Nature Reviews Molecular Cell Biology contents February 2017 Volume 18 Number 2 pp 69-136

If you are unable to see the message below, click here to view.

Advertisement
Nature Index Collaborations 2016  Institutions and countries responsible for some of the highest quality of science research tend to form the strongest alliances and partnerships. Nature Index 2016 Collaborations takes closer look at the most fruitful collaborations; such as the bond between China and the United States.  Access this free supplement for six months!
TABLE OF CONTENTS
February 2017 Volume 18 Number 2
2015 2-year Impact Factor 38.602 Journal Metrics 2-year Median 30	In this issue Research Highlights Reviews Perspectives Also this month Article series: Post-translational modifications Article series: RNA processing and modifications Article series: Cell death and autophagy  Featured article: The nuclear pore complex: understanding its function through structural insight Martin Beck & Ed Hurt
Subscribe   Facebook   RSS   Recommend to library   Twitter
Advertisement
nature.com webcasts Springer Nature presents a custom webcast on: CRISPR/Cas9 strategies for disease modeling and drug discovery Date: Tuesday, 24 January 2017 Time: 8AM PST, 11AM EST, 4PM GMT, 5PM CST  Register for FREE Sponsored by:  The Jackson Laboratory
Advertisement
ELECTRON MICROSCOPY FOR MATERIALS - THE NEXT TEN YEARS Presented by: Zhejiang University | Nature | Nature Materials The conference will feature sessions on nanomaterials, functional materials, structural material, soft matter and biomaterials, and techniques development. May 27-29, 2016 | Zhenjiang, China  Register now!
RESEARCH HIGHLIGHTS Top Synthetic biology: Designer cells tackle diabetes p69 | doi:10.1038/nrm.2016.175 Two studies report on two independent synthetic biology approaches to tackle hyperglycaemia and insulin resistance that are associated with diabetes. PDF RNA Metabolism: Modifying sex in flies p70 | doi:10.1038/nrm.2016.173 Two groups report that N6-methyladenosine (m6A) affects alternative splicing in fruit files, with notable phenotypes in sex determination and the nervous system. PDF Ageing: Forever young p70 | doi:10.1038/nrm.2016.176 Partial reprogramming through short-term expression of OSKM reverses the ageing process in mice. PDF Translation: Smoothening the coding sequence for translation p72 | doi:10.1038/nrm.2016.178 A new mechanism of controlling translation initiation depends on DEAD-box RNA helicases and on RNA structures, including those present in coding sequences. PDF Cell death: Pulling the apoptotic trigger for necrosis p72 | doi:10.1038/nrm.2017.1 Secondary necrosis following apoptosis induction is a regulated process that is dependent on the cleavage of DFNA5 by the executioner caspase, caspase 3. PDF IN BRIEF Non-Coding RNA: A class of their own | Development: Metabolism regulates lymphangiogenesis | Translation: Ubiquitylation mediates quality control PDF Molecular Cell Biology JOBS of the week Postdoctoral Researchers Institute of Animal Physiology and Genetics, Czech Academy of Sciences Postdoctoral Scholar in Cancer Biology University of Chicago Postdoctoral Fellow University of Texas Health Science Center at San Antonio Postdoctoral Position-Transplant Wake Forest Baptist Medical Center More Science jobs from Molecular Cell Biology EVENT EMBO - EMBL Symposium: Molecular and Cell Biology of Membranes 21.05.17 Heidelberg, Germany More science events from
Advertisement
Palgrave Macmillan offers a free open access funding support service to enable authors to discover and apply for article processing charge funding available to them. Visit our website for further advice on your funding options, and guidance in approaching funders and institutions, or email openaccess@palgrave.com for more information.
REVIEWS		Top
The nuclear pore complex: understanding its function through structural insight Martin Beck & Ed Hurt p73 | doi:10.1038/nrm.2016.147 Nuclear pore complexes (NPCs) are large protein assemblies that form channels in the nuclear envelope and constitute major routes for nucleocytoplasmic communication. Insights into the complex structure of NPCs provide the basis for understanding their functions and reveal how the dysfunction of their structural components, nucleoporins, contributes to human disease. Abstract | Full Text | PDF | Supplementary information
Article series: Post-translational modifications Metabolic regulation of gene expression through histone acylations Benjamin R. Sabari, Di Zhang, C. David Allis & Yingming Zhao p90 | doi:10.1038/nrm.2016.140 In addition to acetylation, eight types of structurally and functionally different short-chain acylations have recently been identified as important histone Lys modifications: propionylation, butyrylation, 2-hydroxyisobutyrylation, succinylation, malonylation, glutarylation, crotonylation and β-hydroxybutyrylation. These modifications are regulated by enzymatic and metabolic mechanisms and have physiological functions, which include signal-dependent gene activation and metabolic stress. Abstract | Full Text | PDF
Article series: RNA processing and modifications The roles of RNA processing in translating genotype to phenotype Kassie S. Manning & Thomas A. Cooper p102 | doi:10.1038/nrm.2016.139 Genetic variants can produce phenotypic traits through effects on RNA processing, including effects on pre-mRNA splicing, 3' end formation, and RNA stability, localization, structure and translation efficiency. Abstract | Full Text | PDF
Histone variants on the move: substrates for chromatin dynamics Paul B. Talbert & Steven Henikoff p115 | doi:10.1038/nrm.2016.148 Histone variants are typically incorporated into chromatin independently of DNA replication and modify chromatin properties. Recent studies have elucidated how particular histone variants are substrates of histone chaperones, chromatin remodellers and histone-modifying enzymes, thereby modifying DNA replication and repair, transcription and chromatin packaging. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
TIMELINE Article series: Cell death and autophagy Necroptosis in development, inflammation and disease Ricardo Weinlich, Andrew Oberst, Helen M. Beere & Douglas R. Green p127 | doi:10.1038/nrm.2016.149 Several years after the characterization of the role of receptor-interacting serine/threonine protein kinase 1 (RIPK1) in cell survival, inflammation and disease, RIPK1 was implicated in the regulation of a newly identified type of cell death known as necroptosis. This Timeline article describes the discoveries that shed light on the roles of RIPK1, RIPK3, mixed-lineage kinase domain-like protein (MLKL) and other regulators of necroptosis in controlling cell fate. Abstract | Full Text | PDF
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

*2015 Journal Citation Reports (Thomson Reuters, 2016)

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our feedback department Nature Publishing Group | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW. © 2017 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.