Nature Reviews Immunology Contents February 2017 Volume 17 Number 2 pp 77-143

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TABLE OF CONTENTS
February 2017 Volume 17 Number 2
2015 2-year Impact Factor 39.416 Journal Metrics 2-year Median 31	In this issue Research Highlights Reviews Correspondence Also this month Article series: Cell death and immunity  Featured article: Disease tolerance and immunity in host protection against infection Miguel P. Soares, Luis Teixeira & Luis F. Moita
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RESEARCH HIGHLIGHTS Top Inflammation: Inflammasome-related ageing p77 | doi:10.1038/nri.2017.3 Increased expression of inflammasome-related gene modules in older individuals correlates with nucleotide metabolism dysfunction, IL-1β production and cardiovascular disease. PDF Immunometabolism: Complex metabolic responses to microbial stimuli p78 | doi:10.1038/nri.2016.148 Different microbial stimuli lead to specific metabolic programmes in activated human monocytes. PDF Antibody responses: A thymic niche for plasma cells p78 | doi:10.1038/nri.2017.2 Plasma cells accumulate in the ageing thymus and may provide protection against viral infections. PDF Tumour immunology: NLRC3 inhibits mTOR in colorectal cancer p79 | doi:10.1038/nri.2016.152 NLRC3 protects against colorectal cancer by suppressing the proliferation of intestinal epithelial cells through inhibition of the PI3K-AKT-mTOR pathway. PDF Allergy: Neonatal IL-33 drives allergy p80 | doi:10.1038/nri.2016.149 Interleukin-33 is a key driver of type 2 immunity in the developing neonatal lung of mice both in the steady state and in response to allergen exposure. PDF Autoimmune diseases: Inhibitor of adaptor protein shows self-antigen selectivity p80 | doi:10.1038/nri.2017.5 A T cell receptor signalling inhibitor shows efficacy in autoimmune diseases without affecting immune responses to pathogens. PDF T cells: Something to chew on p81 | doi:10.1038/nri.2017.4 Chewing induces the accumulation of T helper 17 cells in the mouth. PDF Nature Reviews Immunology JOBS of the week Director, Cancer Immunology Institute Fox Chase Cancer Center (FCCC) Assistant / Associate Professor of Immunology and Infectious Diseases Harvard T. H. Chan School of Public Health Postdoctoral Fellow in Immunology / Epigenetics / Infection Biology CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences Immunology Scientist Positions New York Blood Center More Science jobs from Nature Reviews Immunology EVENT 18th International Congress of Mucosal Immunology (ICMI 2017) 19.07.17 Washington, D.C, USA More science events from
REVIEWS		Top
Disease tolerance and immunity in host protection against infection Miguel P. Soares, Luis Teixeira & Luis F. Moita p83 | doi:10.1038/nri.2016.136 Disease tolerance is a defence strategy that functions by improving tissue repair or by reducing the detrimental effect of inflammatory signals to prevent the harmful effects of pathogens. This Review describes the mechanisms underlying disease tolerance to infections and how these can be targeted therapeutically. Abstract | Full Text | PDF
Article series: Cell death and immunity Immunogenic cell death in cancer and infectious disease Lorenzo Galluzzi, Aitziber Buqué, Oliver Kepp, Laurence Zitvogel & Guido Kroemer p97 | doi:10.1038/nri.2016.107 Initiation of an adaptive immune response depends on the detection of both antigenic epitopes and adjuvant signals. Infectious pathogens and cancer cells often avoid immune detection by limiting the release of danger signals from dying cells. When is cell death immunogenic and what are the pathophysiological implications of this process? Abstract | Full Text | PDF
Mechanisms of immunomodulation by mammalian and viral decoy receptors: insights from structures Jan Felix & Savvas N. Savvides p112 | doi:10.1038/nri.2016.134 Understanding how decoy receptors for cytokines and chemokines work requires in-depth insights into their structure. In this Review, the authors provide a structural overview of both mammalian and viral decoy receptors and highlight opportunities for leveraging their immunomodulatory activity for therapeutic purposes. Abstract | Full Text | PDF | Supplementary information
RNA-binding proteins in immune regulation: a focus on CCCH zinc finger proteins Mingui Fu & Perry J. Blackshear p130 | doi:10.1038/nri.2016.129 In this Review, the authors summarize recent findings that illustrate the emerging roles of CCCH zinc finger proteins, which are involved in the regulation of multiple steps of RNA metabolism, in the regulation of immune responses including cytokine production, immune cell activation and immune homeostasis. Abstract | Full Text | PDF | Supplementary information
CORRESPONDENCE		Top
The complement system is also important in immunogenic cell death Junfei Jin & Songqing He p143 | doi:10.1038/nri.2016.142 Full Text | PDF
Reply: The complement system is also important in immunogenic cell death Lorenzo Galluzzi, Aitziber Buqué, Oliver Kepp, Laurence Zitvogel & Guido Kroemer p143 | doi:10.1038/nri.2016.143 Full Text | PDF
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