Wednesday, April 5, 2017

Nature Communications - 05 April 2017

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05 April 2017 
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Presented by: Ospedale San Raffaele | Nature

The conference will feature sessions on regeneration in animal models, functional and dysfunctional regeneration in mammals, and new therapeutic approaches to regeneration.

November 16-18, 2017 | Milan, Italy

Presented by: Chinese Academy of Medical Sciences & Peking Union Medical College | Chinese Society for Immunology (CSI) | Nature Reviews Immunology | Nature Immunology | Nature | Nature Communications

This conference will feature sessions on microbiota, cell death, metabolism, technologies, and innate sensing and signaling as they relate to inflammatory diseases and cancer.

September 17-20, 2017 | Beijing, China

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Two-stage opening of the Dover Strait and the origin of island Britain OPEN
Sanjeev Gupta, Jenny S. Collier, David Garcia-Moreno, Francesca Oggioni, Alain Trentesaux, Kris Vanneste, Marc De Batist, Thierry Camelbeeck, Graeme Potter, Brigitte Van Vliet-Lanoë and John C. R. Arthur
Britain’s separation from mainland Europe is believed to be the result of spillover from a proglacial lake in the North Sea, but this has remained unproven. Here, the authors show that the opening of the Dover Strait occurred in two episodes, where initial lake spillover was followed by catastrophic flooding.
04 April 2017 | doi: 10.1038/ncomms15101

Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior OPEN
Sophie Leclercq, Firoz M. Mian, Andrew M. Stanisz, Laure B. Bindels, Emmanuel Cambier, Hila Ben-Amram, Omry Koren, Paul Forsythe and John Bienenstock
There is concern about potential long-term effects of antibiotics on children’s health. Here Leclercq et al. show, in mice, that low doses of penicillin during late pregnancy and early life induce lasting effects on the offspring, including alterations in gut microbiota, brain cytokine levels and behaviour.
04 April 2017 | doi: 10.1038/ncomms15062

Future climate forcing potentially without precedent in the last 420 million years OPEN
Gavin L. Foster, Dana L. Royer and Daniel J. Lunt
Despite an increase in solar output, the Earth’s climate has apparently remained relatively stable over geological time. Here, the authors compile atmospheric CO2 data for the past 420 million years and show that this climatic response is due to the long-term decline in this powerful greenhouse gas.
04 April 2017 | doi: 10.1038/ncomms14845

Quinuclidinium salt ferroelectric thin-film with duodecuple-rotational polarization-directions OPEN
Yu-Meng You, Yuan-Yuan Tang, Peng-Fei Li, Han-Yue Zhang, Wan-Ying Zhang, Yi Zhang, Heng-Yun Ye, Takayoshi Nakamura and Ren-Gen Xiong
Molecular ferroelectric crystals hold promise in data storage applications, yet their preparations by maximizing molecular polarization are challenging. Here, You et al. report quinuclidinium periodate with six rotation axes and grow them in macroscopic ferroelectric thin films via a solution process.
04 April 2017 | doi: 10.1038/ncomms14934

Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice OPEN
Joshua J. White and Roy V. Sillitoe
Dystonia is thought to be driven by impairments in cerebellar signalling. The authors use a mouse genetic approach to silence excitatory transmission in the inferior olive to cerebellum pathway, resulting in dystonia-like signs in the animals which can be alleviated using DBS stimulation of the pathway.
04 April 2017 | doi: 10.1038/ncomms14912

Extinct type of human parvovirus B19 persists in tonsillar B cells OPEN
Lari Pyöriä, Mari Toppinen, Elina Mäntylä, Lea Hedman, Leena-Maija Aaltonen, Maija Vihinen-Ranta, Taru Ilmarinen, Maria Söderlund-Venermo, Klaus Hedman and Maria F. Perdomo
The cell type that hosts parvovirus B19 (B19V) DNA lifelong is currently unknown. Here, the authors identify tonsillar B cells as a reservoir, detect an extinct B19V type in older adults, supporting a long-term association, and show that B19V uptake into B cells is antibody dependent.
04 April 2017 | doi: 10.1038/ncomms14930

IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population OPEN
Daniele C. Nascimento, Paulo H. Melo, Annie R. Piñeros, Raphael G. Ferreira, David F. Colón, Paula B. Donate, Fernanda V. Castanheira, Aline Gozzi, Paula G. Czaikoski, Wanda Niedbala, Marcos C. Borges, Dario S. Zamboni, Foo Y. Liew, Fernando Q. Cunha and Jose C. Alves-Filho
Patients who survive sepsis are at increased risk of infection owing to long-term immunosuppression that is associated with an increase in Treg cell numbers. Here the authors show expansion of the Treg cell population in sepsis mice is driven by IL-33-induced ILC2 activation of IL-10 production by macrophages.
04 April 2017 | doi: 10.1038/ncomms14919

Quantitative 3D analysis of complex single border cell behaviors in coordinated collective cell migration OPEN
Adam Cliffe, David P. Doupé, HsinHo Sung, Isaac Kok Hwee Lim, Kok Haur Ong, Li Cheng and Weimiao Yu
Quantifying cell behaviours in vivo is essential to understanding the mechanisms of collective cell migration. Here the authors present an image analysis toolkit, CCMToolKit, to describe and characterize various modes of coordinated cell movements accompanying collective cell migration in Drosophila border cells.
04 April 2017 | doi: 10.1038/ncomms14905

Human seizures couple across spatial scales through travelling wave dynamics OPEN
L-E Martinet, G. Fiddyment, J. R. Madsen, E. N. Eskandar, W. Truccolo, U. T. Eden, S. S. Cash and M. A. Kramer
The authors record both local and long-range neural activity during human epileptic seizures to study the underlying multi-scale dynamics. They find that coupling of activity across spatial scales increases during seizures through propagating waves that are fit by a model that combines neural activity and potassium concentration dynamics.
04 April 2017 | doi: 10.1038/ncomms14896

Biomimetic catalytic transformation of toxic α-oxoaldehydes to high-value chiral α-hydroxythioesters using artificial glyoxalase I OPEN
Sang Yeon Park, In-Soo Hwang, Hyun-Ju Lee and Choong Eui Song
Glyoxalase I converts toxic methylglyoxal to a thioester. Here the authors report a synthetic analogue capable of enantioselectively converting alpha-keto aldehydes to thioesters via formation of a hemithioacetal, giving access to both enantiomers of a range of alpha-hydroxy thioesters.
04 April 2017 | doi: 10.1038/ncomms14877

Remarkable catalytic activity of dinitrogen-bridged dimolybdenum complexes bearing NHC-based PCP-pincer ligands toward nitrogen fixation OPEN
Aya Eizawa, Kazuya Arashiba, Hiromasa Tanaka, Shogo Kuriyama, Yuki Matsuo, Kazunari Nakajima, Kazunari Yoshizawa and Yoshiaki Nishibayashi
Catalytic nitrogen fixation is a very active research area, given the need to develop mild routes for ammonia production. Here the authors report a PCP-pincer molybdenum complex allowing for highly efficient ammonia generation under ambient conditions.
04 April 2017 | doi: 10.1038/ncomms14874

Glutaredoxin catalysis requires two distinct glutathione interaction sites OPEN
Patricia Begas, Linda Liedgens, Anna Moseler, Andreas J. Meyer and Marcel Deponte
Glutaredoxins have important roles in redox processes. Here the authors show that the enzymatic activity of glutaredoxins requires two distinct glutathione interactions sites, one recognizing the glutathione disulfide substrate and one activating glutathione as a reducing agent.
04 April 2017 | doi: 10.1038/ncomms14835

Mechano-regulated surface for manipulating liquid droplets OPEN
Xin Tang, Pingan Zhu, Ye Tian, Xuechang Zhou, Tiantian Kong and Liqiu Wang
Droplet manipulation is an essential task for designing microfluidic platforms such as lab-on-chip devices. Here Tang et al. develop a non-wettable mesh with reversible liquid adhesion controlled by mechanically inserting wettable pillars which allows for effective and rapid droplet manoeuvring.
04 April 2017 | doi: 10.1038/ncomms14831

A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages OPEN
Mafalda M. A. Pereira, Inês Mahú, Elsa Seixas, Noelia Martinéz-Sánchez, Nadiya Kubasova, Roksana M Pirzgalska, Paul Cohen, Marcelo O Dietrich, Miguel López, Gonçalo J. L. Bernardes and Ana I. Domingos
Diphtheria toxin selectively kills cells engineered to express the diphtheria toxin receptor (DTR). Here the authors report a PEGylated version of diphtheria toxin that does not enter the brain, allowing for ablation of only peripheral cells when using Cre lines that drive DTR expression in both the periphery and in the brain.
03 April 2017 | doi: 10.1038/ncomms14967

Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases OPEN
Hao Yu, Patricia Dranchak, Zhiru Li, Ryan MacArthur, Matthew S. Munson, Nurjahan Mehzabeen, Nathan J. Baird, Kevin P. Battalie, David Ross, Scott Lovell, Clotilde K. S. Carlow, Hiroaki Suga and James Inglese
River blindness, a disease affecting millions throughout the tropics, is caused by parasitic worms. Here, Yu et al. report the discovery and structural characterization of potent macrocyclic peptide inhibitors of iPGM, a nematode-specific phosphoglycerate mutase, as potential leads for novel antimicrobial agents.
03 April 2017 | doi: 10.1038/ncomms14932

Tight cohesion between glycolipid membranes results from balanced water–headgroup interactions OPEN
Matej Kanduč, Alexander Schlaich, Alex H. de Vries, Juliette Jouhet, Eric Maréchal, Bruno Demé, Roland R. Netz and Emanuel Schneck
Glycolipids are commonly found in densely stacked biological membranes, which show unusually strong self-cohesion compared to phospholipid membranes. Here, the authors attribute this phenomenon to the lack of long-range repulsion between glycolipid membranes, a consequence of the headgroup architecture.
03 April 2017 | doi: 10.1038/ncomms14899

Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer’s disease OPEN
Andrew S. P. Lim, Hans-Ulrich Klein, Lei Yu, Lori B. Chibnik, Sanam Ali, Jishu Xu, David A. Bennett and Philip L. De Jager
Diurnal and seasonal rhythms modulate brain function, but we do not know the genomic basis for these rhythms. Here, Lim et al. show diurnal and seasonal rhythms of gene expression in the human brain, their relationship to histone acetylation and DNA methylation, and their disruption in Alzheimer’s disease.
03 April 2017 | doi: 10.1038/ncomms14931

The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA OPEN
Sina Wittmann, Max Renner, Beth R. Watts, Oliver Adams, Miles Huseyin, Carlo Baejen, Kamel El Omari, Cornelia Kilchert, Dong-Hyuk Heo, Tea Kecman, Patrick Cramer, Jonathan M. Grimes and Lidia Vasiljeva
Termination of RNA polymerase II is a critical step in transcription. Here, the authors provide evidence that the fission yeast CID-RRM protein Seb1 is required for termination of coding and non-coding genes through interaction with both the polymerase and the nascent RNA.
03 April 2017 | doi: 10.1038/ncomms14861

Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease OPEN
Annalisa Nobili, Emanuele Claudio Latagliata, Maria Teresa Viscomi, Virve Cavallucci, Debora Cutuli, Giacomo Giacovazzo, Paraskevi Krashia, Francesca Romana Rizzo, Ramona Marino, Mauro Federici, Paola De Bartolo, Daniela Aversa, Maria Concetta Dell’Acqua, Alberto Cordella, Marco Sancandi, Flavio Keller, Laura Petrosini, Stefano Puglisi-Allegra, Nicola Biagio Mercuri, Roberto Coccurello et al.
Dopaminergic dysfunction occurs in Alzheimer’s disease (AD). The authors show that in a mouse model of AD, loss of dopaminergic neurons in the ventral tegmental area, but not the substantia nigra, occurs at early pre-plaque stages, and may contribute to impaired cognition and reward processing.
03 April 2017 | doi: 10.1038/ncomms14727

Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease OPEN
Walter H. A. Kahr, Fred G. Pluthero, Abdul Elkadri, Neil Warner, Marko Drobac, Chang Hua Chen, Richard W. Lo, Ling Li, Ren Li, Qi Li, Cornelia Thoeni, Jie Pan, Gabriella Leung, Irene Lara-Corrales, Ryan Murchie, Ernest Cutz, Ronald M. Laxer, Julia Upton, Chaim M. Roifman, Rae S. M. Yeung et al.
ARPC1B is a component of the actin-related protein 2/3 complex (Arp2/3), which is required for actin filament branching. Kahr et al. show that ARPC1B deficiency in humans is associated with severe multisystem disease that includes platelet abnormalities, eosinophilia, eczema and other indicators of immune disease.
03 April 2017 | doi: 10.1038/ncomms14816

Enabling valley selective exciton scattering in monolayer WSe2 through upconversion OPEN
M. Manca, M. M. Glazov, C. Robert, F. Cadiz, T. Taniguchi, K. Watanabe, E. Courtade, T. Amand, P. Renucci, X. Marie, G. Wang and B. Urbaszek
Monolayer transition metal dichalcogenides host excitons, bound electron-hole pairs that play a pivotal role in optoelectronic applications relying on strong light-matter interaction. Here, the authors unveil the spectroscopic signature of boson scattering of two-dimensional excitons in monolayer WSe2.
03 April 2017 | doi: 10.1038/ncomms14927

A bright triggered twin-photon source in the solid state OPEN
T. Heindel, A. Thoma, M. von Helversen, M. Schmidt, A. Schlehahn, M. Gschrey, P. Schnauber, J. -H. Schulze, A. Strittmatter, J. Beyer, S. Rodt, A. Carmele, A. Knorr and S. Reitzenstein
Photon twins are important for interdisciplinary research fields using non-classical light, such as quantum biology. Here, Heindel et al. demonstrate that a single semiconductor quantum dot integrated into a microlens operates as an efficient photon-pair source.
03 April 2017 | doi: 10.1038/ncomms14870

Learning through ferroelectric domain dynamics in solid-state synapses OPEN
Sören Boyn, Julie Grollier, Gwendal Lecerf, Bin Xu, Nicolas Locatelli, Stéphane Fusil, Stéphanie Girod, Cécile Carrétéro, Karin Garcia, Stéphane Xavier, Jean Tomas, Laurent Bellaiche, Manuel Bibes, Agnès Barthélémy, Sylvain Saïghi and Vincent Garcia
Accurate modelling of memristor dynamics is essential for the development of autonomous learning in artificial neural networks. Through a combined theoretical and experimental study of the polarization switching process in ferroelectric memristors, Boyn et al. establish a model that enables learning and retrieving patterns in a neural system.
03 April 2017 | doi: 10.1038/ncomms14736

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma OPEN
Kenneth Verstraete, Frank Peelman, Harald Braun, Juan Lopez, Dries Van Rompaey, Ann Dansercoer, Isabel Vandenberghe, Kris Pauwels, Jan Tavernier, Bart N. Lambrecht, Hamida Hammad, Hans De Winter, Rudi Beyaert, Guy Lippens and Savvas N. Savvides
The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is a promising therapeutic target. Here the authors characterize the assembly mechanism of the receptor complex driven by human TSLP, and its antagonism by the monoclonal antibody Tezepelumab and a fusion protein comprising the TSLP receptors.
03 April 2017 | doi: 10.1038/ncomms14937

Enzyme catalysed Pictet-Spengler formation of chiral 1,1’-disubstituted- and spiro-tetrahydroisoquinolines OPEN
Benjamin R. Lichman, Jianxiong Zhao, Helen C. Hailes and John M. Ward
The Pictet-Spengler condensation of β-arylethylamine and carbonyl compounds is an important step in the synthesis of bioactive alkaloids. Here, the authors report a Pictet-Spengler reaction between dopamine and unactivated ketones catalysed by norcoclaurine synthase and its engineered variants.
03 April 2017 | doi: 10.1038/ncomms14883

Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses OPEN
S. Dallari, M. Macal, M. E. Loureiro, Y. Jo, L. Swanson, C. Hesser, P. Ghosh and E. I. Zuniga
Type I interferon responses are a core immunoregulatory function of plasmacytoid dendritic cells (pDCs). Here the authors show that SFK family members, including Lyn and Fyn, control type I interferon production in human and mouse pDCs.
03 April 2017 | doi: 10.1038/ncomms14830

On-surface synthesis of aligned functional nanoribbons monitored by scanning tunnelling microscopy and vibrational spectroscopy OPEN
Nataliya Kalashnyk, Kawtar Mouhat, Jihun Oh, Jaehoon Jung, Yangchun Xie, Eric Salomon, Thierry Angot, Frédéric Dumur, Didier Gigmes and Sylvain Clair
On-surface synthesis, in which molecular units assemble and couple on a defined surface, can access rare reaction pathways and products. Here, the authors synthesize functionalized organic nanoribbons on the Ag(110) surface, and monitor the evolution of the covalent reactions by an unorthodox vibrational spectroscopy approach.
03 April 2017 | doi: 10.1038/ncomms14735

Dispersion/dilution enhances phytoplankton blooms in low-nutrient waters OPEN
Yoav Lehahn, Ilan Koren, Shlomit Sharoni, Francesco d’Ovidio, Assaf Vardi and Emmanuel Boss
The degree to which horizontal transport affects phytoplankton ecosystems remains understudied. Here, the authors combine satellite observations, ARGO float data and a simple ecosystem model to explore the impact of horizontal stirring on naturally-stimulated fine-scale phytoplankton blooms.
31 March 2017 | doi: 10.1038/ncomms14868

Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity OPEN
Koenraad Philippaert, Andy Pironet, Margot Mesuere, William Sones, Laura Vermeiren, Sara Kerselaers, Sílvia Pinto, Andrei Segal, Nancy Antoine, Conny Gysemans, Jos Laureys, Katleen Lemaire, Patrick Gilon, Eva Cuypers, Jan Tytgat, Chantal Mathieu, Frans Schuit, Patrik Rorsman, Karel Talavera, Thomas Voets et al.
Steviol glycosides are sweet-tasting compounds isolated from a South American shrub and are increasingly used as sweeteners in foods and beverages. Philippaert et al. demonstrate that steviol glycosides potentiate Ca2+-dependent TRPM5 activity and promote glucose-induced insulin secretion and glucose tolerance.
31 March 2017 | doi: 10.1038/ncomms14733

Synthesizing topological structures containing RNA OPEN
Di Liu, Yaming Shao, Gang Chen, Yuk-Ching Tse-Dinh, Joseph A. Piccirilli and Yossi Weizmann
In vivo, complex topologies have been identified in proteins and DNA, while their existence in RNA is still unclear. Here, the authors design synthetic topological structures containing single stranded RNA, offering tools for investigating biologically relevant questions about RNA topology.
31 March 2017 | doi: 10.1038/ncomms14936

Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage OPEN
Simon G. Pfisterer, Gergana Gateva, Peter Horvath, Juho Pirhonen, Veijo T. Salo, Leena Karhinen, Markku Varjosalo, Samppa J. Ryhänen, Pekka Lappalainen and Elina Ikonen
Lipid droplets (LDs) are cellular organelles dedicated to triacylglycerol storage that can undergo fusion and dissociation events. Here the authors show that formin-like 1-dependent acto-myosin assembly on LDs facilitates their dissociation and, as a consequence, affects hydrolysis and storage of triacylglycerols.
31 March 2017 | doi: 10.1038/ncomms14858

IL-15 sustains IL-7R-independent ILC2 and ILC3 development OPEN
Michelle L. Robinette, Jennifer K. Bando, Wilbur Song, Tyler K. Ulland, Susan Gilfillan and Marco Colonna
ILC2 and ILC3 are generally thought to require IL-7. Here the authors use IL-7 ko mice and provide side-by-side comparison of ILCs from different tissues to show that IL-7 signalling is not required for intestinal ILC maintenance or function and that IL-15 can compensate for absence of IL-7.
31 March 2017 | doi: 10.1038/ncomms14601

Wave-particle energy exchange directly observed in a kinetic Alfvén-branch wave OPEN
Daniel J. Gershman, Adolfo F-Viñas, John C. Dorelli, Scott A. Boardsen, Levon A. Avanov, Paul M. Bellan, Steven J. Schwartz, Benoit Lavraud, Victoria N. Coffey, Michael O. Chandler, Yoshifumi Saito, William R. Paterson, Stephen A. Fuselier, Robert E. Ergun, Robert J. Strangeway, Christopher T. Russell, Barbara L. Giles, Craig J. Pollock, Roy B. Torbert and James L. Burch et al.
Alfvén waves are fundamental plasma modes that provide a mechanism for the transfer of energy between particles and fields. Here the authors confirm experimentally the conservative energy exchange between Alfvén wave fields and plasma particles via high-resolution MMS observations of Earth’s magnetosphere.
31 March 2017 | doi: 10.1038/ncomms14719

PABPN1 gene therapy for oculopharyngeal muscular dystrophy OPEN
A. Malerba, P. Klein, H. Bachtarzi, S. A. Jarmin, G. Cordova, A. Ferry, V. Strings, M. Polay Espinoza, K. Mamchaoui, S. C. Blumen, J. Lacau St Guily, V. Mouly, M. Graham, G. Butler-Browne, D. A. Suhy, C. Trollet and G. Dickson
Oculopharyngeal muscular dystrophy is caused by trinucleotide repeat expansions in the PABPN1 gene. Here the authors use AAV-based gene therapy to knockdown the mutant gene and replace it with a wild-type allele, and show effectiveness in mice and in patient cells.
31 March 2017 | doi: 10.1038/ncomms14848

A tipping point in refreezing accelerates mass loss of Greenland’s glaciers and ice caps OPEN
B. Noël, W. J van de Berg, S. Lhermitte, B. Wouters, H. Machguth, I. Howat, M. Citterio, G. Moholdt, J. T. M. Lenaerts and M. R. van den Broeke
Mass loss of Greenland’s glaciers and ice caps (GICs) is a major contributor to contemporary sea-level rise. Here, the authors identify the year 1997 as a tipping point in GICs mass loss induced by a rapid deterioration of the refreezing capacity of inland snow, resulting in irreversible long-term mass loss.
31 March 2017 | doi: 10.1038/ncomms14730

Rapid electron transfer by the carbon matrix in natural pyrogenic carbon OPEN
Tianran Sun, Barnaby D. A. Levin, Juan J. L. Guzman, Akio Enders, David A. Muller, Largus T. Angenent and Johannes Lehmann
Electron transfer reactions govern most biogeochemical processes, yet we have a limited knowledge of the electrochemistry of pyrogenic carbon, a major component of organic matter. Here, the authors quantify electron transfers between pyrogenic carbon and mineral phases under different pyrolysis temperatures.
31 March 2017 | doi: 10.1038/ncomms14873

Graphene-like nanoribbons periodically embedded with four- and eight-membered rings OPEN
Meizhuang Liu, Mengxi Liu, Limin She, Zeqi Zha, Jinliang Pan, Shichao Li, Tao Li, Yangyong He, Zeying Cai, Jiaobing Wang, Yue Zheng, Xiaohui Qiu and Dingyong Zhong
Graphene nanoribbons consist of carbon atoms arranged in a hexagonal lattice. Despite non-hexagonal rings generally being more unstable, the authors demonstrate the successful synthesis of graphene-like nanoribbons with periodically embedded four- and eight-membered carbon rings, with tailored electronic properties.
31 March 2017 | doi: 10.1038/ncomms14924

Integrated arrays of air-dielectric graphene transistors as transparent active-matrix pressure sensors for wide pressure ranges OPEN
Sung-Ho Shin, Sangyoon Ji, Seiho Choi, Kyoung-Hee Pyo, Byeong Wan An, Jihun Park, Joohee Kim, Ju-Young Kim, Ki-Suk Lee, Soon-Yong Kwon, Jaeyeong Heo, Byong-Guk Park and Jang-Ung Park
Electronic skins and health monitoring devices rely on integrated tactile sensors, which often require tailored degrees of sensitivity in specific pressure ranges. Here, the authors fabricate a versatile matrix array of pressure-sensitive graphene transistors operating in the wide 250 Pa to 3 MPa pressure range.
31 March 2017 | doi: 10.1038/ncomms14950

Development of the macaque face-patch system OPEN
Margaret S. Livingstone, Justin L. Vincent, Michael J. Arcaro, Krishna Srihasam, Peter F. Schade and Tristram Savage
Development of neural circuits for face recognition is not well studied in primates. Here the authors longitudinally track responses to faces in monkeys from about a month of age to two years and demonstrate that face-selective responses emerge in inferotemporal cortex early and gradually stabilize over time.
31 March 2017 | doi: 10.1038/ncomms14897

A retinoraphe projection regulates serotonergic activity and looming-evoked defensive behaviour OPEN
Lu Huang, Tifei Yuan, Minjie Tan, Yue Xi, Yu Hu, Qian Tao, Zhikai Zhao, Jiajun Zheng, Yushui Han, Fuqiang Xu, Minmin Luo, Patricia J. Sollars, Mingliang Pu, Gary E. Pickard, Kwok-Fai So and Chaoran Ren
Neural circuits underlying innate fear are only partially understood. Huang et al. identify a subset of retinal ganglion cells that project to both the dorsal raphe nucleus and the superior colliculus, and show that these RGCs mediate looming-evoked defensive behaviours in mice.
31 March 2017 | doi: 10.1038/ncomms14908

The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction OPEN
Guang Yang, Xinyu Weng, Yuhao Zhao, Xinjian Zhang, Yuanping Hu, Xin Dai, Peng Liang, Peng Wang, LeiLei Ma, Xiaolei Sun, Lei Hou, Huihui Xu, Mingming Fang, Yuehua Li, Thomas Jenuwein, Yong Xu and Aijun Sun
The molecular pathways regulating the cardioprotective activity of deacetylase sirtuin-1 are unknown. Here, Yang et al. show that histone H3K9 methyltransferase SUV39H and HP1gamma cooperatively methylate H3K9 on the sirtuin-1 promoter and inhibit sirtuin-1 transcription, and show that inhibition of SUV39H in mice is cardioprotective.
31 March 2017 | doi: 10.1038/ncomms14941

USP9X regulates centrosome duplication and promotes breast carcinogenesis OPEN
Xin Li, Nan Song, Ling Liu, Xinhua Liu, Xiang Ding, Xin Song, Shangda Yang, Lin Shan, Xing Zhou, Dongxue Su, Yue Wang, Qi Zhang, Cheng Cao, Shuai Ma, Na Yu, Fuquan Yang, Yan Wang, Zhi Yao, Yongfeng Shang and Lei Shi et al.
USP9X is a deubiquitinating enzyme with many known substrates and functions; it has been linked to cancer but the mechanisms remain unclear. Here Li et al. report that USP9X stabilizes the centrosomal protein CEP131 leading to centrosome amplification and breast cancer development.
31 March 2017 | doi: 10.1038/ncomms14866

Pressure modulates the self-cleavage step of the hairpin ribozyme OPEN
Caroline Schuabb, Narendra Kumar, Salome Pataraia, Dominik Marx and Roland Winter
Studying the reactivity of ribozymes under extreme pressure could provide insights to optimize biocatalytic RNA design. Here, the authors show that at high pressure the transesterification step of the hairpin ribozyme self-cleavage reaction accelerates, while the overall process is slower.
30 March 2017 | doi: 10.1038/ncomms14661

Structure and vacancy distribution in copper telluride nanoparticles influence plasmonic activity in the near-infrared OPEN
Tom Willhammar, Kadir Sentosun, Stefanos Mourdikoudis, Bart Goris, Mert Kurttepeli, Marnik Bercx, Dirk Lamoen, Bart Partoens, Isabel Pastoriza-Santos, Jorge Pérez-Juste, Luis M. Liz-Marzán, Sara Bals and Gustaaf Van Tendeloo
CuTe nanocrystals may be used as an alternative to noble metals for plasmonics but requires understanding of the atomic structure and the influence of defects. Here Willhammar et al. use electron tomography to reveal the distribution of vacancies in the nanocrystals and their effect on the optical properties.
30 March 2017 | doi: 10.1038/ncomms14925

Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure OPEN
Garima Jaipuria, Andrei Leonov, Karin Giller, Suresh Kumar Vasa, Łukasz Jaremko, Mariusz Jaremko, Rasmus Linser, Stefan Becker and Markus Zweckstetter
The outer mitochondrial membrane translocator protein (TSPO) mediates several mitochondrial functions and binds cholesterol with a high affinity. Here the authors use solid-state NMR to show that cholesterol binding to TSPO results in allosteric changes that modulate TSPO oligomerization.
30 March 2017 | doi: 10.1038/ncomms14893

FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons OPEN
Lorenzo Errichelli, Stefano Dini Modigliani, Pietro Laneve, Alessio Colantoni, Ivano Legnini, Davide Capauto, Alessandro Rosa, Riccardo De Santis, Rebecca Scarfò, Giovanna Peruzzi, Lei Lu, Elisa Caffarelli, Neil A. Shneider, Mariangela Morlando and Irene Bozzoni
The RNA binding protein FUS functions in several RNA biosynthetic processes and has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS). Here the authors show that FUS controls back-splicing reactions leading to circular RNA (circRNA) production in stem cell-derived motor neurons and that ALS-associated FUS mutations affect the biogenesis of circRNAs.
30 March 2017 | doi: 10.1038/ncomms14741

Allosteric cross-talk in chromatin can mediate drug-drug synergy OPEN
Zenita Adhireksan, Giulia Palermo, Tina Riedel, Zhujun Ma, Reyhan Muhammad, Ursula Rothlisberger, Paul J. Dyson and Curt A. Davey
Allostery and drug-drug synergism can yield potential novel therapies with existing molecules. Here, the authors provide evidence that two unrelated drugs have increased cytotoxicity in cancer cells, which coincides with increased formation of chromatin adducts.
30 March 2017 | doi: 10.1038/ncomms14860

Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy OPEN
Natalie A. Afshari, Robert P. Igo, Nathan J. Morris, Dwight Stambolian, Shiwani Sharma, V. Lakshmi Pulagam, Steven Dunn, John F. Stamler, Barbara J. Truitt, Jacqueline Rimmler, Abraham Kuot, Christopher R. Croasdale, Xuejun Qin, Kathryn P. Burdon, S. Amer Riazuddin, Richard Mills, Sonja Klebe, Mollie A. Minear, Jiagang Zhao, Elmer Balajonda et al.
Fuchs endothelial corneal dystrophy (FECD) is one of the most common reasons for corneal transplantation, and is known to cluster in families. Here, the authors discover new genetic loci associated with FECD with sex-specific effects and implications for disease mechanism.
30 March 2017 | doi: 10.1038/ncomms14898

Epithelial tension in the second heart field promotes mouse heart tube elongation OPEN
Alexandre Francou, Christopher De Bono and Robert G. Kelly
Epithelial progenitor cell growth in the second heart field contributes to heart morphogenesis but how this is regulated at the tissue level is unclear. Here, the authors show that cell elongation, polarized actomyosin and nuclear YAP/TAZ drive epithelial growth and correlate with mechanical tension.
30 March 2017 | doi: 10.1038/ncomms14770

The Par3 polarity protein is an exocyst receptor essential for mammary cell survival OPEN
Syed Mukhtar Ahmed and Ian G. Macara
The exocyst delivers basolateral proteins from the secretory pathway to the plasma membrane of epithelial cells close to tight junctions. Here the authors show that Par3 acts as a docking site for the exocyst to regulate polarized delivery of basolateral proteins and this is essential to prevent apoptosis and promote mammary cell survival.
30 March 2017 | doi: 10.1038/ncomms14867

Sequence-selective encapsulation and protection of long peptides by a self-assembled FeII8L6 cubic cage OPEN
Jesús Mosquera, Bartosz Szyszko, Sarah K. Y. Ho and Jonathan R. Nitschke
One of the challenges of synthetic self-assembled capsules is achieving selective recognition of specific cargoes. Here, authors synthesize a self-assembled porphyrin cubic cage that is capable of sequestering imidazole and thiazole-containing small molecules and peptides, protecting them from proteolysis.
30 March 2017 | doi: 10.1038/ncomms14882

Temperature-tunable Fano resonance induced by strong coupling between Weyl fermions and phonons in TaAs OPEN
B. Xu, Y. M. Dai, L. X. Zhao, K. Wang, R. Yang, W. Zhang, J. Y. Liu, H. Xiao, G. F. Chen, S. A. Trugman, J-X Zhu, A. J. Taylor, D. A. Yarotski, R. P. Prasankumar and X. G. Qiu
The study of lattice vibrations coupled to electronic excitations may provide an avenue for exploring exotic physical phenomena. Here, Xu et al. observe a Fano resonance in the Weyl semimetal TaAs, revealing evidence for a strong coupling between phonons and Weyl fermions.
30 March 2017 | doi: 10.1038/ncomms14933
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Corrigendum: Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis OPEN
Isabel Ohs, Maries van den Broek, Kathrin Nussbaum, Christian Münz, Sebastian J. Arnold, Sergio A. Quezada, Sonia Tugues and Burkhard Becher
04 April 2017 | doi: 10.1038/ncomms15185
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Yueshuang Ke, Yanlong Han, Xiaolan Guo, Jitao Wen, Ke Wang, Xue Jiang, Xue Tian, Xueqing Ba, Istvan Boldogh and Xianlu Zeng
31 March 2017 | doi: 10.1038/ncomms15191

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