Wednesday, March 29, 2017

Nature Communications - 29 March 2017

Nature Communications

Nature Protocols: Poster on the production of Chimeric Antigen Receptor T-cells

This poster overviews the production of (CAR) T-cells, discussing the significant and unique challenges of the production process 

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29 March 2017 
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Nature Insight Frontiers in Biology

This year's Frontiers in Biology Insight features Reviews on how genomics is helping to uncover the peopling of the world, the interplay between morphogens and morphogenesis in determining organismal shape, the factors that influence the immune response to cancer, advances in single-cell genomics, and the effects of base modifications in messenger RNA.
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Focus on Disease models: reproducibility and translation 

Lab Animal, a Nature Research journal focusing on in vivo methods, research and technology with model organisms of human health & disease, presents a special Focus on reproducibility and translation of in vivo research with disease models. 

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September 27-29, 2017 | Seoul, Korea

Presented by: Institute for Basic Science | Institute of Genetics and Developmental Biology, CAS | Nature | Nature Biotechnology

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  Latest Review View all Reviews  
Regioregular narrow-bandgap-conjugated polymers for plastic electronics OPEN
Lei Ying, Fei Huang and Guillermo C. Bazan
The continued search of high-performance semiconductors for organic electronics calls for smart molecular designs. Here, Ying et al. review the recent development of synthesizing regioregular narrow bandgap conjugated polymers and the effect of regioregularity on transistor and photovoltaic performance.
28 March 2017 | doi: 10.1038/ncomms14047
  Latest Correspondence  
Correspondence: Oncogenic MYC persistently upregulates the molecular clock component REV-ERBα OPEN
23 March 2017 | doi: 10.1038/ncomms14862

Correspondence: Reply to ‘Oncogenic MYC persistently upregulates the molecular clock component REV-ERBα’ OPEN
23 March 2017 | doi: 10.1038/ncomms14918
  Latest Articles View all Articles  
A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle OPEN
Shuo Xiao, Jonathan R. Coppeta, Hunter B. Rogers, Brett C. Isenberg, Jie Zhu, Susan A. Olalekan, Kelly E. McKinnon, Danijela Dokic, Alexandra S. Rashedi, Daniel J. Haisenleder, Saurabh S. Malpani, Chanel A. Arnold-Murray, Kuanwei Chen, Mingyang Jiang, Lu Bai, Catherine T. Nguyen, Jiyang Zhang, Monica M. Laronda, Thomas J. Hope, Kruti P. Maniar et al.
The female reproductive tract constitutes the ovary, fallopian tubes, uterus, and cervix, but it is challenging to engineer this system in vitro. Here, the authors develop a microfluidic device (EVATAR) with reproductive tract and peripheral tissues to replicate hormone release of a 28-day menstrual cycle.
28 March 2017 | doi: 10.1038/ncomms14584

Proteogenomic integration reveals therapeutic targets in breast cancer xenografts OPEN
Kuan-lin Huang, Shunqiang Li, Philipp Mertins, Song Cao, Harsha P. Gunawardena, Kelly V. Ruggles, D. R. Mani, Karl R. Clauser, Maki Tanioka, Jerry Usary, Shyam M. Kavuri, Ling Xie, Christopher Yoon, Jana W Qiao, John Wrobel, Matthew A. Wyczalkowski, Petra Erdmann-Gilmore, Jacqueline E. Snider, Jeremy Hoog, Purba Singh et al.
Patient-derived xenografts recapitulate major genomic signatures and transcriptome profiles of their original tumours. Here, the authors, performing proteomic and phosphoproteomic analyses of 24 breast cancer PDX models, demonstrate that druggable candidates can be identified based on a comprehensive proteogenomic profiling.
28 March 2017 | doi: 10.1038/ncomms14864

Stable and solubilized active Au atom clusters for selective epoxidation of cis-cyclooctene with molecular oxygen OPEN
Linping Qian, Zhen Wang, Evgeny V. Beletskiy, Jingyue Liu, Haroldo J. dos Santos, Tiehu Li, Maria do C. Rangel, Mayfair C. Kung and Harold H. Kung
Gold catalysts have previously been reported for the epoxidation of alkenes with molecular oxygen. Here the authors show that, rather than the gold nanoparticles, the active species for this reaction are actually small, soluble gold species stabilized by the oxidised organic products.
28 March 2017 | doi: 10.1038/ncomms14881

Endocannabinoid signalling modulates susceptibility to traumatic stress exposure OPEN
Rebecca J. Bluett, Rita Báldi, Andre Haymer, Andrew D. Gaulden, Nolan D. Hartley, Walker P. Parrish, Jordan Baechle, David J. Marcus, Ramzi Mardam-Bey, Brian C. Shonesy, Md. Jashim Uddin, Lawrence J. Marnett, Ken Mackie, Roger J. Colbran, Danny G. Winder and Sachin Patel
Understanding inter-individual differences in stress-susceptibility could lead to novel treatments and preventative strategies for stress-related pathologies. Here the authors provide evidence that increased endocannabinoid signalling is a resilience factor that buffers against adverse consequences of stress.
28 March 2017 | doi: 10.1038/ncomms14782

Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death OPEN
Laure Botella, Julien Vaubourgeix, Jonathan Livny and Dirk Schnappinger
The transcription termination factor Rho is essential for growth in some bacteria but not in others. Here, Botella et al. show that Rho inactivation causes extensive pervasive transcription and loss of viability of the pathogen Mycobacterium tuberculosis both in vitro and in a mouse model of infection.
28 March 2017 | doi: 10.1038/ncomms14731

Faster phonological processing and right occipito-temporal coupling in deaf adults signal poor cochlear implant outcome OPEN
Diane S. Lazard and Anne-Lise Giraud
Cochlear implants have variable outcomes for adult deafness. Here the authors show that fast responses and specific recruitment of right temporal cortex on a simple visual rhyming task strongly predicts poor implant performance.
28 March 2017 | doi: 10.1038/ncomms14872

Inhibiting the system xC/glutathione axis selectively targets cancers with mutant-p53 accumulation OPEN
David S. Liu, Cuong P. Duong, Sue Haupt, Karen G. Montgomery, Colin M. House, Walid J. Azar, Helen B. Pearson, Oliver M. Fisher, Matthew Read, Glen R. Guerra, Ygal Haupt, Carleen Cullinane, Klas G. Wiman, Lars Abrahmsen, Wayne A. Phillips and Nicholas J. Clemons
Efficient therapeutic strategies to target mutant-p53 cancers are needed. Here, the authors demonstrate the molecular mechanism through which mutant-p53 tumours are susceptible to oxidative damage and propose a potential strategy for targeting such cancers by inhibiting the SLC7A11-glutathione axis.
28 March 2017 | doi: 10.1038/ncomms14844

A Pseudomonas T6SS effector recruits PQS-containing outer membrane vesicles for iron acquisition OPEN
Jinshui Lin, Weipeng Zhang, Juanli Cheng, Xu Yang, Kaixiang Zhu, Yao Wang, Gehong Wei, Pei-Yuan Qian, Zhao-Qing Luo and Xihui Shen
Pathogens require iron for their metabolism and virulence. Here the authors identify an iron acquisition system in Pseudomonas aeruginosa involving a protein secreted by a type VI secretion system, the PQS signalling compound and siderophore receptors.
28 March 2017 | doi: 10.1038/ncomms14888

Dust outpaces bedrock in nutrient supply to montane forest ecosystems OPEN
S. M. Aciego, C. S. Riebe, S. C. Hart, M. A. Blakowski, C. J. Carey, S. M. Aarons, N. C. Dove, J. K. Botthoff, K. W. W. Sims and E. L. Aronson
Dust is an important nutrient source to landscapes, but often the source of dust is poorly constrained. Here, the authors quantify the origin of different dust sources in the Sierra Nevada by analysing dust composition and suggest exogenic dust may drive nutrient budgets in montane ecosystems.
28 March 2017 | doi: 10.1038/ncomms14800

Plasmonic hot electron transport drives nano-localized chemistry OPEN
Emiliano Cortés, Wei Xie, Javier Cambiasso, Adam S. Jermyn, Ravishankar Sundararaman, Prineha Narang, Sebastian Schlücker and Stefan A. Maier
Quantitative understanding of the spatial localization of hot carriers has been elusive. Here Cortes et al. spatially map hot-electron-driven reduction chemistry with 15 nm resolution as a function of time and electromagnetic field polarization for different plasmonic nanostructures.
28 March 2017 | doi: 10.1038/ncomms14880

Functional cis-regulatory modules encoded by mouse-specific endogenous retrovirus OPEN
Vasavi Sundaram, Mayank N. K. Choudhary, Erica Pehrsson, Xiaoyun Xing, Christopher Fiore, Manishi Pandey, Brett Maricque, Methma Udawatta, Duc Ngo, Yujie Chen, Asia Paguntalan, Tammy Ray, Ava Hughes, Barak A. Cohen and Ting Wang
The gene-battery model posits transposable elements (TEs) may be cis-regulatory elements to control gene expression. Here, mouse-specific TEs are shown as binding sites for multiple collaborating transcription factors in embryonic stem cells, and act as cis-regulatory modules in synergistic fashion.
28 March 2017 | doi: 10.1038/ncomms14550

One-step fabrication of crystalline metal nanostructures by direct nanoimprinting below melting temperatures OPEN
Ze Liu
Rapid fabrication of well-controlled metallic nanostructures remains a challenge. Here, the authors directly nanoimprint several different crystalline metals by superplastic forming well below their melting temperatures, obtaining uniform nanostructures with small features and high aspect ratios in one step.
28 March 2017 | doi: 10.1038/ncomms14910

Plasmonic photoluminescence for recovering native chemical information from surface-enhanced Raman scattering OPEN
Kai-Qiang Lin, Jun Yi, Jin-Hui Zhong, Shu Hu, Bi-Ju Liu, Jun-Yang Liu, Cheng Zong, Zhi-Chao Lei, Xiang Wang, Javier Aizpurua, Rubén Esteban and Bin Ren
Localized surface plasmon resonances induce strong modifications of surface-enhanced Raman spectra. Here the authors propose a robust method to retrieve the fingerprint of intrinsic chemical information by using the photoluminescence of the metallic structures to correct the spectra.
28 March 2017 | doi: 10.1038/ncomms14891

Global site-specific N-glycosylation analysis of HIV envelope glycoprotein OPEN
Liwei Cao, Jolene K. Diedrich, Daniel W. Kulp, Matthias Pauthner, Lin He, Sung-Kyu Robin Park, Devin Sok, Ching Yao Su, Claire M. Delahunty, Sergey Menis, Raiees Andrabi, Javier Guenaga, Erik Georgeson, Michael Kubitz, Yumiko Adachi, Dennis R. Burton, William R. Schief, John R. Yates III and James C. Paulson
The analysis of site-specific glycosylation of HIV Envelope glycoprotein (Env) is challenging as it contains 25–30 glycosylation sites with multiple glycan forms at each site. Here the authors present a generally applicable mass spectrometry-based method for site-specific analysis of protein glycosylation that they apply to the analysis of the HIV-1 Env.
28 March 2017 | doi: 10.1038/ncomms14954

A redox-mediated Kemp eliminase OPEN
Aitao Li, Binju Wang, Adriana Ilie, Kshatresh D. Dubey, Gert Bange, Ivan V. Korendovych, Sason Shaik and Manfred T. Reetz
The majority of enzymatic Kemp elimination reactions proceed via a well-established acid-base mechanism. Here, the authors show that cytochrome P450 is able to metabolize the leflunomide drug via a redox Kemp elimination, offering new insights into enzyme catalysis.
28 March 2017 | doi: 10.1038/ncomms14876

Terahertz and mid-infrared plasmons in three-dimensional nanoporous graphene OPEN
Fausto D’Apuzzo, Alba R. Piacenti, Flavio Giorgianni, Marta Autore, Mariangela Cestelli Guidi, Augusto Marcelli, Ulrich Schade, Yoshikazu Ito, Mingwei Chen and Stefano Lupi
Recently, fabrication processes have realised three-dimensional nanoporous graphene. Here, the authors reveal two-dimensional Dirac plasmons in three-dimensional nanoporous graphene disclosing strong plasmonic absorptions tunable from terahertz to mid-infrared via controllable doping level and porosity.
27 March 2017 | doi: 10.1038/ncomms14885

Direct amidation of esters with nitroarenes OPEN
Chi Wai Cheung, Marten Leendert Ploeger and Xile Hu
Direct conversion of esters to amides, while attractive, is often limited to activated esters or highly nucleophilic amines. Here the authors report a nickel-catalysed reductive coupling between unactivated esters and nitroarenes, giving a direct route to aromatic amides.
27 March 2017 | doi: 10.1038/ncomms14878

Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase OPEN
Andre S. Godoy, Gustavo M. A. Lima, Ketllyn I. Z. Oliveira, Naiara U. Torres, Fernando V. Maluf, Rafael V. C. Guido and Glaucius Oliva
The Zika virus outbreak is a global health threat and there is an urgent need for drugs against the virus. Here the authors present the structure of the RNA-dependent RNA-polymerase domain from Zika non-structural protein 5, which is a template for the design of non-nucleoside polymerase inhibitors.
27 March 2017 | doi: 10.1038/ncomms14764

Enhancing titres of therapeutic viral vectors using the transgene repression in vector production (TRiP) system OPEN
H. E. Maunder, J. Wright, B. R. Kolli, C. R. Vieira, T. T. Mkandawire, S. Tatoris, V. Kennedy, S. Iqball, G. Devarajan, S. Ellis, Y. Lad, N. G. Clarkson, K. A. Mitrophanous and D. C. Farley
The maximum titre of therapeutic viral vectors can be adversely affected by the encoded transgene. Here the authors repress transgene expression in producing cells by employing the tryptophan RNA-binding attenuation protein and show that it improves titre of RNA- and DNA-based viral vectors expressing toxic transgenes.
27 March 2017 | doi: 10.1038/ncomms14834

The structure of Zika virus NS5 reveals a conserved domain conformation OPEN
Boxiao Wang, Xiao-Feng Tan, Stephanie Thurmond, Zhi-Min Zhang, Asher Lin, Rong Hai and Jikui Song
The recent outbreak of Zika virus is a major worldwide health concern and effective drugs are currently not available. Here the authors present the structure of Zika non-structural protein 5 and identify a potential drug-binding site, which might facilitate the development of novel antivirals.
27 March 2017 | doi: 10.1038/ncomms14763

Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression OPEN
Weikang Cai, Masaji Sakaguchi, Andre Kleinridders, Gonzalo Gonzalez-Del Pino, Jonathan M. Dreyfuss, Brian T. O’Neill, Alfred K. Ramirez, Hui Pan, Jonathon N. Winnay, Jeremie Boucher, Michael J. Eck and C. Ronald Kahn
Despite being structurally similar, the insulin receptor (IR) and insulin growth factor I receptor (IGF1R) elicit distinct signalling pathways. Here the authors use receptor chimeras to unveil that IR and IGF1R signalling is related primarily to differences in their intracellular juxtamembrane region.
27 March 2017 | doi: 10.1038/ncomms14892

Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF OPEN
Xusheng Wang, Haiyan Chen, Ruiyun Tian, Yiling Zhang, Marina S. Drutskaya, Chengmei Wang, Jianfeng Ge, Zhimeng Fan, Deqiang Kong, Xiaoxiao Wang, Ting Cai, Ying Zhou, Jingwen Wang, Jinmei Wang, Shan Wang, Zhihai Qin, Huanhuan Jia, Yue Wu, Jia Liu, Sergei A. Nedospasov et al.
Hair can be regenerated after skin wounding. Here the authors show that inflammatory macrophages produce TNF that activates Wnt signalling in hair follicle stem cells to drive this hair regeneration after wound repair in mice.
27 March 2017 | doi: 10.1038/ncomms14091

The soybean GmSNAP18 gene underlies two types of resistance to soybean cyst nematode OPEN
Shiming Liu, Pramod K. Kandoth, Naoufal Lakhssassi, Jingwen Kang, Vincent Colantonio, Robert Heinz, Greg Yeckel, Zhou Zhou, Sadia Bekal, Johannes Dapprich, Bjorn Rotter, Silvia Cianzio, Melissa G. Mitchum and Khalid Meksem
Peking-type and PI 88788-type soybeans are both used as sources of resistance against soybean cyst nematode. Here the authors show that in contrast to PI 88788-type resistance, where GmSNAP18 acts in combination with two neighbouring genes, in Peking-type resistance GmSNAP18 acts with GmSHMT08 to confer resistance.
27 March 2017 | doi: 10.1038/ncomms14822

Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy OPEN
Zuqiang Liu, Roshni Ravindranathan, Pawel Kalinski, Z. Sheng Guo and David L. Bartlett
Anti-PD-L1 therapy often fails in cancers with minimal lymphocytic infiltrates and low PD-L1 expression. Here, the authors show that an oncolytic virus increases PD-L1 expression in cancer models and that the combination with an anti-PD-L1 antibody enhances therapy by increasing the infiltration of activated T cells, and reducing exhausted T cells.
27 March 2017 | doi: 10.1038/ncomms14754

Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease OPEN
Zhentao Zhang, Obiamaka Obianyo, Elfriede Dall, Yuhong Du, Haian Fu, Xia Liu, Seong Su Kang, Mingke Song, Shan-Ping Yu, Chiara Cabrele, Mario Schubert, Xiaoguang Li, Jian-Zhi Wang, Hans Brandstetter and Keqiang Ye
Delta-secretases are associated with Alzheimer’s disease (AD) as they cleave both amyloid precursor protein and tau. Here the authors develop a series of orally bioactive small molecule delta-secretase inhibitors and report its therapeutic effects in mouse models of AD.
27 March 2017 | doi: 10.1038/ncomms14740

A coupled human-Earth model perspective on long-term trends in the global marine fishery OPEN
E. D. Galbraith, D. A. Carozza and D. Bianchi
Global marine fish harvest increased over the 20th century, reaching a peak in the 1990s. Here, Galbraith and colleagues analyse a model combining both ecological and economic drivers to weigh the factors most likely to contribute to long-term changes in fish harvests.
27 March 2017 | doi: 10.1038/ncomms14884

Structure and function of the Zika virus full-length NS5 protein OPEN
Baoyu Zhao, Guanghui Yi, Fenglei Du, Yin-Chih Chuang, Robert C. Vaughan, Banumathi Sankaran, C. Cheng Kao and Pingwei Li
Zika virus infection can cause human birth defects and Guillain-Barré syndrome. Here the authors present the structures of the full-length nonstructural protein 5 and its RNA-dependent RNA polymerase domain of Zika virus, which are targets for inhibitors of virus replication.
27 March 2017 | doi: 10.1038/ncomms14762

Lateral orbitofrontal cortex anticipates choices and integrates prior with current information OPEN
Ramon Nogueira, Juan M. Abolafia, Jan Drugowitsch, Emili Balaguer-Ballester, Maria V. Sanchez-Vives and Rubén Moreno-Bote
The orbitofrontal cortex encodes outcomes, expected rewards and values, but it is unclear how this region uses this information to inform action selection. Here, the authors show that lateral orbitofrontal cortex anticipates upcoming choices and combines recent prior information with current sensory information.
24 March 2017 | doi: 10.1038/ncomms14823

The fourth crystallographic closest packing unveiled in the gold nanocluster crystal OPEN
Zibao Gan, Jishi Chen, Juan Wang, Chengming Wang, Man-Bo Li, Chuanhao Yao, Shengli Zhuang, An Xu, Lingling Li and Zhikun Wu
Metal nanoclusters are explored for their precise structures and compelling properties. Here, the authors synthesize a gold cluster with unique structural features, including giant staple motifs, tetrahedral-coordinate μ 4-S atoms, and a helical closest-packed crystallographic pattern that influences the cluster’s photoluminescence.
24 March 2017 | doi: 10.1038/ncomms14739

A chemical chaperone improves muscle function in mice with a RyR1 mutation OPEN
Chang Seok Lee, Amy D. Hanna, Hui Wang, Adan Dagnino-Acosta, Aditya D. Joshi, Mark Knoblauch, Yan Xia, Dimitra K. Georgiou, Jianjun Xu, Cheng Long, Hisayuki Amano, Corey Reynolds, Keke Dong, John C. Martin, William R. Lagor, George G. Rodney, Ergun Sahin, Caroline Sewry and Susan L. Hamilton
Mutations in the RyR1 channel cause core myopathies. Here the authors show that ER stress and the unfolded protein response underlie the pathology caused by a common RyR1 channel mutation, and show that treatment with a chemical chaperone restores muscle function in mice.
24 March 2017 | doi: 10.1038/ncomms14659

Light-sensing via hydrogen peroxide and a peroxiredoxin OPEN
Kristofer Bodvard, Ken Peeters, Friederike Roger, Natalie Romanov, Aeid Igbaria, Niek Welkenhuysen, Gaël Palais, Wolfgang Reiter, Michel B. Toledano, Mikael Käll and Mikael Molin
While yeasts lack dedicated photoreceptors, they nonetheless possess metabolic rhythms responsive to light. Here the authors find that light signalling in budding yeast involves the production of H2O2, which in turn regulates protein kinase A through a peroxiredoxin-thioredoxin redox relay.
24 March 2017 | doi: 10.1038/ncomms14791

High-performance and compact-designed flexible thermoelectric modules enabled by a reticulate carbon nanotube architecture OPEN
Wenbin Zhou, Qingxia Fan, Qiang Zhang, Le Cai, Kewei Li, Xiaogang Gu, Feng Yang, Nan Zhang, Yanchun Wang, Huaping Liu, Weiya Zhou and Sishen Xie
Thermoelectric modules can generate electricity directly from heat and have applications to waste heat-energy conversion. Here Zhou et al. have fabricated a thermoelectric module based on an air-stable n-type single-walled carbon nanotube sheet which can reach a high power factor of 1500 μWm−1K−2.
24 March 2017 | doi: 10.1038/ncomms14886

Monolayer optical memory cells based on artificial trap-mediated charge storage and release OPEN
Juwon Lee, Sangyeon Pak, Young-Woo Lee, Yuljae Cho, John Hong, Paul Giraud, Hyeon Suk Shin, Stephen M. Morris, Jung Inn Sohn, SeungNam Cha and Jong Min Kim
Memory devices are key building blocks of image sensing circuitry. Here, the authors demonstrate a MoS2 monolayer optoelectronic memory device based on charge trapping and subsequent optically-induced charge release, capable of 12-bit operation.
24 March 2017 | doi: 10.1038/ncomms14734

MicroRNA filters Hox temporal transcription noise to confer boundary formation in the spinal cord OPEN
Chung-Jung Li, Tian Hong, Ying-Tsen Tung, Ya-Ping Yen, Ho-Chiang Hsu, Ya-Lin Lu, Mien Chang, Qing Nie and Jun-An Chen
In the spinal cord, some Hox genes are transcribed in progenitors while their proteins are only detected in differentiating postmitotic motor neurons. Here, the authors show that miRNAs (specifically mir-27) regulate post-transcriptional Hoxa5 expression in motor neurons.
24 March 2017 | doi: 10.1038/ncomms14685

Synthesis and reactivity of a mononuclear non-haem cobalt(IV)-oxo complex OPEN
Bin Wang, Yong-Min Lee, Woon-Young Tcho, Samat Tussupbayev, Seoung-Tae Kim, Yujeong Kim, Mi Sook Seo, Kyung-Bin Cho, Yavuz Dede, Brenna C. Keegan, Takashi Ogura, Sun Hee Kim, Takehiro Ohta, Mu-Hyun Baik, Kallol Ray, Jason Shearer and Wonwoo Nam
Terminal CoIV-oxo species are key intermediates in various cobalt-mediated oxidation reactions, but little is known about their chemical properties. Here the authors generate and isolate a mononuclear non-haem CoIV-O complex and analyse its structure and reactivity towards a range of catalytic transformations.
24 March 2017 | doi: 10.1038/ncomms14839

Field-emission from quantum-dot-in-perovskite solids OPEN
F. Pelayo García de Arquer, Xiwen Gong, Randy P. Sabatini, Min Liu, Gi-Hwan Kim, Brandon R. Sutherland, Oleksandr Voznyy, Jixian Xu, Yuangjie Pang, Sjoerd Hoogland, David Sinton and Edward Sargent
Efficient implementation of quantum dot and well architectures are restricted to costly vacuum-epitaxially-grown semiconductors. The authors use quantum dots in perovskite to build field-emission photodiodes that are sensitive across the visible and into the short-wavelength infrared.
24 March 2017 | doi: 10.1038/ncomms14757

Observation of the reversed Cherenkov radiation OPEN
Zhaoyun Duan, Xianfeng Tang, Zhanliang Wang, Yabin Zhang, Xiaodong Chen, Min Chen and Yubin Gong
Reversed Cherenkov radiation has not been observed due to the absence of suitable all-metal left-handed materials for beam transport and suitable couplers for extracting the signal. Here, Duan et al. develop a metamaterial to observe reversed Cherenkov radiation using real charged particles.
23 March 2017 | doi: 10.1038/ncomms14901

Iron minerals within specific microfossil morphospecies of the 1.88 Ga Gunflint Formation OPEN
Kevin Lepot, Ahmed Addad, Andrew H. Knoll, Jian Wang, David Troadec, Armand Béché and Emmanuelle J. Javaux
Fossil microorganisms older than 1.7 billion years are challenging to interpret due to their size, simple shapes, and alteration. Here, in 1.88 billion year old microfossils, the authors show a pattern of cellular preservation and internal iron nanominerals consistent with oxygenic photosynthetic bacteria.
23 March 2017 | doi: 10.1038/ncomms14890

Single-mode dispersive waves and soliton microcomb dynamics OPEN
Xu Yi, Qi-Fan Yang, Xueyue Zhang, Ki Youl Yang, Xinbai Li and Kerry Vahala
Dissipative Kerr solitons in microresonators have recently been shown to generate frequency combs via Cherenkov radiation. Here, Yi et al. demonstrate hysteresis behaviour and a single-mode dispersive wave that can improve the stability of microcombs.
23 March 2017 | doi: 10.1038/ncomms14869

Inelastic collisions of ultracold triplet Rb2 molecules in the rovibrational ground state OPEN
Björn Drews, Markus Deiß, Krzysztof Jachymski, Zbigniew Idziaszek and Johannes Hecker Denschlag
Investigating the collisional behaviour of molecules on the quantum level is the key in understanding and controlling chemical reactions. Here the authors measure inelastic collision rates for ultracold Rb2 dimers in precisely defined quantum states and show that the rates can be tuned via external parameters.
23 March 2017 | doi: 10.1038/ncomms14854

Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions OPEN
Mojca Frank-Bertoncelj, Michelle Trenkmann, Kerstin Klein, Emmanuel Karouzakis, Hubert Rehrauer, Anna Bratus, Christoph Kolling, Maria Armaka, Andrew Filer, Beat A. Michel, Renate E. Gay, Christopher D. Buckley, George Kollias, Steffen Gay and Caroline Ospelt
Arthritis affects different joints variably despite systemic inflammatory cues. Here the authors show anatomical differences in the transcriptome, epigenome and function of synovial fibroblasts that might affect susceptibility to site-specific joint diseases.
23 March 2017 | doi: 10.1038/ncomms14852

Catalytic asymmetric radical aminoperfluoroalkylation and aminodifluoromethylation of alkenes to versatile enantioenriched-fluoroalkyl amines OPEN
Jin-Shun Lin, Fu-Li Wang, Xiao-Yang Dong, Wei-Wei He, Yue Yuan, Su Chen and Xin-Yuan Liu
Methods for the asymmetric introduction of organofluorine groups are often limited by the lack of variability in the starting materials. Here the authors report an asymmetric radical process for the introduction of fluoroalkyl groups using readily available fluoroalkylated sulfonyl chlorides.
23 March 2017 | doi: 10.1038/ncomms14841

Cell-free reconstitution reveals centriole cartwheel assembly mechanisms OPEN
P. Guichard, V. Hamel, M. Le Guennec, N. Banterle, I. Iacovache, V. Nemčíková, I. Flückiger, K. N. Goldie, H. Stahlberg, D. Lévy, B. Zuber and P. Gönczy
The centriole is an organelle composed of rings of SAS-6 proteins that form a cartwheel structure. Here the authors develop a cell-free system to examine core cartwheel assembly of C. reinhardtii proteins and discover that CrSAS-6 has autonomous properties that facilitates self-organized stacking of pairs of rings.
23 March 2017 | doi: 10.1038/ncomms14813

Long-acting protein drugs for the treatment of ocular diseases OPEN
Joy G. Ghosh, Andrew A. Nguyen, Chad E. Bigelow, Stephen Poor, Yubin Qiu, Nalini Rangaswamy, Richard Ornberg, Brittany Jackson, Howard Mak, Tucker Ezell, Vania Kenanova, Elisa de la Cruz, Ana Carrion, Bijan Etemad-Gilbertson, Roxana Garcia Caro, Kan Zhu, Vinney George, Jirong Bai, Radhika Sharma-Nahar, Siyuan Shen et al.
Retinal vascular disease treatments involve frequent pharmacological intraocular administrations. Here the authors present a method to increase the half-life of injected drugs by fusing these to a hyaluronan-binding peptide, which might lead to less frequent retinal disease treatments.
23 March 2017 | doi: 10.1038/ncomms14837

Natural variation in CTB4a enhances rice adaptation to cold habitats OPEN
Zhanying Zhang, Jinjie Li, Yinghua Pan, Jilong Li, Lei zhou, Hongli Shi, Yawen Zeng, Haifeng Guo, Shuming Yang, Weiwei Zheng, Jianping Yu, Xingming Sun, Gangling Li, Yanglin Ding, Liang Ma, Shiquan Shen, Luyuan Dai, Hongliang Zhang, Shuhua Yang, Yan Guo et al.
Low temperature is a major factor limiting productivity in rice. Here the authors show that the CTB4a gene confers cold tolerance to japonica varieties adapted to cold habitats at the booting stage of development, and propose that CTB4a acts via an interaction with the beta subunit of ATP synthase.
23 March 2017 | doi: 10.1038/ncomms14788

A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells OPEN
Gernot Walko, Samuel Woodhouse, Angela Oliveira Pisco, Emanuel Rognoni, Kifayathullah Liakath-Ali, Beate M. Lichtenberger, Ajay Mishra, Stephanie B. Telerman, Priyalakshmi Viswanathan, Meike Logtenberg, Lisa M. Renz, Giacomo Donati, Sven R. Quist and Fiona M. Watt
Individual human epidermal cells differ in their self-renewal ability. Here the authors perform genome-wide pooled RNAi screens to uncover the molecular basis for this heterogeneity, and identify genes conferring a clonal growth advantage on normal and neoplastic human epidermal cells.
23 March 2017 | doi: 10.1038/ncomms14744

PTENβ is an alternatively translated isoform of PTEN that regulates rDNA transcription OPEN
Hui Liang, Xi Chen, Qi Yin, Danhui Ruan, Xuyang Zhao, Cong Zhang, Michael A. McNutt and Yuxin Yin
PTEN is a potent tumour suppressor involved in cell growth, proliferation and survival. Here the authors identify an N-terminal extended isoform of PTEN, termed PTENβ that negatively regulates ribosomal DNA transcription and cell proliferation, expanding the pleiotropic functions of the PTEN family.
23 March 2017 | doi: 10.1038/ncomms14771

Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets OPEN
Mark D. White, Maria Klecker, Richard J. Hopkinson, Daan A. Weits, Carolin Mueller, Christin Naumann, Rebecca O’Neill, James Wickens, Jiayu Yang, Jonathan C. Brooks-Bartlett, Elspeth F. Garman, Tom N. Grossmann, Nico Dissmeyer and Emily Flashman
The N-end rule pathway targets substrate proteins for proteasomal degradation. Here, White et al. show that Arabidopsis PLANT CYSTEINE OXIDASEs show dioxygenase activity producing Cys-sulfinic acid at the N-terminus of target proteins, which then act as direct substrates for arginyl transferase.
23 March 2017 | doi: 10.1038/ncomms14690

Profiling protein expression in circulating tumour cells using microfluidic western blotting OPEN
Elly Sinkala, Elodie Sollier-Christen, Corinne Renier, Elisabet Rosàs-Canyelles, James Che, Kyra Heirich, Todd A. Duncombe, Julea Vlassakis, Kevin A. Yamauchi, Haiyan Huang, Stefanie S. Jeffrey and Amy E. Herr
Circulating tumour cells (CTCs) are rare cells found in the blood of certain cancer patients. Here, the authors develop a cytometry tool that appends a microfluidic western blot to a CTC isolation workflow and apply it to profile a panel of proteins in single CTCs isolated from ER+ breast cancer patients.
23 March 2017 | doi: 10.1038/ncomms14622

Molecular level detection and localization of mechanical damage in collagen enabled by collagen hybridizing peptides OPEN
Jared L. Zitnay, Yang Li, Zhao Qin, Boi Hoa San, Baptiste Depalle, Shawn P. Reese, Markus J. Buehler, S. Michael Yu and Jeffrey A. Weiss
Collagen denaturation is thought to occur during tissue mechanical damage, but its role in damage initiation is still unclear. Here, the authors use a collagen hybridizing peptide to provide insights into the molecular mechanisms leading to collagen unfolding during tendon mechanical stretch.
22 March 2017 | doi: 10.1038/ncomms14913

Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice OPEN
Martina Schweiger, Matthias Romauch, Renate Schreiber, Gernot F. Grabner, Sabrina Hütter, Petra Kotzbeck, Pia Benedikt, Thomas O. Eichmann, Sohsuke Yamada, Oskar Knittelfelder, Clemens Diwoky, Carina Doler, Nicole Mayer, Werner De Cecco, Rolf Breinbauer, Robert Zimmermann and Rudolf Zechner
The enzyme Atgl participates in the breakdown of lipids in adipose tissue. Here the authors show that pharmacological inhibition of Atgl reduces weight gain and improves metabolic health in mice fed a high-fat diet, without causing adverse effects in cardiac muscle associated with genetic depletion of Atgl.
22 March 2017 | doi: 10.1038/ncomms14859

A semisynthetic Atg3 reveals that acetylation promotes Atg3 membrane binding and Atg8 lipidation OPEN
Yi-Tong Li, Cong Yi, Chen-Chen Chen, Huan Lan, Man Pan, Shao-Jin Zhang, Yi-Chao Huang, Chao-Jian Guan, Yi-Ming Li, Li Yu and Lei Liu
Acetylation of Atg3 regulates lipidation of Atg8 and therefore autophagy, but the molecular mechanisms remain unclear. Here, Li et al. semi-synthesize diacetylated Atg3, allowing them to show that acetylated Atg3 enhances Atg8 lipidation by promoting interaction of Atg3 with liposomes containing physiological levels of phosphatidylethanolamine.
22 March 2017 | doi: 10.1038/ncomms14846

Quantitative volumetric Raman imaging of three dimensional cell cultures OPEN
Charalambos Kallepitis, Mads S. Bergholt, Manuel M. Mazo, Vincent Leonardo, Stacey C. Skaalure, Stephanie A. Maynard and Molly M. Stevens
Advances in chemical imaging capability can add to our understanding of complex cellular systems. Here the authors develop a framework for label-free quantitative volumetric Raman spectroscopic imaging and use it to visualize and quantify biomolecules in various 3D cellular systems.
22 March 2017 | doi: 10.1038/ncomms14843

FMNL formins boost lamellipodial force generation OPEN
Frieda Kage, Moritz Winterhoff, Vanessa Dimchev, Jan Mueller, Tobias Thalheim, Anika Freise, Stefan Brühmann, Jana Kollasser, Jennifer Block, Georgi Dimchev, Matthias Geyer, Hans-Joachim Schnittler, Cord Brakebusch, Theresia E. B. Stradal, Marie-France Carlier, Michael Sixt, Josef Käs, Jan Faix and Klemens Rottner
Actin polymerization in lamellipodia of cells is regulated by the Arp2/3 complex and FMNL family formins. Here the authors show that both FMNL2 and FMNL3 contribute to lamellipodium protrusion and structure, and abolishing FMNL2/3 reduces protrusion force generation and migration, without affecting Arp2/3 incorporation.
22 March 2017 | doi: 10.1038/ncomms14832

Constructive quantum interference in a bis-copper six-porphyrin nanoring OPEN
Sabine Richert, Jonathan Cremers, Ilya Kuprov, Martin D. Peeks, Harry L. Anderson and Christiane R. Timmel
Quantum interference in charge transport is attracting interest with applications in nanoelectronics and quantum computing. Here, the authors present a method for quantifying electronic transmission through molecules, and demonstrate constructive quantum interference in a molecule with two identical, parallel coupling paths.
22 March 2017 | doi: 10.1038/ncomms14842

Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20 OPEN
Gan Liu, Luting Zhou, Hai Zhang, Rong Chen, Ye Zhang, Ling Li, Jun-Yu Lu, Hui Jiang, Dong Liu, Shasha Qi, Ying-Ming Jiang, Kai Yin, Zhifang Xie, Yuguang Shi, Yong Liu, Xuetao Cao, Yu-Xia Chen, Dajin Zou and Weiping J. Zhang
De novo lipogenesis is tightly controlled by hormonal and nutritional signals and plays an important role in energy homoeostasis. Here, Liu et al. show that zinc finger protein ZBTB20 regulates the expression of key glycolytic and lipogenic genes by modulating ChREBP expression and transcriptional activity.
22 March 2017 | doi: 10.1038/ncomms14824

Cellular preservation of musculoskeletal specializations in the Cretaceous bird Confuciusornis OPEN
Baoyu Jiang, Tao Zhao, Sophie Regnault, Nicholas P. Edwards, Simon C. Kohn, Zhiheng Li, Roy A. Wogelius, Michael J. Benton and John R. Hutchinson
Birds have a more crouched posture compared to their theropod dinosaur ancestors. Here, Jiang and colleagues describe a lower hindlimb of the Early Cretaceous bird Confuciusornis with soft tissues apparently preserved even as molecules, indicating a somewhat more modern posture in ancient birds.
22 March 2017 | doi: 10.1038/ncomms14779

Endogenous opioids regulate moment-to-moment neuronal communication and excitability OPEN
Bryony L. Winters, Gabrielle C. Gregoriou, Sarah A. Kissiwaa, Oliver A. Wells, Danashi I. Medagoda, Sam M. Hermes, Neil T. Burford, Andrew Alt, Sue A. Aicher and Elena E. Bagley
The endogenous opioid system regulates fear and anxiety, but the underlying cellular mechanism is unclear. Winters et al. shows that in the intercalated cells (ITC) of the amygdala, endogenous opioids suppress glutamatergic inputs via the δ-opioid receptor presynaptically, and reduce the excitability of ITCs via the μ-opioid receptor postsynaptically.
22 March 2017 | doi: 10.1038/ncomms14611
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Corrigendum: Wafer-scale two-dimensional semiconductors from printed oxide skin of liquid metals OPEN
Benjamin J. Carey, Jian Zhen Ou, Rhiannon M. Clark, Kyle J. Berean, Ali Zavabeti, Anthony S. R. Chesman, Salvy P. Russo, Desmond W. M. Lao, Zai-Quan Xu, Qiaoliang Bao, Omid Kavehei, Brant C. Gibson, Michael D. Dickey, Richard B. Kaner, Torben Daeneke and Kourosh Kalantar-Zadeh
22 March 2017 | doi: 10.1038/ncomms15116

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