Nature Reviews Genetics Contents June 2017 Volume 18 Number 6 pp 327-389

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TABLE OF CONTENTS
June 2017 Volume 18 Number 6		Advertisement
2015 2-year Impact Factor 35.898 Journal Metrics 2-year Median 32	In this issue Research Highlights Reviews Also this month Article series: Disease mechanisms Single-cell omics Translational genetics Modes of transcriptional regulation  Featured article: Scaling by shrinking: empowering single-cell 'omics' with microfluidic devices Sanjay M. Prakadan, Alex K. Shalek & David A. Weitz	npj Precision Oncology is a new open access, online-only, peer-reviewed journal committed to publishing cutting-edge scientific research in all aspects of precision oncology from basic science to translational applications, to clinical medicine. The journal is part of the Nature Partner Journals series and published in partnership with The Hormel Institute, University of Minnesota. Explore the benefits of submitting your manuscript.
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RESEARCH HIGHLIGHTS Top Genome organization: In the beginning there was order p327 | doi:10.1038/nrg.2017.37 PDF Technique: A mosaic of enhancer function in single cells p328 | doi:10.1038/nrg.2017.34 PDF Mutations: Dawn of the Human Knockout Project p328 | doi:10.1038/nrg.2017.35 PDF Evolutionary genetics: Fantastic beasts — cephalopod RNA recoding p329 | doi:10.1038/nrg.2017.31 PDF Nature Reviews Genetics JOBS of the week Postdoctoral Fellows in Statistical Genetics / Computational Biology Columbia University Postdoctoral positions in Cancer Genetics and / or CRISPR screens at MD Anderson The University of Texas MD Anderson Cancer Center Postdoctoral / Graduate Student Positions - Medical Genetics University of Alberta Post-doctoral Positions in Skeletal muscle Stem Cells and molecular medicine Biology of the neuromuscular system Team IMRB U955-E10 Bioinformatician or Statistician for Genomics, Systems Biology and mining of Big clinical data in brain disorders: A collaboration between University of Copenhagen (DK) and the Broad Institute (US) Capital Region of Denmark More Science jobs from Nature Reviews Genetics EVENT The 6th Genetics and Genomics Conference (GC 2017) 01.12.17 Sanya, China More science events from
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REVIEWS		Top
Article series: Disease mechanisms Genetics of coronary artery disease: discovery, biology and clinical translation Amit V. Khera & Sekar Kathiresan p331 | doi:10.1038/nrg.2016.160 The past decade has seen tremendous progress in understanding the genetic architecture of coronary artery disease (CAD). Khera and Kathiresan review research efforts that have improved our understanding of the genetic drivers of CAD, and discuss the promises and challenges of integrating genetic information into routine clinical practice. Abstract | Full Text | PDF
Article series: Single-cell omics Scaling by shrinking: empowering single-cell 'omics' with microfluidic devices Sanjay M. Prakadan, Alex K. Shalek & David A. Weitz p345 | doi:10.1038/nrg.2017.15 As the genetic and phenotypic heterogeneities among cells become more appreciated, there is increasing demand for technologies that facilitate high-throughput and high-efficiency single-cell 'omic' analyses in miniaturized and automated formats. This Review discusses the diverse microfluidic methodologies — with a primary focus on valve-, droplet- and nanowell-based platforms — for characterization of the genomes, epigenomes, transcriptomes and proteomes of single cells, and addresses technical considerations and future opportunities. Abstract | Full Text | PDF
Article series: Translational genetics Autism genetics: opportunities and challenges for clinical translation Jacob A. S. Vorstman, Jeremy R. Parr, Daniel Moreno-De-Luca, Richard J. L. Anney, John I. Nurnberger Jr & Joachim F. Hallmayer p362 | doi:10.1038/nrg.2017.4 Various large studies have provided unprecedented insights into the genetics of autism spectrum disorders (ASDs). This Review discusses the challenges and opportunities of translating genetic and biological insights into clinical progress for ASDs, in areas including genetic testing, ASD classification, genetic counselling, comorbidities and therapeutics. Abstract | Full Text | PDF | Supplementary information
Article series: Modes of transcriptional regulation The X chromosome in space Teddy Jegu, Eric Aeby & Jeannie T. Lee p377 | doi:10.1038/nrg.2017.17 Three-dimensional genome organization can shape gene expression by facilitating interactions between regulatory elements. The authors review the process of X-chromosome inactivation with a focus on chromatin organization and subnuclear localization of the active and inactive X chromosomes, as well as the potential roles of long non-coding RNAs. Abstract | Full Text | PDF
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