In the middle of innovation, medicine, growth, and so much more, Destination Medical Center (DMC) is transforming Rochester, MN. DMC is a 20-year, $5.6 billion economic development plan. Together, DMC and Mayo Clinic are accelerating new advancements in life science research, medical technology, patient care, and education.
Bioprocessing Technologies in Stem Cell Research: Challenges and Chances for Commercialization The 1st Stem Cell Community Day brings together experts from industry and academia to discuss recent achievements, challenges, and chances in stem cell bioprocessing for research and commercial manufacturing. Register now and submit your abstract! www.stemcellday.de
Sometimes, a drug can remedy a chemical imbalance or surgery can repair a structural failure, but there are times when there is no substitute for replacing a part with human tissue or an entire organ. Rapid advances in regenerative medicine are bringing that possibility closer to reality.
A joint focus with Nature Reviews Drug Discovery on RNA-based therapeutics presents a series of articles detailing recent progress in chemistries and delivery technologies that have propelled the clinical advancement of oligonucleotide therapies as well as highlighting commercial advances in RNA vaccines.
The commercial tipping point p181 doi:10.1038/nbt.3829 RNA-based therapeutics are poised to become successful commercial products, but wide adoption across the biopharmaceutical industry will likely take a few more years.
The 'anti-hype' vaccine pp193 - 197 Laura DeFrancesco doi:10.1038/nbt.3812 After years under the radar, RNA vaccines are finally emerging as immunotherapies to combat pandemics and cancer. But as Laura DeFrancesco reports, clinical validation remains elusive.
Worth the RISC? pp198 - 202 Ken Garber doi:10.1038/nbt.3810 The long, tortuous race to market a therapeutic based on RNA interference (RNAi) may be nearing its end. Ken Garber reports.
Faster, Simpler Biological LC-MS/MS Analysis Shimadzu's Clinical Laboratory Automation Module, a fully integrated sample pretreatment module for LC-MS/MS, automatically performs all of the processes necessary for analyzing blood and other biological samples, providing more precise results by reducing human error and improving laboratory safety and efficiency. Learn more.
The chemical evolution of oligonucleotide therapies of clinical utility pp238 - 248 Anastasia Khvorova and Jonathan K Watts doi:10.1038/nbt.3765 Refinements in the chemistries employed in oligonucleotide therapeutics have galvanized clinical progress. The complex interplay between chemical modifications and integration into sequence architecture is discussed in the context of antisense and small-interfering RNA drugs.
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