired the stemness of early passage mesenchymal stem cells for treatment of cartilage defects Tongmeng Jiang, Guojie Xu, Qiuyan Wang, Lihui Yang, Li Zheng, Jinmin Zhao and Xingdong Zhang Cell Death Dis 2017 8: e2851; 10.1038/cddis.2017.215 Abstract | Full Text Long noncoding RNA CRNDE stabilized by hnRNPUL2 accelerates cell proliferation and migration in colorectal carcinoma via activating Ras/MAPK signaling pathways Huijuan Jiang, Yiqing Wang, Meiling Ai, Haowei Wang, Zhijiao Duan, Huanan Wang, Li Zhao, Jiang Yu, Yanqing Ding and Shuang Wang Cell Death Dis 2017 8: e2862; 10.1038/cddis.2017.258 Abstract | Full Text Damage-induced neuronal endopeptidase (DINE) enhances axonal regeneration potential of retinal ganglion cells after optic nerve injury Aoi Kaneko, Sumiko Kiryu-Seo, Sakiko Matsumoto and Hiroshi Kiyama Cell Death Dis 2017 8: e2847; 10.1038/cddis.2017.212 Abstract | Full Text Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers necrosis of B-precursor leukemia cells with high surface CD44 expression Shin Kasai, Yoshiyuki Furuichi, Norie Ando, Keiko Kagami, Masako Abe, Takaya Nakane, Kumiko Goi, Takeshi Inukai, Sei Saitoh, Shinichi Ohno, Shogo Okazaki, Osamu Nagano, Hideyuki Saya and Kanji Sugita Cell Death Dis 2017 8: e2857; 10.1038/cddis.2017.249 Abstract | Full Text BST2 confers cisplatin resistance via NF-κB signaling in nasopharyngeal cancer Chun-mei Kuang, Xiang Fu, Yi-jun Hua, Wen-di Shuai, Zhi-hua Ye, Yingchang Li, Qi-hua Peng, Yi-zhuo Li, Shuai Chen, Chao-nan Qian, Wenlin Huang and Ran-yi Liu Cell Death Dis 2017 8: e2874; 10.1038/cddis.2017.271 Abstract | Full Text KDM2B, an H3K36-specific demethylase, regulates apoptotic response of GBM cells to TRAIL Ibrahim Cagri Kurt, Ilknur Sur, Ezgi Kaya, Ahmet Cingoz, Selena Kazancioglu, Zeynep Kahya, Omer Duhan Toparlak, Filiz Senbabaoglu, Zeynep Kaya, Ezgi Ozyerli, Sercin Karahüseyinoglu, Nathan A Lack, Zeynep H Gümüs, Tamer T Onder and Tugba Bagci-Onder Cell Death Dis 2017 8: e2897; 10.1038/cddis.2017.288 Abstract | Full Text Simvastatin treatment boosts benefits of apoptotic cell infusion in murine lung fibrosis Ye-JI Lee, Meung-Joo Kim, Young-So Yoon, Youn-Hee Choi, Hee-Sun Kim and Jihee Lee Kang Cell Death Dis 2017 8: e2860; 10.1038/cddis.2017.260 Abstract | Full Text Long non-coding RNA ATB promotes malignancy of esophageal squamous cell carcinoma by regulating miR-200b/Kindlin-2 axis Zhongwen Li, Xiaoliang Wu, Ling Gu, Qi Shen, Wen Luo, Chuangzhong Deng, Qianghua Zhou, Xinru Chen, Yanjie Li, ZuanFu Lim, Xing Wang, Jiahong Wang and Xianzi Yang Cell Death Dis 2017 8: e2888; 10.1038/cddis.2017.245 Abstract | Full Text Tumor-suppressive miR-26a and miR-26b inhibit cell aggressiveness by regulating FUT4 in colorectal cancer Yang Li, Zheng Sun, Bing Liu, Yujia Shan, Lifen Zhao and Li Jia Cell Death Dis 2017 8: e2892; 10.1038/cddis.2017.281 Abstract | Full Text Osteoblastic heparan sulfate glycosaminoglycans control bone remodeling by regulating Wnt signaling and the crosstalk between bone surface and marrow cells Rafik Mansouri, Yohann Jouan, Eric Hay, Claudine Blin-Wakkach, Monique Frain, Agnès Ostertag, Carole Le Henaff, Caroline Marty, Valérie Geoffroy, Pierre J Marie, Martine Cohen-Solal and Dominique Modrowski Cell Death Dis 2017 8: e2902; 10.1038/cddis.2017.287 Abstract | Full Text Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury Sofie Martens, Manhyung Jeong, Wulf Tonnus, Friederike Feldmann, Sam Hofmans, Vera Goossens, Nozomi Takahashi, Jan Hinrich Bräsen, Eun-Woo Lee, Pieter Van der Veken, Jurgen Joossens, Koen Augustyns, Simone Fulda, Andreas Linkermann, Jaewhan Song and Peter Vandenabeele Cell Death Dis 2017 8: e2904; 10.1038/cddis.2017.298 Abstract | Full Text Essential but partially redundant roles for POU4F1/Brn-3a and POU4F2/Brn-3b transcription factors in the developing heart Lauren J Maskell, Kashif Qamar, Aram A Babakr, Thomas A Hawkins, Richard J Heads and Vishwanie S Budhram-Mahadeo Cell Death Dis 2017 8: e2861; 10.1038/cddis.2017.185 Abstract | Full Text Oocyte-specific deletion of furin leads to female infertility by causing early secondary follicle arrest in mice Tie-Gang Meng, Meng-Wen Hu, Xue-Shan Ma, Lin Huang, Qiu-Xia Liang, Yue Yuan, Yi Hou, Hongmei Wang, Heide Schatten, Zhen-Bo Wang and Qing-Yuan Sun Cell Death Dis 2017 8: e2846; 10.1038/cddis.2017.231 Abstract | Full Text ARRDC4 regulates enterovirus 71-induced innate immune response by promoting K63 polyubiquitination of MDA5 through TRIM65 Jun Meng, Zhenyu Yao, Yaqing He, Renli Zhang, Yanwei Zhang, Xiangjie Yao, Hong Yang, Long Chen, Zhen Zhang, Hailong Zhang, Xueqin Bao, Gang Hu, Tangchun Wu and Jinquan Cheng Cell Death Dis 2017 8: e2866; 10.1038/cddis.2017.257 Abstract | Full Text Acquired cross-linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption Stefan Meyer, Adam Stevens, Roberto Paredes, Marion Schneider, Michael J Walker, Andrew J K Williamson, Maria-Belen Gonzalez-Sanchez, Stephanie Smetsers, Vineet Dalal, Hsiang Ying Teng, Daniel J White, Sam Taylor, Joanne Muter, Andrew Pierce, Chiara de Leonibus, Davy A P Rockx, Martin A Rooimans, Elaine Spooncer, Stacey Stauffer, Kajal Biswas, Barbara Godthelp, Josephine Dorsman, Peter E Clayton, Shyam K Sharan and Anthony D Whetton Cell Death Dis 2017 8: e2875; 10.1038/cddis.2017.264 Abstract | Full Text Mutant p53 dictates the oncogenic activity of c-Abl in triple-negative breast cancers Chevaun D Morrison, Jenny C Chang, Ruth A Keri and William P Schiemann Cell Death Dis 2017 8: e2899; 10.1038/cddis.2017.294 Abstract | Full Text Ubiquitin-dependent regulation of Cdc42 by XIAP Arun Murali, Jaeyoung Shin, Hajime Yurugi, Aswini Krishnan, Masato Akutsu, Alejandro Carpy, Boris Macek and Krishnaraj Rajalingam Cell Death Dis 2017 8: e2900; 10.1038/cddis.2017.305 Abstract | Full Text Oroxylin A suppresses the development and growth of colorectal cancer through reprogram of HIF1α-modulated fatty acid metabolism Ting Ni, Zihao He, Yuanyuan Dai, Jingyue Yao, Qinglong Guo and Libin Wei Cell Death Dis 2017 8: e2865; 10.1038/cddis.2017.261 Abstract | Full Text HIV integrase inhibitor, Elvitegravir, impairs RAG functions and inhibits V(D)J recombination Mayilaadumveettil Nishana, Namrata M Nilavar, Rupa Kumari, Monica Pandey and Sathees C Raghavan Cell Death Dis 2017 8: e2852; 10.1038/cddis.2017.237 Abstract | Full Text Cdc20 directs proteasome-mediated degradation of the tumor suppressor SMAR1 in higher grades of cancer through the anaphase promoting complex Debasish Paul, Suvankar Ghorai, U S Dinesh, Praveenkumar Shetty, Samit Chattopadhyay and Manas Kumar Santra Cell Death Dis 2017 8: e2882; 10.1038/cddis.2017.270 Abstract | Full Text Disease-linked connexin26 S17F promotes volar skin abnormalities and mild wound healing defects in mice Eric Press, Katanya C Alaga, Kevin Barr, Qing Shao, Felicitas Bosen, Klaus Willecke and Dale W Laird Cell Death Dis 2017 8: e2845; 10.1038/cddis.2017.234 Abstract | Full Text Ochratoxin A-induced autophagy in vitro and in vivo promotes porcine circovirus type 2 replication Gang Qian, Dandan Liu, Junfa Hu, Fang Gan, Lili Hou, Xingxiang Chen and Kehe Huang Cell Death Dis 2017 8: e2909; 10.1038/cddis.2017.303 Abstract | Full Text Mitochondrial AKAP1 supports mTOR pathway and tumor growth Laura Rinaldi, Maria Sepe, Rossella Delle Donne, Kristel Conte, Antonietta Arcella, Domenica Borzacchiello, Stefano Amente, Fernanda De Vita, Monia Porpora, Corrado Garbi, Maria A Oliva, Claudio Procaccini, Deriggio Faicchia, Giuseppe Matarese, Federica Zito Marino, Gaetano Rocco, Sara Pignatiello, Renato Franco, Luigi Insabato, Barbara Majello and Antonio Feliciello Cell Death Dis 2017 8: e2842; 10.1038/cddis.2017.241 Abstract | Full Text Reduced brain UCP2 expression mediated by microRNA-503 contributes to increased stroke susceptibility in the high-salt fed stroke-prone spontaneously hypertensive rat Speranza Rubattu, Rosita Stanzione, Franca Bianchi, Maria Cotugno, Maurizio Forte, Floriana Della Ragione, Salvatore Fioriniello, Maurizio D'Esposito, Simona Marchitti, Michele Madonna, Simona Baima, Giorgio Morelli, Sebastiano Sciarretta, Luigi Sironi, Paolo Gelosa and Massimo Volpe Cell Death Dis 2017 8: e2891; 10.1038/cddis.2017.278 Abstract | Full Text Protein kinase A activation by the anti-cancer drugs ABT-737 and thymoquinone is caspase-3-dependent and correlates with platelet inhibition and apoptosis Natalia Rukoyatkina, Elke Butt, Hariharan Subramanian, Viacheslav O Nikolaev, Igor Mindukshev, Ulrich Walter, Stepan Gambaryan and Peter M Benz Cell Death Dis 2017 8: e2898; 10.1038/cddis.2017.290 Abstract | Full Text Cytoprotective effect of neuropeptides on cancer stem cells: vasoactive intestinal peptide-induced antiapoptotic signaling Konduru S Sastry, Aouatef Ismail Chouchane, Ena Wang, George Kulik, Francesco M Marincola and Lotfi Chouchane Cell Death Dis 2017 8: e2844; 10.1038/cddis.2017.226 Abstract | Full Text Autophagy blockade and lysosomal membrane permeabilization contribute to lead-induced nephrotoxicity in primary rat proximal tubular cells Xiang-Bin Song, Gang Liu, Fei Liu, Zhen-Gui Yan, Zhen-Yong Wang, Zong-Ping Liu and Lin Wang Cell Death Dis 2017 8: e2863; 10.1038/cddis.2017.262 Abstract | Full Text Loss of the novel mitochondrial protein FAM210B promotes metastasis via PDK4-dependent metabolic reprogramming Shujuan Sun, Jia Liu, Meisong Zhao, Yingyan Han, Pingbo Chen, Qingqing Mo, Beibei Wang, Gang Chen, Yong Fang, Yuan Tian, Jianfeng Zhou, Ding Ma, Qinglei Gao and Peng Wu Cell Death Dis 2017 8: e2870; 10.1038/cddis.2017.273 Abstract | Full Text Long noncoding RNA UCA1 induced by SP1 promotes cell proliferation via recruiting EZH2 and activating AKT pathway in gastric cancer Zhen-Qiang Wang, Qiang Cai, Lei Hu, Chang-Yu He, Jian-Fang Li, Zhi-Wei Quan, Bing-Ya Liu, Chen Li and Zheng-Gang Zhu Cell Death Dis 2017 8: e2839; 10.1038/cddis.2017.143 Abstract | Full Text Isodeoxyelephantopin induces protective autophagy in lung cancer cells via Nrf2-p62-keap1 feedback loop Yang Wang, Jing Zhang, Zhi-Hao Huang, Xiao-Hui Huang, Wei-Bin Zheng, Xing-Feng Yin, Yao-Lan Li, Bin Li and Qing-Yu He Cell Death Dis 2017 8: e2876; 10.1038/cddis.2017.265 Abstract | Full Text Inhibition of cancer growth in vitro and in vivo by a novel ROS-modulating agent with ability to eliminate stem-like cancer cells Jiankang Wang, Bingling Luo, Xiaobing Li, Wenhua Lu, Jing Yang, Yumin Hu, Peng Huang and Shijun Wen Cell Death Dis 2017 8: e2887; 10.1038/cddis.2017.272 Abstract | Full Text Role of peroxiredoxin2 downregulation in recurrent miscarriage through regulation of trophoblast proliferation and apoptosis Fan Wu, Fuju Tian, Weihong Zeng, Xiaorui Liu, Jianxia Fan, Yi Lin and Yan Zhang Cell Death Dis 2017 8: e2908; 10.1038/cddis.2017.301 Abstract | Full Text Promoting tumorigenesis in nasopharyngeal carcinoma, NEDD8 serves as a potential theranostic target Ping Xie, Jun-Ping Yang, Yun Cao, Li-Xia Peng, Li-Sheng Zheng, Rui Sun, Dong-Fang Meng, Meng-Yao Wang, Yan Mei, Yuan-Yuan Qiang, Li Cao, Yan-Qun Xiang, Dong-Hua Luo, Jing-Ping Yun, Bi-Jun Huang, Li-Jun Jia and Chao-Nan Qian Cell Death Dis 2017 8: e2834; 10.1038/cddis.2017.195 Abstract | Full Text E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis Tong-Peng Xu, Yan-Fen Wang, Wei-Liang Xiong, Pei Ma, Wen-Yu Wang, Wen-Ming Chen, Ming-De Huang, Rui Xia, Rong Wang, Er-Bao Zhang, Yan-Wen Liu, Wei De and Yong-Qian Shu Cell Death Dis 2017 8: e2837; 10.1038/cddis.2017.205 Abstract | Full Text RGD-modified oncolytic adenovirus-harboring shPKM2 exhibits a potent cytotoxic effect in pancreatic cancer via autophagy inhibition and apoptosis promotion Yanni Xu, Liang Chu, Sujing Yuan, Yuanqin Yang, Yu Yang, Bin Xu, Kangjian Zhang, Xin-Yuan Liu, Ruwei Wang, Ling Fang, Zhinan Chen and Zongsuo Liang Cell Death Dis 2017 8: e2835; 10.1038/cddis.2017.230 Abstract | Full Text Histone deacetylase 3 overexpression in human cholangiocarcinoma and promotion of cell growth via apoptosis inhibition Yuyao Yin, Mingming Zhang, Robert Gregory Dorfman, Yang Li, Zhenguo Zhao, Yida Pan, Qian Zhou, Shan Huang, Shimin Zhao, Yuling Yao and Xiaoping Zou Cell Death Dis 2017 8: e2856; 10.1038/cddis.2016.457 Abstract | Full Text Loss of epidermal AP1 transcription factor function reduces filaggrin level, alters chemokine expression and produces an ichthyosis-related phenotype Christina A Young, Ellen A Rorke, Gautam Adhikary, Wen Xu and Richard L Eckert Cell Death Dis 2017 8: e2840; 10.1038/cddis.2017.238 Abstract | Full Text Connective tissue growth factor promotes temozolomide resistance in glioblastoma through TGF-β1-dependent activation of Smad/ERK signaling Huijun Zeng, Zhao Yang, Ningbo Xu, Boyang Liu, Zhao Fu, Changlin Lian and Hongbo Guo Cell Death Dis 2017 8: e2885; 10.1038/cddis.2017.248 Abstract | Full Text Deficiency of pigment epithelium-derived factor in nasopharyngeal carcinoma cells triggers the epithelial–mesenchymal transition and metastasis Ting Zhang, Ping Yin, Zichen Zhang, Banglao Xu, Di Che, Zhiyu Dai, Chang Dong, Ping Jiang, Honghai Hong, Zhonghan Yang, Ti Zhou, Jianyong Shao, Zumin Xu, Xia Yang and Guoquan Gao Cell Death Dis 2017 8: e2838; 10.1038/cddis.2017.114 Abstract | Full Text Interaction between autophagy and senescence is required for dihydroartemisinin to alleviate liver fibrosis Zili Zhang, Zhen Yao, Shifeng Zhao, Jiangjuan Shao, Anping Chen, Feng Zhang and Shizhong Zheng Cell Death Dis 2017 8: e2886; 10.1038/cddis.2017.255 Abstract | Full Text EIF3D promotes gallbladder cancer development by stabilizing GRK2 kinase and activating PI3K-AKT signaling pathway Fei Zhang, Shanshan Xiang, Yang Cao, Maolan Li, Qiang Ma, Haibin Liang, Huaifeng Li, Yuanyuan Ye, Yijian Zhang, Lin Jiang, Yunping Hu, Jian Zhou, Xuefeng Wang, Yong Zhang, Lei Nie, Xiao Liang, Wei Gong and Yingbin Liu Cell Death Dis 2017 8: e2868; 10.1038/cddis.2017.263 Abstract | Full Text The role of MAP2 kinases and p38 kinase in acute murine liver injury models Jun Zhang, Robert W M Min, Khanh Le, Sheng Zhou, Mariam Aghajan, Tin A Than, Sanda Win and Neil Kaplowitz Cell Death Dis 2017 8: e2903; 10.1038/cddis.2017.295 Abstract | Full Text EGR-1/ASPP1 inter-regulatory loop promotes apoptosis by inhibiting cyto-protective autophagy Kunming Zhao, Miao Yu, Yifu Zhu, Dong Liu, Qiong Wu and Ying Hu Cell Death Dis 2017 8: e2869; 10.1038/cddis.2017.268 Abstract | Full Text MiR-125b regulates proliferation and apoptosis of nasopharyngeal carcinoma by targeting A20/NF-κB signaling pathway Zhen Zheng, Jia-Quan Qu, Hong-Mei Yi, Xu Ye, Wei Huang, Ta Xiao, Jiao-Yang Li, Yuan-Yuan Wang, Juan Feng, Jin-Feng Zhu, Shan-Shan Lu, Hong Yi and Zhi-Qiang Xiao Cell Death Dis 2017 8: e2855; 10.1038/cddis.2017.211 Abstract | Full Text Cystatin C as a potential therapeutic mediator against Parkinson’s disease via VEGF-induced angiogenesis and enhanced neuronal autophagy in neurovascular units Jing Zou, Zhaoyu Chen, Xiaobo Wei, Zhigang Chen, Yongmei Fu, Xiaoyan Yang, Dan Chen, Rui Wang, Peter Jenner, Jia-Hong Lu, Min Li, Zhuohua Zhang, Beisha Tang, Kunlin Jin and Qing Wang Cell Death Dis 2017 8: e2854; 10.1038/cddis.2017.240 Abstract | Full Text Correspondence Top EMT-Regulome: a database for EMT-related regulatory interactions, motifs and network Zhangxiang Zhao, Wenbin Zhou, Yue Han, Fuduan Peng, Ruiping Wang, Ruihan Yu, Chengyu Wang, Haihai Liang, Zheng Guo and Yunyan Gu Cell Death Dis 2017 8: e2872; 10.1038/cddis.2017.267 Full Text A hypoxia-inducible factor 1α null splice variant lacking exon 10 Xiangyu Zhou, Weijia Zeng, Rui Peng and Hongyan Wang Cell Death Dis 2017 8: e2873; 10.1038/cddis.2017.269 Full Text Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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