Tuesday, March 21, 2017

Nature Reviews Molecular Cell Biology contents April 2017 Volume 18 Number 4 pp 211-273

If you are unable to see the message below, click here to view.

Nature Reviews Molecular Cell Biology


Advertisement
Nature Reviews Immunology and Nature Reviews Molecular Cell Biology: Poster on Bone marrow niches and HSC fates

This poster shows the signalling pathways between stromal and haematopoietic cells of the bone marrow niche that direct the fate of haematopoietic stem cells. 

Download

Produced with support from 
STEMCELL Technologies
 
 
TABLE OF CONTENTS
 
April 2017 Volume 18 Number 4
Nature Reviews Molecular Cell Biology cover

2015 2-year Impact Factor 38.602 Journal Metrics 2-year Median 30

In this issue
Research Highlights
Reviews

Also this month
 Featured article:
RNA-based recognition and targeting: sowing the seeds of specificity
Stanislaw A. Gorski, Jörg Vogel & Jennifer A. Doudna
Subscribe
 
Facebook
 
RSS
 
Recommend to library
 
Twitter
 
Advertisement
The 2017 Symposium on Translational Epigenetics will explore this rapidly growing area of investigation in biomedicine which may be key to developing novel therapies for some of the most important and intractable diseases. The symposium features talks from outstanding, international speakers in the field of translational epigenetics. Registration is free but places are limited.
 
Advertisement
Looking to recruit? Limited time offer from Naturejobs: 

Get a 20% discount on our Premium job posting package when you buy before March 31, 2017.

  • Reach a potential audience of 10.8 million users* via nature.com
  • Be seen first by candidates — your position will appear at the top of related searches for 60 days and be displayed prominently on the Naturejobs home page as Job of the Week.
  • Plus appear as 'Featured' in search results
Post a job now.

* Publisher data 2016
 
 
Advertisement
NATURE CONFERENCE ON INFLAMMATORY DISEASES
Presented by: Chinese Academy of Medical Sciences & Peking Union Medical College | Chinese Society for Immunology (CSI) | Nature Reviews Immunology | Nature Immunology | Nature | Nature Communications

This conference will feature sessions on microbiota, cell death, metabolism, technologies, and innate sensing and signaling as they relate to inflammatory diseases and cancer.

September 17-20, 2017 | Beijing, China

REGISTER NOW!
 
RESEARCH HIGHLIGHTSTop

Stem cells: Self-consumption will keep your blood young
p211 | doi:10.1038/nrm.2017.19
Autophagy is shown to restrict metabolic activation of adult haematopoietic stem cells, thereby contributing to the maintenance of their quiescence and stem cell potential throughout life.
PDF


Non-coding RNA: The cancer link(RNA) between PIP3 and AKT
p212 | doi:10.1038/nrm.2017.18
The specific binding of the lincRNA LINK-A tothe phospholipid PIP3 and the kinase AKT activates AKT and promotes tumorigenesis and resistance to AKT inhibitors.
PDF


In the news
p212 | doi:10.1038/nrm.2017.23
Co-culturing embryonic stem cells and trophoblast stem cells in a 3D scaffold recreates early steps of mouse embryogenesis.
PDF


Epigenetics: DNA methylation prevents intragenic transcription
p212 | doi:10.1038/nrm.2017.25
DNA methylation by DNMT3B within the bodies of genes prevents aberrant transcription initiation.
PDF


JOURNAL CLUB
Unclogging sickle cell anaemia

p214 | doi:10.1038/nrm.2017.17
Li and Lodish describe how a shift in our understanding of the molecular basis of sickle cell anaemia has led to clinical success.
PDF


Protein metabolism: Counteracting toxic protein aggregation
p214 | doi:10.1038/nrm.2017.24
Sirtuin 2 deacetylates the amino terminus of [alpha]-synuclein, thereby favouring its aggregation and toxicity associated with neurodegenerative diseases.
PDF



IN BRIEF

Cell signalling: Notch under tension | Chromosome biology: Trimethylation of CENP-A supports mitotic fidelity | Membrane dynamics: PERKs of plasma membrane-ER communication
PDF

Molecular Cell Biology
JOBS of the week
Calling Protein Scientists interested in treating Infectious Diseases
Immunocore
PhD Scientist – Immunology
Vedanta BioSciences
Research Technician II, Molecular Biology
Fred Hutchinson Cancer Research Center
Postdoctoral Training in GLP-1 Metabolism
Case Western Reserve University, School of Medicine
Professor (W3) MOLECULAR AND CELLULAR BOTANY
Ruhr-Universität Bochum
More Science jobs from
Molecular Cell Biology
EVENT
Single Cell Omics
17.09.17
Siena, Italy
More science events from
Advertisement
nature.com webcasts

Join us for our upcoming webcast followed by live Q&A:
NEW INNOVATIONS IN DRUG DELIVERY TECHNOLOGY 

Presented by BioPharma Dealmakers

Date: Wednesday, March 29, 2017
Time: 8AM PDT | 11AM EDT | 4PM BST | 5PM CEST

REGISTER FOR FREE

Sponsored by: Corium International | Portal Instruments Inc. | TissueGen Inc. | TrioxNano
 
 
REVIEWSTop
RNA-based recognition and targeting: sowing the seeds of specificity
Stanislaw A. Gorski, Jörg Vogel & Jennifer A. Doudna
p215 | doi:10.1038/nrm.2016.174
Insights into eukaryotic, bacterial and archaeal RNA-based regulatory systems, including microRNAs, small interfering RNAs, clustered regularly interspaced short palindromic repeats (CRISPR) RNA and small RNAs that are dependent on the RNA chaperone protein Hfq, have revealed that they achieve specificity using similar strategies. Specifically, the presentation of short 'seed sequences' within a ribonucleoprotein complex facilitates the search for and recognition of targets.
Abstract | Full Text | PDF
Mechanisms and functions of nuclear envelope remodelling
Rosemarie Ungricht & Ulrike Kutay
p229 | doi:10.1038/nrm.2016.153
The nuclear envelope is more than a static barrier between the nuclear and cytoplasmic compartments. It is very dynamic and undergoes extensive remodelling in response to mechanical challenges as well as during cell division, growth and differentiation.
Abstract | Full Text | PDF
Functions of bromodomain-containing proteins and their roles in homeostasis and cancer
Takao Fujisawa & Panagis Filippakopoulos
p246 | doi:10.1038/nrm.2016.143
Bromodomains (BRDs) are domains found in diverse proteins that recognize acetylated Lys residues, primarily on histones. Hence, BRD-containing proteins serve as readers of protein acetylation and engage in the regulation of gene expression. Recent studies have provided new insights into the physiological roles of BRD-containing proteins and their deregulation in cancer.
Abstract | Full Text | PDF | Supplementary information
The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domain
Kevin M. Harlen & L. Stirling Churchman
p263 | doi:10.1038/nrm.2017.10
The carboxy-terminal domain (CTD) of RNA polymerase II is a repetitive and unstructured domain that is dynamically modified by post-translational modifications, which collectively constitute the 'CTD code'. Recent studies have revealed how CTD function is also promoted by phase separation in the presence of other low-complexity domains.
Abstract | Full Text | PDF
nature events
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.

Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com
More Nature Events
*2015 Journal Citation Reports (Thomson Reuters, 2016)

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount
(You will need to log in to be recognised as a nature.com registrant).

For further technical assistance, please contact our registration department

For print subscription enquiries, please contact our subscription department

For other enquiries, please contact our feedback department

Nature Publishing Group | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA

Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston

Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW.

© 2017 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.

nature publishing group

No comments: