Nature Reviews Genetics Contents February 2017 Volume 18 Number 2 pp67-142

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Unexplored opportunities in the druggable human genome This poster presents a categorization of human proteins based on the amount of data on them, highlighting a knowledge deficit and indicating novel drug discovery opportunities.  Download the Poster free online Produced with support from:   Illuminating the Druggable Genome Knowledge Management Center  (IDG KMC)
TABLE OF CONTENTS
February 2017 Volume 18 Number 2
Impact Factor 35.898 *	In this issue Research Highlights Reviews Also this month Article series: Regulatory elements Study designs Disease mechanisms  Featured article: Regulatory activities of transposable elements: from conflicts to benefits Edward B. Chuong, Nels C. Elde & Cédric Feschotte
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Environmental Microbial Biofilms and Human Microbiomes: Drivers of Future Sustainability  February 12-15, 2017 | Nanyang Executive Centre, Singapore Presented by: Nanyang Technological University (NTU) | Singapore Centre for Environmental Life Sciences Engineering (SCELSE) | npj Biofilms and Microbiomes  Register now!
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RESEARCH HIGHLIGHTS Top Genetic screens: Combining CRISPR perturbations and RNA-seq p67 | doi:10.1038/nrg.2016.171 PDF Development: Modifying sex in flies p68 | doi:10.1038/nrg.2016.164 PDF Genetic engineering: A genome-editing off switch p68 | doi:10.1038/nrg.2016.166 PDF Genetic engineering: CREATE-ing genome-wide designed mutations p69 | doi:10.1038/nrg.2016.163 PDF RNA: The code in the cap p70 | doi:10.1038/nrg.2016.165 PDF Functional genomics: Screening for lncRNA function p70 | doi:10.1038/nrg.2016.168 PDF Genetics JOBS of the week Postdoctoral Positions Cincinnati Children's Hospital Medical Center (CCHMC) Associate Research Scientist Columbia University Assistant / Associate Professor of Medicine Massachusetts General Hospital & Harvard Medical School Postdoctoral Position at USC University of Southern California Research Fellow Dana-Farber Cancer Institute (DFCI) More Science jobs from Genetics EVENT 2017 IMB Conference-Gene Regulation by the Numbers 06.19.17 Mainz, Germany More science events from
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CRISPR Calendar 2017 To celebrate the continuing rise to fame of the CRISPR system, the Nature Reviews Genetics 2017 CRISPR calendar highlights the underlying biology of CRISPR, as well as its diverse range of exciting potential applications in genetic research, biotechnology and therapeutics.  Download the calendar free online Produced with support from  OriGene
REVIEWS		Top
Article series: Regulatory elements Regulatory activities of transposable elements: from conflicts to benefits Edward B. Chuong, Nels C. Elde & Cédric Feschotte p71 | doi:10.1038/nrg.2016.139 Transposable elements (TEs) are widely known for their deleterious consequences of selfish propagation and mutagenesis. However, as described in this Review, TEs also provide hosts with rich, beneficial gene-regulatory machinery in the form of regulatory DNA elements and TE-derived gene products. The authors highlight the diverse regulatory contributions of TEs to organismal physiology and pathology, provide a framework for responsibly assigning functional roles to TEs and offer visions for the future. Abstract | Full Text | PDF
Article series: Study designs Making sense of genomic islands of differentiation in light of speciation Jochen B. W. Wolf & Hans Ellegren p87 | doi:10.1038/nrg.2016.133 To characterize the genetic underpinnings of speciation, genome scans can identify genomic regions that differ between divergent populations of wild organisms. In this Review, Wolf and Ellegren describe the methodological details of these approaches and how genomic islands of differentiation should be interpreted cautiously in the search for 'speciation genes'. They also discuss methodological best practice that takes into consideration genomic differentiation occurring through speciation-independent evolutionary processes. Abstract | Full Text | PDF | Supplementary information
Order from clutter: selective interactions at mammalian replication origins Mirit I. Aladjem & Christophe E. Redon p101 | doi:10.1038/nrg.2016.141 Genome-wide mapping, mathematical models and functional genetic analyses suggest that distinct molecular interactions at replication initiation sites underlie the regulation of DNA replication in metazoans. In this Review, the authors discuss recent insights into these DNA-protein interactions, and the genetic and epigenetic features of mammalian replication origins. Abstract | Full Text | PDF
Dissecting the genetics of complex traits using summary association statistics Bogdan Pasaniuc & Alkes L. Price p117 | doi:10.1038/nrg.2016.142 Investigating the genetic basis of complex traits and diseases using individual-level genetic data from genome-wide association studies is often hampered by privacy concerns and logistical considerations. Here, the authors review recent statistical methods that leverage summary association data, which are widely available and can circumvent these issues. Abstract | Full Text | PDF
Article series: Disease mechanisms Mosaicism in health and disease — clones picking up speed Lars A. Forsberg, David Gisselsson & Jan P. Dumanski p128 | doi:10.1038/nrg.2016.145 Many genetic studies focus on germline-inherited genomic variation. However, there is increasing realization that mutations occurring during our lifetime are so frequent and pervasive that, in all likelihood, no two of our cells are truly genetically identical. In this Review, the authors describe the detection, molecular nature and dynamics of this under-appreciated post-zygotic variation, and discuss the implications for normal human physiology and disease. Abstract | Full Text | PDF
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*2015 Journal Citation Report (Thomson Reuters, 2016)

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