The EMBO Journal Table of Contents for 15 February 2017; Vol. 36, No. 4

15 February 2017 | Volume 36, Number 4 Submit Table of Contents News & Views Review Articles Resource Volume 36, Number 4 News & Views Balancing signals in the intestinal niche To ensure correct cell fate decisions during gut regeneration, intestinal subepithelial myofibroblasts regulate opposing gradients of Wnt and BMP signaling in the crypts via ANGPTL2 secretion. Sanne M van Neerven and Louis Vermeulen Published online 03.02.2017 Self‐regulating ubiquitin ligases Nedd4 exemplifies the first E3 that is reversibly inactivated rather than degraded upon auto‐ubiquitylation. Spencer Hill and Gary Kleiger Published online 13.01.2017 TRAPPing Rab18 in lipid droplets Mammalian TRAnsport Protein Particle TRAPPII is a new GEF for Rab18 and recruits it to lipid droplets to control lipid homeostasis. Francesca Zappa, Rossella Venditti, and Maria Antonietta De Matteis Published online 27.01.2017 Review Focus: Metabolism: Nutrient sensing and TOR signaling in yeast and mammals As part of our metabolism focus, this review summarizes how nutrient availability is recognized and integrated by the conserved TOR cell growth regulator. Asier González and Michael N Hall Published online 17.01.2017 Articles ANGPTL2 expression in the intestinal stem cell niche controls epithelial regeneration and homeostasis ANGPTL2 is secreted upon intestinal injury and regulates the balance between β‐catenin and BMP signaling to promote intestinal stem cell maintenance and proliferation. Haruki Horiguchi, Motoyoshi Endo, Kohki Kawane, Tsuyoshi Kadomatsu, Kazutoyo Terada, Jun Morinaga, Kimi Araki, Keishi Miyata, and Yuichi Oike Published online 02.01.2017 Ubiquitylation‐dependent oligomerization regulates activity of Nedd4 ligases Ubiquitin ligase auto‐modification results in reversible inactivation rather than proteasomal degradation in a HECT‐domain E3 family. Ilan Attali, William Sam Tobelaim, Avinash Persaud, Khatereh Motamedchaboki, Kobi J Simpson‐Lavy, Bayan Mashahreh, Olga Levin‐Kravets, Tal Keren‐Kaplan, Inbar Pilzer, Martin Kupiec, Reuven Wiener, Dieter A Wolf, Daniela Rotin, and Gali Prag Published online 09.01.2017 COPI–TRAPPII activates Rab18 and regulates its lipid droplet association Mammalian TRAPPII serves as a GEF for Rab18 and, together with COPI, regulates its recruitment onto the lipid droplet surface, thereby controlling lipid homeostasis. Chunman Li, Xiaomin Luo, Shan Zhao, Gavin KY Siu, Yongheng Liang, Hsiao Chang Chan, Ayano Satoh, and Sidney SB Yu Published online 21.12.2016 Calcium‐permeable AMPA receptors and silent synapses in cocaine‐conditioned place preference Postsynaptic scaffold proteins PSD‐93, PSD‐95, and SAP102 differentially affect nucleus accumbens and association of drug reward/context in mice. Avani Shukla, Anna Beroun, Myrto Panopoulou, Peter A Neumann, Seth GN Grant, M Foster Olive, Yan Dong, and Oliver M Schlüter Published online 11.01.2017 The complete structure of the chloroplast 70S ribosome in complex with translation factor pY The first high‐resolution cryo‐EM structure of the chloroplast ribosome sheds light on the role for chloroplast‐specific ribosomal proteins and illustrates how protein synthesis is regulated by translation factor pY. Philipp Bieri, Marc Leibundgut, Martin Saurer, Daniel Boehringer, and Nenad Ban Published online 22.12.2016 Translational control of lipogenic enzymes in the cell cycle of synchronous, growing yeast cells Ribosome profiling reveals the coordinated translational activation of lipogenic enzyme transcripts in growing, unperturbed budding yeast cells progressing synchronously through the cell cycle. Heidi M Blank, Ricardo Perez, Chong He, Nairita Maitra, Richard Metz, Joshua Hill, Yuhong Lin, Charles D Johnson, Vytas A Bankaitis, Brian K Kennedy, Rodolfo Aramayo, and Michael Polymenis Published online 05.01.2017 Cell cycle‐regulated ubiquitination of tankyrase 1 by RNF8 and ABRO1/BRCC36 controls the timing of sister telomere resolution Reversible modification with K63‐linked ubiquitin chains regulates poly(ADP‐ribose) polymerization at telomeres to ensure that telomeres are resolved in the G2/M window of the cell cycle. Ekta Tripathi and Susan Smith Published online 19.12.2016 MRTF potentiates TEAD‐YAP transcriptional activity causing metastasis Crosstalk with transcription factor MRTF enhances TEAD‐YAP oncogenic activity, coordinating signal transduction of extracellular GPCR ligands involved in cancer cell invasion or actin cytoskeletal disruption. Tackhoon Kim, Daehee Hwang, Dahye Lee, Jeong‐Hwan Kim, Seon‐Young Kim, and Dae‐Sik Lim Published online 27.12.2016 Mycobacterium tuberculosis protease MarP activates a peptidoglycan hydrolase during acid stress Proteolytic activation of the peptidoglycan hydrolase RipA ensures the separation of mycobacterial progeny cells in acidic environments such as host cell phagosomes. Helene Botella, Julien Vaubourgeix, Myung Hee Lee, Naomi Song, Weizhen Xu, Hideki Makinoshima, Michael S Glickman, and Sabine Ehrt Published online 05.01.2017 Resource Fluorescence‐based ATG8 sensors monitor localization and function of LC3/GABARAP proteins New peptide sensors have been developed to monitor localization and fate of individual LC3s and GABARAPs of the mATG8 family, which serve as a central platform for autophagosome biogenesis. Alexandra Stolz, Mateusz Putyrski, Ivana Kutle, Jessica Huber, Chunxin Wang, Viktória Major, Sachdev S Sidhu, Richard J Youle, Vladimir V Rogov, Volker Dötsch, Andreas Ernst, and Ivan Dikic Published online 27.12.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.