Wednesday, May 17, 2017

Nature Chemical Biology Contents: May 2017, Volume 13 No 6 pp 559 - 691

If you are unable to see the message below, click here to view.
Nature Chemical Biology

Advertisement webcasts

Springer Nature presents a custom webcast on: 3D High-Content Screening of Organoids for Drug Discovery. 

Register for FREE

Date: Wednesday 24th May
Time: 8AM PDT | 11AM EDT | 4PM BST | 5PM CEST

Sponsored by: Perkin Elmer

June 2017 Volume 13, Issue 6

Research Highlights
News and Views
Brief Communications

Recommend to library

The 1st Symposium on Nucleic Acid Modifications will bring together key players in the previously segregated fields of RNA and DNA modifications, which are now merging to create a brand new interdisciplinary research field that includes chemical biology, structural biology, bioinformatics, biophysics and cell biology, developmental biology and epigenetics. The symposium will outline the major developments in this rapidly developing field, and includes talks from leaders in this exciting area of study.  


Focus on Chemical approaches in developmental biology

Focus on Chemical approaches in developmental biology
The development of model organisms such as zebrafish and worms progresses from a single cell to tissues and organs. In this issue, a collection of articles highlights advances and opportunities at the intersection of developmental and chemical biology.
Focus on Chemical approaches in developmental biology



Shaping embryonic development   p559
The growing intersection between chemical tools and principles and developmental biology is providing new insights into the molecular-level details of developmental processes.



Small-molecule phenotypic screening with stem cells   pp560 - 563
Andrei Ursu, Hans R Scholer and Herbert Waldmann
To fully leverage the potential of human-induced pluripotent stem cells (hiPSCs), improved and standardized reprogramming methods and large-scale collections of hiPSC lines are needed, and the stem cell community must embrace chemical biology methodology for target identification and validation.

Unraveling cell-to-cell signaling networks with chemical biology   pp564 - 568
Zev J Gartner, Jennifer A Prescher and Luke D Lavis
Cell-to-cell signaling networks, although poorly understood, guide tissue development, regulate tissue function and may become dysregulated in disease. Chemical biologists can develop the next generation of tools to untangle these complex and dynamic networks of interacting cells.

Research Highlights


Synthetic biology: Return to sender | Enzymology: Radical ring resizing | Infectious disease: A lethal sugar fix | Plant development: Get lit on steroids

News and Views


Signal Transduction: Notch catches a Jagged edge   pp570 - 571
Stephen C Blacklow
Notch signaling is an essential cell-cell communication pathway that influences numerous cell fate decisions during development. Structural and biochemical studies of a Notch-Jagged complex dramatically advance current understanding of ligand recognition, and reveal evidence of catch-bond behavior in the complex.

Immunology: Mind the immuno-connection gap   pp572 - 573
Wolfgang Link
Biologic drugs that modulate the immune system have revolutionized the therapeutic landscape for several selected cancer types. A new study reports an image-based assay system to monitor cell-cell interactions, identifying small-molecule compounds with immunomodulatory capacity.

See also: Article by Vladimer et al.

Optogenetics: Switching with red and blue   pp573 - 574
Fuun Kawano, Fan Shi and Masayuki Yazawa
Multiple optogenetic technologies are required to control biological activity simultaneously with different colors of light. Optimizing a near-infrared-induced heterodimerization system, which can be combined with blue-light-controlled domains, enables precise spatiotemporal control of target molecules in live mammalian cells.

See also: Article by Redchuk et al.

Protein degradation: DCAFinating splicing   pp575 - 576
Georg E Winter
Chemical control of protein homeostasis and induction of protein destabilization are emerging therapeutic strategies. Two recent studies identify a set of sulfonamides that can modulate the CRL4DCAF15 E3 ligase complex to target the splicing factor RBM39 for proteasomal degradation.

See also: Article by Uehara et al.

Nature Chemical Biology
JOBS of the week
Postdoctoral position in chemical biology
Ecole Normale Superieure (ENS Paris)
PhD position in chemical biology
Ecole Normale Superieure (ENS Paris)
The Scripps Research Institute
Full-time Faculty Position in Earth System Science
Universidad del Rosario, Bogotá Colombia
Multiple Faculty Positions at ShanghaiTech University
ShanghaiTech University
More Science jobs from
Nature Chemical Biology
World Congress on Marine Science
16 - 17 November 2017
Atlanta, USA
More science events from



Small-molecule pheromones and hormones controlling nematode development   pp577 - 586
Rebecca A Butcher

Illuminating developmental biology through photochemistry   pp587 - 598
Lukasz Kowalik and James K Chen



The perception of strigolactones in vascular plants   pp599 - 606
Shelley Lumba, Duncan Holbrook-Smith and Peter McCourt

Brief Communications


CRISPR-Cas9 strategy for activation of silent Streptomyces biosynthetic gene clusters   pp607 - 609
Mingzi M Zhang, Fong Tian Wong, Yajie Wang, Shangwen Luo, Yee Hwee Lim et al.

Most microbial biosynthetic gene clusters are inactive under laboratory culture conditions. A CRISPR-Cas9 genome-editing approach in Streptomyces species enables the targeted activation of silent gene clusters and production of encoded natural products.
Chemical compounds

Structural and functional insight into human O-GlcNAcase   pp610 - 612
Christian Roth, Sherry Chan, Wendy A Offen, Glyn R Hemsworth, Lianne I Willems et al.

Crystal structures of human O-GlcNAc hydrolase (hOGA) fragments show that hOGA's dimeric structure is organized by swapping of an α-helical element and reveal features of inhibitor binding to the catalytic domain.

Insights into activity and inhibition from the crystal structure of human O-GlcNAcase   pp613 - 615
Nathaniel L Elsen, Sangita B Patel, Rachael E Ford, Dawn L Hall, Fred Hess et al.

Crystallographic analysis of human O-GlcNAc hydrolase (hOGA) fragments containing the catalytic domain, including structures in complex with known inhibitors, suggests that OGA is functional as a dimer and defines opportunities for structure-based drug design.



Chemical screening identifies ATM as a target for alleviating senescence   pp616 - 623
Hyun Tae Kang, Joon Tae Park, Kobong Choi, Yongsub Kim, Hyo Jei Claudia Choi et al.

Ataxia telangiectasia mutated (ATM) directly interacts with and phosphorylates the V-ATPase V1 subunit ATP6V1G1, thereby decreasing V1-V0 assembly in the V-ATPase. Attenuation of ATM activity results in lysosomal pH acidification, recovery of autophagy and alleviation of senescence.

Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase   pp624 - 632
Stephanie M Stanford, Alexander E Aleshin, Vida Zhang, Robert J Ardecky, Michael P Hedrick et al.

The generation of low-molecular-weight protein tyrosine phosphatase (LMPTP) knockout mice combined with the identification of a small-molecule uncompetitive LMPTP inhibitor reveals a role for LMPTP in regulating insulin resistance.
Chemical compounds

Near-infrared optogenetic pair for protein regulation and spectral multiplexing   pp633 - 639
Taras A Redchuk, Evgeniya S Omelina, Konstantin G Chernov and Vladislav V Verkhusha

The engineering of Q-PAS1, a single-domain variant of PpsR2, led to an optimized optogenetic system based on the Q-PAS1-BphP1 interaction, which was applied to the regulation of transcription, epigenetic state and protein localization by near-infrared light.

AtaT blocks translation initiation by N-acetylation of the initiator tRNAfMet   pp640 - 646
Dukas Jurenas, Sneha Chatterjee, Albert Konijnenberg, Frank Sobott, Louis Droogmans et al.

Characterization of an enterohaemorrhagic E. coli toxin-antitoxin system reveals that the toxin AtaT specifically acetylates Met-tRNAfMet at the methionyl amine, making it incompetent for translation initiation, which inhibits translation.

Phosphorylated glycosphingolipids essential for cholesterol mobilization in Caenorhabditis elegans   pp647 - 654
Sebastian Boland, Ulrike Schmidt, Vyacheslav Zagoriy, Julio L Sampaio, Raphael F Fritsche et al.

mmPEGC-C22 is a nonsterol glycolipid involved in early Caenorhabditis elegans larval development that can rescue the growth-arrest phenotype caused by sterol deficiency and is controlled by TGF-β to help mobilize internal sterol pools.
Chemical compounds

Mechanistic insights into energy conservation by flavin-based electron bifurcation   pp655 - 659
Carolyn E Lubner, David P Jennings, David W Mulder, Gerrit J Schut, Oleg A Zadvornyy et al.

Structural analysis and spectroscopy elucidate how pairs of electrons are bifurcated in a flavoenzyme by generating an unstable flavin semiquinone, thus coupling exergonic and endergonic oxidation-reduction reactions.

Using the pimeloyl-CoA synthetase adenylation fold to synthesize fatty acid thioesters   pp660 - 667
Menglu Wang, Lucile Moynie, Peter J Harrison, Van Kelly, Andrew Piper et al.

Structures of pimeloyl-CoA synthetase (BioW) provide insights into its catalytic mechanism and how it selects the correct length of dicarboxylic acid substrate, guiding engineering to make the enzyme capable of producing alternative CoA products.
Chemical compounds
See also: Article by Estrada et al.

The pimeloyl-CoA synthetase BioW defines a new fold for adenylate-forming enzymes   pp668 - 674
Paola Estrada, Miglena Manandhar, Shi-Hui Dong, Jaigeeth Deveryshetty, Vinayak Agarwal et al.

Structural analysis of pimeloyl-CoA synthetase (BioW) provides insight into how the enzyme ensures proper substrate positioning and how a key residue ensures proofreading of the reaction through hydrolysis of noncognate adenylated substrates.
Chemical compounds
See also: Article by Wang et al.

Selective degradation of splicing factor CAPERα by anticancer sulfonamides   pp675 - 680
Taisuke Uehara, Yukinori Minoshima, Koji Sagane, Naoko Hata Sugi, Kaoru Ogawa Mitsuhashi et al.

A series of sulfonamides induced the ubiquitin-mediated degradation of the U2AF-related splicing factor, coactivator of activating protein-1 and estrogen receptor α (CAPERα), by promoting direct binding between CAPERα and the CRL4 substrate receptor DCAF15.
Chemical compounds

Global survey of the immunomodulatory potential of common drugs   pp681 - 690
Gregory I Vladimer, Berend Snijder, Nikolaus Krall, Johannes W Bigenzahn, Kilian V M Huber et al.

A high-content screening platform that measures the immunological potential of small-molecule and biologic drugs by computationally determining changes in the physical interactions among peripheral mononuclear leukocytes revealed known immunomodulators and also approved drugs as regulators of unexpected targets, including MST1R.



Corrigendum: Full antagonism of the estrogen receptor without a prototypical ligand side chain   p691
Sathish Srinivasan, Jerome C Nwachukwu, Nelson E Bruno, Venkatasubramanian Dharmarajan, Devrishi Goswami et al.



Erratum: A Vibrio cholerae autoinducer-receptor pair that controls biofilm formation   p691
Kai Papenfort, Justin E Silpe, Kelsey R Schramma, Jian-Ping Cong, Mohammad R Seyedsayamdost et al.

Erratum: Full antagonism of the estrogen receptor without a prototypical ligand side chain   p691
Sathish Srinivasan, Jerome C Nwachukwu, Nelson E Bruno, Venkatasubramanian Dharmarajan, Devrishi Goswami et al.

nature events
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.
Find the latest scientific conferences, courses, meetings and symposia on For event advertising opportunities across the Nature Publishing Group portfolio please contact
More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your account at:
(You will need to log in to be recognised as a registrant)

For further technical assistance, please contact our registration department

For print subscription enquiries, please contact our subscription department

For other enquiries, please contact our customer feedback department

Nature Publishing Group | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA

Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston

Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW.

© 2017 Macmillan Publishers Limited, part of Springer Nature. All Rights Reserved.

nature publishing group

No comments: