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Nature Communications -15 February 2017

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The molecular basis of endothelial cell plasticity OPEN
Elisabetta Dejana, Karen K. Hirschi and Michael Simons
Vascular endothelium possesses remarkable plasticity in response to cues from its surroundings, leading to great heterogeneity of endothelial cells in different vascular beds. Here the authors explain the molecular basis of endothelial plasticity during embryogenesis and in various diseases.
09 February 2017 | doi: 10.1038/ncomms14361
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Live birth in an archosauromorph reptile OPEN
Jun Liu, Chris L. Organ, Michael J. Benton, Matthew C. Brandley and Jonathan C. Aitchison
Although live birth evolved repeatedly in other clades, it has not been found in archosauromorphs, the group including modern birds and crocodilians. Here, the authors describe a fossilized pregnant Dinocephalosaurus from ∼245 million years ago, providing evidence of live birth in archosauromorphs.
14 February 2017 | doi: 10.1038/ncomms14445

Extreme oceanographic forcing and coastal response due to the 2015–2016 El Niño OPEN
Patrick L. Barnard, Daniel Hoover, David M. Hubbard, Alex Snyder, Bonnie C. Ludka, Jonathan Allan, George M. Kaminsky, Peter Ruggiero, Timu W. Gallien, Laura Gabel, Diana McCandless, Heather M. Weiner, Nicholas Cohn, Dylan L. Anderson and Katherine A. Serafin
ENSO end members El Niño and La Niña are linked to elevated coastal hazards across the Pacific region. Here, the authors show that the wave conditions and coastal response for the 2015–16 El Niño indicate that it was one of the most significant events of the last 145 years.
14 February 2017 | doi: 10.1038/ncomms14365

Muscle-specific CRISPR/Cas9 dystrophin gene editing ameliorates pathophysiology in a mouse model for Duchenne muscular dystrophy OPEN
Niclas E. Bengtsson, John K. Hall, Guy L. Odom, Michael P. Phelps, Colin R. Andrus, R. David Hawkins, Stephen D. Hauschka, Joel R. Chamberlain and Jeffrey S. Chamberlain
CRISPR/Cas9-mediated gene editing is an emerging strategy to treat Duchenne muscular dystrophy. Here the authors develop multiple CRISPR/Cas9-based approaches to correct different dystrophin gene mutations, and show significant restoration of dystrophin expression in skeletal and cardiac muscle in mice.
14 February 2017 | doi: 10.1038/ncomms14454

Regional cooling caused recent New Zealand glacier advances in a period of global warming OPEN
Andrew N. Mackintosh, Brian M. Anderson, Andrew M. Lorrey, James A. Renwick, Prisco Frei and Sam M. Dean
Many New Zealand glaciers advanced during recent global warming, bucking a worldwide trend of glacier retreat. Here, the authors show that these glacier advances were forced by a sequence of unusually cool years in the New Zealand region, rather than a period of increased precipitation.
14 February 2017 | doi: 10.1038/ncomms14202

Pervasive translational regulation of the cell signalling circuitry underlies mammalian development OPEN
Kotaro Fujii, Zhen Shi, Olena Zhulyn, Nicolas Denans and Maria Barna
Gene expression is regulated at several levels, including through the modulation of protein translation. Here the authors find that translation control diversifies gene expression between developing tissues and regulates major signalling pathways through a complex landscape of upstream open reading frames (uORFs).
14 February 2017 | doi: 10.1038/ncomms14443

Three-dimensional surface topography of graphene by divergent beam electron diffraction OPEN
Tatiana Latychevskaia, Wei-Hao Hsu, Wei-Tse Chang, Chun-Yueh Lin and Ing-Shouh Hwang
Graphene, and other 2D materials, do not exist as strictly planar sheets but instead have topographic ripples on the sub-nanometre scale. Here, Latychevskaia et al. present a method to non-invasively image ripples in 2D materials with a single-shot, wide-area, electron diffraction measurement.
14 February 2017 | doi: 10.1038/ncomms14440

A genome-wide association study yields five novel thyroid cancer risk loci OPEN
Julius Gudmundsson, Gudmar Thorleifsson, Jon K. Sigurdsson, Lilja Stefansdottir, Jon G. Jonasson, Sigurjon A. Gudjonsson, Daniel F. Gudbjartsson, Gisli Masson, Hrefna Johannsdottir, Gisli H. Halldorsson, Simon N. Stacey, Hannes Helgason, Patrick Sulem, Leigha Senter, Huiling He, Sandya Liyanarachchi, Matthew D. Ringel, Esperanza Aguillo, Angeles Panadero, Enrique Prats et al.
Non-medullary thyroid cancers include papillary and follicular subtypes, and are the most common type of thyroid cancer. Here, the authors extend previous work by performing a large genome-wide association study and find five novel loci associated with this disease.
14 February 2017 | doi: 10.1038/ncomms14517

Integrated genomic analyses of de novo pathways underlying atypical meningiomas OPEN
Akdes Serin Harmancı, Mark W. Youngblood, Victoria E. Clark, Süleyman Coşkun, Octavian Henegariu, Daniel Duran, E. Zeynep Erson-Omay, Leon D. Kaulen, Tong Ihn Lee, Brian J. Abraham, Matthias Simon, Boris Krischek, Marco Timmer, Roland Goldbrunner, S. Bülent Omay, Jacob Baranoski, Burçin Baran, Geneive Carrión-Grant, Hanwen Bai, Ketu Mishra-Gorur et al.
Meningiomas are mostly benign brain tumours with the potential for becoming atypical or malignant. Here, the authors show that primary atypical meningiomas are epigenetically and genetically distinct from benign and progressed tumours, highlighting possible therapeutic targets such as PRC2.
14 February 2017 | doi: 10.1038/ncomms14433

Chemical and entropic control on the molecular self-assembly process OPEN
Daniel M. Packwood, Patrick Han and Taro Hitosugi
Molecular self-assembly is controlled by chemical and entropic factors, but theory has not been able to differentiate the role of each. Here, the authors unambiguously address this question for self-assembly on metal surfaces, using a new computational method that bridges coarse-grained and atomistic approaches.
14 February 2017 | doi: 10.1038/ncomms14463

Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential OPEN
Evan Bardot, Damelys Calderon, Francis Santoriello, Songyan Han, Kakit Cheung, Bharati Jadhav, Ingo Burtscher, Stanley Artap, Rajan Jain, Jonathan Epstein, Heiko Lickert, Valerie Gouon-Evans, Andrew J. Sharp and Nicole C. Dubois
The progenitor populations that contribute to the key cardiac lineages in a chamber-specific manner are unknown. Here, the authors identify Foxa2+ progenitor population, which is specified at gastrulation, as contributing primarily to cardiovascular cells of both ventricles and the epicardium in mice.
14 February 2017 | doi: 10.1038/ncomms14428

Regulating the spatial distribution of metal nanoparticles within metal-organic frameworks to enhance catalytic efficiency OPEN
Qiu Yang, Wenxian Liu, Bingqing Wang, Weina Zhang, Xiaoqiao Zeng, Cong Zhang, Yongji Qin, Xiaoming Sun, Tianpin Wu, Junfeng Liu, Fengwei Huo and Jun Lu
Composites incorporating metallic nanoparticles into metal-organic frameworks are potentially useful but controlling the nanoparticle spatial distribution is challenging. Here, the authors report a strategy that accomplishes this by using a metal oxide as both support and sacrificial template.
14 February 2017 | doi: 10.1038/ncomms14429

The non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progression OPEN
Ning Qing Liu, Menno ter Huurne, Luan N. Nguyen, Tianran Peng, Shuang-Yin Wang, James B. Studd, Onkar Joshi, Halit Ongen, Jesper B Bramsen, Jian Yan, Claus L. Andersen, Jussi Taipale, Emmanouil T. Dermitzakis, Richard S. Houlston, Nina C. Hubner and Hendrik G. Stunnenberg
Functional characterisation of non-coding risk variants for colorectal cancer is missing. Here the authors conduct a large-scale proteome-wide analysis of disease associated SNPs to characterize allele-specific transcription factor binding landscape in colorectal cancer and identify one functionally significant SNP.
14 February 2017 | doi: 10.1038/ncomms14418

Low-frequency theta oscillations in the human hippocampus during real-world and virtual navigation OPEN
Véronique D. Bohbot, Milagros S. Copara, Jean Gotman and Arne D. Ekstrom
Rhythmic oscillations in theta frequency range (7–9 Hz) are observed in rodents during navigation. Here the authors demonstrate robust similar theta rhythmicity in human hippocampus during both real and virtual movements.
14 February 2017 | doi: 10.1038/ncomms14415

Infection-derived lipids elicit an immune deficiency circuit in arthropods OPEN
Dana K. Shaw, Xiaowei Wang, Lindsey J. Brown, Adela S. Oliva Chávez, Kathryn E. Reif, Alexis A. Smith, Alison J. Scott, Erin E. McClure, Vishant M. Boradia, Holly L. Hammond, Eric J. Sundberg, Greg A. Snyder, Lei Liu, Kathleen DePonte, Margarita Villar, Massaro W. Ueti, José de la Fuente, Robert K. Ernst, Utpal Pal, Erol Fikrig et al.
The insect IMD signalling pathway detects invading pathogens. Here the authors show that ticks have an alternative IMD system that lacks peptidoglycan receptors, IMD and FADD, and is instead reliant on interaction of the E3 ligase XIAP with the E2 conjugating enzyme Bendless.
14 February 2017 | doi: 10.1038/ncomms14401

Quantifying cerebral contributions to pain beyond nociception OPEN
Choong-Wan Woo, Liane Schmidt, Anjali Krishnan, Marieke Jepma, Mathieu Roy, Martin A. Lindquist, Lauren Y. Atlas and Tor D. Wager
Pain is affected by cerebral processes in addition to afferent nociceptive input. Here the authors develop an fMRI-based signature that predicts pain independent of the intensity of nociceptive signals and mediates the pain-modulating effects of several cognitive interventions.
14 February 2017 | doi: 10.1038/ncomms14211

A ligand-directed divergent catalytic approach to establish structural and functional scaffold diversity OPEN
Yen-Chun Lee, Sumersing Patil, Christopher Golz, Carsten Strohmann, Slava Ziegler, Kamal Kumar and Herbert Waldmann
Synthetic methods that efficiently construct structurally diverse molecular scaffolds are attractive routes to diversely bioactive molecules. Here the authors report a method whereby common starting materials are converted to structurally and functionally diverse products by changing the catalyst ligand.
14 February 2017 | doi: 10.1038/ncomms14043

Robust microscale superlubricity under high contact pressure enabled by graphene-coated microsphere OPEN
Shu-Wei Liu, Hua-Ping Wang, Qiang Xu, Tian-Bao Ma, Gui Yu, Chenhui Zhang, Dechao Geng, Zhiwei Yu, Shengguang Zhang, Wenzhong Wang, Yuan-Zhong Hu, Hui Wang and Jianbin Luo
Superlubricity can be unstable in graphene systems, especially under high applied loads. Here the authors use microspheres uniformly coated by graphene to measure friction between 2D materials and show that superlow friction is preserved for long periods of time under high loads and various atmospheres.
14 February 2017 | doi: 10.1038/ncomms14029

In situ study on atomic mechanism of melting and freezing of single bismuth nanoparticles OPEN
Yingxuan Li, Ling Zang, Daniel L. Jacobs, Jie Zhao, Xiu Yue and Chuanyi Wang
The atomic mechanisms of reversible phase transitions are challenging to probe experimentally. Here, the authors induce melting and freezing processes in bismuth nanoparticles inside a high-resolution electron microscope, observing the atom-level stages of this phase transition pathway in real time.
13 February 2017 | doi: 10.1038/ncomms14462

Exfoliation of natural van der Waals heterostructures to a single unit cell thickness OPEN
Matěj Velický, Peter S. Toth, Alexander M. Rakowski, Aidan P. Rooney, Aleksey Kozikov, Colin R. Woods, Artem Mishchenko, Laura Fumagalli, Jun Yin, Viktor Zólyomi, Thanasis Georgiou, Sarah J. Haigh, Kostya S. Novoselov and Robert A. W. Dryfe
Layered materials are held together by weak van der Waals forces facilitating layer-by-layer cleavage. Here, the authors demonstrate mechanical exfoliation of a naturally occurring franckeite mineral heterostructure, possessing p-type conductivity and remarkable electrochemical properties.
13 February 2017 | doi: 10.1038/ncomms14410

Self-organizing actin patterns shape membrane architecture but not cell mechanics OPEN
M. Fritzsche, D. Li, H. Colin-York, V. T. Chang, E. Moeendarbary, J. H. Felce, E. Sezgin, G. Charras, E. Betzig and C. Eggeling
In vitro models of actin organization show the formation of vortices, asters and stars. Here Fritzsche et al. show that such actin structures form in living cells in a manner dependent on the Arp2/3 complex but not myosin, and such structures influence membrane architecture but not cortex elasticity.
13 February 2017 | doi: 10.1038/ncomms14347

Franckeite as a naturally occurring van der Waals heterostructure OPEN
Aday J. Molina-Mendoza, Emerson Giovanelli, Wendel S. Paz, Miguel Angel Niño, Joshua O. Island, Charalambos Evangeli, Lucía Aballe, Michael Foerster, Herre S. J. van der Zant, Gabino Rubio-Bollinger, Nicolás Agraït, J. J. Palacios, Emilio M. Pérez and Andres Castellanos-Gomez
Van der Waals heterostructures have been so far mostly assembled by artificial stacking of individual 2D layers with diverse functionalities. Here, the authors shift the focus demonstrating the exfoliation of a naturally occurring franckeite heterostructure, a p-type narrow band-gap semiconductor.
13 February 2017 | doi: 10.1038/ncomms14409

Recurrently deregulated lncRNAs in hepatocellular carcinoma OPEN
Yang Yang, Lei Chen, Jin Gu, Hanshuo Zhang, Jiapei Yuan, Qiuyu Lian, Guishuai Lv, Siqi Wang, Yang Wu, Yu-Cheng T. Yang, Dongfang Wang, Yang Liu, Jing Tang, Guijuan Luo, Yang Li, Long Hu, Xinbao Sun, Dong Wang, Mingzhou Guo, Qiaoran Xi et al.
Long noncoding-RNAs have been linked to hepatocellular carcinoma (HCC) and some can be used as prognostic markers. Here the authors, by analysing RNA-seq in 60 clinical samples from 20 patients, provide a resource of functional lncRNAs and biomarkers associated with HCC tumorigenesis and metastasis.
13 February 2017 | doi: 10.1038/ncomms14421

Modulating supramolecular binding of carbon dioxide in a redox-active porous metal-organic framework OPEN
Zhenzhong Lu, Harry G. W. Godfrey, Ivan da Silva, Yongqiang Cheng, Mathew Savage, Floriana Tuna, Eric J. L. McInnes, Simon J. Teat, Kevin J. Gagnon, Mark D. Frogley, Pascal Manuel, Svemir Rudić, Anibal J. Ramirez-Cuesta, Timothy L. Easun, Sihai Yang and Martin Schröder
Gaining molecular-level insight into host–guest binding interactions is fundamentally important, but experimentally challenging. Here, Schröder and co-workers study CO2–host hydrogen bonding interactions in a pair of isostructural redox-active VIII/VIV MOFs using neutron scattering and diffraction techniques.
13 February 2017 | doi: 10.1038/ncomms14212

Indications of chemical bond contrast in AFM images of a hydrogen-terminated silicon surface OPEN
Hatem Labidi, Mohammad Koleini, Taleana Huff, Mark Salomons, Martin Cloutier, Jason Pitters and Robert A. Wolkow
Whether and under what circumstances chemical bonds could be imaged via force microscopy is a controversial topic. Here authors develop a particular combination of model surface, imaging procedures and simulation approach and discuss possible indications of chemical contrast in imaging data they obtain.
13 February 2017 | doi: 10.1038/ncomms14222

Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma OPEN
Aviram Mizrachi, Yosi Shamay, Janki Shah, Samuel Brook, Joanne Soong, Vinagolu K. Rajasekhar, John L. Humm, John H. Healey, Simon N. Powell, José Baselga, Daniel A. Heller, Adriana Haimovitz-Friedman and Maurizio Scaltriti
Head and neck squamous cell carcinomas (HNSCC) often harbour PIK3CA mutations but PI3Kα inhibitors can cause some side effects. Here, the authors develop P-selectin targeted nanoparticles to enhance tumour-specific delivery of a PI3Kα inhibitor to HNSCC PDX and orthotopic xenograft models.
13 February 2017 | doi: 10.1038/ncomms14292

Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity OPEN
Dmitriy Zamarin, Rikke B. Holmgaard, Jacob Ricca, Tamar Plitt, Peter Palese, Padmanee Sharma, Taha Merghoub, Jedd D. Wolchok and James P. Allison
Oncolytic viruses induce a variety of immune targets in the infected tumours. Here, the authors show that Newcastle Disease Virus (NDV) upregulates the inducible co-stimulator (ICOS) on T cells and that intratumoral targeting of ICOS with engineered NDV in combination with CTLA-4 blockade induces systemic anti-tumour immunity in mice.
13 February 2017 | doi: 10.1038/ncomms14340

Modelling filovirus maintenance in nature by experimental transmission of Marburg virus between Egyptian rousette bats OPEN
Amy J. Schuh, Brian R. Amman, Megan E. B. Jones, Tara K. Sealy, Luke S. Uebelhoer, Jessica R. Spengler, Brock E. Martin, Jo Ann D. Coleman-McCray, Stuart T. Nichol and Jonathan S. Towner
Bats are natural hosts for Marburg virus (MARV), but the mechanism of bat-to-bat transmission is unclear. Here, Schuh et al. monitor MARV infection in a cohort of 38 bats over nine months, find ‘supershedders’ and show that MARV can horizontally transmit between bats.
13 February 2017 | doi: 10.1038/ncomms14446

Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours OPEN
Luwei Tao, Dongxi Xiang, Ying Xie, Roderick T. Bronson and Zhe Li
Several breast cancers may originate from mammary luminal cells and inactivating mutations of p53 are present in most triple-negative breast cancers. Here, the authors show that loss of p53 from luminal cells in mice results in their clonal expansion and mammary tumour formation.
13 February 2017 | doi: 10.1038/ncomms14431

Advanced rechargeable aluminium ion battery with a high-quality natural graphite cathode OPEN
Di-Yan Wang, Chuan-Yu Wei, Meng-Chang Lin, Chun-Jern Pan, Hung-Lung Chou, Hsin-An Chen, Ming Gong, Yingpeng Wu, Chunze Yuan, Michael Angell, Yu-Ju Hsieh, Yu-Hsun Chen, Cheng-Yen Wen, Chun-Wei Chen, Bing-Joe Hwang, Chia-Chun Chen and Hongjie Dai
Rechargeable aluminium ion batteries are an emerging class of energy storage device. Here the authors reveal high-quality natural graphite as a promising cathode for Al-ion batteries, also identifying chloroaluminate anion intercalation in graphite by Raman spectroscopy.
13 February 2017 | doi: 10.1038/ncomms14283

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes OPEN
Jessica F. Almine, Craig A. J. O’Hare, Gillian Dunphy, Ismar R. Haga, Rangeetha J. Naik, Abdelmadjid Atrih, Dympna J. Connolly, Jordan Taylor, Ian R. Kelsall, Andrew G. Bowie, Philippa M. Beard and Leonie Unterholzner
The role of IFI16 as a DNA sensor is highly controversial. With support from a Nature Communications back-to-back publication from Jønsson et al., the authors here provide functional evidence that IFI16 is involved in DNA sensing via the cGAS-STING pathway in human keratinocytes.
13 February 2017 | doi: 10.1038/ncomms14392

A metamorphic inorganic framework that can be switched between eight single-crystalline states OPEN
Caihong Zhan, Jamie M. Cameron, David Gabb, Thomas Boyd, Ross S. Winter, Laia Vilà-Nadal, Scott G. Mitchell, Stefan Glatzel, Joachim Breternitz, Duncan H. Gregory, De-Liang Long, Andrew Macdonell and Leroy Cronin
Crystal engineering is a powerful process for assembling complex materials but tends to require organic building blocks, which can limit stability. Here, the authors use inorganic polyoxometalates to assemble an all-inorganic metamorphic framework that can be switched between eight distinct states.
13 February 2017 | doi: 10.1038/ncomms14185

Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice OPEN
Ana Andres-Hernando, Nanxing Li, Christina Cicerchi, Shinichiro Inaba, Wei Chen, Carlos Roncal-Jimenez, Myphuong T. Le, Michael F. Wempe, Tamara Milagres, Takuji Ishimoto, Mehdi Fini, Takahiko Nakagawa, Richard J. Johnson and Miguel A. Lanaspa
The polyol pathway, which converts glucose into sorbitol and fructose, is active in chronic conditions like hepatic steatosis and chronic kidney disease. Here, Andres-Hernando et al. show that fructose production promotes renal injury and fructokinase inhibition protects against kidney damage during ischaemic acute kidney disease.
13 February 2017 | doi: 10.1038/ncomms14181

Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state OPEN
Iebe Rossey, Morgan S. A. Gilman, Stephanie C. Kabeche, Koen Sedeyn, Daniel Wrapp, Masaru Kanekiyo, Man Chen, Vicente Mas, Jan Spitaels, José A. Melero, Barney S. Graham, Bert Schepens, Jason S. McLellan and Xavier Saelens
Neutralizing antibodies for respiratory syncytial virus (RSV) can reduce disease in hospitalized children, but current options show limited efficacy. Here, the authors isolate potent single-domain antibodies from llamas that recognize the prefusion conformation of RSV F and prevent RSV replication in mice.
13 February 2017 | doi: 10.1038/ncomms14158

Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise OPEN
Tanya R. Cully, Robyn M. Murphy, Llion Roberts, Truls Raastad, Robert G. Fassett, Jeff S. Coombes, Isuru D. Jayasinghe and Bradley S. Launikonis
Heavy-load eccentric exercise causes an increase in cytoplasmic Ca2+ that can damage muscles. Here the authors show that the t-tubule system remodels into vacuoles that can sequester calcium from the cytoplasm and are not responsive to store-operated Ca2+ entry, thereby potentially protecting muscles against elevated [Ca2+].
13 February 2017 | doi: 10.1038/ncomms14266

Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease OPEN
Rocio Gomez-Pastor, Eileen T. Burchfiel, Daniel W. Neef, Alex M. Jaeger, Elisa Cabiscol, Spencer U. McKinstry, Argenia Doss, Alejandro Aballay, Donald C. Lo, Sergey S. Akimov, Christopher A. Ross, Cagla Eroglu and Dennis J. Thiele
Huntington’s disease (HD) is caused by misfolding of mutant Htt protein. The authors find that in HD models, the decreased expression of heat shock transcription factor 1 that usually protects against protein misfolding, is in part caused by elevated CK2α’ kinase and Fbxw7 E3 ligase expression.
13 February 2017 | doi: 10.1038/ncomms14405

Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2 OPEN
Nuria Cerdá-Esteban, Heike Naumann, Silvia Ruzittu, Nancy Mah, Igor M. Pongrac, Corinna Cozzitorto, Angela Hommel, Miguel A. Andrade-Navarro, Ezio Bonifacio and Francesca M. Spagnoli
Liver and pancreas cells arise from a common endoderm progenitor in the embryo, but what regulates their cell fate is unclear. Here, the authors show that expression of the Three-Amino-acid-Loop-Extension (TALE) homeobox TG-interacting factor 2 (TGIF2) in hepatocytes reprogrammes the cells to a pancreatic fate.
13 February 2017 | doi: 10.1038/ncomms14127

Colloidal crystals with diamond symmetry at optical lengthscales OPEN
Yifan Wang, Ian C. Jenkins, James T. McGinley, Talid Sinno and John C. Crocker
Colloidal crystals arranged in a diamond lattice are desirable for photonic applications, yet are challenging to create. Here, Wang et al. show the self-assembly of a binary system composed of two interlocked diamond structures with lattice spacing comparable to the wavelength of visible light.
13 February 2017 | doi: 10.1038/ncomms14173

Ubiquitous strong electron–phonon coupling at the interface of FeSe/SrTiO3 OPEN
Chaofan Zhang, Zhongkai Liu, Zhuoyu Chen, Yanwu Xie, Ruihua He, Shujie Tang, Junfeng He, Wei Li, Tao Jia, Slavko N. Rebec, Eric Yue Ma, Hao Yan, Makoto Hashimoto, Donghui Lu, Sung-Kwan Mo, Yasuyuki Hikita, Robert G. Moore, Harold Y. Hwang, Dunghai Lee and Zhixun Shen et al.
Whether electron–phonon coupling is a generic feature in FeSe/SrTiO3 to enhance superconductivity remains unclear. Here, Zhang et al. report replica bands in FeSe/SrTiO3(110), suggesting a common mechanism in FeSe on SrTiO3 with different surface terminations.
10 February 2017 | doi: 10.1038/ncomms14468

Mismatch between marine plankton range movements and the velocity of climate change OPEN
William J. Chivers, Anthony W. Walne and Graeme C. Hays
Marine plankton are the basis of the oceanic food chain. Here, Chivers and colleagues use ocean-basin wide plankton population data over six decades to show huge differences in the response of different plankton groups to climate change with major implications for the marine ecosystem and fisheries.
10 February 2017 | doi: 10.1038/ncomms14434

Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy OPEN
Devon C. Crawford, Denise M. O. Ramirez, Brent Trauterman, Lisa M. Monteggia and Ege T. Kavalali
Emerging evidence suggests that spontaneous neurotransmitter release contributes to the maintenance of synaptic efficacy. Here the authors selectively reduce spontaneous glutamatergic transmission while leaving the stimulus-evoked responses intact and show that this leads to homeostatic scaling at the postsynaptic side in cultured neurons and alters synaptic plasticity in acute brain slices.
10 February 2017 | doi: 10.1038/ncomms14436

Optogenetic control of cellular forces and mechanotransduction OPEN
Léo Valon, Ariadna Marín-Llauradó, Thomas Wyatt, Guillaume Charras and Xavier Trepat
Cellular mechanical forces are regulated by Rho GTPases. Here the authors develop an optogenetic system to control the spatiotemporal activity of RhoA, and show that directing a RhoA activator to the plasma membrane causes contraction and YAP nuclear localization, whereas directing it to the mitochondria causes relaxation.
10 February 2017 | doi: 10.1038/ncomms14396

Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression OPEN
Wen Wen Xu, Bin Li, Xin Yuan Guan, Sookja K. Chung, Yang Wang, Yim Ling Yip, Simon Y. K. Law, Kin Tak Chan, Nikki P. Y. Lee, Kwok Wah Chan, Li Yan Xu, En Min Li, Sai Wah Tsao, Qing-Yu He and Annie L. M. Cheung
Cancer cells can affect cancer progression by producing systemic effects. Here, the authors show that IGF2 produced by oesophageal cancer cells increases secretion of VEGF from cancer-associated fibroblasts resulting in systemic mobilization of bone marrow-derived cells and increased metastases.
10 February 2017 | doi: 10.1038/ncomms14399

Half-metre sea-level fluctuations on centennial timescales from mid-Holocene corals of Southeast Asia OPEN
Aron J. Meltzner, Adam D. Switzer, Benjamin P. Horton, Erica Ashe, Qiang Qiu, David F. Hill, Sarah L. Bradley, Robert E. Kopp, Emma M. Hill, Jędrzej M. Majewski, Danny H. Natawidjaja and Bambang W. Suwargadi
Despite concern over anticipated eustatic sea-level rise, our understanding of past relative sea level, including regional deviations from the global average, is limited. Here, the authors show evidence for synchronous 0.6-m sea-level fluctuations between 6850 and 6500 yr BP at three sites across Southeast Asia.
10 February 2017 | doi: 10.1038/ncomms14387

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP OPEN
K. L. Jønsson, A. Laustsen, C. Krapp, K. A. Skipper, K. Thavachelvam, D. Hotter, J. H. Egedal, M. Kjolby, P. Mohammadi, T. Prabakaran, L. K. Sørensen, C. Sun, S. B. Jensen, C. K. Holm, R. J. Lebbink, M. Johannsen, M. Nyegaard, J. G. Mikkelsen, F. Kirchhoff, S. R. Paludan et al.
The role of IFI16 as a DNA sensor is highly controversial. With support from a Nature Communications back-to-back publication from Almine et al. the authors here provide functional evidence that IFI16 is required for DNA sensing via the cGAS-STING pathway in human macrophages.
10 February 2017 | doi: 10.1038/ncomms14391

Observation of solid–solid transitions in 3D crystals of colloidal superballs OPEN
Janne-Mieke Meijer, Antara Pal, Samia Ouhajji, Henk N. W. Lekkerkerker, Albert P. Philipse and Andrei V. Petukhov
Experimental understanding of anisotropic colloid self-organization has not yet caught up with theory. Here, the authors find that the experimental phase behaviour of superballs is more complex than predicted, revealing a solid-solid transition from a plastic crystal to two rhombohedral crystal phases with distinct stacking types.
10 February 2017 | doi: 10.1038/ncomms14352

Ancient hybridization fuels rapid cichlid fish adaptive radiations OPEN
Joana I. Meier, David A. Marques, Salome Mwaiko, Catherine E. Wagner, Laurent Excoffier and Ole Seehausen
Cichlids underwent a rapid diversification in the Lake Victoria region, expanding to more than 700 species within 150,000 years. Here, Meier and colleagues show that an ancient hybridization between two divergent cichlid lineages generated high genetic diversity that facilitated the rapid radiation.
10 February 2017 | doi: 10.1038/ncomms14363

Topical tacrolimus for the treatment of secondary lymphedema OPEN
Jason C. Gardenier, Raghu P. Kataru, Geoffrey E. Hespe, Ira L. Savetsky, Jeremy S. Torrisi, Gabriela D. García Nores, Dawit K. Jowhar, Matthew D. Nitti, Ryan C. Schofield, Dean C. Carlow and Babak J. Mehrara
Secondary lymphedema is a debilitating disease with no cure. Here the authors show that topical application of an FDA-approved anti-T cell drug tacrolimus potently prevents development and alleviates pathologic changes of established lymphedema in mice, suggesting a new treatment for human patients.
10 February 2017 | doi: 10.1038/ncomms14345

Conformational changes in intact dengue virus reveal serotype-specific expansion OPEN
Xin-Xiang Lim, Arun Chandramohan, Xin Ying Elisa Lim, Nirmalya Bag, Kamal Kant Sharma, Melissa Wirawan, Thorsten Wohland, Shee-Mei Lok and Ganesh S. Anand
Temperature differences between mosquitoes and humans trigger structural changes in dengue virus 2 (DENV2) particles, but not in other DENV serotypes. Here, using HDXMS, the authors describe serotype-specific expansion of intact viral particles of DENV1 and DENV2 at 28 °C (mosquitoes), 37 °C (humans) and 40 °C (fever).
10 February 2017 | doi: 10.1038/ncomms14339

Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling OPEN
Olga Barca-Mayo, Meritxell Pons-Espinal, Philipp Follert, Andrea Armirotti, Luca Berdondini and Davide De Pietri Tonelli
Core clock genes, such as Bmal1, are expressed in astrocytes, but their contribution to the timekeeping system is unknown. Barca-Mayo et al. report that deletion of Bmal1 in Glast+ astrocytes alters the neuronal clock through GABA signalling, leading to abnormal circadian locomotor behaviour and impaired cognition in mice.
10 February 2017 | doi: 10.1038/ncomms14336

P113 is a merozoite surface protein that binds the N terminus of Plasmodium falciparum RH5 OPEN
Francis Galaway, Laura G. Drought, Maria Fala, Nadia Cross, Alison C. Kemp, Julian C. Rayner and Gavin J. Wright
The secreted Plasmodium falciparum protein RH5 is essential for invasion of erythrocytes and is a promising vaccine candidate. Here, Galaway et al. show that the N-terminal region of RH5 binds the GPI-anchored merozoite surface protein P113 and can elicit invasion-blocking antibodies.
10 February 2017 | doi: 10.1038/ncomms14333

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors OPEN
Moritz Schütte, Thomas Risch, Nilofar Abdavi-Azar, Karsten Boehnke, Dirk Schumacher, Marlen Keil, Reha Yildiriman, Christine Jandrasits, Tatiana Borodina, Vyacheslav Amstislavskiy, Catherine L. Worth, Caroline Schweiger, Sandra Liebs, Martin Lange, Hans- Jörg Warnatz, Lee M. Butcher, James E. Barrett, Marc Sultan, Christoph Wierling, Nicole Golob-Schwarzl et al.
The heterogeneity of colorectal cancer has important clinical and therapeutic implications. Here the authors analysed the responses of a large biobank of organoids and xenografts derived from colorectal patients to a panel of clinically relevant therapeutic agents to identify genes signatures associated with drug response.
10 February 2017 | doi: 10.1038/ncomms14262

Control of finite critical behaviour in a small-scale social system OPEN
Bryan C. Daniels, David C. Krakauer and Jessica C. Flack
Proximity to criticality can be advantageous under changing conditions, but it also entails reduced robustness. Here, the authors analyse fight sizes in a macaque society and find not only that it sits near criticality, but also that the distance from the critical point is tunable through adjustment of individual behaviour and social conflict management.
10 February 2017 | doi: 10.1038/ncomms14301

Epstein–Barr virus particles induce centrosome amplification and chromosomal instability OPEN
Anatoliy Shumilov, Ming-Han Tsai, Yvonne T. Schlosser, Anne-Sophie Kratz, Katharina Bernhardt, Susanne Fink, Tuba Mizani, Xiaochen Lin, Anna Jauch, Josef Mautner, Annette Kopp-Schneider, Regina Feederle, Ingrid Hoffmann and Henri-Jacques Delecluse
Infection with Epstein–Barr virus (EBV) is associated with increased risk of cancer development. Here the authors show that EBV particles, and more specifically the viral protein BNRF1, induce centrosome amplification and chromosomal instability in host cells in the absence of chronic infection.
10 February 2017 | doi: 10.1038/ncomms14257

Bacterial community dynamics are linked to patterns of coral heat tolerance OPEN
Maren Ziegler, Francois O. Seneca, Lauren K. Yum, Stephen R. Palumbi and Christian R. Voolstra
Coral-associated microbes could enhance the capacity of their host organism to respond to environmental change. Ziegler and colleagues use a reciprocal transplant experiment to show that microbiomes of heat-tolerant corals are more resilient to change than those of heat-sensitive corals.
10 February 2017 | doi: 10.1038/ncomms14213

Obliquity-paced climate change recorded in Antarctic debris-covered glaciers OPEN
Sean L. Mackay and David R. Marchant
The degree to which debris-covered glaciers record past environmental conditions is debated. Here, the authors show that obliquity-paced variations in solar radiation over the past ∼220 ka are expressed in Mullins glacier as repetitive changes in englacial debris and corresponding surface topography.
10 February 2017 | doi: 10.1038/ncomms14194

Quantum lock-in force sensing using optical clock Doppler velocimetry OPEN
Ravid Shaniv and Roee Ozeri
Existing force sensors are designed for driving frequencies above tens of kHz due to heating and sensitivity loss. Here the authors demonstrate precise force metrology for below kHz frequency range by combining the Doppler-shifted optical transition in trapped ion and quantum lock-in technique.
10 February 2017 | doi: 10.1038/ncomms14157

Chip-based quantum key distribution OPEN
P. Sibson, C. Erven, M. Godfrey, S. Miki, T. Yamashita, M. Fujiwara, M. Sasaki, H. Terai, M. G. Tanner, C. M. Natarajan, R. H. Hadfield, J. L. O’Brien and M. G. Thompson
Quantum key distribution has not been widely adopted in part due to technical hurdles preventing it being fully integrated in classical communication networks. Here the authors report quantum key distribution between two photonic chips manufactured with state-of-the-art telecoms industry processes.
09 February 2017 | doi: 10.1038/ncomms13984

Dpath software reveals hierarchical haemato-endothelial lineages of Etv2 progenitors based on single-cell transcriptome analysis OPEN
Wuming Gong, Tara L. Rasmussen, Bhairab N. Singh, Naoko Koyano-Nakagawa, Wei Pan and Daniel J. Garry
Single-cell RNA sequencing has enabled great advances in understanding developmental biology but reconstructing cellular lineages from this data remains challenging. Here the authors develop an algorithm, dpath, which models the lineage relationships of underlying single cells based on single cell RNA seq data and apply it to study lineage progression of Etv2 expressing progenitors.
09 February 2017 | doi: 10.1038/ncomms14362

Boninite-like intraplate magmas from Manihiki Plateau require ultra-depleted and enriched source components OPEN
Roman Golowin, Maxim Portnyagin, Kaj Hoernle, Folkmar Hauff, Andrey Gurenko, Dieter Garbe-Schönberg, Reinhard Werner and Simon Turner
Large igneous provinces may form very quickly, but compositions often differ. Here, the authors find that boninite-like rocks at Manihiki are a result of re-melting of an ultra-depleted source therefore putting into question that all boninitic rocks on Earth must be related to subduction processes.
09 February 2017 | doi: 10.1038/ncomms14322

Molecular composition of organic matter controls methylmercury formation in boreal lakes OPEN
Andrea G. Bravo, Sylvain Bouchet, Julie Tolu, Erik Björn, Alejandro Mateos-Rivera and Stefan Bertilsson
Neurotoxic methylmercury can be found in high levels in aquatic systems, but the role of organic matter in methylmercury formation is not well understood. Here, Bravo et al. show that plankton-derived organic compounds enhance formation rates in boreal lakes.
09 February 2017 | doi: 10.1038/ncomms14255

On the post-glacial spread of human commensal Arabidopsis thaliana OPEN
Cheng-Ruei Lee, Hannes Svardal, Ashley Farlow, Moises Exposito-Alonso, Wei Ding, Polina Novikova, Carlos Alonso-Blanco, Detlef Weigel and Magnus Nordborg
Population structure of the model plant Arabidopsis thaliana is shaped by glacial refugia and recent admixture. Here the authors show that genetically distinct groups of A. thaliana have spread east-west across Europe since the most recent ice age, likely as a result of human activity.
09 February 2017 | doi: 10.1038/ncomms14458

Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling OPEN
Chun-Hua Liu, Zheng Gong, Zong-Lai Liang, Zhi-Xin Liu, Fan Yang, Yu-Jing Sun, Ming-Liang Ma, Yi-Jing Wang, Chao-Ran Ji, Yu-Hong Wang, Mei-Jie Wang, Fu-Ai Cui, Amy Lin, Wen-Shuai Zheng, Dong-Fang He, Chang-xiu Qu, Peng Xiao, Chuan-Yong Liu, Alex R. B. Thomsen, Thomas Joseph Cahill et al.
Angiotensin II type 1 receptor (AT1R)-mediated acute catecholamine release is modulated by β-arrestin. Here the authors show that β-arrestin-1 recruits the Ca2+ channel TRPC3 and the PLCγ to the AT1R-β-arrestin complex, triggering G protein-independent calcium influx and catecholamine secretion.
09 February 2017 | doi: 10.1038/ncomms14335

Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination OPEN
Yu Zheng, David T. Miyamoto, Ben S. Wittner, James P. Sullivan, Nicola Aceto, Nicole Vincent Jordan, Min Yu, Nezihi Murat Karabacak, Valentine Comaills, Robert Morris, Rushil Desai, Niyati Desai, Erin Emmons, John D. Milner, Richard J. Lee, Chin-Lee Wu, Lecia V. Sequist, Wilhelm Haas, David T. Ting, Mehmet Toner et al.
Circulating tumour cells contribute to metastatic spread. Here the authors find that beta-chain of haemoglobin is overexpressed in those cells and protects them from oxidative stress, prolonging their survival in circulation and thereby increasing the likelihood of metastasis formation.
09 February 2017 | doi: 10.1038/ncomms14344

Wave-based liquid-interface metamaterials OPEN
N Francois, H Xia, H Punzmann, P W Fontana and M Shats
Here, Francois et al. propose a method of remotely shaping particle trajectories by using rotating waves on a liquid gas interface. The superposition of orthogonal standing waves creates angular momentum which is transferred from waves to floating microparticles, guiding them along closed trajectories.
09 February 2017 | doi: 10.1038/ncomms14325

Strong coupling and high-contrast all-optical modulation in atomic cladding waveguides OPEN
Liron Stern, Boris Desiatov, Noa Mazurski and Uriel Levy
Studying the effects of quantum coherence and shifts in nanoscale atomic cladding waveguides is challenging. Here, Stern et al. construct a highly compact serpentine silicon-nitride atomic vapour cladding waveguide and observe phenomena such as van-der-Waals shifts, dynamical stark shifts and strong coupling.
09 February 2017 | doi: 10.1038/ncomms14461

Magnetism and local symmetry breaking in a Mott insulator with strong spin orbit interactions OPEN
L. Lu, M. Song, W. Liu, A. P. Reyes, P. Kuhns, H. O. Lee, I. R. Fisher and V. F. Mitrović
Local probing into the microscopic degrees of freedom is highly desired to understand emergent exotic quantum phases. Here, the authors report a canted ferromagnetic phase preceded by local point symmetry breaking at low temperature in Ba2NaOsO6, acquired by probing into the spin, orbital and lattice degrees of freedom.
09 February 2017 | doi: 10.1038/ncomms14407

Using graphene networks to build bioinspired self-monitoring ceramics OPEN
Olivier T. Picot, Victoria G. Rocha, Claudio Ferraro, Na Ni, Eleonora D’Elia, Sylvain Meille, Jerome Chevalier, Theo Saunders, Ton Peijs, Mike J. Reece and Eduardo Saiz
Micro- and nanostructures found in nature can be adopted to new uses and materials in engineered composites. Here authors demonstrate large enhancements in toughness and electrical conductivity in a ceramic upon addition of graphene at low (1 volume %) levels.
09 February 2017 | doi: 10.1038/ncomms14425

Tunable thermal expansion in framework materials through redox intercalation OPEN
Jun Chen, Qilong Gao, Andrea Sanson, Xingxing Jiang, Qingzhen Huang, Alberto Carnera, Clara Guglieri Rodriguez, Luca Olivi, Lei Wang, Lei Hu, Kun Lin, Yang Ren, Zheshuai Lin, Cong Wang, Lin Gu, Jinxia Deng, J. Paul Attfield and Xianran Xing
The positive thermal expansion exhibited by most materials at increased temperatures is a severe issue for many high precision applications. Here, Xing and co-workers show that redox intercalation of Li ions into a ScF3 framework offers effective control of the thermal expansion for this simple material.
09 February 2017 | doi: 10.1038/ncomms14441

Microenvironment-derived factors driving metastatic plasticity in melanoma OPEN
Isabella S. Kim, Silja Heilmann, Emily R. Kansler, Yan Zhang, Milena Zimmer, Kajan Ratnakumar, Robert L. Bowman, Theresa Simon-Vermot, Myles Fennell, Ralph Garippa, Liang Lu, William Lee, Travis Hollmann, Joao B. Xavier and Richard M. White
Phenotype switching is a form of plasticity that allows melanoma cancer cells that leave the primary tumour to invade secondary sites, to switch from an invasive to a proliferative state. Here the authors identify EDN3, and its synthetic enzyme ECE2, as a regulator of melanoma plasticity in the microenvironment.
09 February 2017 | doi: 10.1038/ncomms14343

Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement OPEN
Nikaïa Smith, Nicolas Pietrancosta, Sophia Davidson, Jacques Dutrieux, Lise Chauveau, Pasquale Cutolo, Michel Dy, Daniel Scott-Algara, Bénédicte Manoury, Onofrio Zirafi, Isabelle McCort-Tranchepain, Thierry Durroux, Françoise Bachelerie, Olivier Schwartz, Jan Münch, Andreas Wack, Sébastien Nisole and Jean-Philippe Herbeuval
Plasmacytoid dendritic cells produce type I interferons in response to viral sensing. Here the authors show that amines inhibit these plasmacytoid dendritic cell responses through CXCR4 engagement.
09 February 2017 | doi: 10.1038/ncomms14253

Surface single-molecule dynamics controlled by entropy at low temperatures OPEN
J. C. Gehrig, M. Penedo, M. Parschau, J. Schwenk, M. A. Marioni, E. W. Hudson and H. J. Hug
STM is capable of imaging the configurations of molecules on surfaces and measuring the rate of transitions between them. Here the authors demonstrate that, controlled by the STM tip position, the entropic and conservative forces on the molecule can modify the rate by orders of magnitude.
09 February 2017 | doi: 10.1038/ncomms14404

Small genomic insertions form enhancers that misregulate oncogenes OPEN
Brian J. Abraham, Denes Hnisz, Abraham S. Weintraub, Nicholas Kwiatkowski, Charles H. Li, Zhaodong Li, Nina Weichert-Leahey, Sunniyat Rahman, Yu Liu, Julia Etchin, Benshang Li, Shuhong Shen, Tong Ihn Lee, Jinghui Zhang, A. Thomas Look, Marc R. Mansour and Richard A. Young
Sequencing initiatives have detected multiple types of mutations in cancer. Here the authors, analysing enhancer-targeting sequence data, show that small insertions in transcriptional enhancers are frequently found near oncogenes, and demonstrate how one mutation deregulates expression of LMO2 in leukemia cells.
09 February 2017 | doi: 10.1038/ncomms14385

Slow-light-enhanced energy efficiency for graphene microheaters on silicon photonic crystal waveguides OPEN
Siqi Yan, Xiaolong Zhu, Lars Hagedorn Frandsen, Sanshui Xiao, N. Asger Mortensen, Jianji Dong and Yunhong Ding
Slow light can be used to sustain strong light–matter interaction in silicon photonics. Here, the authors combine graphene with a silicon slow-light photonic crystal waveguide, demonstrating a fast and energy-efficient graphene microheater.
09 February 2017 | doi: 10.1038/ncomms14411

Dynamics of auditory cortical activity during behavioural engagement and auditory perception OPEN
Ioana Carcea, Michele N. Insanally and Robert C. Froemke
Sensory perception is enhanced with behavioural engagement. Here the authors show that when rats initiate stimulus delivery in an auditory recognition task, activity of auditory cortex neurons is modulated and optogenetic disruption of this activity affects performance.
08 February 2017 | doi: 10.1038/ncomms14412

Amygdala-hippocampal dynamics during salient information processing OPEN
Jie Zheng, Kristopher L. Anderson, Stephanie L. Leal, Avgusta Shestyuk, Gultekin Gulsen, Lilit Mnatsakanyan, Sumeet Vadera, Frank P. K. Hsu, Michael A. Yassa, Robert T. Knight and Jack J. Lin
Amygdala and hippocampus are involved in processing motivationally salient stimuli but the precise circuit dynamics of the interaction is not understood. Here the authors show that in response to fearful faces in humans, theta/alpha oscillations in the amygdala modulate hippocampal activity dynamics.
08 February 2017 | doi: 10.1038/ncomms14413

p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation OPEN
Ashwini Hinge, Juying Xu, Jose Javier, Eucabeth Mose, Sachin Kumar, Reuben Kapur, Edward F. Srour, Punam Malik, Bruce J. Aronow and Marie-Dominique Filippi
The success of hematopoietic stem cell (HSC) transplantation relies on understanding what regulates the fate decision to self-renew. Here, the authors show using both in vitro assays and in vivo transplantation that loss of the RhoGAP p190-B enhances self-renewal by inhibiting TGFβ/p38 signalling.
08 February 2017 | doi: 10.1038/ncomms14382

Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination OPEN
Hong Zan, Connie Tat, Zhifang Qiu, Julia R. Taylor, Justin A. Guerrero, Tian Shen and Paolo Casali
Class switch DNA recombination (CSR) is critical for maturation of antibody response, and relies on Ku-mediated NHEJ of DSBs in the IgH S regions for recombination. This study shows Rad52 contributes to CSR through a Ku-independent alternative NHEJ that introduces microhomologies in S–S junctions.
08 February 2017 | doi: 10.1038/ncomms14244

Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus OPEN
Muhammad Myn Uddin, Izumi Ohigashi, Ryo Motosugi, Tomomi Nakayama, Mie Sakata, Jun Hamazaki, Yasumasa Nishito, Immanuel Rode, Keiji Tanaka, Tatsuya Takemoto, Shigeo Murata and Yousuke Takahama
Foxn1 is involved in thymic epithelial cell (TEC) and CD8+ T cell development. Here the authors show this development requires Foxn1 binding proximal to, and inducing transcription of, the gene encoding β5t in cortical TECs.
08 February 2017 | doi: 10.1038/ncomms14419

Recurring RNA structural motifs underlie the mechanics of L1 stalk movement OPEN
Srividya Mohan and Harry F Noller
Translocation of the tRNA on the ribosome is associated with large-scale molecular movements of the ribosomal L1 stalk. Here the authors identify the key determinants that allow these dramatic movements, and suggest they represent general strategies used to enable large-scale motions in functional RNAs.
08 February 2017 | doi: 10.1038/ncomms14285

Metal-centred azaphosphatriptycene gear with a photo- and thermally driven mechanical switching function based on coordination isomerism OPEN
Hitoshi Ube, Yoshihiro Yasuda, Hiroyasu Sato and Mitsuhiko Shionoya
In metal-based molecular motors, the motion is generally triggered by changes in the ligand coordination around the metal centre. Here, the authors synthesize a molecular gear that switches between states through photo- and thermally driven geometrical isomerization around a platinum ion.
08 February 2017 | doi: 10.1038/ncomms14296

Scanning tunnelling spectroscopy as a probe of multi-Q magnetic states of itinerant magnets OPEN
Maria N. Gastiasoro, Ilya Eremin, Rafael M. Fernandes and Brian M. Andersen
It remains difficult to distinguish single-Q and multi-Q magnetic states experimentally. Here, Gastiasoro et al. show that the magnetic configuration of an itinerant system can be mapped out to the local density of states near a magnetic impurity, distinguishing unambiguously between single-Q and multi-Q phases.
08 February 2017 | doi: 10.1038/ncomms14317

Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging OPEN
Michael F. Cuccarese, J. Matthew Dubach, Christina Pfirschke, Camilla Engblom, Christopher Garris, Miles A. Miller, Mikael J. Pittet and Ralph Weissleder
Tumour-associated macrophages (TAM) can be used as prognostic indicators in cancer. Here, the authors establish a platform for high-throughput 3D microscopy in murine lung carcinoma that allows to visualize TAMs infiltration throughout the entire lung, response to CSF-1R blockade and nanoparticle drug delivery.
08 February 2017 | doi: 10.1038/ncomms14293

Innovation and constraint leading to complex multicellularity in the Ascomycota OPEN
Tu Anh Nguyen, Ousmane H. Cissé, Jie Yun Wong, Peng Zheng, David Hewitt, Minou Nowrousian, Jason E. Stajich and Gregory Jedd
The fungal Ascomycota provide a model phylum to investigate the evolution of complex multicellularity. Here, the authors combine genome sequencing with comparative and functional genomics to identify diverse endomembrane related machineries associated with the gain and loss of fungal complexity.
08 February 2017 | doi: 10.1038/ncomms14444

Slow cooling and highly efficient extraction of hot carriers in colloidal perovskite nanocrystals OPEN
Mingjie Li, Saikat Bhaumik, Teck Wee Goh, Muduli Subas Kumar, Natalia Yantara, Michael Grätzel, Subodh Mhaisalkar, Nripan Mathews and Tze Chien Sum
Harvesting excess energy from above-band gap photons could lead to solar cells which exceed conventional efficiency limits. Li et al., study hot carrier cooling in hybrid perovskite materials with reduced dimensionality using transient absorption spectroscopy and demonstrate efficient hot-electron extraction in such systems.
08 February 2017 | doi: 10.1038/ncomms14350

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome OPEN
Yingying Zhang, Sheng Sean Su, Shubo Zhao, Zhentao Yang, Chuan-Qi Zhong, Xin Chen, Qixu Cai, Zhang-Hua Yang, Deli Huang, Rui Wu and Jiahuai Han
Mitochondrial reactive oxygen species (ROS) promote necroptosis and the receptor interacting protein 1 (RIP1) is a key player in this form of cell death. Here, the authors show that cysteine residues in RIP1 sense ROS and oxidation of the cysteines triggers RIP1 autophosphorylation, which promotes functional necrosome formation.
08 February 2017 | doi: 10.1038/ncomms14329

Humans have already increased the risk of major disruptions to Pacific rainfall OPEN
Scott B. Power, François P. D. Delage, Christine T. Y. Chung, Hua Ye and Bradley F. Murphy
Intermittent rainfall changes over the Pacific Ocean can profoundly disrupt lives and ecosystems in many locations. Here, the authors show that the risk of such changes has increased, and that the risk could – even with a reduction in greenhouse gas emissions - remain elevated for decades to come.
08 February 2017 | doi: 10.1038/ncomms14368

Electron–acoustic phonon coupling in single crystal CH3NH3PbI3 perovskites revealed by coherent acoustic phonons OPEN
Pierre-Adrien Mante, Constantinos C. Stoumpos, Mercouri G. Kanatzidis and Arkady Yartsev
Carrier mobility is a basic semiconductor property. Mante et al., use femtosecond lasers to investigate coherent acoustic phonons and relate their deformation potentials to estimate the intrinsic electron and hole mobilities of CH3NH3PbI3 single crystals to be 2,800 and 9,400 cm2 V−1 s−1, respectively.
08 February 2017 | doi: 10.1038/ncomms14398

Reconciled rat and human metabolic networks for comparative toxicogenomics and biomarker predictions OPEN
Edik M. Blais, Kristopher D. Rawls, Bonnie V. Dougherty, Zhuo I. Li, Glynis L. Kolling, Ping Ye, Anders Wallqvist and Jason A. Papin
The rat is a widely-used model for human biology, but we must be aware of metabolic differences. Here, the authors reconstruct the genome-scale metabolic network of the rat, and after reconciling it with an improved human metabolic model, demonstrate the power of the models to integrate toxicogenomics data, providing species-specific biomarker predictions in response to a panel of drugs.
08 February 2017 | doi: 10.1038/ncomms14250

Unravelling exceptional acetylene and carbon dioxide adsorption within a tetra-amide functionalized metal-organic framework OPEN
Florian Moreau, Ivan da Silva, Nada H. Al Smail, Timothy L. Easun, Mathew Savage, Harry G. W. Godfrey, Stewart F. Parker, Pascal Manuel, Sihai Yang and Martin Schröder
Understanding the mechanism of gas-sorbent interactions at a molecular level is important for the design of improved gas storage materials. Here, the authors study the binding domains of carbon dioxide and acetylene in a tetra-amide functionalized metal-organic framework at crystallographic resolution.
08 February 2017 | doi: 10.1038/ncomms14085

Soil networks become more connected and take up more carbon as nature restoration progresses OPEN
Elly Morriën, S. Emilia Hannula, L. Basten Snoek, Nico R. Helmsing, Hans Zweers, Mattias de Hollander, Raquel Luján Soto, Marie-Lara Bouffaud, Marc Buée, Wim Dimmers, Henk Duyts, Stefan Geisen, Mariangela Girlanda, Rob I. Griffiths, Helene-Bracht Jørgensen, John Jensen, Pierre Plassart, Dirk Redecker, Rűdiger M Schmelz, Olaf Schmidt et al.
Effects of habitat restoration on belowground organisms and ecosystem processes are poorly understood. Morriën and colleagues show that changes in the composition and network interactions of soil biota lead to improved carbon uptake efficiency when formerly cultivated land is restored.
08 February 2017 | doi: 10.1038/ncomms14349

Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress OPEN
Nam Hee Kim, Yong Hoon Cha, Jueun Lee, Seon-Hyeong Lee, Ji Hye Yang, Jun Seop Yun, Eunae Sandra Cho, Xianglan Zhang, Miso Nam, Nami Kim, Young-Su Yuk, So Young Cha, Yoonmi Lee, Joo Kyung Ryu, Sunghyouk Park, Jae-Ho Cheong, Sang Won Kang, Soo-Youl Kim, Geum-Sook Hwang, Jong In Yook et al.
Cancer cell survival under metabolic stress is a critical step for metastasis. Here, the authors show that under glucose deprivation, Snail, a key regulator of the metastatic process, promotes survival by diverting glucose to the pentose phosphate pathway through repression of phosphofructokinase PFKP.
08 February 2017 | doi: 10.1038/ncomms14374

Phylointeractomics reconstructs functional evolution of protein binding OPEN
Dennis Kappei, Marion Scheibe, Maciej Paszkowski-Rogacz, Alina Bluhm, Toni Ingolf Gossmann, Sabrina Dietz, Mario Dejung, Holger Herlyn, Frank Buchholz, Matthias Mann and Falk Butter
Since protein interactions can be sensitive to small sequence changes, phylogenomics alone gives limited insight into protein functional evolution. Here, the authors illustrate how the combination of phylogenomics and interaction proteomics helps elucidate protein functional evolution with a study of the shelterin complex evolution.
08 February 2017 | doi: 10.1038/ncomms14334

Dosage sensitivity is a major determinant of human copy number variant pathogenicity OPEN
Alan M. Rice and Aoife McLysaght
Copy number variants (CNVs) cause significant genomic variation in humans and may be benign or may cause disease. Here, the authors show that pathogenic CNVs are evolutionarily constrained compared with benign, pointing to dosage sensitivity as a potential cause of disease.
08 February 2017 | doi: 10.1038/ncomms14366

LncRNA AK023948 is a positive regulator of AKT OPEN
Pratirodh Koirala, Jianguo Huang, Tsui-Ting Ho, Fangting Wu, Xianfeng Ding and Yin-Yuan Mo
The function of many human long non-coding RNAs (lncRNAs) is still undetermined. Here, the authors setup a gain of function CRISPR-based screen and identify a lncRNA that positively regulates AKT activity by interacting with the RNA helicase DHX9 resulting in stabilization of PI3K regulatory subunit p85.
08 February 2017 | doi: 10.1038/ncomms14422

X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3 OPEN
Chiara Olcese, Mitali P. Patel, Amelia Shoemark, Santeri Kiviluoto, Marie Legendre, Hywel J. Williams, Cara K. Vaughan, Jane Hayward, Alice Goldenberg, Richard D. Emes, Mustafa M. Munye, Laura Dyer, Thomas Cahill, Jeremy Bevillard, Corinne Gehrig, Michel Guipponi, Sandra Chantot, Philippe Duquesnoy, Lucie Thomas, Ludovic Jeanson et al.
Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disease resulting in reduced mucus clearance and impaired lung function. Here, the authors show that mutations in PIH1D3 are responsible for an X-linked form of PCD, affecting assembly of a subset of inner arm dyneins.
08 February 2017 | doi: 10.1038/ncomms14279
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  Latest Errata  
Erratum: Confirmation of the topology of the Wendelstein 7-X magnetic field to better than 1:100,000 OPEN
T. Sunn Pedersen, M. Otte, S. Lazerson, P. Helander, S. Bozhenkov, C. Biedermann, T. Klinger, R. C. Wolf, H-S Bosch and The Wendelstein 7-X Team
14 February 2017 | doi: 10.1038/ncomms14491

Erratum: In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters OPEN
Adekunle T. Bademosi, Elsa Lauwers, Pranesh Padmanabhan, Lorenzo Odierna, Ye Jin Chai, Andreas Papadopulos, Geoffrey J. Goodhill, Patrik Verstreken, Bruno van Swinderen and Frédéric A Meunier
09 February 2017 | doi: 10.1038/ncomms14492
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