Nature Milestones: Antibodies presents an interactive timeline on the history of antibodies covering everything from their initial description in antisera through to their application in immunotherapy. The timeline includes written content, video interviews and animations.
Lab Animal, a Nature Research journal focusing on in vivo methods, research and technology with model organisms of human health & disease, presents a special Focus on reproducibility and translation of in vivo research with disease models.
Speaking out about gender imbalance in invited speakers improves diversity pp475 - 478 Robyn S Klein, Rhonda Voskuhl, Benjamin M Segal, Bonnie N Dittel, Thomas E Lane et al. doi:10.1038/ni.3707 Omissions of qualified women scientists from major meeting programs continue to occur despite a surge in articles indicating persistent gender-discriminatory practices in hiring and promotion, and calls for gender balance in conference organizing committees.
IRE1 gives weight to obesity-associated inflammation pp479 - 480 Bojan Bujisic and Fabio Martinon doi:10.1038/ni.3725 IRE1α is a stress sensor that is activated by a high-fat diet. In adipose-tissue macrophages, it serves as a major switch toward pro-inflammatory M1 polarization and thereby contributes to obesity and associated diseases.
The immune system as a social network pp481 - 482 Andreas Bergthaler and Jörg Menche doi:10.1038/ni.3727 The immune system employs a multitude of molecules, cells and organs that act together throughout the entire body to guard human health. Much like in a social network, immune cells can exert full functionality only through effective collaboration and communication.
IRAP+ endosomes restrict TLR9 activation and signaling pp509 - 518 Joel Babdor, Delphyne Descamps, Aimé Cézaire Adiko, Mira Tohmé, Sophia Maschalidi et al. doi:10.1038/ni.3711 The receptor TLR9 needs to be carefully regulated to avoid recognition of self nucleic acids and ensuing autoinflammation. Saveanu and colleagues demonstrate a further level of regulation through the retention of TLR9 in IRAP+ endosomes.
Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation pp573 - 582 Bingfei Yu, Kai Zhang, J Justin Milner, Clara Toma, Runqiang Chen et al. doi:10.1038/ni.3706 Distinct transcription factors influence cell fate, including the generation of effector or memory CD8+ T cells. Goldrath, Wang and colleagues have developed a Page-Rank analysis that shows that the transcription factors YY1 and Nr3c1, which are expressed constitutively, promote the differentiation of effector cells or memory cells, respectively.
Animal and human health are closely linked. This Outlook examines how climate change is pushing diseases into formerly 'safe' regions of the world, the challenges in treating parasites, the efforts to vaccinate gorillas against Ebola and how a holistic approach to disease could further the well-being of animals.
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