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Nature Cell Biology contents: February 2017 Volume 19 Number 2, pp 77 - 143

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February 2017 Volume 19, Issue 2

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Growing, splitting and stacking myosin II filaments   pp77 - 79
Margaret A. Titus
Spectacular images of the process of myosin II filament formation and organization in migrating cells are unveiled by super-resolution imaging. A combination of short- and long-range interactions with actin filaments is seen to play a critical role in filament partitioning and alignment into contractile actin arcs and stress fibres.

See also: Article by Beach et al. | Letter by Hu et al.

CPEB4 links the clock and the UPR to protect the liver   pp79 - 81
Paul C. Moore and Scott A. Oakes
Under misfolded protein stress, the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to restore homeostasis, or commits the cell to apoptosis. A study now uncovers how the UPR is governed by the circadian clock to adjust ER protein-folding capacity to metabolic demand and protect against liver damage.

See also: Article by Maillo et al.

Lnc-ing ROR1–HER3 and Hippo signalling in metastasis   pp81 - 83
Wei Zhuo and Yibin Kang
Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in cancer progression. The previously uncharacterized lncRNA MAYA is now shown to promote bone metastasis by bridging ROR1–HER3 and Hippo–YAP pathways. Neuregulin-induced HER3 phosphorylation by ROR1 recruits a MAYA-containing protein complex to methylate Hippo/MST1 and activate YAP target genes that are essential for bone metastasis.

See also: Article by Li et al.

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Actin dynamics and competition for myosin monomer govern the sequential amplification of myosin filaments   pp85 - 93
Jordan R. Beach, Kyle S. Bruun, Lin Shao, Dong Li, Zac Swider et al.
Using structured illumination microscopy, Beach et al. and Hu et al. visualize the assembly of myosin II filaments in cells, describing a filament-partitioning mechanism, and long-range self-organization of filaments, respectively.

See also: Letter by Hu et al. | News and Views by Titus

Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress   pp94 - 105
Carlos Maillo, Judit Martín, David Sebastián, Maribel Hernández-Alvarez, Mar García-Rocha et al.
Maillo et al. show that in hepatocytes ER stress upregulates CPEB4 through the UPR and circadian clock, leading to CPEB4-mediated translation for mitochondrial and ER homeostasis. CPEB4 loss leads to ageing- and high fat diet-induced liver steatosis.

See also: News and Views by Moore & Oakes

A ROR1–HER3–lncRNA signalling axis modulates the Hippo–YAP pathway to regulate bone metastasis   pp106 - 119
Chunlai Li, Shouyu Wang, Zhen Xing, Aifu Lin, Ke Liang et al.
Li et al. show that ROR1–HER3 receptor tyrosine kinase signalling in breast cancer cells inhibits the MST1/2 Hippo pathway kinases through a lncRNA termed MAYA. The resulting activation of YAP promotes osteoclast differentiation for bone metastasis.

See also: News and Views by Zhuo & Kang

Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments   pp120 - 132
Georg Fluegen, Alvaro Avivar-Valderas, Yarong Wang, Michael R. Padgen, James K. Williams et al.
Aguirre-Ghiso and colleagues report that hypoxia in the primary tumour microenvironment leads to upregulation of a dormancy signature in the tumour cells that persists after their dissemination to distant sites, permitting them to evade therapy.

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Long-range self-organization of cytoskeletal myosin II filament stacks   pp133 - 141
Shiqiong Hu, Kinjal Dasbiswas, Zhenhuan Guo, Yee-Han Tee, Visalatchi Thiagarajan et al.
Using structured illumination microscopy, Beach et al. and Hu et al. visualize the assembly of myosin II filaments in cells, describing a filament-partitioning mechanism, and long-range self-organization of filaments, respectively.

See also: Article by Beach et al. | News and Views by Titus



Corrigendum: Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development   p142
Jonathan Henninger, Buyung Santoso, Stefan Hans, Ellen Durand, Jessica Moore et al.

Corrigendum: Mitotic internalization of planar cell polarity proteins preserves tissue polarity   p143
Danelle Devenport, Daniel Oristian, Evan Heller and Elaine Fuchs

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