Tuesday, May 16, 2017

Nature Reviews Genetics Contents June 2017 Volume 18 Number 6 pp 327-389

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Nature Reviews Genetics

A new open access journal dedicated to publishing the most important scientific advances in all aspects of genomics and its application in the practice of medicine.

Part of the Nature Partner Journals series, the journal is published in partnership with the Center of Excellence in Genomic Medicine Research. 

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Nature Reviews Genetics cover
2015 2-year Impact Factor 35.898 Journal Metrics 2-year Median 32
In this issue
Research Highlights

Also this month
Article series:
Disease mechanisms
Single-cell omics
Translational genetics
Modes of transcriptional regulation
 Featured article:
Scaling by shrinking: empowering single-cell 'omics' with microfluidic devices
Sanjay M. Prakadan, Alex K. Shalek & David A. Weitz

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The 1st Symposium on Nucleic Acid Modifications will bring together key players in the previously segregated fields of RNA and DNA modifications, which are now merging to create a brand new interdisciplinary research field that includes chemical biology, structural biology, bioinformatics, biophysics and cell biology, developmental biology and epigenetics. The symposium will outline the major developments in this rapidly developing field, and includes talks from leaders in this exciting area of study. www.imb.de/2017nucmod  

September 27-29, 2017 | Seoul, Korea

Presented by: Institute for Basic Science | Institute of Genetics and Developmental Biology, CAS | Nature | Nature Biotechnology


September 17-19, 2017 | Seattle, WA, USA

Presented by: Adaptive Biotechnologies | Nature Immunology | Nature Medicine | Nature Biotechnology


Genome organization: In the beginning there was order
p327 | doi:10.1038/nrg.2017.37

Technique: A mosaic of enhancer function in single cells
p328 | doi:10.1038/nrg.2017.34

Mutations: Dawn of the Human Knockout Project
p328 | doi:10.1038/nrg.2017.35

Evolutionary genetics: Fantastic beasts — cephalopod RNA recoding
p329 | doi:10.1038/nrg.2017.31

Nature Reviews Genetics
JOBS of the week
Postdoctoral Fellows in Statistical Genetics / Computational Biology
Columbia University
Postdoctoral positions in Cancer Genetics and / or CRISPR screens at MD Anderson
The University of Texas MD Anderson Cancer Center
Postdoctoral / Graduate Student Positions - Medical Genetics
University of Alberta
Post-doctoral Positions in Skeletal muscle Stem Cells and molecular medicine
Biology of the neuromuscular system Team IMRB U955-E10
Bioinformatician or Statistician for Genomics, Systems Biology and mining of Big clinical data in brain disorders: A collaboration between University of Copenhagen (DK) and the Broad Institute (US)
Capital Region of Denmark
More Science jobs from
Nature Reviews Genetics
The 6th Genetics and Genomics Conference (GC 2017)
Sanya, China
More science events from
AGRICULTURAL GENOMICS 2017 - Functional Genomics toward Green Crops for Sustainable Agriculture 

Hosting Organizations: National Key Laboratory of Crop Genetic Improvement | Huazhong Agricultural University | Nature Genetics | Nature Plants | Nature Communications

October 25-27, 2017
Conference Hall, National Key Laboratory of Crop Genetic Improvement | Wuhan, China
Article series: Disease mechanisms
Genetics of coronary artery disease: discovery, biology and clinical translation
Amit V. Khera & Sekar Kathiresan
p331 | doi:10.1038/nrg.2016.160
The past decade has seen tremendous progress in understanding the genetic architecture of coronary artery disease (CAD). Khera and Kathiresan review research efforts that have improved our understanding of the genetic drivers of CAD, and discuss the promises and challenges of integrating genetic information into routine clinical practice.
Abstract | Full Text | PDF

Article series: Single-cell omics
Scaling by shrinking: empowering single-cell 'omics' with microfluidic devices
Sanjay M. Prakadan, Alex K. Shalek & David A. Weitz
p345 | doi:10.1038/nrg.2017.15
As the genetic and phenotypic heterogeneities among cells become more appreciated, there is increasing demand for technologies that facilitate high-throughput and high-efficiency single-cell 'omic' analyses in miniaturized and automated formats. This Review discusses the diverse microfluidic methodologies — with a primary focus on valve-, droplet- and nanowell-based platforms — for characterization of the genomes, epigenomes, transcriptomes and proteomes of single cells, and addresses technical considerations and future opportunities.
Abstract | Full Text | PDF

Article series: Translational genetics
Autism genetics: opportunities and challenges for clinical translation
Jacob A. S. Vorstman, Jeremy R. Parr, Daniel Moreno-De-Luca, Richard J. L. Anney, John I. Nurnberger Jr & Joachim F. Hallmayer
p362 | doi:10.1038/nrg.2017.4
Various large studies have provided unprecedented insights into the genetics of autism spectrum disorders (ASDs). This Review discusses the challenges and opportunities of translating genetic and biological insights into clinical progress for ASDs, in areas including genetic testing, ASD classification, genetic counselling, comorbidities and therapeutics.
Abstract | Full Text | PDF | Supplementary information

Article series: Modes of transcriptional regulation
The X chromosome in space
Teddy Jegu, Eric Aeby & Jeannie T. Lee
p377 | doi:10.1038/nrg.2017.17
Three-dimensional genome organization can shape gene expression by facilitating interactions between regulatory elements. The authors review the process of X-chromosome inactivation with a focus on chromatin organization and subnuclear localization of the active and inactive X chromosomes, as well as the potential roles of long non-coding RNAs.
Abstract | Full Text | PDF

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