Tuesday, January 31, 2017

Nature Reviews Immunology Contents February 2017 Volume 17 Number 2 pp 77-143

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Nature Reviews Immunology

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Produced with support from Agios Pharmaceuticals, Inc.
February 2017 Volume 17 Number 2
Nature Reviews Immunology cover
2015 2-year Impact Factor 39.416 Journal Metrics 2-year Median 31
In this issue
Research Highlights

Also this month
Article series:
Cell death and immunity
 Featured article:
Disease tolerance and immunity in host protection against infection
Miguel P. Soares, Luis Teixeira & Luis F. Moita
Recommend to library

Inflammation: Inflammasome-related ageing
p77 | doi:10.1038/nri.2017.3
Increased expression of inflammasome-related gene modules in older individuals correlates with nucleotide metabolism dysfunction, IL-1β production and cardiovascular disease.


Immunometabolism: Complex metabolic responses to microbial stimuli
p78 | doi:10.1038/nri.2016.148
Different microbial stimuli lead to specific metabolic programmes in activated human monocytes.


Antibody responses: A thymic niche for plasma cells
p78 | doi:10.1038/nri.2017.2
Plasma cells accumulate in the ageing thymus and may provide protection against viral infections.


Tumour immunology: NLRC3 inhibits mTOR in colorectal cancer
p79 | doi:10.1038/nri.2016.152
NLRC3 protects against colorectal cancer by suppressing the proliferation of intestinal epithelial cells through inhibition of the PI3K-AKT-mTOR pathway.


Allergy: Neonatal IL-33 drives allergy
p80 | doi:10.1038/nri.2016.149
Interleukin-33 is a key driver of type 2 immunity in the developing neonatal lung of mice both in the steady state and in response to allergen exposure.


Autoimmune diseases: Inhibitor of adaptor protein shows self-antigen selectivity
p80 | doi:10.1038/nri.2017.5
A T cell receptor signalling inhibitor shows efficacy in autoimmune diseases without affecting immune responses to pathogens.


T cells: Something to chew on
p81 | doi:10.1038/nri.2017.4
Chewing induces the accumulation of T helper 17 cells in the mouth.


Nature Reviews Immunology
JOBS of the week
Director, Cancer Immunology Institute
Fox Chase Cancer Center (FCCC)
Assistant / Associate Professor of Immunology and Infectious Diseases
Harvard T. H. Chan School of Public Health
Postdoctoral Fellow in Immunology / Epigenetics / Infection Biology
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Immunology Scientist Positions
New York Blood Center
More Science jobs from
Nature Reviews Immunology
18th International Congress of Mucosal Immunology (ICMI 2017)
Washington, D.C, USA
More science events from
Disease tolerance and immunity in host protection against infection
Miguel P. Soares, Luis Teixeira & Luis F. Moita
p83 | doi:10.1038/nri.2016.136
Disease tolerance is a defence strategy that functions by improving tissue repair or by reducing the detrimental effect of inflammatory signals to prevent the harmful effects of pathogens. This Review describes the mechanisms underlying disease tolerance to infections and how these can be targeted therapeutically.
Abstract | Full Text | PDF
Article series: Cell death and immunity
Immunogenic cell death in cancer and infectious disease
Lorenzo Galluzzi, Aitziber Buqué, Oliver Kepp, Laurence Zitvogel & Guido Kroemer
p97 | doi:10.1038/nri.2016.107
Initiation of an adaptive immune response depends on the detection of both antigenic epitopes and adjuvant signals. Infectious pathogens and cancer cells often avoid immune detection by limiting the release of danger signals from dying cells. When is cell death immunogenic and what are the pathophysiological implications of this process?
Abstract | Full Text | PDF
Mechanisms of immunomodulation by mammalian and viral decoy receptors: insights from structures
Jan Felix & Savvas N. Savvides
p112 | doi:10.1038/nri.2016.134
Understanding how decoy receptors for cytokines and chemokines work requires in-depth insights into their structure. In this Review, the authors provide a structural overview of both mammalian and viral decoy receptors and highlight opportunities for leveraging their immunomodulatory activity for therapeutic purposes.
Abstract | Full Text | PDF | Supplementary information
RNA-binding proteins in immune regulation: a focus on CCCH zinc finger proteins
Mingui Fu & Perry J. Blackshear
p130 | doi:10.1038/nri.2016.129
In this Review, the authors summarize recent findings that illustrate the emerging roles of CCCH zinc finger proteins, which are involved in the regulation of multiple steps of RNA metabolism, in the regulation of immune responses including cytokine production, immune cell activation and immune homeostasis.
Abstract | Full Text | PDF | Supplementary information
The complement system is also important in immunogenic cell death
Junfei Jin & Songqing He
p143 | doi:10.1038/nri.2016.142
Full Text | PDF
Reply: The complement system is also important in immunogenic cell death
Lorenzo Galluzzi, Aitziber Buqué, Oliver Kepp, Laurence Zitvogel & Guido Kroemer
p143 | doi:10.1038/nri.2016.143
Full Text | PDF
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