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Stably expressing CRISPR Cas9. Ideal for CRISPR sgRNA validation, library screening, and sgRNA mediated knockouts and knockins
Human: H1299- Cas9, HEK293T- Cas9, HeLa- Cas9, A549 - Cas9, MCF-7 - Cas9, MDA-MB-231 - Cas9, HepG2 - Cas9, AGS - Cas9, BXPC-3 - Cas9, SNU-475, HT-29, LoVo, KATO111, SK-BR-3
Mouse: Neuro2a - Cas9
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Sponsored by: The Jackson Laboratory | | | | | | | Latest Articles | View all Articles | | | Caloric restriction improves health and survival of rhesus monkeys OPEN | | Julie A. Mattison, Ricki J. Colman, T. Mark Beasley, David B. Allison, Joseph W. Kemnitz, George S. Roth, Donald K. Ingram, Richard Weindruch, Rafael de Cabo and Rozalyn M. Anderson | | Caloric restriction (CR) delays ageing of model organisms, but whether it works in nonhuman primates has been controversial. Here, the authors pool and reanalyse data from two long-running CR primate studies, concluding that moderate CR indeed improves health and survival of rhesus monkeys. | | 17 January 2017 | doi: 10.1038/ncomms14063 | | | Electronic control of gene expression and cell behaviour in Escherichia coli through redox signalling OPEN | | Tanya Tschirhart, Eunkyoung Kim, Ryan McKay, Hana Ueda, Hsuan-Chen Wu, Alex Eli Pottash, Amin Zargar, Alejandro Negrete, Joseph Shiloach, Gregory F. Payne and William E. Bentley | | Synthetic biology offers the ability to explore new ways of manipulating gene expression and function. Here the authors demonstrate an electrogenetic device that allows control of transcription by an exogenous electrical signal. | | 17 January 2017 | doi: 10.1038/ncomms14030 | | | Weakening of annual temperature cycle over the Tibetan Plateau since the 1870s OPEN | | Jianping Duan, Jan Esper, Ulf Büntgen, Lun Li, Elena Xoplaki, Huan Zhang, Lily Wang, Yongjie Fang and Jürg Luterbacher | | Weakening of the Tibetan Plateau’s annual temperature cycle has been observed in recent decades, yet the long-term context remains unknown. Here, the authors reconstruct a 300-year temperature record from tree-ring width and maximum latewood density, which indicates the onset of weakening as early as the 1870s. | | 17 January 2017 | doi: 10.1038/ncomms14008 | | | Mate choice in fruit flies is rational and adaptive OPEN | | Devin Arbuthnott, Tatyana Y. Fedina, Scott D. Pletcher and Daniel E. L. Promislow | | A characteristic of rational behaviour is that it is transitive, such that preferences are ranked in a strict linear order. Here, Arbuthnott and colleagues show that mate choice in the fruit fly, Drosophila melanogaster, is transitive at the population level and that preferred mates produce more offspring. | | 17 January 2017 | doi: 10.1038/ncomms13953 | | | Targeted DNA sequencing and in situ mutation analysis using mobile phone microscopy OPEN | | Malte Kühnemund, Qingshan Wei, Evangelia Darai, Yingjie Wang, Iván Hernández-Neuta, Zhao Yang, Derek Tseng, Annika Ahlford, Lucy Mathot, Tobias Sjöblom, Aydogan Ozcan and Mats Nilsson | | On-site diagnostics technologies allow for rapid, cost-effective diagnosis with a particular importance for remote communities. Here the authors demonstrate the use of mobile phone based microscopy for targeted DNA sequencing and in situ point mutation detection in tumours. | | 17 January 2017 | doi: 10.1038/ncomms13913 | | | Cardiac afferent activity modulates the expression of racial stereotypes OPEN | | Ruben T. Azevedo, Sarah N. Garfinkel, Hugo D. Critchley and Manos Tsakiris | | Black individuals are racially stereotyped as threatening but how bodily signals may affect these misperceptions is not known. Here Azevedo and colleagues show that these race-driven responses are affected by the cardiac cycle, being more biased when arterial baroreceptor activation is maximal. | | 17 January 2017 | doi: 10.1038/ncomms13854 | | | Electrically tunable organic–inorganic hybrid polaritons with monolayer WS2 OPEN | | Lucas C. Flatten, David M. Coles, Zhengyu He, David G. Lidzey, Robert A. Taylor, Jamie H. Warner and Jason M. Smith | | Hybrid polariton states originating from the strong coupling of photonic and excitonic states hold promise for control of nonlinear light behaviour. Here, the authors fabricate a microcavity containing organic dye and WS2, featuring hybrid polaritons arising from both Frenkel and Wannier-Mott excitons. | | 17 January 2017 | doi: 10.1038/ncomms14097 | | | Pten is necessary for the quiescence and maintenance of adult muscle stem cells OPEN | | Feng Yue, Pengpeng Bi, Chao Wang, Tizhong Shan, Yaohui Nie, Timothy L. Ratliff, Timothy P. Gavin and Shihuan Kuang | | Pten is known to regulate haematopoietic stem cell functions. Here the authors show that Pten alteration of Notch signalling has stage-specific muscle regenerative functions in muscle stem cells by preventing premature differentiation of quiescent cells and enhancing the self-renewal of activated cells. | | 17 January 2017 | doi: 10.1038/ncomms14328 | | | Dynamical importance of van der Waals saddle and excited potential surface in C(1D)+D2 complex-forming reaction OPEN | | Zhitao Shen, Haitao Ma, Chunfang Zhang, Mingkai Fu, Yanan Wu, Wensheng Bian and Jianwei Cao | | It is commonly held that van der Waals wells are inevitable in chemical reactions. Here, the authors show that weak van der Waals forces in the entrance channel of a prototypical complex-forming reaction cause a van der Waals saddle instead, with different dynamical effects from a well at low collision energies. | | 17 January 2017 | doi: 10.1038/ncomms14094 | | | Thermal engineering of FAPbI3 perovskite material via radiative thermal annealing and in situ XRD OPEN | | Vanessa L. Pool, Benjia Dou, Douglas G. Van Campen, Talysa R. Klein-Stockert, Frank S. Barnes, Sean E. Shaheen, Md I. Ahmad, Maikel F. A. M. van Hest and Michael F. Toney | | Processing is crucial to ensure material quality and stability in perovskite solar cells. Here, Pool et al. develop a scalable infrared annealing method and use in situ XRD to map the processing phase space relative to the device efficiency. This provides a tool to determine processing requirements. | | 17 January 2017 | doi: 10.1038/ncomms14075 | | | Interfacial superconductivity in a bi-collinear antiferromagnetically ordered FeTe monolayer on a topological insulator OPEN | | S. Manna, A. Kamlapure, L. Cornils, T. Hänke, E. M. J. Hedegaard, M. Bremholm, B. B. Iversen, Ph. Hofmann, J. Wiebe and R. Wiesendanger | | The microscopic picture of how superconductivity is linked to antiferromagnetic order in Fe-based compounds remains elusive. Here, Manna et al. report superconducting correlations which spatially coexist with bi-collinear antiferromagnetic order in a one unit cell thin layer of FeTe grown on Bi2Te3. | | 17 January 2017 | doi: 10.1038/ncomms14074 | | | A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity OPEN | | Xiaojie Xu, Zhongyi Fan, Chaoyang Liang, Ling Li, Lili Wang, Yingchun Liang, Jun Wu, Shaohong Chang, Zhifeng Yan, Zhaohui Lv, Jing Fu, Yang Liu, Shuai Jin, Tao Wang, Tian Hong, Yishan Dong, Lihua Ding, Long Cheng, Rui Liu, Shenbo Fu et al. | | CDC25 phosphatases are important cell cycle regulators. Here, the authors show that the LIM domain-containing proteins (for example, FHL1) induce inhibitory CDC25 phosphorylation resulting in radioresistance and that a specific peptide can increase tumour radiosensitivity by increasing CDC25 activity. | | 17 January 2017 | doi: 10.1038/ncomms14059 | | | High-throughput quantitation of inorganic nanoparticle biodistribution at the single-cell level using mass cytometry OPEN | | Yu-Sang Sabrina Yang, Prabhani U. Atukorale, Kelly D. Moynihan, Ahmet Bekdemir, Kavya Rakhra, Li Tang, Francesco Stellacci and Darrell J. Irvine | | Assessing nanomaterials at the single cell level has proven to be complicated due to the limitations of existing techniques. Here, the authors utilised single-cell mass cytometry by time-of-flight as a label-free technique to analyse nanoparticle distribution within cells. | | 17 January 2017 | doi: 10.1038/ncomms14069 | | | Creating stable Floquet–Weyl semimetals by laser-driving of 3D Dirac materials OPEN | | Hannes Hübener, Michael A. Sentef, Umberto De Giovannini, Alexander F. Kemper and Angel Rubio | | Creating and controlling topological states of matter has become a central goal in condensed matter physics. Here, the authors report a predictive Floquet engineering of various topological phases in Na3Bi by using femtosecond laser pulses. | | 17 January 2017 | doi: 10.1038/ncomms13940 | | | Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease OPEN | | Edmund J. Keliher, Yu-Xiang Ye, Gregory R. Wojtkiewicz, Aaron D. Aguirre, Benoit Tricot, Max L. Senders, Hannah Groenen, Francois Fay, Carlos Perez-Medina, Claudia Calcagno, Giuseppe Carlucci, Thomas Reiner, Yuan Sun, Gabriel Courties, Yoshiko Iwamoto, Hye-Yeong Kim, Cuihua Wang, John W. Chen, Filip K. Swirski, Hsiao-Ying Wey et al. | | In vivo imaging of inflammation is crucial for detection and monitoring of many pathologies and noninvasive macrophage quantification has been suggested as a possible approach. Here Keliher et al. describe novel polyglucose nanoparticle tracers that are rapidly excreted by the kidney and with high affinity for macrophages in atherosclerotic plaques. | | 16 January 2017 | doi: 10.1038/ncomms14064 | | | Super-emitters in natural gas infrastructure are caused by abnormal process conditions OPEN | | Daniel Zavala-Araiza, Ramón A Alvarez, David R. Lyon, David T. Allen, Anthony J. Marchese, Daniel J. Zimmerle and Steven P. Hamburg | | A large proportion of methane emissions from natural gas production sites are released by a fraction of high-emitting sources. Here, using Monte Carlo simulations, the authors reveal that super-emitters occur due to abnormal process conditions, explaining component and site-based inventory discrepancies. | | 16 January 2017 | doi: 10.1038/ncomms14012 | | | Direct visualization of hydrogen absorption dynamics in individual palladium nanoparticles OPEN | | Tarun C. Narayan, Fariah Hayee, Andrea Baldi, Ai Leen Koh, Robert Sinclair and Jennifer A. Dionne | | It remains unclear why energy storage systems with nanoscale constituents are less susceptible to stress-induced damage than their bulk counterparts. Here, the authors probe in real time the intercalation-driven phase transitions of nanoscale palladium hydride, finding that these nanoparticles are able to fix crystallographic flaws as they form. | | 16 January 2017 | doi: 10.1038/ncomms14020 | | | Long-term efficient organic photovoltaics based on quaternary bulk heterojunctions OPEN | | Minwoo Nam, Minjeong Cha, Hyun Hwi Lee, Kahyun Hur, Kyu-Tae Lee, Jaehong Yoo, Il Ki Han, S. Joon Kwon and Doo-Hyun Ko | | Organic photovoltaics suffer from degradation. Here, Nam et al. develop a quaternary blend and fabricate devices which lose 28% of their initial efficiency after one year of operation at 65 °C. | | 16 January 2017 | doi: 10.1038/ncomms14068 | | | Sox17 drives functional engraftment of endothelium converted from non-vascular cells OPEN | | William Schachterle, Chaitanya R. Badwe, Brisa Palikuqi, Balvir Kunar, Michael Ginsberg, Raphael Lis, Masataka Yokoyama, Olivier Elemento, Joseph M. Scandura and Shahin Rafii | | Endothelial cells (ECs) are promising strategies to treat vasculopathies but little is known about the factors that sustain EC identity and govern functional integration into vasculature after transplantation. Here the authors show that Ets factors and Sox17 convert nonvascular cells to vascular cells with stable EC identity and function. | | 16 January 2017 | doi: 10.1038/ncomms13963 | | | Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD OPEN | | Xiaohua Yu, Yong Zhang, Tingting Li, Zhao Ma, Haixue Jia, Qian Chen, Yixia Zhao, Lili Zhai, Ran Zhong, Changyin Li, Xiaoting Zou, Jiao Meng, Antony K. Chen, Pier Lorenzo Puri, Meihong Chen and Dahai Zhu | | Long non-coding RNAs are important regulators of many diverse biological processes. Here the authors describe Linc-RAM, which regulates myogenesis by binding MyoD and promoting the assembly of the MyoD–Baf60c–Brg1 complex at target genes. | | 16 January 2017 | doi: 10.1038/ncomms14016 | | | Cubosomes from hierarchical self-assembly of poly(ionic liquid) block copolymers OPEN | | Hongkun He, Khosrow Rahimi, Mingjiang Zhong, Ahmed Mourran, David R. Luebke, Hunaid B. Nulwala, Martin Möller and Krzysztof Matyjaszewski | | Generally cubosomes are formed by the self-assembly of surfactants such as lipids and are used as adsorbents or in host-guest applications. Here the authors have shown that an amphiphilic block copolymer can form nanoscale cuboidal particles with a bicontinuous cubic phase. | | 16 January 2017 | doi: 10.1038/ncomms14057 | | | Universal and uniquely human factors in spontaneous number perception OPEN | | Stephen Ferrigno, Julian Jara-Ettinger, Steven T. Piantadosi and Jessica F. Cantlon | | Perception of numerical quantities has been demonstrated in humans and animals; however, whether this is a natural ability is not clear. Here the authors show that human children and adults as well as monkeys spontaneously use number over surface area to categorize dot stimuli and this preference is enhanced with numerical literacy. | | 16 January 2017 | doi: 10.1038/ncomms13968 | | | Massively parallel digital transcriptional profiling of single cells OPEN | | Grace X. Y. Zheng, Jessica M. Terry, Phillip Belgrader, Paul Ryvkin, Zachary W. Bent, Ryan Wilson, Solongo B. Ziraldo, Tobias D. Wheeler, Geoff P. McDermott, Junjie Zhu, Mark T. Gregory, Joe Shuga, Luz Montesclaros, Jason G. Underwood, Donald A. Masquelier, Stefanie Y. Nishimura, Michael Schnall-Levin, Paul W. Wyatt, Christopher M. Hindson, Rajiv Bharadwaj et al. | | Single-cell gene expression analysis is challenging. This work describes a new droplet-based single cell RNA-seq platform capable of processing tens of thousands of cells across 8 independent samples in minutes, and demonstrates cellular subtypes and host–donor chimerism in transplant patients. | | 16 January 2017 | doi: 10.1038/ncomms14049 | | | Repo-Man/PP1 regulates heterochromatin formation in interphase OPEN | | Inês J. de Castro, James Budzak, Maria L. Di Giacinto, Lorena Ligammari, Ezgi Gokhan, Christos Spanos, Daniela Moralli, Christine Richardson, Jose I. de las Heras, Silvia Salatino, Eric C. Schirmer, Katharine S. Ullman, Wendy A. Bickmore, Catherine Green, Juri Rappsilber, Sarah Lamble, Martin W. Goldberg, Veronica Vinciotti and Paola Vagnarelli | | Repo-Man is a chromosome-binding subunit of protein phosphatase 1 to regulate mitosis. Here, de Castro and colleagues show that Repo-Man also regulates heterochromatin during interphase, and regulates gene repression and chromatin organization. | | 16 January 2017 | doi: 10.1038/ncomms14048 | | | The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor OPEN | | Jie Xu, Weihua Zhou, Fei Yang, Guoan Chen, Haomin Li, Yongchao Zhao, Pengyuan Liu, Hua Li, Mingjia Tan, Xiufang Xiong and Yi Sun | | F-box proteins β-TrCP1 and SKP2 act as oncogenes by promoting targeted degradation of critical protein substrates. Here, the authors identify an axis of F-box proteins β-TrCP1-FBXW2-SKP2 where FBXW2 is a substrate of β-TrCP1 but mediates the degradation of SKP2, thus acting as a tumour suppressor. | | 16 January 2017 | doi: 10.1038/ncomms14002 | | | A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis OPEN | | Silvia Moretti, Giorgia Renga, Vasilis Oikonomou, Claudia Galosi, Marilena Pariano, Rossana G. Iannitti, Monica Borghi, Matteo Puccetti, Marco De Zuani, Carlo E. Pucillo, Giuseppe Paolicelli, Teresa Zelante, Jean-Christophe Renauld, Oxana Bereshchenko, Paolo Sportoletti, Vincenzina Lucidi, Maria Chiara Russo, Carla Colombo, Ersilia Fiscarelli, Cornelia Lass-Flörl et al. | | In patients with cystic fibrosis, IL-9 signalling is increased. The authors describe an inflammatory loop in which IL-9 produced by Th9 cells drives mast cells to produce IL-2, resulting in ILC2 cell activation, and show inhibition of this loop with blocking antibodies to IL-9 in a mouse model of pulmonary infection. | | 16 January 2017 | doi: 10.1038/ncomms14017 | | | Limiting parental feedback disrupts vocal development in marmoset monkeys OPEN | | Yasemin B. Gultekin and Steffen R. Hage | | The development of mature vocal patterns is shaped by parental influence in many animals. Here, Gultekin and Hage show that parental feedback not only influences vocal development, but is indeed necessary for juvenile marmosets to acquire normal vocal behaviour. | | 16 January 2017 | doi: 10.1038/ncomms14046 | | | Centrality in the host–pathogen interactome is associated with pathogen fitness during infection OPEN | | Núria Crua Asensio, Elisabet Muñoz Giner, Natalia Sánchez de Groot and Marc Torrent Burgas | | Hubs tend to be essential for function in protein networks within organisms. Here, the authors show that during infection, it is the proteins with high centrality in the Y. pestis host–pathogen interactome that are most important for pathogen fitness during infection, and highlight the importance of pathogen proteins that likely cause significant perturbation of the host interactome. | | 16 January 2017 | doi: 10.1038/ncomms14092 | | | Prediction and real-time compensation of qubit decoherence via machine learning OPEN | | Sandeep Mavadia, Virginia Frey, Jarrah Sastrawan, Stephen Dona and Michael J. Biercuk | | Control engineering techniques are promising for realizing stable quantum systems to counter their extreme fragility. Here the authors use techniques from machine learning to enable real-time feedback suppression of decoherence in a trapped ion qubit by predicting its future stochastic evolution. | | 16 January 2017 | doi: 10.1038/ncomms14106 | | | Interfacing broadband photonic qubits to on-chip cavity-protected rare-earth ensembles OPEN | | Tian Zhong, Jonathan M. Kindem, Jake Rochman and Andrei Faraon | | Solid-state emitters enable broadband quantum information storage, but they are affected by decoherence resulting from inhomogeneous broadening. Here the authors suppress this effect via cavity protection at the single photon level in an ensemble of rare-earth ions coupled to a nanophotonic resonator. | | 16 January 2017 | doi: 10.1038/ncomms14107 | | | Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity OPEN | | Julie Salomon, Cécile Gaston, Jérémy Magescas, Boris Duvauchelle, Danielle Canioni, Lucie Sengmanivong, Adeline Mayeux, Grégoire Michaux, Florence Campeotto, Julie Lemale, Jérôme Viala, Françoise Poirier, Nicolas Minc, Jacques Schmitz, Nicole Brousse, Benoit Ladoux, Olivier Goulet and Delphine Delacour | | EpCAM is an unconventional epithelia-specific cell–cell adhesion molecule, that is mutated in the majority of cases of Congenital Tufting Enteropathy. Here the authors show that loss of EpCAM causes a concentration of contractile activity at tricellular junctions, leading to aberrant apical domain and tight junction displacement. | | 13 January 2017 | doi: 10.1038/ncomms13998 | | | K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression OPEN | | Zhenyue Hao, Yi Sheng, Gordon S. Duncan, Wanda Y. Li, Carmen Dominguez, Jennifer Sylvester, Yu-Wen Su, Gloria H.Y. Lin, Bryan E. Snow, Dirk Brenner, Annick You-Ten, Jillian Haight, Satoshi Inoue, Andrew Wakeham, Alisha Elford, Sara Hamilton, Yi Liang, Juan C. Zúñiga-Pflücker, Housheng Hansen He, Pamela S. Ohashi et al. | | The E3 ligase Mule has been previously reported to be essential for B cell development and function by modulating p53 ubiquitination and degradation. Here Hao et al. identify KLF4 as a novel ubiquitination target of Mule and show it controls T cell proliferation and autoimmunity. | | 13 January 2017 | doi: 10.1038/ncomms14003 | | | TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling OPEN | | Liam A. Hurst, Benjamin J. Dunmore, Lu Long, Alexi Crosby, Rafia Al-Lamki, John Deighton, Mark Southwood, Xudong Yang, Marko Z. Nikolic, Blanca Herrera, Gareth J. Inman, John R. Bradley, Amer A. Rana, Paul D. Upton and Nicholas W. Morrell | | Reduced BMP receptor II signalling underlies pulmonary arterial hypertension (PAH). Here, Hurst et al. show that TNFα subverts BMP signalling by increasing BMP6 expression and signalling via an alternative BMP receptor, ALK2, in pulmonary artery smooth muscle cells to drive abnormal proliferation and PAH. | | 13 January 2017 | doi: 10.1038/ncomms14079 | | | Topological frustration of artificial spin ice OPEN | | Jasper Drisko, Thomas Marsh and John Cumings | | Frustrated systems display rich behaviour due to unsatisfied competing interactions. Here, the authors report extended frustration by introducing controlled topological defects into square artificial spin ice lattices, demonstrating the potential of lattice topology to induce frustration. | | 13 January 2017 | doi: 10.1038/ncomms14009 | | | A minimal length rigid helical peptide motif allows rational design of modular surfactants OPEN | | Sudipta Mondal, Maxim Varenik, Daniel Nir Bloch, Yoav Atsmon-Raz, Guy Jacoby, Lihi Adler-Abramovich, Linda J.W. Shimon, Roy Beck, Yifat Miller, Oren Regev and Ehud Gazit | | Emulsifiers are used in the pharmaceutical, food, cosmetic, and biomedical industry. Here the authors fabricate rigid helical peptides that can perform as emulsifiers and thickeners, which typically requires synergistic effects of surfactants and polysaccharides. | | 13 January 2017 | doi: 10.1038/ncomms14018 | | | Signature of type-II Weyl semimetal phase in MoTe2 OPEN | | J. Jiang, Z.K. Liu, Y. Sun, H.F. Yang, C.R. Rajamathi, Y.P. Qi, L.X. Yang, C. Chen, H. Peng, C-C. Hwang, S.Z. Sun, S-K. Mo, I. Vobornik, J. Fujii, S.S.P. Parkin, C. Felser, B.H. Yan and Y.L. Chen | | A special class of topological Weyl semimetal state is predicted without respecting Lorentz symmetry. Here, Jiang et al. report direct visualization of the unique surface Fermi arcs of MoTe2, confirming its type-II topological Weyl semimetal nature. | | 13 January 2017 | doi: 10.1038/ncomms13973 | | | Heterogeneity in mantle carbon content from CO2-undersaturated basalts OPEN | | M. Le Voyer, K.A. Kelley, E. Cottrell and E.H. Hauri | | Melting dynamics are affected by the amount of carbon in the Earth’s mantle. Le Voyer et al. report undegassed carbon concentrations from olivine-hosted melt inclusions from the Mid-Atlantic Ridge finding that carbon content varies by two orders of magnitude thus introducing heterogeneity into the upper mantle. | | 13 January 2017 | doi: 10.1038/ncomms14062 | | | Expeditious diastereoselective synthesis of elaborated ketones via remote Csp3–H functionalization OPEN | | Wei Shu, Adriana Lorente, Enrique Gómez-Bengoa and Cristina Nevado | | C-H activation is a powerful method to form functionalised molecules, but is particularly challenging for unactivated sp3 sites. Here the authors report a directing-group-free radical cascade process for converting vinyl azides and carboxylic acids to tetralone derivatives in high diastereoselectivity. | | 13 January 2017 | doi: 10.1038/ncomms13832 | | | Resilient cooperators stabilize long-run cooperation in the finitely repeated Prisoner’s Dilemma OPEN | | Andrew Mao, Lili Dworkin, Siddharth Suri and Duncan J. Watts | | Studying the dynamics of learning in repeated games of cooperation is complicated by the short duration of traditional experiments. Here the authors perform a virtual prisoner's dilemma game over twenty consecutive days, finding that a minority of resilient co-operators can sustain cooperation indefinitely. | | 13 January 2017 | doi: 10.1038/ncomms13800 | | | A RuBisCO-mediated carbon metabolic pathway in methanogenic archaea OPEN | | Takunari Kono, Sandhya Mehrotra, Chikako Endo, Natsuko Kizu, Mami Matusda, Hiroyuki Kimura, Eiichi Mizohata, Tsuyoshi Inoue, Tomohisa Hasunuma, Akiho Yokota, Hiroyoshi Matsumura and Hiroki Ashida | | Although not photosynthetic, some archaea possess RuBisCO, one of the enzymes characteristic of the photosynthetic Calvin-Benson cycle, but apparently lack another one, phosphoribulokinase (PRK). Here the authors describe a carbon metabolic pathway in methanogenic archaea, involving RuBisCO and PRK. | | 13 January 2017 | doi: 10.1038/ncomms14007 | | | Hydrogenation of iron in the early stage of Earth’s evolution OPEN | | Riko Iizuka-Oku, Takehiko Yagi, Hirotada Gotou, Takuo Okuchi, Takanori Hattori and Asami Sano-Furukawa | | The Earth’s core has lower density than pure iron and many studies have looked into which light elements may be present. The authors here carry out in situ high pressure and temperature neutron experiments indicating that hydrogen may have been the first light element to dissolve into the iron core. | | 13 January 2017 | doi: 10.1038/ncomms14096 | | | Microbes can help explain the evolution of host altruism OPEN | | Ohad Lewin-Epstein, Ranit Aharonov and Lilach Hadany | | The origins of altruism have fascinated us for centuries. Here, the authors propose that altruistic behaviour could be explained by microbes manipulating their hosts to act altruistically towards other hosts that may carry related microbes, and show that microbe-mediated altruism can evolve in a wide range of circumstances. | | 12 January 2017 | doi: 10.1038/ncomms14040 | | | Local dimensionality determines imaging speed in localization microscopy OPEN | | Patrick Fox-Roberts, Richard Marsh, Karin Pfisterer, Asier Jayo, Maddy Parsons and Susan Cox | | Localisation microscopy enables nanometre-scale imaging of biological samples, but the method is too slow to use on dynamic systems. Here, the authors develop a mathematical model that optimises the number of frames required and estimates the maximum speed for super-resolution imaging. | | 12 January 2017 | doi: 10.1038/ncomms13558 | | | Correlation-driven transport asymmetries through coupled spins in a tunnel junction OPEN | | Matthias Muenks, Peter Jacobson, Markus Ternes and Klaus Kern | | Spin-spin correlation is fundamental to many material properties but challenging to measure in nanomagnetic systems. Muenks et al. show that correlations between a localized spin and the electrons of its hosting bath can be quantified when coupled to another spin by an asymmetry in the differential conductance. | | 11 January 2017 | doi: 10.1038/ncomms14119 | | | Shifting molecular localization by plasmonic coupling in a single-molecule mirage OPEN | | Mario Raab, Carolin Vietz, Fernando Daniel Stefani, Guillermo Pedro Acuna and Philip Tinnefeld | | The near-field interaction of single emitters and plasmonic structures can alter the perceived physical location of the emitter. Here, Raab et al. use DNA origami and far-field super-resolution microscopy to quantitatively evaluate this localization offset for gold nanoparticles. | | 11 January 2017 | doi: 10.1038/ncomms13966 | | | Large fault slip peaking at trench in the 2011 Tohoku-oki earthquake OPEN | | Tianhaozhe Sun, Kelin Wang, Toshiya Fujiwara, Shuichi Kodaira and Jiangheng He | | The 2011 Tohoku-oki earthquake slip occurred on the shallowest part of the megathrust, but the nature of the shallow slip has been poorly constrained. Here, the authors model bathymetry differences before and after the earthquake to determine that the slip exceeded 60 m increasing towards the trench. | | 11 January 2017 | doi: 10.1038/ncomms14044 | | | Topological Dirac nodal lines and surface charges in fcc alkaline earth metals OPEN | | Motoaki Hirayama, Ryo Okugawa, Takashi Miyake and Shuichi Murakami | | The nodal-line semimetals exhibit an intriguing interplay between topology, symmetry and materials science. Here, Hirayama et al. predict a nodal-line semimetal phase resulting from the pi Berry phase in alkaline-earth metals, and show that the nodal lines give rise to surface polarization charge, which is eventually screened by bulk carriers. | | 11 January 2017 | doi: 10.1038/ncomms14022 | | | The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia OPEN | | Krishnendu Chakraborty, Mahesh Raundhal, Bill B. Chen, Christina Morse, Yulia Y. Tyurina, Anupriya Khare, Timothy B. Oriss, Rachael Huff, Janet S. Lee, Claudette M. St. Croix, Simon Watkins, Rama K. Mallampalli, Valerian E. Kagan, Anuradha Ray and Prabir Ray | | Non-resolving bacterial pneumonia results in lung tissue damage owing to overactive inflammation. Here the authors show that the mitochondrial DAMP cardiolipin contributes to persistent inflammation by SUMOylating PPARγ, which promotes binding of the corepressor NCOR/HDAC3 complex to the IL-10 promoter. | | 11 January 2017 | doi: 10.1038/ncomms13944 | | | Observational evidence for cloud cover enhancement over western European forests OPEN | | Adriaan J. Teuling, Christopher M. Taylor, Jan Fokke Meirink, Lieke A. Melsen, Diego G. Miralles, Chiel C. van Heerwaarden, Robert Vautard, Annemiek I. Stegehuis, Gert-Jan Nabuurs and Jordi Vilà-Guerau de Arellano | | Forests impact continental-scale moisture recycling, but their impact on regional-scale cloud cover is little known. Here, using satellite observations, Teuling et al. illustrate enhanced cloud cover over regional forested areas in western Europe due to the establishment of a forest-breeze circulation. | | 11 January 2017 | doi: 10.1038/ncomms14065 | | | | | | | | | | | | | Latest Erratum | | | | | | | | Advertisement | | Open for Submissions
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