The EMBO Journal Table of Contents for 2 May 2017; Vol. 36, No. 9

2 May 2017 | Volume 36, Number 9 Submit Table of Contents News & Views Review Articles Volume 36, Number 9 News & Views TRAIL‐ and TNF‐induced signaling complexes—so similar yet so different The recent implication of LUBAC and other NF‐κB activators in TRAIL death receptor complexes demands new models for the bifurcation of cytotoxic and pro‐inflammatory signaling. Harald Wajant Published online 11.04.2017 Cut in translation: ribosome‐dependent mRNA decay Bacterial RNase Rae1 cleaves mRNAs undergoing active translation in a codon‐specific manner, thus highlighting the tight coupling between transcription and translation in prokaryotes. David Lalaouna and Eric Massé Published online 10.04.2017 Review Non‐coding RNAs: the dark side of nuclear–mitochondrial communication The crosstalk between nuclear genome activity and mitochondrial function relies on multiple mechanisms, involving signal transduction and transcriptional control. This review summarizes and reflects on how the rapidly growing pool of non‐coding RNAs contributes to this process. Roberto Vendramin, Jean‐Christophe Marine, and Eleonora Leucci Published online 17.03.2017 Articles Uncoupling of neurogenesis and differentiation during retinal development In vivo cell lineage tracking shows that developing neurons in the zebrafish retina do not adhere to a stereotypic neurogenesis‐migration‐differentiation sequence, but that there is unexpected flexibility in neurodevelopmental programs. Peter Engerer, Sachihiro C Suzuki, Takeshi Yoshimatsu, Prisca Chapouton, Nancy Obeng, Benjamin Odermatt, Philip R Williams, Thomas Misgeld, and Leanne Godinho Published online 03.03.2017 The linear ubiquitin chain assembly complex regulates TRAIL‐induced gene activation and cell death LUBAC emerges as a crucial component of TRAIL signalling complexes I and II, restricting apoptosis and necroptosis while promoting cytokine production. Elodie Lafont, Chahrazade Kantari‐Mimoun, Peter Draber, Diego De Miguel, Torsten Hartwig, Matthias Reichert, Sebastian Kupka, Yutaka Shimizu, Lucia Taraborrelli, Maureen Spit, Martin R Sprick, and Henning Walczak Published online 03.03.2017 Rae1/YacP, a new endoribonuclease involved in ribosome‐dependent mRNA decay in Bacillus subtilis The discovery of a ribosome‐binding RNase that cleaves its mRNA substrates in a reading frame‐dependent manner expands the toolkit for post‐transcriptional control in bacteria. Magali Leroy, Jérémie Piton, Laetitia Gilet, Olivier Pellegrini, Caroline Proux, Jean‐Yves Coppée, Sabine Figaro, and Ciarán Condon Published online 31.03.2017 An ATR‐dependent function for the Ddx19 RNA helicase in nuclear R‐loop metabolism A nucleopore‐associated mRNA export factor has an unexpected, distinct nuclear role in genome stability maintenance after DNA damage. Dana Hodroj, Bénédicte Recolin, Kamar Serhal, Susan Martinez, Nikolay Tsanov, Raghida Abou Merhi, and Domenico Maiorano Published online 17.03.2017 Sex‐specific, reciprocal regulation of ERα and miR‐22 controls muscle lipid metabolism in male mice ERα binds the miRNA‐22 precursor and prevents its processing, while mature miR‐22 represses ERα translation. This feedback loop leads to sex‐specific levels of ERα in muscle with consequences for muscular lipid metabolism and body weight. Judith Schweisgut, Christian Schutt, Stas Wüst, Astrid Wietelmann, Bart Ghesquière, Peter Carmeliet, Stefan Dröse, Kenneth S Korach, Thomas Braun, and Thomas Boettger Published online 17.03.2017 miR‐31 mutants reveal continuous glial homeostasis in the adult Drosophila brain The adult fly brain shows continued glial turnover mediated by a novel miR‐31a‐expressing gliogenic progenitor pool. Lynette Caizhen Foo, Shilin Song, and Stephen Michael Cohen Published online 20.03.2017 MTCL1 plays an essential role in maintaining Purkinje neuron axon initial segment Loss of MTCL1‐dependent microtubule stabilization affects localization of the ankyrin‐G scaffold, causing Purkinje cell degeneration and abnormal motor coordination. Tomoko Satake, Kazunari Yamashita, Kenji Hayashi, Satoko Miyatake, Miwa Tamura‐Nakano, Hiroshi Doi, Yasuhide Furuta, Go Shioi, Eriko Miura, Yukari H Takeo, Kunihiro Yoshida, Hiroyuki Yahikozawa, Naomichi Matsumoto, Michisuke Yuzaki, and Atsushi Suzuki Published online 10.03.2017 A covalently bound inhibitor triggers EZH2 degradation through CHIP‐mediated ubiquitination Aberrant activation of PRC2 can block expression of key tumor suppressors and contribute to oncogenesis. The discovery of a drug that triggers specific degradation of PRC2 component EZH2 offers a new therapeutic strategy for cancer treatment. Xu Wang, Wei Cao, Jianjun Zhang, Ming Yan, Qin Xu, Xiangbing Wu, Lixin Wan, Zhiyuan Zhang, Chenping Zhang, Xing Qin, Meng Xiao, Dongxia Ye, Yuyang Liu, Zeguang Han, Shaomeng Wang, Li Mao, Wenyi Wei, and Wantao Chen Published online 20.03.2017 Arabidopsis RETINOBLASTOMA RELATED directly regulates DNA damage responses through functions beyond cell cycle control The tumor suppressor plant homolog transcriptionally regulates damage response and cell death pathways, but also directly cooperates with the repair factor BRCA1 to maintain genome integrity after damage. Beatrix M Horvath, Hana Kourova, Szilvia Nagy, Edit Nemeth, Zoltan Magyar, Csaba Papdi, Zaki Ahmad, Gabino F Sanchez‐Perez, Serena Perilli, Ikram Blilou, Aladár Pettkó‐Szandtner, Zsuzsanna Darula, Tamas Meszaros, Pavla Binarova, Laszlo Bogre, and Ben Scheres Published online 20.03.2017 The retinoblastoma homolog RBR1 mediates localization of the repair protein RAD51 to DNA lesions in Arabidopsis In plants, the conserved transcriptional repressor of cell cycle and DNA repair genes has a surprising additional function directly at DNA break sites. Sascha Biedermann, Hirofumi Harashima, Poyu Chen, Maren Heese, Daniel Bouyer, Kostika Sofroni, and Arp Schnittger Published online 20.03.2017   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.