Wednesday, May 17, 2017

Nature Communications - 17 May 2017

Nature Communications

Nature Outlook: Animal Health

Animal and human health are closely linked. This Outlook examines how climate change is pushing diseases into formerly 'safe' regions of the world, the challenges in treating parasites, the efforts to vaccinate gorillas against Ebola and how a holistic approach to disease could further the well-being of animals. 

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17 May 2017 
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Nature Research symposium: Metamaterials and Grand Challenges

Nature Communications, Nature Materials and Nature Photonics present a symposium which will cover the potential of metamaterials to address the so-called "grand challenges" in research. The symposium will take place at the upcoming Metamaterials'2017 conference in Marseille, 28 August — 2 September. 

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Presented by: Ospedale San Raffaele | Nature

The conference will feature sessions on regeneration in animal models, functional and dysfunctional regeneration in mammals, and new therapeutic approaches to regeneration.

November 16-18, 2017 | Milan, Italy
  Latest Articles View all Articles  
A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice OPEN
Monica M. Laronda, Alexandra L. Rutz, Shuo Xiao, Kelly A. Whelan, Francesca E. Duncan, Eric W. Roth, Teresa K. Woodruff and Ramille N. Shah
There is a clinical need to develop a bioengineering system to support ovary transplantation. Here, the authors generate a bioprosthetic ovary using 3D printed scaffolds of varying pore architectures to support follicle survival and ovarian function in sterilized mice.
16 May 2017 | doi: 10.1038/ncomms15261

Inferring personal economic status from social network location OPEN
Shaojun Luo, Flaviano Morone, Carlos Sarraute, Matías Travizano and Hernán A. Makse
It is believed that patterns of social ties are related to individuals’ financial status. Here the authors substantiate this concept by quantitatively demonstrating that a measure of an individual’s location and influence within their social network can be used to infer their economic wellness.
16 May 2017 | doi: 10.1038/ncomms15227

Onset of meso-scale turbulence in active nematics OPEN
Amin Doostmohammadi, Tyler N. Shendruk, Kristian Thijssen and Julia M. Yeomans
Bacteria continuously inject energy into their surroundings and thus induce chaotic like flows, namely meso-scale turbulence. Here, the authors show that transition to meso-scale turbulence and inertial turbulence observed in pipes share the same scaling behavior that belongs to the directed percolation universality class.
16 May 2017 | doi: 10.1038/ncomms15326

High precision hyperfine measurements in Bismuth challenge bound-state strong-field QED OPEN
Johannes Ullmann, Zoran Andelkovic, Carsten Brandau, Andreas Dax, Wolfgang Geithner, Christopher Geppert, Christian Gorges, Michael Hammen, Volker Hannen, Simon Kaufmann, Kristian König, Yuri A. Litvinov, Matthias Lochmann, Bernhard Maaß, Johann Meisner, Tobias Murböck, Rodolfo Sánchez, Matthias Schmidt, Stefan Schmidt, Markus Steck et al.
Precision measurements provide a sensitive test of fundamental constants and their uncertainties. Here the authors precisely measure the hyperfine structure splitting in bismuth ions, and report significant discrepancy with the theoretical prediction of quantum electrodynamics.
16 May 2017 | doi: 10.1038/ncomms15484

Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis OPEN
Mei Zhou, Hong Yang, R. Marc Learned, Hui Tian and Lei Ling
Fibroblast Growth Factor 19 (FGF19) neutralizing antibodies inhibit hepatocellular carcinoma (HCC) growth but have safety issues. Here, the authors show that FGF19 promotes HCC by activating STAT3 signalling via IL-6 production and that targeting IL-6 pathway abolishes FGF19-induced HCC without side effects.
16 May 2017 | doi: 10.1038/ncomms15433

South-American plate advance and forced Andean trench retreat as drivers for transient flat subduction episodes OPEN
Gerben Schepers, Douwe J. J. van Hinsbergen, Wim Spakman, Martha E. Kosters, Lydian M. Boschman and Nadine McQuarrie
How flat slabs at subduction zones are created remains unclear. Here, the authors show that the Nazca slab has retreated at ∼2 cm per year since 50 Ma but no rollback has occurred in the last ∼12 Myr in the flat slab, implying that an overpressured sub-slab mantle can impede rollback and maintain a flat slab.
16 May 2017 | doi: 10.1038/ncomms15249

Injection and controlled motion of conducting domain walls in improper ferroelectric Cu-Cl boracite OPEN
Raymond G.P. McQuaid, Michael P. Campbell, Roger W. Whatmore, Amit Kumar and J. Marty Gregg
Conducting ferroelectric domain walls constitute a new class of functional material, but to achieve site-specific injection and annihilation of such walls is challenging. Here, McQuaid et al. report site-specific injection of such walls in Cu3B7O13Cl created by local point-stress and controlled by electric field.
16 May 2017 | doi: 10.1038/ncomms15105

Whole genome analysis of a schistosomiasis-transmitting freshwater snail OPEN
Coen M. Adema, LaDeana W. Hillier, Catherine S. Jones, Eric S. Loker, Matty Knight, Patrick Minx, Guilherme Oliveira, Nithya Raghavan, Andrew Shedlock, Laurence Rodrigues do Amaral, Halime D. Arican-Goktas, Juliana G. Assis, Elio Hideo Baba, Olga L. Baron, Christopher J. Bayne, Utibe Bickham-Wright, Kyle K. Biggar, Michael Blouin, Bryony C. Bonning, Chris Botka et al.
Biomphalaria glabrata is a fresh water snail that acts as a host for trematode Schistosoma mansoni that causes intestinal infection in human. This work describes the genome and transcriptome analyses from 12 different tissues of B glabrata, and identify genes for snail behavior and evolution.
16 May 2017 | doi: 10.1038/ncomms15451

Post-supereruption recovery at Toba Caldera OPEN
Adonara E. Mucek, Martin Danišík, Shanaka L. de Silva, Axel K. Schmitt, Indyo Pratomo and Matthew A. Coble
Toba Caldera in Indonesia had one of the largest volcanic eruptions over the last 100 kyr and has since undergone periods of resurgence. Here, the authors present zircon and sediment age data showing resurgence started after the climactic eruption and lasted until 2.7 ka, advancing west and south.
16 May 2017 | doi: 10.1038/ncomms15248

Mutant KRAS promotes malignant pleural effusion formation OPEN
Theodora Αgalioti, Anastasios D. Giannou, Anthi C. Krontira, Nikolaos I. Kanellakis, Danai Kati, Malamati Vreka, Mario Pepe, Μagda Spella, Ioannis Lilis, Dimitra E. Zazara, Eirini Nikolouli, Nikolitsa Spiropoulou, Andreas Papadakis, Konstantina Papadia, Apostolos Voulgaridis, Vaggelis Harokopos, Panagiota Stamou, Silke Meiners, Oliver Eickelberg, Linda A. Snyder et al.
Malignant pleural effusion (MPE) is a lethal condition associated with various cancers. Here, the authors show that cancer cells with KRAS mutations promote MPE by recruiting myeloid cells via CCL2 signalling and that pharmaceutical targeting of KRAS results in reduced MPE incidence and volume in mouse models.
16 May 2017 | doi: 10.1038/ncomms15205

Controlling photophysical properties of ultrasmall conjugated polymer nanoparticles through polymer chain packing OPEN
Hubert Piwoński, Tsuyoshi Michinobu and Satoshi Habuchi
Synthesis of small conjugated polymer nanoparticles (Pdots) with bright and stable fluorescence is an active challenge. Here, the authors introduce a strategy to fabricate ultrasmall Pdots with high fluorescence intensity by using twisted, rather than planar, conjugated polymers, lending new insight into the molecular design of Pdots.
16 May 2017 | doi: 10.1038/ncomms15256

Joint morphogenetic cells in the adult mammalian synovium OPEN
Anke J. Roelofs, Janja Zupan, Anna H. K. Riemen, Karolina Kania, Sharon Ansboro, Nathan White, Susan M. Clark and Cosimo De Bari
The stem cells that maintain and repair adult joint tissues in mammals, including articular cartilage, remain incompletely defined. Here the authors perform lineage tracing studies in adult mice and find an ontogenetically defined progenitor cell population that is functional in the synovial joint and distinct from previously reported mesenchymal stem cell populations.
16 May 2017 | doi: 10.1038/ncomms15040

An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors OPEN
David P. Scanlon, Alaji Bah, Mickaël Krzeminski, Wenbo Zhang, Heather L. Leduc-Pessah, Yi Na Dong, Julie D. Forman-Kay and Michael W. Salter
N-methyl D-aspartate receptor (NMDAR) activity is modulated by Src tyrosine kinase via the mitochondrial protein NADH dehydrogenase subunit 2 (ND2). Here the authors show that ND2 interacts with the transmembrane region of NMDAR GluN1 subunit, a process that is crucial for Src regulation of NMDAR activity.
16 May 2017 | doi: 10.1038/ncomms15220

Plastic roles of pericytes in the blood–retinal barrier OPEN
Do Young Park, Junyeop Lee, Jaeryung Kim, Kangsan Kim, Seonpyo Hong, Sangyeul Han, Yoshiaki Kubota, Hellmut G. Augustin, Lei Ding, Jin Woo Kim, Hail Kim, Yulong He, Ralf H. Adams and Gou Young Koh
Blood-retinal barrier (BRB) is composed of tightly connected endothelium and supporting pericytes and glia. Here, the authors show that pericytes are crucial for BRB buildup during retinal development and its maintenance in adult retinas in response to VEGF-A-induced endothelial sensitization by regulating the Tie2/FOXO1/Ang2 axis.
16 May 2017 | doi: 10.1038/ncomms15296

Exosomes maintain cellular homeostasis by excreting harmful DNA from cells OPEN
Akiko Takahashi, Ryo Okada, Koji Nagao, Yuka Kawamata, Aki Hanyu, Shin Yoshimoto, Masaki Takasugi, Sugiko Watanabe, Masato T Kanemaki, Chikashi Obuse and Eiji Hara
The role of exosomes in intercellular communication is well established, however less in known about the biological roles of exosome secretion in exosome-secreting cells. Here the authors show that exosome secretion controls cellular homeostasis in exosome-secreting cells by removing harmful cytoplasmic DNA from cells.
16 May 2017 | doi: 10.1038/ncomms15287

Voltage-controlled interlayer coupling in perpendicularly magnetized magnetic tunnel junctions OPEN
T. Newhouse-Illige, Yaohua Liu, M. Xu, D. Reifsnyder Hickey, A. Kundu, H. Almasi, Chong Bi, X. Wang, J. W. Freeland, D. J. Keavney, C. J. Sun, Y. H. Xu, M. Rosales, X. M. Cheng, Shufeng Zhang, K. A. Mkhoyan and W. G. Wang
Exploring electric field controlled magnetism enables high efficiency and low energy consumption spintronic devices. Here, by manipulating oxygen vacancies and magnetic moment, the authors achieve voltage control of magnetic interlayer coupling in GdO x based magnetic tunnel junctions.
16 May 2017 | doi: 10.1038/ncomms15232

An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role OPEN
Kannan Natarajan, Andrew C. McShan, Jiansheng Jiang, Vlad K Kumirov, Rui Wang, Huaying Zhao, Peter Schuck, Mulualem E. Tilahun, Lisa F. Boyd, Jinfa Ying, Ad Bax, David H. Margulies and Nikolaos G. Sgourakis
Binding of T cell receptors (TCR) to peptide-loaded major histocompatibility complexes (p/MHC) leads to T-cell activation. Here the authors give structural insights into T-cell signalling and show that p/MHC binding induces conformational changes at the membrane-proximal site of the TCR.
16 May 2017 | doi: 10.1038/ncomms15260

Power generator driven by Maxwell’s demon OPEN
Kensaku Chida, Samarth Desai, Katsuhiko Nishiguchi and Akira Fujiwara
The study of Maxwell's demon provides a link between information thermodynamics and modern electronics. Using integrated nanometer-scale transistors in a single electron box configuration, Chida et al., demonstrate the extraction of electrical power by Maxwell’s demon.
16 May 2017 | doi: 10.1038/ncomms15301

Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells OPEN
Sandra Tavares, André Filipe Vieira, Anna Verena Taubenberger, Margarida Araújo, Nuno Pimpao Martins, Catarina Brás-Pereira, António Polónia, Maik Herbig, Clara Barreto, Oliver Otto, Joana Cardoso, José B. Pereira-Leal, Jochen Guck, Joana Paredes and Florence Janody
When cells acquire a malignant phenotype they become less stiff and this helps migration and invasion favouring metastasis. Here the authors show that Src-driven cell transformation and transition to a less stiff state follows an event of membrane stiffening due to stress fibres accumulation.
16 May 2017 | doi: 10.1038/ncomms15237

Nanogenerator-based dual-functional and self-powered thin patch loudspeaker or microphone for flexible electronics OPEN
Wei Li, David Torres, Ramón Díaz, Zhengjun Wang, Changsheng Wu, Chuan Wang, Zhong Lin Wang and Nelson Sepúlveda
Self-powered nanogenerators by harvesting energy from the environment are desirable for future portable and wearable electronics. Li et al. show the use of ferroelectret nanogenerators to build microphone or loudspeaker, which convert electrical signals to mechanical motions in a reversible manner.
16 May 2017 | doi: 10.1038/ncomms15310

Anthropogenic iron oxide aerosols enhance atmospheric heating OPEN
Nobuhiro Moteki, Kouji Adachi, Sho Ohata, Atsushi Yoshida, Tomoo Harigaya, Makoto Koike and Yutaka Kondo
Iron oxide nanoparticles contribute to shortwave absorption in the form of desert dust. Moteki et al. show that iron oxide particles of anthropogenic origin, potentially from motor vehicles and blast furnaces, also contribute to atmospheric heating over East Asia.
16 May 2017 | doi: 10.1038/ncomms15329

A hybrid cloud read aligner based on MinHash and kmer voting that preserves privacy OPEN
Victoria Popic and Serafim Batzoglou
Outsourcing computation for genomic data processing offers the ability to allocate massive computing power and storage on demand. Here, Popic and Batzoglou develop a hybrid cloud aligner for sequence read mapping that preserves privacy with competitive accuracy and speed.
16 May 2017 | doi: 10.1038/ncomms15311

Protein-protein interactions and metabolite channelling in the plant tricarboxylic acid cycle OPEN
Youjun Zhang, Katherine F. M. Beard, Corné Swart, Susan Bergmann, Ina Krahnert, Zoran Nikoloski, Alexander Graf, R. George Ratcliffe, Lee J. Sweetlove, Alisdair R. Fernie and Toshihiro Obata
A metabolon is a complex of sequential metabolic enzymes that channels substrates directly between enzymes, thus optimizing metabolic flux. Here Zhang et al. provide protein interaction and isotope dilution data that support the existence of a metabolon that channels both citrate and fumarate in the plant TCA cycle.
16 May 2017 | doi: 10.1038/ncomms15212

Tuning colloidal quantum dot band edge positions through solution-phase surface chemistry modification OPEN
Daniel M. Kroupa, Márton Vörös, Nicholas P. Brawand, Brett W. McNichols, Elisa M. Miller, Jing Gu, Arthur J. Nozik, Alan Sellinger, Giulia Galli and Matthew C. Beard
The band edge positions of semiconductors decide their optoelectronic properties. Here, the authors establish a simple ligand exchange strategy to tune the band edge positions of colloidal PbS semiconductor quantum dots, revealing clear relationships between surface chemistry and band edge position.
16 May 2017 | doi: 10.1038/ncomms15257

Link between light-triggered Mg-banding and chamber formation in the planktic foraminifera Neogloboquadrina dutertrei OPEN
Jennifer S. Fehrenbacher, Ann D. Russell, Catherine V. Davis, Alexander C. Gagnon, Howard J. Spero, John B. Cliff, Zihua Zhu and Pamela Martin
The degree to which the diurnal light/dark cycle influences Mg-heterogeneity in foraminifera with complex shell morphologies remains unknown. Here, using highly spatially resolved analytical techniques, the authors investigate Mg-banding and calcification in isotope-labelled Neogloboquadrina dutertrei specimens.
15 May 2017 | doi: 10.1038/ncomms15441

Density structure of Earth’s lowermost mantle from Stoneley mode splitting observations OPEN
Paula Koelemeijer, Arwen Deuss and Jeroen Ritsema
Large-low-shear-wave velocity provinces (LLSVPs) are present at the core–mantle boundary. Here, the authors show that splitting of Stoneley modes is probably due to a lower density of LLSVPs than the surrounding mantle because of the presence of post-perovskite, chemical heterogeneity or both.
15 May 2017 | doi: 10.1038/ncomms15241

Explosive eruption, flank collapse and megatsunami at Tenerife ca. 170 ka OPEN
Raphaël Paris, Juan J. Coello Bravo, María E. Martín González, Karim Kelfoun and François Nauret
Oceanic shield volcanoes flank failures can generate large tsunamis. Here, the authors provide evidence that two tsunamis impacted the coast of Tenerife 170 Ma, the first generated by volcano flank failure and the second following a debris avalanche of the edifice during an on-going ignimbrite-forming eruption.
15 May 2017 | doi: 10.1038/ncomms15246

Diffusive and martensitic nucleation kinetics in solid-solid transitions of colloidal crystals OPEN
Yi Peng, Wei Li, Feng Wang, Tim Still, Arjun G. Yodh and Yilong Han
Solid-solid transitions between different crystalline structures have broad implications in earth science, steel and ceramic materials. Peng et al. show a transformation pathway that starts off as being martensitic then switches to diffusive at the single particle level in a colloidal system under pressure.
15 May 2017 | doi: 10.1038/ncomms14978

Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins OPEN
Hyeog Kang, Shinichi Oka, Duck-Yeon Lee, Junhong Park, Angel M. Aponte, Young-Sang Jung, Jacob Bitterman, Peiyong Zhai, Yi He, Hamed Kooshapur, Rodolfo Ghirlando, Nico Tjandra, Sean B. Lee, Myung K. Kim, Junichi Sadoshima and Jay H. Chung
The deacetylase Sirt1, known to regulate many cellular functions, can be activated by energy deprivation, however the mechanism is unclear. Here, the authors show that ATP inhibits Sirt1 by binding to the C-terminal domain, and energy deprivation derepresses Sirt1 activity by lowering the ATP level.
15 May 2017 | doi: 10.1038/ncomms15560

Observation of the universal magnetoelectric effect in a 3D topological insulator OPEN
V. Dziom, A. Shuvaev, A. Pimenov, G. V. Astakhov, C. Ames, K. Bendias, J. Böttcher, G. Tkachov, E. M. Hankiewicz, C. Brüne, H. Buhmann and L. W. Molenkamp
The electrodynamics of topological insulators has been predicted to show a new magnetoelectric term, but this hasn’t been observed. Here, Dziom et al. observe a universal Faraday rotation angle equal to the fine structure constant, evidencing the so-called topological magnetoelectric effect.
15 May 2017 | doi: 10.1038/ncomms15197

In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity OPEN
Nicholas C. Wu, Geramie Grande, Hannah L. Turner, Andrew B. Ward, Jia Xie, Richard A. Lerner and Ian A. Wilson
Broadly neutralizing antibodies (bnAbs) against influenza hemagglutinin (HA) have yielded insights for antiviral development. Here, the authors employ saturated mutagenesis of the paratope region of a bnAb combined with yeast display screening using H1 and H3 HAs, and find that a tradeoff exists between Ab affinity and breadth that influenced by disparate modes of receptor binding.
15 May 2017 | doi: 10.1038/ncomms15371

Absorptive pinhole collimators for ballistic Dirac fermions in graphene OPEN
Arthur W. Barnard, Alex Hughes, Aaron L. Sharpe, Kenji Watanabe, Takashi Taniguchi and David Goldhaber-Gordon
Shaping and guiding the flow of ballistic electrons is at the core of electron optics; however in graphene this is hindered by chiral tunneling. Here, the authors experimentally demonstrate an electron collimator based on hBN-encapsulated ballistic graphene, capable of emitting narrow electron beams.
15 May 2017 | doi: 10.1038/ncomms15418

An in-plane magnetic chiral dichroism approach for measurement of intrinsic magnetic signals using transmitted electrons OPEN
Dongsheng Song, Amir H. Tavabi, Zi-An Li, András Kovács, Ján Rusz, Wenting Huang, Gunther Richter, Rafal E. Dunin-Borkowski and Jing Zhu
Electron energy-loss magnetic chiral dichroism enables the measurement of the local magnetic properties of a material using a transmission electron microscope, but is limited to signals in the electron-beam direction. Here, the authors demonstrate a method to extend this to in-plane magnetic signals too.
15 May 2017 | doi: 10.1038/ncomms15348

Probing nanofriction and Aubry-type signatures in a finite self-organized system OPEN
J. Kiethe, R. Nigmatullin, D. Kalincev, T. Schmirander and T. E. Mehlstäubler
Superlubricity has been predicted and observed at an atomistic level, yet its dynamics is not well understood due to the lack of in situ characterization of contact surfaces. Kiethe et al. use a trapped two-dimensional ion crystal as a model for the study of nanofriction in self-organized structures.
15 May 2017 | doi: 10.1038/ncomms15364

Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17 OPEN
Kohei Arasaki, Yumi Mikami, Stephanie R. Shames, Hiroki Inoue, Yuichi Wakana and Mitsuo Tagaya
The pathogenic bacterium Legionella pneumophila replicates within macrophages. Here, the authors show that L. pneumophila secretes an effector protein that cleaves the host protein syntaxin 17, thus inhibiting autophagy and staurosporine-induced apoptosis in the host cell.
15 May 2017 | doi: 10.1038/ncomms15406

Neural circuits for long-term water-reward memory processing in thirsty Drosophila OPEN
Wei-Huan Shyu, Tai-Hsiang Chiu, Meng-Hsuan Chiang, Yu-Chin Cheng, Ya-Lun Tsai, Tsai-Feng Fu, Tony Wu and Chia-Lin Wu
Distinct subsets of dopaminergic PAM neurons have been shown to be involved in short-term and long-term memory for sugar reward. Here the authors report the neural circuits and the cellular and molecular mechanisms for short-term and long-term memory for water reward in thirsty Drosophila.
15 May 2017 | doi: 10.1038/ncomms15230

Dynamic diversity of synthetic supramolecular polymers in water as revealed by hydrogen/deuterium exchange OPEN
Xianwen Lou, René P. M. Lafleur, Christianus M. A. Leenders, Sandra M. C. Schoenmakers, Nicholas M. Matsumoto, Matthew B. Baker, Joost L. J. van Dongen, Anja R. A. Palmans and E W Meijer
Understanding the dynamics of supramolecular architectures without using labels is crucial for developing advanced biosystems. Here, the authors show kinetic hydrogen/deuterium exchange profiles for a series of water-soluble supramolecular polymers.
15 May 2017 | doi: 10.1038/ncomms15420

Transcriptomic and macroevolutionary evidence for phenotypic uncoupling between frog life history phases OPEN
Katharina C. Wollenberg Valero, Joan Garcia-Porta, Ariel Rodríguez, Mónica Arias, Abhijeet Shah, Roger Daniel Randrianiaina, Jason L. Brown, Frank Glaw, Felix Amat, Sven Künzel, Dirk Metzler, Raphael D. Isokpehi and Miguel Vences
In animals with complex life cycles, selection on one life phase may constrain adaptation in another phase. Here the authors find that, during the adaptive radiation of mantellid frogs, the evolution of tadpole and adult morphologies has been uncoupled through phase-specific gene expression.
15 May 2017 | doi: 10.1038/ncomms15213

Mid-infrared coincidence measurements on twin photons at room temperature OPEN
M. Mancinelli, A. Trenti, S. Piccione, G. Fontana, J. S. Dam, P. Tidemand-Lichtenberg, C. Pedersen and L. Pavesi
Quantum optics in the mid-infrared is difficult due to the lack of suitable detectors. Here the authors show that by spectral translation it is possible to develop a room temperature mid-infrared detector suitable for coincidence measurements on non-degenerate twin photons.
15 May 2017 | doi: 10.1038/ncomms15184

Controllable cyanation of carbon-hydrogen bonds by zeolite crystals over manganese oxide catalyst OPEN
Liang Wang, Guoxiong Wang, Jian Zhang, Chaoqun Bian, Xiangju Meng and Feng-Shou Xiao
Sustainable strategies for nitrile synthesis are needed. Here, the authors report an environmentally benign, selective heterogeneous catalyst for the synthesis of nitriles by the oxidative cyanation of carbon and hydrogen (C-H) bonds, which comprises nanoscale manganese oxide catalysts fixed inside a zeolite crystal.
15 May 2017 | doi: 10.1038/ncomms15240

New Blatter-type radicals from a bench-stable carbene OPEN
Jacob A. Grant, Zhou Lu, David E. Tucker, Bryony M. Hockin, Dmitry S. Yufit, Mark A. Fox, Ritu Kataky, Victor Chechik and AnnMarie C. O’Donoghue
Blatter’s radicals are highly valuable stable organic free radicals, comprising a heterocyclic ring system functionalized with a heteroaryl or alkyl group at the C-3 position. Here, the authors report a synthetic strategy to obtain Blatter’s radical substituted with an amine and amide group.
15 May 2017 | doi: 10.1038/ncomms15088

Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment OPEN
Kyun-Do Kim, Seyeon Bae, Tara Capece, Hristina Nedelkovska, Rafael G. de Rubio, Alan V. Smrcka, Chang-Duk Jun, Woojin Jung, Byeonghak Park, Tae-il Kim and Minsoo Kim
Regulatory T cells (Tregs) promote immune suppression in the tumour. Here, the authors show that Tregs suppress cytotoxic T lymphocyte (CTL) activity by impairing Ca2+ signalling and that adoptive transfer of CTLs engineered with an optogenetic control of Ca2+ overcome the immune suppression at the tumour site.
15 May 2017 | doi: 10.1038/ncomms15365

Energy efficiency to reduce residential electricity and natural gas use under climate change OPEN
Janet L. Reyna and Mikhail V. Chester
Climate change may alter building energy demand. Here, the authors quantify changes in residential electricity and natural gas demand in Los Angeles County and find that rising temperatures may increase electricity demand by 41–87% between 2020 and 2060, but improved efficiency could lower this increase to 28%.
15 May 2017 | doi: 10.1038/ncomms14916

Actomyosin meshwork mechanosensing enables tissue shape to orient cell force OPEN
Soline Chanet, Callie J. Miller, Eeshit Dhaval Vaishnav, Bard Ermentrout, Lance A. Davidson and Adam C. Martin
Large-scale tissue reorganization requires the generation of directional tension, which requires orientation of the cytoskeleton. Here Chanet et al. alter tissue shape and tension in the Drosophila embryo to show that geometric and mechanical constraints act as cues to orient the cytoskeleton and tension.
15 May 2017 | doi: 10.1038/ncomms15014

YAP regulates cell mechanics by controlling focal adhesion assembly OPEN
Giorgia Nardone, Jorge Oliver-De La Cruz, Jan Vrbsky, Cecilia Martini, Jan Pribyl, Petr Skládal, Martin Pešl, Guido Caluori, Stefania Pagliari, Fabiana Martino, Zuzana Maceckova, Marian Hajduch, Andres Sanz-Garcia, Nicola Maria Pugno, Gorazd Bernard Stokin and Giancarlo Forte
The transcriptional co-activator YAP is known to operate downstream of mechanical signals arising from the cell niche. Here the authors demonstrate that YAP controls cell mechanics, force development and adhesion strength by promoting the transcription of genes related to focal adhesions.
15 May 2017 | doi: 10.1038/ncomms15321

Progressive approach to eruption at Campi Flegrei caldera in southern Italy OPEN
Christopher R.J. Kilburn, Giuseppe De Natale and Stefano Carlino
Forecasting eruptions at large calderas remains difficult. Here, the authors apply an elastic-brittle failure model to Campi Flegrei to show that successive episodes of unrest lead to a long-term accumulation of stress in the crust, such that conditions may be becoming more favourable to eruption.
15 May 2017 | doi: 10.1038/ncomms15312

Dehydration-driven stress transfer triggers intermediate-depth earthquakes OPEN
Thomas P. Ferrand, Nadège Hilairet, Sarah Incel, Damien Deldicque, Loïc Labrousse, Julien Gasc, Joerg Renner, Yanbin Wang, Harry W. Green II and Alexandre Schubnel
Intermediate-depth earthquakes (30-300 km) occur in subducting oceanic slabs, but their generation mechanism remains enigmatic. Here, the authors show through high-pressure and dehydration experiments of antigorite that dehydration-driven stress transfer triggers intermediate-depth earthquakes.
15 May 2017 | doi: 10.1038/ncomms15247

Low phosphate activates STOP1-ALMT1 to rapidly inhibit root cell elongation OPEN
Coline Balzergue, Thibault Dartevelle, Christian Godon, Edith Laugier, Claudia Meisrimler, Jean-Marie Teulon, Audrey Creff, Marie Bissler, Corinne Brouchoud, Agnès Hagège, Jens Müller, Serge Chiarenza, Hélène Javot, Noëlle Becuwe-Linka, Pascale David, Benjamin Péret, Etienne Delannoy, Marie-Christine Thibaud, Jean Armengaud, Steffen Abel et al.
Low Pi availability inhibits primary root growth, but the sensory mechanisms are not known. Here the authors uncover a signalling pathway regulating Pi-mediated root growth inhibition in Arabidopsis, involving the transcription factor STOP1, its direct target ALMT1, a malate channel, and ferroxidase LPR1.
15 May 2017 | doi: 10.1038/ncomms15300

Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4 OPEN
Lucia Campos Carrascosa, Matthias Klein, Yohko Kitagawa, Christina Lückel, Federico Marini, Anika König, Anna Guralnik, Hartmann Raifer, Stefanie Hagner-Benes, Diana Rädler, Andreas Böck, Cholho Kang, Michael Lohoff, Holger Garn, Bianca Schaub, Friederike Berberich-Siebelt, Shimon Sakaguchi, Tobias Bopp and Magdalena Huber
IFN-γ signalling inhibits production of IL-9, the defining cytokine of the Th9 cell subset. Here the authors show that IFN-γ does this by driving IRF1 to compete with IRF4 for Il9 promoter binding and skewing these cells towards a Th1 phenotype, an effect that reduces asthmatic inflammation in mice.
12 May 2017 | doi: 10.1038/ncomms15366

Pore configuration landscape of granular crystallization OPEN
M. Saadatfar, H. Takeuchi, V. Robins, N. Francois and Y. Hiraoka
Emergence and growth of crystalline domains in granular media remains under-explored. Here, the authors analyse tomographic snapshots from partially recrystallized packings of spheres using persistent homology and find agreement with proposed transitions based on continuous deformation of octahedral and tetrahedral voids.
12 May 2017 | doi: 10.1038/ncomms15082

Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells OPEN
Rodrigo Vazquez-Lombardi, Claudia Loetsch, Daniela Zinkl, Jennifer Jackson, Peter Schofield, Elissa K. Deenick, Cecile King, Tri Giang Phan, Kylie E. Webster, Jonathan Sprent and Daniel Christ
Interleukin-2 (IL-2) is a T-cell proliferating factor used for cancer immunotherapy. Here, the authors develop a long-lived variant of IL-2 that, mutated in its binding domain, drives a much more potent tumour regression by depleting CD25+ CD4+ regulatory T-cells via targeting them for phagocytosis.
12 May 2017 | doi: 10.1038/ncomms15373

Underwater Leidenfrost nanochemistry for creation of size-tailored zinc peroxide cancer nanotherapeutics OPEN
Mady Elbahri, Ramzy Abdelaziz, Duygu Disci-Zayed, Shahin Homaeigohar, Justyna Sosna, Dieter Adam, Lorenz Kienle, Torben Dankwort and Moheb Abdelaziz
Water can function as a sustainable reactor for the synthesis of size-controlled, functional nanoparticles. Here, the authors introduce an underwater Leidenfrost synthesis that reproduces the dynamic chemistry of the deep ocean, in which anticancer therapeutic ZnO2 nanoclusters form in an overheated zone and migrate to colder water to continue growth.
12 May 2017 | doi: 10.1038/ncomms15319

L-selectin mechanochemistry restricts neutrophil priming in vivo OPEN
Zhenghui Liu, Tadayuki Yago, Nan Zhang, Sumith R. Panicker, Ying Wang, Longbiao Yao, Padmaja Mehta-D’souza, Lijun Xia, Cheng Zhu and Rodger P. McEver
Neutrophil adhesion is tightly regulated to enforce protective immunity, but it is unclear how mechanochemical processes such as catch bonds and slip bonds modulate neutrophils in vivo. Here the authors show that a point mutation in the adhesion molecule L-selectin alters mechanochemical regulation to affect neutrophil functions in mice.
12 May 2017 | doi: 10.1038/ncomms15196

A TRIM insertion in the promoter of Ms2 causes male sterility in wheat OPEN
Chuan Xia, Lichao Zhang, Cheng Zou, Yongqiang Gu, Jialei Duan, Guangyao Zhao, Jiajie Wu, Yue Liu, Xiaohua Fang, Lifeng Gao, Yuannian Jiao, Jiaqiang Sun, Yinghong Pan, Xu Liu, Jizeng Jia and Xiuying Kong
The male-sterile ms2 mutant has facilitated commercial production of wheat for over 40 years. Here, Xia et al. map Ms2 and describe how a retrotransposon insertion event in the regulatory element of an orphan gene is associated with expression in anthers and development of male sterility.
12 May 2017 | doi: 10.1038/ncomms15407

Tunable and low-loss correlated plasmons in Mott-like insulating oxides OPEN
Teguh Citra Asmara, Dongyang Wan, Yongliang Zhao, Muhammad Aziz Majidi, Christopher T. Nelson, Mary C. Scott, Yao Cai, Bixing Yan, Daniel Schmidt, Ming Yang, Tao Zhu, Paolo E. Trevisanutto, Mallikarjuna R. Motapothula, Yuan Ping Feng, Mark B. H. Breese, Matthew Sherburne, Mark Asta, Andrew Minor, T. Venkatesan and Andrivo Rusydi et al.
Conventional plasmons in metals often suffer from high plasmonic loss in the optical range. Here, the authors report a distinct form of tunable correlated plasmons in Mott-like insulating Sr1−x NbO3+δ films, with multiple plasmon frequencies and low loss in the visible-ultraviolet range.
12 May 2017 | doi: 10.1038/ncomms15271

Charcoal evidence that rising atmospheric oxygen terminated Early Jurassic ocean anoxia OPEN
Sarah J. Baker, Stephen P. Hesselbo, Timothy M. Lenton, Luís V. Duarte and Claire M. Belcher
Numerical models predict that during an oceanic anoxic event (OAE), increased organic carbon burial drives a rise in atmospheric oxygen leading to the event’s termination. Here, the authors present evidence suggesting that the Toarcian OAE was terminated by rising oxygen and associated fire-feedbacks.
12 May 2017 | doi: 10.1038/ncomms15018

A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs OPEN
Raquel M. Melero-Fernandez de Mera, Li-Li Li, Arkadiusz Popinigis, Katryna Cisek, Minna Tuittila, Leena Yadav, Andrius Serva and Michael J. Courtney
Light-sensitive regulators of protein kinases could offer valuable insights into intracellular signalling. Here the authors design an optogenetic inhibitor of c-Jun N-terminal kinase (JNK) and show evidence for resonance in JNK signalling circuits in neurons, and use the same design principle to develop an inhibitor for p38MAPK.
12 May 2017 | doi: 10.1038/ncomms15017

Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain OPEN
Eric B. Gibbs, Feiyue Lu, Bede Portz, Michael J. Fisher, Brenda P. Medellin, Tatiana N. Laremore, Yan Jessie Zhang, David S. Gilmour and Scott A. Showalter
The RNA polymerase II C-terminal domain acts as a hub to coordinate transcription and nascent mRNA processing. Here the authors identify a phosphorylation-dependent switch in the trans-to-cis isomerization of proline in the CTD heptad repeats that make those repeats susceptible to further modifications by regulatory enzymes.
12 May 2017 | doi: 10.1038/ncomms15233

An integrated parity-time symmetric wavelength-tunable single-mode microring laser OPEN
Weilin Liu, Ming Li, Robert S. Guzzon, Erik J. Norberg, John S. Parker, Mingzhi Lu, Larry A. Coldren and Jianping Yao
The breaking of parity-time symmetric gain and loss profiles can be used to achieve single-mode lasing in coupled microring resonators. Here, Liu et al. show that this effect can be electrically controlled with a tunable lasing wavelength and strong sidemode suppression.
12 May 2017 | doi: 10.1038/ncomms15389

Using shape to turn off blinking for two-colour multiexciton emission in CdSe/CdS tetrapods OPEN
Nimai Mishra, Noah J. Orfield, Feng Wang, Zhongjian Hu, Sachidananda Krishnamurthy, Anton V. Malko, Joanna L. Casson, Han Htoon, Milan Sykora and Jennifer A. Hollingsworth
CdSe/CdS tetrapods exhibit the unusual trait of two-colour multiexcitonic emission. Here Mishra et al. study this type of dual emission at the single-nanocrystal level. By tuning arm diameter and length they seek to understand shape-dependent evolution of the emission and of blinking behaviour.
12 May 2017 | doi: 10.1038/ncomms15083

RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma OPEN
Coralie Dorard, Charlène Estrada, Céline Barbotin, Magalie Larcher, Alexandra Garancher, Jessy Leloup, Friedrich Beermann, Manuela Baccarini, Celio Pouponnot, Lionel Larue, Alain Eychène and Sabine Druillennec
The melanoma-driver mutations in NRAS and BRAF are mutually exclusive but the contribution of RAF signalling downstream of NRAS remains to be clarified. Here, using mouse models, the authors show specific roles of each member of the RAF family at different stages of melanomagenesis.
12 May 2017 | doi: 10.1038/ncomms15262

Image-guided genomics of phenotypically heterogeneous populations reveals vascular signalling during symbiotic collective cancer invasion OPEN
J. Konen, E. Summerbell, B. Dwivedi, K. Galior, Y. Hou, L. Rusnak, A. Chen, J. Saltz, W. Zhou, L. H. Boise, P. Vertino, L. Cooper, K. Salaita, J. Kowalski and A. I. Marcus
The mechanisms linking phenotypic heterogeneity to collective cancer invasion are unclear. Here the authors develop an image-guided genomic technique to select and amplify leader and follower cells from in vitro invading cell packs and find a cooperative symbiotic relationship between these two cell populations.
12 May 2017 | doi: 10.1038/ncomms15078

Face classification using electronic synapses OPEN
Peng Yao, Huaqiang Wu, Bin Gao, Sukru Burc Eryilmaz, Xueyao Huang, Wenqiang Zhang, Qingtian Zhang, Ning Deng, Luping Shi, H.-S. Philip Wong and He Qian
Using chips that mimic the human brain to perform cognitive tasks, namely neuromorphic computing, calls for low power and high efficiency hardware. Here, Yao et al. show on-chip analogue weight storage by integrating non-volatile resistive memory into a CMOS platform and test it in facial recognition.
12 May 2017 | doi: 10.1038/ncomms15199

Real-time atomistic observation of structural phase transformations in individual hafnia nanorods OPEN
Bethany M. Hudak, Sean W. Depner, Gregory R. Waetzig, Anjana Talapatra, Raymundo Arroyave, Sarbajit Banerjee and Beth S. Guiton
The high-temperature tetragonal phase of HfO2 is technologically useful but difficult to stabilize at room temperature. Here, the authors observe in real-time the transformation of a HfO2 nanorod from its room temperature to tetragonal phase, at 1000° less than its bulk temperature, suggesting that size confinement may kinetically trap this phase.
12 May 2017 | doi: 10.1038/ncomms15316

Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC OPEN
Deborah Y. Kwon, Ying-Tao Zhao, Janine M. Lamonica and Zhaolan Zhou
CRISPR-Cas9 has been utilized, through the fusion of catalytic dead nuclease with chromatin-remodellers, to modify the epigenetic state of specific loci. Here the authors manipulate locus-specific histone acetylation and describe the parameters that need to be considered for its use.
12 May 2017 | doi: 10.1038/ncomms15315

Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain OPEN
Bede Portz, Feiyue Lu, Eric B. Gibbs, Joshua E. Mayfield, M. Rachel Mehaffey, Yan Jessie Zhang, Jennifer S. Brodbelt, Scott A. Showalter and David S. Gilmour
The C-terminal domain (CTD) of RNA polymerase II is composed of a series of heptad repeats that exhibit some degree of sequence variation and that are subject to extensive phosphorylation. Here the authors provide evidence that local structural variations within the CTD are functionally important.
12 May 2017 | doi: 10.1038/ncomms15231

Giant five-photon absorption from multidimensional core-shell halide perovskite colloidal nanocrystals OPEN
Weiqiang Chen, Saikat Bhaumik, Sjoerd A. Veldhuis, Guichuan Xing, Qiang Xu, Michael Grätzel, Subodh Mhaisalkar, Nripan Mathews and Tze Chien Sum
The small high-order multi-photon action cross-section of traditional biological imaging media presents a fundamental limitation for deep-tissue nonlinear optical imaging. Here the authors overcome this limitation by employing multidimensional core–shell perovskite nanocrystals.
12 May 2017 | doi: 10.1038/ncomms15198

PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3 OPEN
Jorge A. Benitez, Jianhui Ma, Matteo D’Antonio, Antonia Boyer, Maria Fernanda Camargo, Ciro Zanca, Stephen Kelly, Alireza Khodadadi-Jamayran, Nathan M. Jameson, Michael Andersen, Hrvoje Miletic, Shahram Saberi, Kelly A. Frazer, Webster K. Cavenee and Frank B. Furnari
PTEN mutations are frequent in glioblastoma and often are associated with therapeutic resistance. Here, the authors demonstrate that PTEN regulates gene expression at the chromatin level by interacting with the histone chaperone DAXX and H3.3, and that DAXX inhibition inhibits PTEN-deficient GBM growth in vivo.
12 May 2017 | doi: 10.1038/ncomms15223

BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks OPEN
Winston X. Yan, Reza Mirzazadeh, Silvano Garnerone, David Scott, Martin W. Schneider, Tomasz Kallas, Joaquin Custodio, Erik Wernersson, Yinqing Li, Linyi Gao, Yana Federova, Bernd Zetsche, Feng Zhang, Magda Bienko and Nicola Crosetto
Double-strand breaks are a major DNA lesion that can occur by endogenous and exogenous processes. Here the authors present BLISS—Breaks Labelling In Situ and Sequencing—to map breaks across the genome.
12 May 2017 | doi: 10.1038/ncomms15058

Quantum vertex model for reversible classical computing OPEN
C. Chamon, E. R. Mucciolo, A. E. Ruckenstein and Z.-C. Yang
Solutions of computations can be encoded in the ground state of many-body spin models. Here the authors show that solutions to generic reversible classical computations can be encoded in the ground state of a vertex model, which can be reached without finite temperature phase transitions.
12 May 2017 | doi: 10.1038/ncomms15303

Formation of printable granular and colloidal chains through capillary effects and dielectrophoresis OPEN
Zbigniew Rozynek, Ming Han, Filip Dutka, Piotr Garstecki, Arkadiusz Józefczak and Erik Luijten
Conductive colloidal chains are promising for electronics but difficult to synthesize outside of a liquid environment. Here, the authors use field-directed assembly and capillary effects to pull conductive particle chains out of a suspension, which remain held together by flexible liquid bridges even after the external field is turned off.
12 May 2017 | doi: 10.1038/ncomms15255

Imaging of pH in vivo using hyperpolarized 13C-labelled zymonic acid OPEN
Stephan Düwel, Christian Hundshammer, Malte Gersch, Benedikt Feuerecker, Katja Steiger, Achim Buck, Axel Walch, Axel Haase, Steffen J. Glaser, Markus Schwaiger and Franz Schilling
Local pH alterations can be manifestations of pathologies such as cancer, inflammation and ischaemia. Here Düwel et al. show hyperpolarized 13C-labelled zymonic acid can be used as a non-invasive probe to map and measure pH in vivo, suggesting it as a candidate for clinical imaging and a diagnostic tool.
11 May 2017 | doi: 10.1038/ncomms15126

Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti OPEN
Jinshu Xu, Hiroo Ueno, Chelsea Y. Xu, Binglai Chen, Irving L. Weissman and Pin-Xian Xu
The adult mammalian cochlear sensory epithelium consists of mechanosensory hair cells and supporting cells but hair cells cannot regenerate. Here, the authors identify multipotent progenitors that arise from Eya1-expressing otic cells that can regenerate hair cells in mice after 1 week of age.
11 May 2017 | doi: 10.1038/ncomms15046

Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania OPEN
Tom Parks, Mariana M. Mirabel, Joseph Kado, Kathryn Auckland, Jaroslaw Nowak, Anna Rautanen, Alexander J. Mentzer, Eloi Marijon, Xavier Jouven, Mai Ling Perman, Tuliana Cua, John K. Kauwe, John B. Allen, Henry Taylor, Kathryn J. Robson, Charlotte M. Deane, Andrew C. Steer, Adrian V. S. Hill, Pacific Islands Rheumatic Heart Disease Genetics Network, Lori Allen et al.
Rheumatic heart disease (RHD) is a chronic auto-inflammatory reaction to group A streptococcal infection, and frequently occurs in individuals from the South Pacific. This study finds a novel association between an immunoglobulin heavy chain allele and risk of RHD in Pacific Islanders and South Asians.
11 May 2017 | doi: 10.1038/ncomms14946

Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation OPEN
Carlos Boto, Emanuel Quartin, Yijun Cai, Alberto Martín-Lorenzo, María Begoña García Cenador, Sandra Pinto, Rajeev Gupta, Tariq Enver, Isidro Sánchez-García, Dengli Hong, Ricardo Pires das Neves and Lino Ferreira
Leukaemia cells resident in the bone marrow niche are often resistant to conventional therapies. In this study, the authors develop light-sensitive, polymeric, retinoic acid-containing nanoparticles that are able to modulate the differentiation of resistant leukaemia cells both in vitro and in vivo.
11 May 2017 | doi: 10.1038/ncomms15204

ISCA1 is essential for mitochondrial Fe4S4 biogenesis in vivo OPEN
Lena Kristina Beilschmidt, Sandrine Ollagnier de Choudens, Marjorie Fournier, Ioannis Sanakis, Marc-André Hograindleur, Martin Clémancey, Geneviève Blondin, Stéphane Schmucker, Aurélie Eisenmann, Amélie Weiss, Pascale Koebel, Nadia Messaddeq, Hélène Puccio and Alain Martelli
The mitochondrial proteins ISCA1 and ISCA2 form a complex that is involved in the biogenesis of Fe–S clusters. Here the authors report that ISCA1 and ISCA2 interact differently with proteins of the Fe–S machinery and that under certain conditions, ISCA2 seems dispensable for Fe–S biogenesis.
11 May 2017 | doi: 10.1038/ncomms15124

PPKs mediate direct signal transfer from phytochrome photoreceptors to transcription factor PIF3 OPEN
Weimin Ni, Shou-Ling Xu, Eduardo González-Grandío, Robert J. Chalkley, Andreas F. R. Huhmer, Alma L. Burlingame, Zhi-Yong Wang and Peter H. Quail
Phytochrome photoreceptors mediate degradation of PIF transcription factors in the nucleus in response to light. Here Ni et al. identify a family of nuclear protein kinases that interact with photoactivated phytochrome B and facilitate phytochrome-induced phosphorylation and degradation of PIF3.
11 May 2017 | doi: 10.1038/ncomms15236

Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells OPEN
Ilaria Elia, Dorien Broekaert, Stefan Christen, Ruben Boon, Enrico Radaelli, Martin F. Orth, Catherine Verfaillie, Thomas G. P. Grünewald and Sarah-Maria Fendt
Metastasizing cancer cells rewire their metabolism to support their malignant phenotypes. Here, the authors show that the acquisition of a metastatic phenotype in breast cancer cell lines results in increased proline catabolism and that inhibition of this pathway decreases lung metastasis formation in two mouse models.
11 May 2017 | doi: 10.1038/ncomms15267

Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression OPEN
Carmen Corciulo, Matin Lendhey, Tuere Wilder, Hanna Schoen, Alexander Samuel Cornelissen, Gregory Chang, Oran D. Kennedy and Bruce N. Cronstein
Osteoarthritis (OA) is a debilitating and destructive joint disease for which disease modifying drugs are not available. Here the authors show that extracellular adenosine signalling via the A2AR receptor on chondrocytes is needed to prevent OA and that liposome-bound adenosine injection can treat the pathology in rats.
11 May 2017 | doi: 10.1038/ncomms15019

Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity OPEN
Joseph S. Bednash, Nathaniel Weathington, James Londino, Mauricio Rojas, Dexter L. Gulick, Robert Fort, SeungHye Han, Alison C. McKelvey, Bill B. Chen and Rama K. Mallampalli
How NALP7 inflammasome formation is regulated is unclear. Here the authors show that STAMBP prevents lysosomal degradation of NALP7 and present BC-1471 as a potential therapeutic STAMBP inhibitor, showing it can reduce TLR-induced IL-1β production.
11 May 2017 | doi: 10.1038/ncomms15203

Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates OPEN
Olena Kis, Rayan Kaedbey, Signy Chow, Arnavaz Danesh, Mark Dowar, Tiantian Li, Zhihua Li, Jessica Liu, Mark Mansour, Esther Masih-Khan, Tong Zhang, Scott V. Bratman, Amit M. Oza, Suzanne Kamel-Reid, Suzanne Trudel and Trevor J. Pugh
Genetic profiling of multiple myeloma requires painful bone marrow biopsies. Here, the authors develop an alternative non-invasive method for sequencing of five oncogenes in circulating cell-free DNA from myeloma patients, demonstrating 96% concordance with bone marrow tumour profiling results.
11 May 2017 | doi: 10.1038/ncomms15086

Tau association with synaptic vesicles causes presynaptic dysfunction OPEN
Lujia Zhou, Joseph McInnes, Keimpe Wierda, Matthew Holt, Abigail G. Herrmann, Rosemary J. Jackson, Yu-Chun Wang, Jef Swerts, Jelle Beyens, Katarzyna Miskiewicz, Sven Vilain, Ilse Dewachter, Diederik Moechars, Bart De Strooper, Tara L. Spires-Jones, Joris De Wit and Patrik Verstreken
Mislocalisation of tau occurs in several neurodegenerative diseases and is thought to contribute to synaptic function. The authors show that presynaptically, tau binds to synaptic vesicles via the N-terminus which contributes to synaptic dysfunction.
11 May 2017 | doi: 10.1038/ncomms15295

Molecular basis for blue light-dependent phosphorylation of Arabidopsis cryptochrome 2 OPEN
Qing Liu, Qin Wang, Weixian Deng, Xu Wang, Mingxin Piao, Dawei Cai, Yaxing Li, William D. Barshop, Xiaolan Yu, Tingting Zhou, Bin Liu, Yoshito Oka, James Wohlschlegel, Zecheng Zuo and Chentao Lin
Plant cryptochromes are regulated by blue-light dependent phosphorylation. Here the authors map the in vivo phosphorylation sites of Arabidopsis cryptochrome 2 and identify four closely related kinases that act to both activate and destabilize the receptor in response to blue light.
11 May 2017 | doi: 10.1038/ncomms15234

Structure and interstitial iodide migration in hybrid perovskite methylammonium lead iodide OPEN
J. L. Minns, P. Zajdel, D. Chernyshov, W. van Beek and M. A. Green
The mechanism underpinning the photovoltaic effect in hybrid perovskite solar cells has remained unclear. Here, Green and co-workers suggest that iodide ions in methylammonium lead iodide perovskite migrate via interstitial sites and undergo a redox reaction to form molecular iodine and free electrons.
11 May 2017 | doi: 10.1038/ncomms15152

Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite OPEN
Eduardo H. Morales, Camilo A. Pinto, Roberto Luraschi, Claudia M. Muñoz-Villagrán, Fabián A. Cornejo, Scott W. Simpkins, Justin Nelson, Felipe A. Arenas, Jeff S. Piotrowski, Chad L. Myers, Hirotada Mori and Claudio C. Vásquez
The mechanisms of action of the antibacterial metalloid tellurite are unclear. Here, the authors show that tellurite induces an accumulation of hydroxyl radical and intermediates of heme biosynthesis in E. coli, and that the heme precursor 5-aminolevulinic acid potentiates tellurite toxicity.
11 May 2017 | doi: 10.1038/ncomms15320

Fast oxygen diffusion and iodide defects mediate oxygen-induced degradation of perovskite solar cells OPEN
Nicholas Aristidou, Christopher Eames, Irene Sanchez-Molina, Xiangnan Bu, Jan Kosco, M. Saiful Islam and Saif A. Haque
Determining the degradation pathways in lead halide perovskites is key to its development as a viable solar technology. Aristidou et al. identify iodide vacancies as the preferred sites in mediating the photo-induced formation of superoxide species from intercalated oxygen.
11 May 2017 | doi: 10.1038/ncomms15218

Super-diffusion of excited carriers in semiconductors OPEN
Ebrahim Najafi, Vsevolod Ivanov, Ahmed Zewail and Marco Bernardi
Determining the spatial dynamics of excited carriers will provide a more complete understanding of ultrafast carrier dynamics in materials. Using scanning ultrafast electron microscopy, Najafi et al. are able to observe the spatiotemporal dynamics of excited electron and hole carriers in silicon.
11 May 2017 | doi: 10.1038/ncomms15177

Tuning the effective spin-orbit coupling in molecular semiconductors OPEN
Sam Schott, Erik R. McNellis, Christian B. Nielsen, Hung-Yang Chen, Shun Watanabe, Hisaaki Tanaka, Iain McCulloch, Kazuo Takimiya, Jairo Sinova and Henning Sirringhaus
Organic semiconductors with long spin lifetime hold promise for future spintronics devices that can process and store information. Here, Schott et al. perform a systematic study of the strength of spin-orbit coupling and its effect on spin lifetime over 32 promising molecules with high charge mobility.
11 May 2017 | doi: 10.1038/ncomms15200

High-efficiency and high-power rechargeable lithium–sulfur dioxide batteries exploiting conventional carbonate-based electrolytes OPEN
Hyeokjun Park, Hee-Dae Lim, Hyung-Kyu Lim, Won Mo Seong, Sehwan Moon, Youngmin Ko, Byungju Lee, Youngjoon Bae, Hyungjun Kim and Kisuk Kang
Commercial electrolytes for lithium ion batteries cannot be used for current metal-gas batteries due to the instability despite various merits. Here, the authors successfully exploit a widely used carbonate-based electrolyte to boost the electrochemical performance of lithium-sulfur dioxide batteries for the first time.
11 May 2017 | doi: 10.1038/ncomms14989

C. elegans chromosomes connect to centrosomes by anchoring into the spindle network OPEN
Stefanie Redemann, Johannes Baumgart, Norbert Lindow, Michael Shelley, Ehssan Nazockdast, Andrea Kratz, Steffen Prohaska, Jan Brugués, Sebastian Fürthauer and Thomas Müller-Reichert
A connection between centrosomes and chromosomes is a key feature of mitotic spindles. Here the authors generate 3D reconstructions of whole mitotic spindles in early C. elegans embryos and show that chromosomes are anchored by the entire spindle network and that connections through kinetochore microtubules are few and likely very transient.
11 May 2017 | doi: 10.1038/ncomms15288

Kondo blockade due to quantum interference in single-molecule junctions OPEN
Andrew K. Mitchell, Kim G. L. Pedersen, Per Hedegård and Jens Paaske
Exploring the interplay of quantum effects enriches the scientific and technological understanding in nanoscale devices. The authors find that two apparently different quantum effects, quantum interference and the Kondo effect, can be unified to describe electron transport in single-molecule junctions.
11 May 2017 | doi: 10.1038/ncomms15210

Dust-wind interactions can intensify aerosol pollution over eastern China OPEN
Yang Yang, Lynn M. Russell, Sijia Lou, Hong Liao, Jianping Guo, Ying Liu, Balwinder Singh and Steven J. Ghan
Anthropogenic aerosol and calm conditions give rise to winter haze episodes in eastern China. Yang et al. show that these weak winds also decrease natural dust emissions, reducing the land–ocean temperature difference and associated winds, enhancing air stagnation and pollution in this region.
11 May 2017 | doi: 10.1038/ncomms15333

The transcriptional repressor complex FRS7-FRS12 regulates flowering time and growth in Arabidopsis OPEN
Andrés Ritter, Sabrina Iñigo, Patricia Fernández-Calvo, Ken S. Heyndrickx, Stijn Dhondt, Hua Shi, Liesbeth De Milde, Robin Vanden Bossche, Rebecca De Clercq, Dominique Eeckhout, Mily Ron, David E. Somers, Dirk Inzé, Kris Gevaert, Geert De Jaeger, Klaas Vandepoele, Laurens Pauwels and Alain Goossens
The plant circadian clock regulates numerous developmental processes such as seasonal growth and flowering time. Here Ritter et al. identify two transcription factors, FRS7 and FRS12, which interact to form a repressor complex that regulates clock output partially by controlling the expression of GIGANTEA and PIF4.
11 May 2017 | doi: 10.1038/ncomms15235

TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice OPEN
Maria Cristina Marrone, Annunziato Morabito, Michela Giustizieri, Valerio Chiurchiù, Alessandro Leuti, Marzia Mattioli, Sara Marinelli, Loredana Riganti, Marta Lombardi, Emanuele Murana, Antonio Totaro, Daniele Piomelli, Davide Ragozzino, Sergio Oddi, Mauro Maccarrone, Claudia Verderio and Silvia Marinelli
TRPV1 is known to be expressed in peripheral structures and the spinal cord, especially for pain processing. Here the authors show that in the brain, in particular the anterior cingulate cortex, TRPV1 is functionally expressed in microglia; stimulation of TRPV1 activates microglia, which in turn affects glutamatergic neurotransmission.
10 May 2017 | doi: 10.1038/ncomms15292

Hybrid supercapacitors for reversible control of magnetism OPEN
Alan Molinari, Philipp M. Leufke, Christian Reitz, Subho Dasgupta, Ralf Witte, Robert Kruk and Horst Hahn
The ability to electrically control magnetism could enable a new generation of low-power electronic devices. Here the authors show that charging and discharging of supercapacitors are powerful tools to achieve reversible above-room-temperature magnetoelectric effects.
10 May 2017 | doi: 10.1038/ncomms15339

Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression OPEN
Kévin Contrepois, Clément Coudereau, Bérénice A. Benayoun, Nadine Schuler, Pierre-François Roux, Oliver Bischof, Régis Courbeyrette, Cyril Carvalho, Jean-Yves Thuret, Zhihai Ma, Céline Derbois, Marie-Claire Nevers, Hervé Volland, Christophe E. Redon, William M. Bonner, Jean-François Deleuze, Clotilde Wiel, David Bernard, Michael P. Snyder, Claudia E. Rübe et al.
Senescence of mammalian cells is characterized by proliferative arrest and expression of an inflammatory phenotype. Here the authors show the H2A variant H2A.J, found only in mammals, accumulates following persistent DNA damage or natural aging.
10 May 2017 | doi: 10.1038/ncomms14995

TNFα drives mitochondrial stress in POMC neurons in obesity OPEN
Chun-Xia Yi, Marc Walter, Yuanqing Gao, Soledad Pitra, Beata Legutko, Stefanie Kälin, Clarita Layritz, Cristina García-Cáceres, Maximilian Bielohuby, Martin Bidlingmaier, Stephen C. Woods, Alexander Ghanem, Karl-Klaus Conzelmann, Javier E. Stern, Martin Jastroch and Matthias H. Tschöp
Long-term consumption of a calorie-rich diet persistently activates brain microglia. Here, the authors show that microglial activity in mouse brains oscillates daily in conjunction with feeding, and that TNFα, secreted by activated microglia, induces mitochondrial stress in satiety-promoting POMC neurons.
10 May 2017 | doi: 10.1038/ncomms15143

Exchange pathways of plastoquinone and plastoquinol in the photosystem II complex OPEN
Floris J. Van Eerden, Manuel N. Melo, Pim W. J. M. Frederix, Xavier Periole and Siewert J. Marrink
Plastoquinone (PLQ) shuttles electrons between photosystem II (PSII) and cytochrome b6f. Here the authors perform molecular dynamics simulations and propose that PLQ enters the exchange cavity of PSII by a promiscuous diffusion mechanism whereby three different channels each act as entry and exit points.
10 May 2017 | doi: 10.1038/ncomms15214

HLA-DP84Gly constitutively presents endogenous peptides generated by the class I antigen processing pathway OPEN
Yuki Yamashita, Mark Anczurowski, Munehide Nakatsugawa, Makito Tanaka, Yuki Kagoya, Ankit Sinha, Kenji Chamoto, Toshiki Ochi, Tingxi Guo, Kayoko Saso, Marcus O. Butler, Mark D. Minden, Thomas Kislinger and Naoto Hirano
MHC class I and II molecules generally present endogenous and exogenous peptides, respectively, through distinct mechanisms. Here, the authors show that the class II molecule HLA-DP84Gly uses both class I and II mechanisms to constitutively present peptides.
10 May 2017 | doi: 10.1038/ncomms15244

Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis OPEN
Jia-Lin Huang, Gan Jiang, Qing-Xiang Song, Xiao Gu, Meng Hu, Xiao-Lin Wang, Hua-Hua Song, Le-Pei Chen, Ying-Ying Lin, Di Jiang, Jun Chen, Jun-Feng Feng, Yong-Ming Qiu, Ji-Yao Jiang, Xin-Guo Jiang, Hong-Zhuan Chen and Xiao-Ling Gao
Drug delivery in brain tumours is still a significant clinical concern. In this study, the authors develop a biomimetic lipoprotein nanoparticle for the efficient delivery of ATF5 siRNA in Ras-activated brain cancer cells, where the nanoparticle is internalized by macropinocytosis in a Ras-dependent manner.
10 May 2017 | doi: 10.1038/ncomms15144

Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration OPEN
Seung-Min Shin, Dong-Ki Choi, Keunok Jung, Jeomil Bae, Ji-sun Kim, Seong-wook Park, Ki-Hoon Song and Yong-Sung Kim
Oncogenic RAS mutants are key anti-cancer targets as KRas mutations are very frequent in human cancers. Here, the authors engineer a cytosol-penetrating anti-Ras antibody and demonstrate its ability to block RAS-effector protein interactions inhibiting tumour growth of Ras mutant-driven cancers.
10 May 2017 | doi: 10.1038/ncomms15090

Senescent tumor cells lead the collective invasion in thyroid cancer OPEN
Young Hwa Kim, Yong Won Choi, Jeonghun Lee, Euy Young Soh, Jang-Hee Kim and Tae Jun Park
The senescence-associated secretory phenotype of stromal cells can promote tumorigenesis. Here, the authors show that senescent cancer cells are localized at the invasive front in human papillary thyroid carcinoma, and that senescent cancer cells drive collective invasion via CXCL12 in mouse models.
10 May 2017 | doi: 10.1038/ncomms15208

Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection OPEN
Rileen Sinha, Andrew G. Winer, Michael Chevinsky, Christopher Jakubowski, Ying-Bei Chen, Yiyu Dong, Satish K. Tickoo, Victor E. Reuter, Paul Russo, Jonathan A. Coleman, Chris Sander, James J. Hsieh and A. Ari Hakimi
Cell lines are central to cancer research, but knowing which cell lines are the best representative of actual tumours is a major challenge. Here the authors provide a resource assessment of 65 renal cell lines to assist researchers in selecting suitable lines for studying specific renal carcinoma subtypes.
10 May 2017 | doi: 10.1038/ncomms15165

Experimental test of photonic entanglement in accelerated reference frames OPEN
Matthias Fink, Ana Rodriguez-Aramendia, Johannes Handsteiner, Abdul Ziarkash, Fabian Steinlechner, Thomas Scheidl, Ivette Fuentes, Jacques Pienaar, Timothy C. Ralph and Rupert Ursin
The unification of the theory of relativity and quantum mechanics is a long-standing challenge in physics. Here the authors investigate the effects of a wide range of accelerations on an entangled photon pair, providing an upper bound for the effects of non-inertial frames on quantum systems.
10 May 2017 | doi: 10.1038/ncomms15304

Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming OPEN
Marcial Camacho, Jayeeta Basu, Thorsten Trimbuch, Shuwen Chang, Cristina Pulido-Lozano, Shwu-Shin Chang, Irina Duluvova, Masin Abo-Rady, Josep Rizo and Christian Rosenmund
The interaction between RIM and the C2A domain of Munc13 is known to be required for synaptic vesicle priming. Here the authors show new implications of the C2A domain of Munc13, through its dynamic interaction with RIM, in orchestrating a wide range of modulatory operations that shape vesicle docking, priming and neurotransmitter release.
10 May 2017 | doi: 10.1038/ncomms15293

Light-induced unfolding and refolding of supramolecular polymer nanofibres OPEN
Bimalendu Adhikari, Yuki Yamada, Mitsuaki Yamauchi, Kengo Wakita, Xu Lin, Keisuke Aratsu, Tomonori Ohba, Takashi Karatsu, Martin J. Hollamby, Nobutaka Shimizu, Hideaki Takagi, Rie Haruki, Shin-ichi Adachi and Shiki Yagai
Dynamically controlling the conformations of 1D elongated supramolecular polymers can induce functions comparable to protein folding/unfolding. Here the authors show light-induced conformational changes of azobenzene-based supramolecular polymers from helically coiled to extended/randomly coiled conformations.
10 May 2017 | doi: 10.1038/ncomms15254

Actively addressed single pixel full-colour plasmonic display OPEN
Daniel Franklin, Russell Frank, Shin-Tson Wu and Debashis Chanda
Tuning of plasmonic nanostructures has yet to cover a full colour basis set with a single nanostructure. Franklin et al. demonstrate a liquid crystal-plasmonic system that covers the full red-green-blue colour basis set as a function of voltage and which can be actively addressed with thin-film-transistor technology.
10 May 2017 | doi: 10.1038/ncomms15209

Large polarization gradients and temperature-stable responses in compositionally-graded ferroelectrics OPEN
Anoop R. Damodaran, Shishir Pandya, Yubo Qi, Shang-Lin Hsu, Shi Liu, Christopher Nelson, Arvind Dasgupta, Peter Ercius, Colin Ophus, Liv R. Dedon, Josh C. Agar, Hongling Lu, Jialan Zhang, Andrew M. Minor, Andrew M. Rappe and Lane W. Martin
Future technologies based on ferroelectric materials will require new routes to control the nature of polar order. Through a combined experimental and theoretical study of compositionally and strain-graded Ba1-xSrxTiO3 heterostructures, Damodaran et al. demonstrate the ability to engineer large polarization gradients and temperature-stable susceptibilities.
10 May 2017 | doi: 10.1038/ncomms14961

Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells OPEN
Yuying Liu, Xiaoyu Liang, Xiaonan Yin, Jiadi Lv, Ke Tang, Jingwei Ma, Tiantian Ji, Huafeng Zhang, Wenqian Dong, Xun Jin, Degao Chen, Yanchun Li, Songyan Zhang, Heidi Q. Xie, Bin Zhao, Tong Zhao, Jinzhi Lu, Zhuo-Wei Hu, Xuetao Cao, F. Xiao-Feng Qin et al.
Tumour repopulating cells (TRC) are stem-like cells that can escape immune-mediated killing. Here, the authors show IFN-γ results in either dormancy or apoptosis of TRC depending on the activation of the IDO1 metabolic pathway, and that combining IFN-γ with IDO1 inhibitors results in enhanced tumour regression.
10 May 2017 | doi: 10.1038/ncomms15207

Selective C70 encapsulation by a robust octameric nanospheroid held together by 48 cooperative hydrogen bonds OPEN
Grzegorz Markiewicz, Anna Jenczak, Michał Kołodziejski, Julian J. Holstein, Jeremy K. M. Sanders and Artur R Stefankiewicz
Individual hydrogen bonds are weak, so self-assembling multiple components via hydrogen bonding is a significant challenge. Here the authors report a robust, enantiopure nanocapsule held together by 48 cooperative hydrogen bonds, and use it for the selective binding of C70.
10 May 2017 | doi: 10.1038/ncomms15109

Climate warming reduces the temporal stability of plant community biomass production OPEN
Zhiyuan Ma, Huiying Liu, Zhaorong Mi, Zhenhua Zhang, Yonghui Wang, Wei Xu, Lin Jiang and Jin-Sheng He
Temporal stability of plant communities is driven by several mechanisms and may be influenced by climate change. Here it is shown that warming, but not precipitation, reduces species asynchrony in an alpine grassland, leading to lower biomass temporal stability.
10 May 2017 | doi: 10.1038/ncomms15378
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Corrigendum: Structural basis of synaptic vesicle assembly promoted by α-synuclein OPEN
Giuliana Fusco, Tillmann Pape, Amberley D. Stephens, Pierre Mahou, Ana Rita Costa, Clemens F. Kaminski, Gabriele S. Kaminski Schierle, Michele Vendruscolo, Gianluigi Veglia, Christopher M. Dobson and Alfonso De Simone
11 May 2017 | doi: 10.1038/ncomms15667

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