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Nature Reviews Molecular Cell Biology contents February 2017 Volume 18 Number 2 pp 69-136

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Nature Reviews Molecular Cell Biology

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February 2017 Volume 18 Number 2
Nature Reviews Molecular Cell Biology cover

2015 2-year Impact Factor 38.602 Journal Metrics 2-year Median 30

In this issue
Research Highlights

Also this month
Article series:
Post-translational modifications
Article series:
RNA processing and modifications
Article series:
Cell death and autophagy
 Featured article:
The nuclear pore complex: understanding its function through structural insight
Martin Beck & Ed Hurt
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Synthetic biology: Designer cells tackle diabetes
p69 | doi:10.1038/nrm.2016.175
Two studies report on two independent synthetic biology approaches to tackle hyperglycaemia and insulin resistance that are associated with diabetes.

RNA Metabolism: Modifying sex in flies
p70 | doi:10.1038/nrm.2016.173
Two groups report that N6-methyladenosine (m6A) affects alternative splicing in fruit files, with notable phenotypes in sex determination and the nervous system.

Ageing: Forever young
p70 | doi:10.1038/nrm.2016.176
Partial reprogramming through short-term expression of OSKM reverses the ageing process in mice.

Translation: Smoothening the coding sequence for translation
p72 | doi:10.1038/nrm.2016.178
A new mechanism of controlling translation initiation depends on DEAD-box RNA helicases and on RNA structures, including those present in coding sequences.

Cell death: Pulling the apoptotic trigger for necrosis
p72 | doi:10.1038/nrm.2017.1
Secondary necrosis following apoptosis induction is a regulated process that is dependent on the cleavage of DFNA5 by the executioner caspase, caspase 3.


Non-Coding RNA: A class of their own | Development: Metabolism regulates lymphangiogenesis | Translation: Ubiquitylation mediates quality control

Molecular Cell Biology
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The nuclear pore complex: understanding its function through structural insight
Martin Beck & Ed Hurt
p73 | doi:10.1038/nrm.2016.147
Nuclear pore complexes (NPCs) are large protein assemblies that form channels in the nuclear envelope and constitute major routes for nucleocytoplasmic communication. Insights into the complex structure of NPCs provide the basis for understanding their functions and reveal how the dysfunction of their structural components, nucleoporins, contributes to human disease.
Abstract | Full Text | PDF | Supplementary information
Article series: Post-translational modifications
Metabolic regulation of gene expression through histone acylations
Benjamin R. Sabari, Di Zhang, C. David Allis & Yingming Zhao
p90 | doi:10.1038/nrm.2016.140
In addition to acetylation, eight types of structurally and functionally different short-chain acylations have recently been identified as important histone Lys modifications: propionylation, butyrylation, 2-hydroxyisobutyrylation, succinylation, malonylation, glutarylation, crotonylation and β-hydroxybutyrylation. These modifications are regulated by enzymatic and metabolic mechanisms and have physiological functions, which include signal-dependent gene activation and metabolic stress.
Abstract | Full Text | PDF
Article series: RNA processing and modifications
The roles of RNA processing in translating genotype to phenotype
Kassie S. Manning & Thomas A. Cooper
p102 | doi:10.1038/nrm.2016.139
Genetic variants can produce phenotypic traits through effects on RNA processing, including effects on pre-mRNA splicing, 3' end formation, and RNA stability, localization, structure and translation efficiency.
Abstract | Full Text | PDF
Histone variants on the move: substrates for chromatin dynamics
Paul B. Talbert & Steven Henikoff
p115 | doi:10.1038/nrm.2016.148
Histone variants are typically incorporated into chromatin independently of DNA replication and modify chromatin properties. Recent studies have elucidated how particular histone variants are substrates of histone chaperones, chromatin remodellers and histone-modifying enzymes, thereby modifying DNA replication and repair, transcription and chromatin packaging.
Abstract | Full Text | PDF | Supplementary information
Article series: Cell death and autophagy
Necroptosis in development, inflammation and disease
Ricardo Weinlich, Andrew Oberst, Helen M. Beere & Douglas R. Green
p127 | doi:10.1038/nrm.2016.149
Several years after the characterization of the role of receptor-interacting serine/threonine protein kinase 1 (RIPK1) in cell survival, inflammation and disease, RIPK1 was implicated in the regulation of a newly identified type of cell death known as necroptosis. This Timeline article describes the discoveries that shed light on the roles of RIPK1, RIPK3, mixed-lineage kinase domain-like protein (MLKL) and other regulators of necroptosis in controlling cell fate.
Abstract | Full Text | PDF
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