Nature Cell Biology contents: February 2017 Volume 19 Number 2, pp 77 - 143

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Advertisement hTERT-immortalized Cell Lines from ATCC Enjoy the best of both worlds: the in vivo nature of primary cells & the continuous survival of cell lines. Human telomerase reverse transcriptase (hTERT) immortalized cell lines exhibit tissue-specific features, express differentiation-specific proteins, and retain consistency from experiment to experiment. Use hTERT cell lines in your disease model studies today!  Learn more>>  TABLE OF CONTENTS February 2017 Volume 19, Issue 2 News and Views Articles Letter Corrigenda Advertisement Nature Biomedical Engineering - NOW LIVE The first issue of Nature Biomedical Engineering is now live and available for free.  Click here to access the issue. Remember to follow us on Twitter @NatBME or sign up to receive the e-alert. Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Nature Outlook: Lysosomal Storage Disorders Lysosomal storage disorders are individually rare but collectively common. The study of these diseases is not only leading to better treatments, but also revealing many of the secrets of this underappreciated organelle. Access the Outlook > Produced with support from: Alexion Pharmaceuticals, Inc. Ultragenyx Pharmaceutical Inc. Produced with support of a grant from: Shire plc BioMarin Pharmaceutical Inc     Advertisement An open access journal dedicated to highlighting the most important scientific advances in Parkinson's disease research, spanning the motor and non-motor disorders of Parkinson's disease. Part of the Nature Partner Journals series, npj Parkinson's Disease is published in partnership with the Parkinson's Disease Foundation. Open for submissions >>   News and Views Top Growing, splitting and stacking myosin II filaments   pp77 - 79 Margaret A. Titus doi:10.1038/ncb3468 Spectacular images of the process of myosin II filament formation and organization in migrating cells are unveiled by super-resolution imaging. A combination of short- and long-range interactions with actin filaments is seen to play a critical role in filament partitioning and alignment into contractile actin arcs and stress fibres. See also: Article by Beach et al. | Letter by Hu et al. CPEB4 links the clock and the UPR to protect the liver   pp79 - 81 Paul C. Moore and Scott A. Oakes doi:10.1038/ncb3460 Under misfolded protein stress, the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to restore homeostasis, or commits the cell to apoptosis. A study now uncovers how the UPR is governed by the circadian clock to adjust ER protein-folding capacity to metabolic demand and protect against liver damage. See also: Article by Maillo et al. Lnc-ing ROR1–HER3 and Hippo signalling in metastasis   pp81 - 83 Wei Zhuo and Yibin Kang doi:10.1038/ncb3467 Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in cancer progression. The previously uncharacterized lncRNA MAYA is now shown to promote bone metastasis by bridging ROR1–HER3 and Hippo–YAP pathways. Neuregulin-induced HER3 phosphorylation by ROR1 recruits a MAYA-containing protein complex to methylate Hippo/MST1 and activate YAP target genes that are essential for bone metastasis. See also: Article by Li et al. Cell Biology JOBS of the week Doctoral Research Fellow in Hematopoietic Stem Cell Biology KU Leuven, Stem Cell Institute Postdoctoral Researchers Institute of Animal Physiology and Genetics, Czech Academy of Sciences Postdoctoral Scholar in Cancer Biology University of Chicago Postdoctoral Fellow University of Texas Health Science Center at San Antonio Faculty Positions Vanderbilt Center for Bone Biology Vanderbilt Department of Medicine More Science jobs from Cell Biology EVENT EMBO - EMBL Symposium: Molecular and Cell Biology of Membranes 21.05.17 Heidelberg, Germany More science events from Advertisement Thousands of single cells. One solution.  From the industry leaders in sequencing and Droplet Digital™ technologies, Illumina and Bio-Rad provide a robust, scalable, and user-friendly workflow enabling transcriptome profiling of hundreds to tens of thousands of single cells.   Articles Top Actin dynamics and competition for myosin monomer govern the sequential amplification of myosin filaments   pp85 - 93 Jordan R. Beach, Kyle S. Bruun, Lin Shao, Dong Li, Zac Swider et al. doi:10.1038/ncb3463 Using structured illumination microscopy, Beach et al. and Hu et al. visualize the assembly of myosin II filaments in cells, describing a filament-partitioning mechanism, and long-range self-organization of filaments, respectively. See also: Letter by Hu et al. | News and Views by Titus Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress   pp94 - 105 Carlos Maillo, Judit Martín, David Sebastián, Maribel Hernández-Alvarez, Mar García-Rocha et al. doi:10.1038/ncb3461 Maillo et al. show that in hepatocytes ER stress upregulates CPEB4 through the UPR and circadian clock, leading to CPEB4-mediated translation for mitochondrial and ER homeostasis. CPEB4 loss leads to ageing- and high fat diet-induced liver steatosis. See also: News and Views by Moore & Oakes A ROR1–HER3–lncRNA signalling axis modulates the Hippo–YAP pathway to regulate bone metastasis   pp106 - 119 Chunlai Li, Shouyu Wang, Zhen Xing, Aifu Lin, Ke Liang et al. doi:10.1038/ncb3464 Li et al. show that ROR1–HER3 receptor tyrosine kinase signalling in breast cancer cells inhibits the MST1/2 Hippo pathway kinases through a lncRNA termed MAYA. The resulting activation of YAP promotes osteoclast differentiation for bone metastasis. See also: News and Views by Zhuo & Kang Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments   pp120 - 132 Georg Fluegen, Alvaro Avivar-Valderas, Yarong Wang, Michael R. Padgen, James K. Williams et al. doi:10.1038/ncb3465 Aguirre-Ghiso and colleagues report that hypoxia in the primary tumour microenvironment leads to upregulation of a dormancy signature in the tumour cells that persists after their dissemination to distant sites, permitting them to evade therapy. Advertisement nature.com webcasts Pixels to data: Quantitative cell biology using high-content imaging and analysis. Date: Tuesday 28 February 2017 Time: 8AM PST, 11AM EST, 4PM GMT, 5PM CET Register Sponsor: PerkinElmer   Letter Top Long-range self-organization of cytoskeletal myosin II filament stacks   pp133 - 141 Shiqiong Hu, Kinjal Dasbiswas, Zhenhuan Guo, Yee-Han Tee, Visalatchi Thiagarajan et al. doi:10.1038/ncb3466 Using structured illumination microscopy, Beach et al. and Hu et al. visualize the assembly of myosin II filaments in cells, describing a filament-partitioning mechanism, and long-range self-organization of filaments, respectively. See also: Article by Beach et al. | News and Views by Titus Corrigenda Top Corrigendum: Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development   p142 Jonathan Henninger, Buyung Santoso, Stefan Hans, Ellen Durand, Jessica Moore et al. doi:10.1038/ncb3462 Corrigendum: Mitotic internalization of planar cell polarity proteins preserves tissue polarity   p143 Danelle Devenport, Daniel Oristian, Evan Heller and Elaine Fuchs doi:10.1038/ncb3469 Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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