| |  | | | | |  |
Advertisement | | REGENERATION 2017
Presented by: Ospedale San Raffaele | Nature
The conference will feature sessions on regeneration in animal models, functional and dysfunctional regeneration in mammals, and new therapeutic approaches to regeneration.
November 16-18, 2017 | Milan, Italy
REGISTER NOW! |  | | | | | |
Advertisement | | NATURE CONFERENCE ON INFLAMMATORY DISEASES
Presented by: Chinese Academy of Medical Sciences & Peking Union Medical College | Chinese Society for Immunology (CSI) | Nature Reviews Immunology | Nature Immunology | Nature | Nature Communications
This conference will feature sessions on microbiota, cell death, metabolism, technologies, and innate sensing and signaling as they relate to inflammatory diseases and cancer.
September 17-20, 2017 | Beijing, China
REGISTER NOW! |  | | | | | | | | | | Nature Communications - all content now freely available including back files
As of January 2016, the journal only publishes open access content, and legacy subscription content published in Nature Communications prior to 2016 has been made freely accessible. For more information visit our website.
Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | | | Latest Articles | View all Articles | | | | | Two-stage opening of the Dover Strait and the origin of island Britain OPEN | | | Sanjeev Gupta, Jenny S. Collier, David Garcia-Moreno, Francesca Oggioni, Alain Trentesaux, Kris Vanneste, Marc De Batist, Thierry Camelbeeck, Graeme Potter, Brigitte Van Vliet-Lanoë and John C. R. Arthur | | | Britain’s separation from mainland Europe is believed to be the result of spillover from a proglacial lake in the North Sea, but this has remained unproven. Here, the authors show that the opening of the Dover Strait occurred in two episodes, where initial lake spillover was followed by catastrophic flooding. | | | 04 April 2017 | doi: 10.1038/ncomms15101 | | |
| Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior OPEN | | | Sophie Leclercq, Firoz M. Mian, Andrew M. Stanisz, Laure B. Bindels, Emmanuel Cambier, Hila Ben-Amram, Omry Koren, Paul Forsythe and John Bienenstock | | | There is concern about potential long-term effects of antibiotics on children’s health. Here Leclercq et al. show, in mice, that low doses of penicillin during late pregnancy and early life induce lasting effects on the offspring, including alterations in gut microbiota, brain cytokine levels and behaviour. | | | 04 April 2017 | doi: 10.1038/ncomms15062 | | |
| Future climate forcing potentially without precedent in the last 420 million years OPEN | | | Gavin L. Foster, Dana L. Royer and Daniel J. Lunt | | | Despite an increase in solar output, the Earth’s climate has apparently remained relatively stable over geological time. Here, the authors compile atmospheric CO2 data for the past 420 million years and show that this climatic response is due to the long-term decline in this powerful greenhouse gas. | | | 04 April 2017 | doi: 10.1038/ncomms14845 | | |
| Quinuclidinium salt ferroelectric thin-film with duodecuple-rotational polarization-directions OPEN | | | Yu-Meng You, Yuan-Yuan Tang, Peng-Fei Li, Han-Yue Zhang, Wan-Ying Zhang, Yi Zhang, Heng-Yun Ye, Takayoshi Nakamura and Ren-Gen Xiong | | | Molecular ferroelectric crystals hold promise in data storage applications, yet their preparations by maximizing molecular polarization are challenging. Here, You et al. report quinuclidinium periodate with six rotation axes and grow them in macroscopic ferroelectric thin films via a solution process. | | | 04 April 2017 | doi: 10.1038/ncomms14934 | | |
| Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice OPEN | | | Joshua J. White and Roy V. Sillitoe | | | Dystonia is thought to be driven by impairments in cerebellar signalling. The authors use a mouse genetic approach to silence excitatory transmission in the inferior olive to cerebellum pathway, resulting in dystonia-like signs in the animals which can be alleviated using DBS stimulation of the pathway. | | | 04 April 2017 | doi: 10.1038/ncomms14912 | | |
| Extinct type of human parvovirus B19 persists in tonsillar B cells OPEN | | | Lari Pyöriä, Mari Toppinen, Elina Mäntylä, Lea Hedman, Leena-Maija Aaltonen, Maija Vihinen-Ranta, Taru Ilmarinen, Maria Söderlund-Venermo, Klaus Hedman and Maria F. Perdomo | | | The cell type that hosts parvovirus B19 (B19V) DNA lifelong is currently unknown. Here, the authors identify tonsillar B cells as a reservoir, detect an extinct B19V type in older adults, supporting a long-term association, and show that B19V uptake into B cells is antibody dependent. | | | 04 April 2017 | doi: 10.1038/ncomms14930 | | |
| IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population OPEN | | | Daniele C. Nascimento, Paulo H. Melo, Annie R. Piñeros, Raphael G. Ferreira, David F. Colón, Paula B. Donate, Fernanda V. Castanheira, Aline Gozzi, Paula G. Czaikoski, Wanda Niedbala, Marcos C. Borges, Dario S. Zamboni, Foo Y. Liew, Fernando Q. Cunha and Jose C. Alves-Filho | | | Patients who survive sepsis are at increased risk of infection owing to long-term immunosuppression that is associated with an increase in Treg cell numbers. Here the authors show expansion of the Treg cell population in sepsis mice is driven by IL-33-induced ILC2 activation of IL-10 production by macrophages. | | | 04 April 2017 | doi: 10.1038/ncomms14919 | | |
| Quantitative 3D analysis of complex single border cell behaviors in coordinated collective cell migration OPEN | | | Adam Cliffe, David P. Doupé, HsinHo Sung, Isaac Kok Hwee Lim, Kok Haur Ong, Li Cheng and Weimiao Yu | | | Quantifying cell behaviours in vivo is essential to understanding the mechanisms of collective cell migration. Here the authors present an image analysis toolkit, CCMToolKit, to describe and characterize various modes of coordinated cell movements accompanying collective cell migration in Drosophila border cells. | | | 04 April 2017 | doi: 10.1038/ncomms14905 | | |
| Human seizures couple across spatial scales through travelling wave dynamics OPEN | | | L-E Martinet, G. Fiddyment, J. R. Madsen, E. N. Eskandar, W. Truccolo, U. T. Eden, S. S. Cash and M. A. Kramer | | | The authors record both local and long-range neural activity during human epileptic seizures to study the underlying multi-scale dynamics. They find that coupling of activity across spatial scales increases during seizures through propagating waves that are fit by a model that combines neural activity and potassium concentration dynamics. | | | 04 April 2017 | doi: 10.1038/ncomms14896 | | |
| Glutaredoxin catalysis requires two distinct glutathione interaction sites OPEN | | | Patricia Begas, Linda Liedgens, Anna Moseler, Andreas J. Meyer and Marcel Deponte | | | Glutaredoxins have important roles in redox processes. Here the authors show that the enzymatic activity of glutaredoxins requires two distinct glutathione interactions sites, one recognizing the glutathione disulfide substrate and one activating glutathione as a reducing agent. | | | 04 April 2017 | doi: 10.1038/ncomms14835 | | |
| Mechano-regulated surface for manipulating liquid droplets OPEN | | | Xin Tang, Pingan Zhu, Ye Tian, Xuechang Zhou, Tiantian Kong and Liqiu Wang | | | Droplet manipulation is an essential task for designing microfluidic platforms such as lab-on-chip devices. Here Tang et al. develop a non-wettable mesh with reversible liquid adhesion controlled by mechanically inserting wettable pillars which allows for effective and rapid droplet manoeuvring. | | | 04 April 2017 | doi: 10.1038/ncomms14831 | | |
| A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages OPEN | | | Mafalda M. A. Pereira, Inês Mahú, Elsa Seixas, Noelia Martinéz-Sánchez, Nadiya Kubasova, Roksana M Pirzgalska, Paul Cohen, Marcelo O Dietrich, Miguel López, Gonçalo J. L. Bernardes and Ana I. Domingos | | | Diphtheria toxin selectively kills cells engineered to express the diphtheria toxin receptor (DTR). Here the authors report a PEGylated version of diphtheria toxin that does not enter the brain, allowing for ablation of only peripheral cells when using Cre lines that drive DTR expression in both the periphery and in the brain. | | | 03 April 2017 | doi: 10.1038/ncomms14967 | | |
| Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases OPEN | | | Hao Yu, Patricia Dranchak, Zhiru Li, Ryan MacArthur, Matthew S. Munson, Nurjahan Mehzabeen, Nathan J. Baird, Kevin P. Battalie, David Ross, Scott Lovell, Clotilde K. S. Carlow, Hiroaki Suga and James Inglese | | | River blindness, a disease affecting millions throughout the tropics, is caused by parasitic worms. Here, Yu et al. report the discovery and structural characterization of potent macrocyclic peptide inhibitors of iPGM, a nematode-specific phosphoglycerate mutase, as potential leads for novel antimicrobial agents. | | | 03 April 2017 | doi: 10.1038/ncomms14932 | | |
| Tight cohesion between glycolipid membranes results from balanced water–headgroup interactions OPEN | | | Matej Kanduč, Alexander Schlaich, Alex H. de Vries, Juliette Jouhet, Eric Maréchal, Bruno Demé, Roland R. Netz and Emanuel Schneck | | | Glycolipids are commonly found in densely stacked biological membranes, which show unusually strong self-cohesion compared to phospholipid membranes. Here, the authors attribute this phenomenon to the lack of long-range repulsion between glycolipid membranes, a consequence of the headgroup architecture. | | | 03 April 2017 | doi: 10.1038/ncomms14899 | | |
| Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer’s disease OPEN | | | Andrew S. P. Lim, Hans-Ulrich Klein, Lei Yu, Lori B. Chibnik, Sanam Ali, Jishu Xu, David A. Bennett and Philip L. De Jager | | | Diurnal and seasonal rhythms modulate brain function, but we do not know the genomic basis for these rhythms. Here, Lim et al. show diurnal and seasonal rhythms of gene expression in the human brain, their relationship to histone acetylation and DNA methylation, and their disruption in Alzheimer’s disease. | | | 03 April 2017 | doi: 10.1038/ncomms14931 | | |
| The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA OPEN | | | Sina Wittmann, Max Renner, Beth R. Watts, Oliver Adams, Miles Huseyin, Carlo Baejen, Kamel El Omari, Cornelia Kilchert, Dong-Hyuk Heo, Tea Kecman, Patrick Cramer, Jonathan M. Grimes and Lidia Vasiljeva | | | Termination of RNA polymerase II is a critical step in transcription. Here, the authors provide evidence that the fission yeast CID-RRM protein Seb1 is required for termination of coding and non-coding genes through interaction with both the polymerase and the nascent RNA. | | | 03 April 2017 | doi: 10.1038/ncomms14861 | | |
| Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease OPEN | | | Annalisa Nobili, Emanuele Claudio Latagliata, Maria Teresa Viscomi, Virve Cavallucci, Debora Cutuli, Giacomo Giacovazzo, Paraskevi Krashia, Francesca Romana Rizzo, Ramona Marino, Mauro Federici, Paola De Bartolo, Daniela Aversa, Maria Concetta Dell’Acqua, Alberto Cordella, Marco Sancandi, Flavio Keller, Laura Petrosini, Stefano Puglisi-Allegra, Nicola Biagio Mercuri, Roberto Coccurello et al. | | | Dopaminergic dysfunction occurs in Alzheimer’s disease (AD). The authors show that in a mouse model of AD, loss of dopaminergic neurons in the ventral tegmental area, but not the substantia nigra, occurs at early pre-plaque stages, and may contribute to impaired cognition and reward processing. | | | 03 April 2017 | doi: 10.1038/ncomms14727 | | |
| Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease OPEN | | | Walter H. A. Kahr, Fred G. Pluthero, Abdul Elkadri, Neil Warner, Marko Drobac, Chang Hua Chen, Richard W. Lo, Ling Li, Ren Li, Qi Li, Cornelia Thoeni, Jie Pan, Gabriella Leung, Irene Lara-Corrales, Ryan Murchie, Ernest Cutz, Ronald M. Laxer, Julia Upton, Chaim M. Roifman, Rae S. M. Yeung et al. | | | ARPC1B is a component of the actin-related protein 2/3 complex (Arp2/3), which is required for actin filament branching. Kahr et al. show that ARPC1B deficiency in humans is associated with severe multisystem disease that includes platelet abnormalities, eosinophilia, eczema and other indicators of immune disease. | | | 03 April 2017 | doi: 10.1038/ncomms14816 | | |
| Enabling valley selective exciton scattering in monolayer WSe2 through upconversion OPEN | | | M. Manca, M. M. Glazov, C. Robert, F. Cadiz, T. Taniguchi, K. Watanabe, E. Courtade, T. Amand, P. Renucci, X. Marie, G. Wang and B. Urbaszek | | | Monolayer transition metal dichalcogenides host excitons, bound electron-hole pairs that play a pivotal role in optoelectronic applications relying on strong light-matter interaction. Here, the authors unveil the spectroscopic signature of boson scattering of two-dimensional excitons in monolayer WSe2. | | | 03 April 2017 | doi: 10.1038/ncomms14927 | | |
| A bright triggered twin-photon source in the solid state OPEN | | | T. Heindel, A. Thoma, M. von Helversen, M. Schmidt, A. Schlehahn, M. Gschrey, P. Schnauber, J. -H. Schulze, A. Strittmatter, J. Beyer, S. Rodt, A. Carmele, A. Knorr and S. Reitzenstein | | | Photon twins are important for interdisciplinary research fields using non-classical light, such as quantum biology. Here, Heindel et al. demonstrate that a single semiconductor quantum dot integrated into a microlens operates as an efficient photon-pair source. | | | 03 April 2017 | doi: 10.1038/ncomms14870 | | |
| Learning through ferroelectric domain dynamics in solid-state synapses OPEN | | | Sören Boyn, Julie Grollier, Gwendal Lecerf, Bin Xu, Nicolas Locatelli, Stéphane Fusil, Stéphanie Girod, Cécile Carrétéro, Karin Garcia, Stéphane Xavier, Jean Tomas, Laurent Bellaiche, Manuel Bibes, Agnès Barthélémy, Sylvain Saïghi and Vincent Garcia | | | Accurate modelling of memristor dynamics is essential for the development of autonomous learning in artificial neural networks. Through a combined theoretical and experimental study of the polarization switching process in ferroelectric memristors, Boyn et al. establish a model that enables learning and retrieving patterns in a neural system. | | | 03 April 2017 | doi: 10.1038/ncomms14736 | | |
| Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma OPEN | | | Kenneth Verstraete, Frank Peelman, Harald Braun, Juan Lopez, Dries Van Rompaey, Ann Dansercoer, Isabel Vandenberghe, Kris Pauwels, Jan Tavernier, Bart N. Lambrecht, Hamida Hammad, Hans De Winter, Rudi Beyaert, Guy Lippens and Savvas N. Savvides | | | The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is a promising therapeutic target. Here the authors characterize the assembly mechanism of the receptor complex driven by human TSLP, and its antagonism by the monoclonal antibody Tezepelumab and a fusion protein comprising the TSLP receptors. | | | 03 April 2017 | doi: 10.1038/ncomms14937 | | |
| On-surface synthesis of aligned functional nanoribbons monitored by scanning tunnelling microscopy and vibrational spectroscopy OPEN | | | Nataliya Kalashnyk, Kawtar Mouhat, Jihun Oh, Jaehoon Jung, Yangchun Xie, Eric Salomon, Thierry Angot, Frédéric Dumur, Didier Gigmes and Sylvain Clair | | | On-surface synthesis, in which molecular units assemble and couple on a defined surface, can access rare reaction pathways and products. Here, the authors synthesize functionalized organic nanoribbons on the Ag(110) surface, and monitor the evolution of the covalent reactions by an unorthodox vibrational spectroscopy approach. | | | 03 April 2017 | doi: 10.1038/ncomms14735 | | |
| Dispersion/dilution enhances phytoplankton blooms in low-nutrient waters OPEN | | | Yoav Lehahn, Ilan Koren, Shlomit Sharoni, Francesco d’Ovidio, Assaf Vardi and Emmanuel Boss | | | The degree to which horizontal transport affects phytoplankton ecosystems remains understudied. Here, the authors combine satellite observations, ARGO float data and a simple ecosystem model to explore the impact of horizontal stirring on naturally-stimulated fine-scale phytoplankton blooms. | | | 31 March 2017 | doi: 10.1038/ncomms14868 | | |
| Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity OPEN | | | Koenraad Philippaert, Andy Pironet, Margot Mesuere, William Sones, Laura Vermeiren, Sara Kerselaers, Sílvia Pinto, Andrei Segal, Nancy Antoine, Conny Gysemans, Jos Laureys, Katleen Lemaire, Patrick Gilon, Eva Cuypers, Jan Tytgat, Chantal Mathieu, Frans Schuit, Patrik Rorsman, Karel Talavera, Thomas Voets et al. | | | Steviol glycosides are sweet-tasting compounds isolated from a South American shrub and are increasingly used as sweeteners in foods and beverages. Philippaert et al. demonstrate that steviol glycosides potentiate Ca2+-dependent TRPM5 activity and promote glucose-induced insulin secretion and glucose tolerance. | | | 31 March 2017 | doi: 10.1038/ncomms14733 | | |
| Synthesizing topological structures containing RNA OPEN | | | Di Liu, Yaming Shao, Gang Chen, Yuk-Ching Tse-Dinh, Joseph A. Piccirilli and Yossi Weizmann | | | In vivo, complex topologies have been identified in proteins and DNA, while their existence in RNA is still unclear. Here, the authors design synthetic topological structures containing single stranded RNA, offering tools for investigating biologically relevant questions about RNA topology. | | | 31 March 2017 | doi: 10.1038/ncomms14936 | | |
| Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage OPEN | | | Simon G. Pfisterer, Gergana Gateva, Peter Horvath, Juho Pirhonen, Veijo T. Salo, Leena Karhinen, Markku Varjosalo, Samppa J. Ryhänen, Pekka Lappalainen and Elina Ikonen | | | Lipid droplets (LDs) are cellular organelles dedicated to triacylglycerol storage that can undergo fusion and dissociation events. Here the authors show that formin-like 1-dependent acto-myosin assembly on LDs facilitates their dissociation and, as a consequence, affects hydrolysis and storage of triacylglycerols. | | | 31 March 2017 | doi: 10.1038/ncomms14858 | | |
| IL-15 sustains IL-7R-independent ILC2 and ILC3 development OPEN | | | Michelle L. Robinette, Jennifer K. Bando, Wilbur Song, Tyler K. Ulland, Susan Gilfillan and Marco Colonna | | | ILC2 and ILC3 are generally thought to require IL-7. Here the authors use IL-7 ko mice and provide side-by-side comparison of ILCs from different tissues to show that IL-7 signalling is not required for intestinal ILC maintenance or function and that IL-15 can compensate for absence of IL-7. | | | 31 March 2017 | doi: 10.1038/ncomms14601 | | |
| Wave-particle energy exchange directly observed in a kinetic Alfvén-branch wave OPEN | | | Daniel J. Gershman, Adolfo F-Viñas, John C. Dorelli, Scott A. Boardsen, Levon A. Avanov, Paul M. Bellan, Steven J. Schwartz, Benoit Lavraud, Victoria N. Coffey, Michael O. Chandler, Yoshifumi Saito, William R. Paterson, Stephen A. Fuselier, Robert E. Ergun, Robert J. Strangeway, Christopher T. Russell, Barbara L. Giles, Craig J. Pollock, Roy B. Torbert and James L. Burch et al. | | | Alfvén waves are fundamental plasma modes that provide a mechanism for the transfer of energy between particles and fields. Here the authors confirm experimentally the conservative energy exchange between Alfvén wave fields and plasma particles via high-resolution MMS observations of Earth’s magnetosphere. | | | 31 March 2017 | doi: 10.1038/ncomms14719 | | |
| PABPN1 gene therapy for oculopharyngeal muscular dystrophy OPEN | | | A. Malerba, P. Klein, H. Bachtarzi, S. A. Jarmin, G. Cordova, A. Ferry, V. Strings, M. Polay Espinoza, K. Mamchaoui, S. C. Blumen, J. Lacau St Guily, V. Mouly, M. Graham, G. Butler-Browne, D. A. Suhy, C. Trollet and G. Dickson | | | Oculopharyngeal muscular dystrophy is caused by trinucleotide repeat expansions in the PABPN1 gene. Here the authors use AAV-based gene therapy to knockdown the mutant gene and replace it with a wild-type allele, and show effectiveness in mice and in patient cells. | | | 31 March 2017 | doi: 10.1038/ncomms14848 | | |
| A tipping point in refreezing accelerates mass loss of Greenland’s glaciers and ice caps OPEN | | | B. Noël, W. J van de Berg, S. Lhermitte, B. Wouters, H. Machguth, I. Howat, M. Citterio, G. Moholdt, J. T. M. Lenaerts and M. R. van den Broeke | | | Mass loss of Greenland’s glaciers and ice caps (GICs) is a major contributor to contemporary sea-level rise. Here, the authors identify the year 1997 as a tipping point in GICs mass loss induced by a rapid deterioration of the refreezing capacity of inland snow, resulting in irreversible long-term mass loss. | | | 31 March 2017 | doi: 10.1038/ncomms14730 | | |
| Rapid electron transfer by the carbon matrix in natural pyrogenic carbon OPEN | | | Tianran Sun, Barnaby D. A. Levin, Juan J. L. Guzman, Akio Enders, David A. Muller, Largus T. Angenent and Johannes Lehmann | | | Electron transfer reactions govern most biogeochemical processes, yet we have a limited knowledge of the electrochemistry of pyrogenic carbon, a major component of organic matter. Here, the authors quantify electron transfers between pyrogenic carbon and mineral phases under different pyrolysis temperatures. | | | 31 March 2017 | doi: 10.1038/ncomms14873 | | |
| Graphene-like nanoribbons periodically embedded with four- and eight-membered rings OPEN | | | Meizhuang Liu, Mengxi Liu, Limin She, Zeqi Zha, Jinliang Pan, Shichao Li, Tao Li, Yangyong He, Zeying Cai, Jiaobing Wang, Yue Zheng, Xiaohui Qiu and Dingyong Zhong | | | Graphene nanoribbons consist of carbon atoms arranged in a hexagonal lattice. Despite non-hexagonal rings generally being more unstable, the authors demonstrate the successful synthesis of graphene-like nanoribbons with periodically embedded four- and eight-membered carbon rings, with tailored electronic properties. | | | 31 March 2017 | doi: 10.1038/ncomms14924 | | |
| Integrated arrays of air-dielectric graphene transistors as transparent active-matrix pressure sensors for wide pressure ranges OPEN | | | Sung-Ho Shin, Sangyoon Ji, Seiho Choi, Kyoung-Hee Pyo, Byeong Wan An, Jihun Park, Joohee Kim, Ju-Young Kim, Ki-Suk Lee, Soon-Yong Kwon, Jaeyeong Heo, Byong-Guk Park and Jang-Ung Park | | | Electronic skins and health monitoring devices rely on integrated tactile sensors, which often require tailored degrees of sensitivity in specific pressure ranges. Here, the authors fabricate a versatile matrix array of pressure-sensitive graphene transistors operating in the wide 250 Pa to 3 MPa pressure range. | | | 31 March 2017 | doi: 10.1038/ncomms14950 | | |
| Development of the macaque face-patch system OPEN | | | Margaret S. Livingstone, Justin L. Vincent, Michael J. Arcaro, Krishna Srihasam, Peter F. Schade and Tristram Savage | | | Development of neural circuits for face recognition is not well studied in primates. Here the authors longitudinally track responses to faces in monkeys from about a month of age to two years and demonstrate that face-selective responses emerge in inferotemporal cortex early and gradually stabilize over time. | | | 31 March 2017 | doi: 10.1038/ncomms14897 | | |
| A retinoraphe projection regulates serotonergic activity and looming-evoked defensive behaviour OPEN | | | Lu Huang, Tifei Yuan, Minjie Tan, Yue Xi, Yu Hu, Qian Tao, Zhikai Zhao, Jiajun Zheng, Yushui Han, Fuqiang Xu, Minmin Luo, Patricia J. Sollars, Mingliang Pu, Gary E. Pickard, Kwok-Fai So and Chaoran Ren | | | Neural circuits underlying innate fear are only partially understood. Huang et al. identify a subset of retinal ganglion cells that project to both the dorsal raphe nucleus and the superior colliculus, and show that these RGCs mediate looming-evoked defensive behaviours in mice. | | | 31 March 2017 | doi: 10.1038/ncomms14908 | | |
| The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction OPEN | | | Guang Yang, Xinyu Weng, Yuhao Zhao, Xinjian Zhang, Yuanping Hu, Xin Dai, Peng Liang, Peng Wang, LeiLei Ma, Xiaolei Sun, Lei Hou, Huihui Xu, Mingming Fang, Yuehua Li, Thomas Jenuwein, Yong Xu and Aijun Sun | | | The molecular pathways regulating the cardioprotective activity of deacetylase sirtuin-1 are unknown. Here, Yang et al. show that histone H3K9 methyltransferase SUV39H and HP1gamma cooperatively methylate H3K9 on the sirtuin-1 promoter and inhibit sirtuin-1 transcription, and show that inhibition of SUV39H in mice is cardioprotective. | | | 31 March 2017 | doi: 10.1038/ncomms14941 | | |
| USP9X regulates centrosome duplication and promotes breast carcinogenesis OPEN | | | Xin Li, Nan Song, Ling Liu, Xinhua Liu, Xiang Ding, Xin Song, Shangda Yang, Lin Shan, Xing Zhou, Dongxue Su, Yue Wang, Qi Zhang, Cheng Cao, Shuai Ma, Na Yu, Fuquan Yang, Yan Wang, Zhi Yao, Yongfeng Shang and Lei Shi et al. | | | USP9X is a deubiquitinating enzyme with many known substrates and functions; it has been linked to cancer but the mechanisms remain unclear. Here Li et al. report that USP9X stabilizes the centrosomal protein CEP131 leading to centrosome amplification and breast cancer development. | | | 31 March 2017 | doi: 10.1038/ncomms14866 | | |
| Pressure modulates the self-cleavage step of the hairpin ribozyme OPEN | | | Caroline Schuabb, Narendra Kumar, Salome Pataraia, Dominik Marx and Roland Winter | | | Studying the reactivity of ribozymes under extreme pressure could provide insights to optimize biocatalytic RNA design. Here, the authors show that at high pressure the transesterification step of the hairpin ribozyme self-cleavage reaction accelerates, while the overall process is slower. | | | 30 March 2017 | doi: 10.1038/ncomms14661 | | |
| Structure and vacancy distribution in copper telluride nanoparticles influence plasmonic activity in the near-infrared OPEN | | | Tom Willhammar, Kadir Sentosun, Stefanos Mourdikoudis, Bart Goris, Mert Kurttepeli, Marnik Bercx, Dirk Lamoen, Bart Partoens, Isabel Pastoriza-Santos, Jorge Pérez-Juste, Luis M. Liz-Marzán, Sara Bals and Gustaaf Van Tendeloo | | | CuTe nanocrystals may be used as an alternative to noble metals for plasmonics but requires understanding of the atomic structure and the influence of defects. Here Willhammar et al. use electron tomography to reveal the distribution of vacancies in the nanocrystals and their effect on the optical properties. | | | 30 March 2017 | doi: 10.1038/ncomms14925 | | |
| Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure OPEN | | | Garima Jaipuria, Andrei Leonov, Karin Giller, Suresh Kumar Vasa, Łukasz Jaremko, Mariusz Jaremko, Rasmus Linser, Stefan Becker and Markus Zweckstetter | | | The outer mitochondrial membrane translocator protein (TSPO) mediates several mitochondrial functions and binds cholesterol with a high affinity. Here the authors use solid-state NMR to show that cholesterol binding to TSPO results in allosteric changes that modulate TSPO oligomerization. | | | 30 March 2017 | doi: 10.1038/ncomms14893 | | |
| FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons OPEN | | | Lorenzo Errichelli, Stefano Dini Modigliani, Pietro Laneve, Alessio Colantoni, Ivano Legnini, Davide Capauto, Alessandro Rosa, Riccardo De Santis, Rebecca Scarfò, Giovanna Peruzzi, Lei Lu, Elisa Caffarelli, Neil A. Shneider, Mariangela Morlando and Irene Bozzoni | | | The RNA binding protein FUS functions in several RNA biosynthetic processes and has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS). Here the authors show that FUS controls back-splicing reactions leading to circular RNA (circRNA) production in stem cell-derived motor neurons and that ALS-associated FUS mutations affect the biogenesis of circRNAs. | | | 30 March 2017 | doi: 10.1038/ncomms14741 | | |
| Allosteric cross-talk in chromatin can mediate drug-drug synergy OPEN | | | Zenita Adhireksan, Giulia Palermo, Tina Riedel, Zhujun Ma, Reyhan Muhammad, Ursula Rothlisberger, Paul J. Dyson and Curt A. Davey | | | Allostery and drug-drug synergism can yield potential novel therapies with existing molecules. Here, the authors provide evidence that two unrelated drugs have increased cytotoxicity in cancer cells, which coincides with increased formation of chromatin adducts. | | | 30 March 2017 | doi: 10.1038/ncomms14860 | | |
| Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy OPEN | | | Natalie A. Afshari, Robert P. Igo, Nathan J. Morris, Dwight Stambolian, Shiwani Sharma, V. Lakshmi Pulagam, Steven Dunn, John F. Stamler, Barbara J. Truitt, Jacqueline Rimmler, Abraham Kuot, Christopher R. Croasdale, Xuejun Qin, Kathryn P. Burdon, S. Amer Riazuddin, Richard Mills, Sonja Klebe, Mollie A. Minear, Jiagang Zhao, Elmer Balajonda et al. | | | Fuchs endothelial corneal dystrophy (FECD) is one of the most common reasons for corneal transplantation, and is known to cluster in families. Here, the authors discover new genetic loci associated with FECD with sex-specific effects and implications for disease mechanism. | | | 30 March 2017 | doi: 10.1038/ncomms14898 | | |
| Epithelial tension in the second heart field promotes mouse heart tube elongation OPEN | | | Alexandre Francou, Christopher De Bono and Robert G. Kelly | | | Epithelial progenitor cell growth in the second heart field contributes to heart morphogenesis but how this is regulated at the tissue level is unclear. Here, the authors show that cell elongation, polarized actomyosin and nuclear YAP/TAZ drive epithelial growth and correlate with mechanical tension. | | | 30 March 2017 | doi: 10.1038/ncomms14770 | | |
| The Par3 polarity protein is an exocyst receptor essential for mammary cell survival OPEN | | | Syed Mukhtar Ahmed and Ian G. Macara | | | The exocyst delivers basolateral proteins from the secretory pathway to the plasma membrane of epithelial cells close to tight junctions. Here the authors show that Par3 acts as a docking site for the exocyst to regulate polarized delivery of basolateral proteins and this is essential to prevent apoptosis and promote mammary cell survival. | | | 30 March 2017 | doi: 10.1038/ncomms14867 | | |
| Sequence-selective encapsulation and protection of long peptides by a self-assembled FeII8L6 cubic cage OPEN | | | Jesús Mosquera, Bartosz Szyszko, Sarah K. Y. Ho and Jonathan R. Nitschke | | | One of the challenges of synthetic self-assembled capsules is achieving selective recognition of specific cargoes. Here, authors synthesize a self-assembled porphyrin cubic cage that is capable of sequestering imidazole and thiazole-containing small molecules and peptides, protecting them from proteolysis. | | | 30 March 2017 | doi: 10.1038/ncomms14882 | | |
| Temperature-tunable Fano resonance induced by strong coupling between Weyl fermions and phonons in TaAs OPEN | | | B. Xu, Y. M. Dai, L. X. Zhao, K. Wang, R. Yang, W. Zhang, J. Y. Liu, H. Xiao, G. F. Chen, S. A. Trugman, J-X Zhu, A. J. Taylor, D. A. Yarotski, R. P. Prasankumar and X. G. Qiu | | | The study of lattice vibrations coupled to electronic excitations may provide an avenue for exploring exotic physical phenomena. Here, Xu et al. observe a Fano resonance in the Weyl semimetal TaAs, revealing evidence for a strong coupling between phonons and Weyl fermions. | | | 30 March 2017 | doi: 10.1038/ncomms14933 | | | | | | | | | | | | | Latest Corrigendum | | | | | | | | | | | | Latest Erratum | | | | | | | | | |
Advertisement | | Nature Insight Plants
This Insight highlights pertinent issues in plant research, including signalling in plant immunity, plant interactions with the environment, progress in agricultural genomics and harnessing the quantum properties of photosynthesis for human-made energy conversion systems. | | | | | | |
Advertisement | | | | | | |
Advertisement | | Open for Submissions Online-only and open access, npj Primary Care Respiratory Medicine is the only fully-indexed scientific journal devoted to the management of respiratory diseases in primary care. Explore the benefits of submitting your next research article. |  | | | | | | | | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.
Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Research portfolio please contact natureevents@nature.com | | | | | | | | You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at:www.nature.com/myaccount
(You will need to log in to be recognised as a nature.com registrant)
For further technical assistance, please contact our registration department
For other enquiries, please contact our customer feedback department
Nature Research | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA
Nature Research's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston
Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW.
© 2013 Nature Research, a division of Macmillan Publishers Limited. All Rights Reserved. |  | | | |
No comments:
Post a Comment