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| TABLE OF CONTENTS |
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| May 2017 Volume 17 Number 5 | Advertisement |
| 2015 2-year Impact Factor 39.416 Journal Metrics 2-year Median 31 | In this issue
  Research Highlights
Reviews
Perspectives
|  April 2017 marks the 25th Anniversary of Nature Genetics! To celebrate, the editors have selected some past papers which are free to read for a limited time.
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npj Vaccines is an online-only, open access, multidisciplinary journal dedicated to publishing cutting-edge research and development on human and veterinary vaccines. npj Vaccines is now open for submissions.
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| RESEARCH HIGHLIGHTS | Top | Immunometabolism: Stress-induced macrophage polarization
p277 | doi:10.1038/nri.2017.41
Activation of the IRE1α-mediated stress response pathway in adipose tissue macrophages suppresses M2 polarization.
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Neuroimmunology: Immune signals packaged in the brain
p278 | doi:10.1038/nri.2017.43
Astrocyte-shed extracellular vesicles provide long-distance messages to promote peripheral immune responses following brain injury.
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Insect Immunity: Mechanism of adaptive immunity found in the fruitfly
p278 | doi:10.1038/nri.2017.44
Haemocytes in Drosophila melanogaster facilitate antiviral immunity by amplifying and systemically disseminating RNA interference-mediated responses via exosome-like vesicles. Moreover, they allow for immune memory, akin to adaptive immune responses in mammals.
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Microbiota: Diet can protect against type 1 diabetes
p279 | doi:10.1038/nri.2017.40
Microbial metabolites can protect mice from diabetes by decreasing the frequency of autoreactive T cells and promoting the frequency of regulatory T cells.
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JOURNAL CLUB
Finding order in chaos
p280 | doi:10.1038/nri.2017.20
Linda Sherman describes a 1991 study by Hans-Georg Rammensee and colleagues that defines allele-specific motifs required for the binding of peptides to MHC molecules.
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Cytokines: Oncostatin M - a new target in IBD?
p280 | doi:10.1038/nri.2017.45
Oncostatin M promotes intestinal inflammation and can predict responsiveness to anti-TNF therapy in patients with inflammatory bowel diseases.
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| | | | | Advertisement | | | | | | | | | | | REVIEWS | Top | Mechanisms of central tolerance for B cells
David Nemazee
p281 | doi:10.1038/nri.2017.19
Receptor editing and apoptosis have crucial roles in promoting the central tolerance of B cells to self-antigens. Defects of these processes can result in autoimmunity or immunodeficiency disease in humans and mice.
Abstract | Full Text | PDF
| Generation of diversity in thymic epithelial cells
Yousuke Takahama, Izumi Ohigashi, Song Baik & Graham Anderson
p295 | doi:10.1038/nri.2017.12
The generation of a diverse T cell repertoire depends on heterogeneous populations of thymic epithelial cells (TECs). Here, the authors explain how different subsets of TECs support and coordinate different stages of T cell development to ensure the selection of a functional and self-tolerant T cell repertoire.
Abstract | Full Text | PDF
| Liver macrophages in tissue homeostasis and disease
Oliver Krenkel & Frank Tacke
p306 | doi:10.1038/nri.2017.11
This Review describes the different populations of monocytes and macrophages, including Kupffer cells, that are found in the liver. The authors discuss the immune functions of these cells in the homeostatic liver as well as during liver infection and disease.
Abstract | Full Text | PDF
| New insights into mononuclear phagocyte biology from the visual system
Nancy J. Reyes, Emily G. O'Koren & Daniel R. Saban
p322 | doi:10.1038/nri.2017.13
This Review describes the distinct mononuclear phagocyte system (MPS) cells that are found in the different compartments of the eye. The authors discuss the importance of MPS cells for maintaining tissue homeostasis and explain how these cells contribute to eye pathology following a loss of immune privilege.
Abstract | Full Text | PDF
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PerkinElmer |  | | | | | | | | | | PERSPECTIVES | Top | TIMELINE
Article series: Cell death and immunity
Programmed cell death and the immune system
Shigekazu Nagata & Masato Tanaka
p333 | doi:10.1038/nri.2016.153
In this Timeline article, Shigekazu Nagata and Masato Tanaka highlight some of the key discoveries that have shaped the field of programmed cell death over the past 50 years and explain their relevance for the immune system.
Abstract | Full Text | PDF
| | | | Advertisement | | Online-only and open access, npj Primary Care Respiratory Medicine is the only fully-indexed scientific journal devoted to the management of respiratory diseases in primary care.
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| *2014 Journal Citation Report (Thomson Reuters, 2015) |
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