The EMBO Journal Table of Contents for 01 December 2016; Vol. 35, No. 23

01 December 2016 | Volume 35, Number 23 Submit Table of Contents News & Views Articles Resource Corrigendum Volume 35, Number 23 News & Views Present and not reporting for duty: dsRNAi in mammalian cells New findings suggest that anti‐viral RNA interference defenses in mammals are merely masked by the interferon system, but have not been supplanted by it. Joseph M Luna, Xianfang Wu, and Charles M Rice Published online 10.11.2016 What's hot about otoferlin A new mouse model provides insight into fever‐induced hearing loss in human patients carrying missense mutations in otoferlin. Karen B Avraham Published online 07.11.2016 Articles Inactivation of the type I interferon pathway reveals long double‐stranded RNA‐mediated RNA interference in mammalian cells While RNAi is a known antiviral mechanism in plants and invertebrates, its contribution in mammals is only revealed upon ablation of the interferon pathway. Pierre V Maillard, Annemarthe G Van der Veen, Safia Deddouche‐Grass, Neil C Rogers, Andres Merits, and Caetano Reis e Sousa Published online 04.11.2016 Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants A mouse model of the human otoferlin Ile515Thr mutation provides insight into auditory synaptopathy at normal temperature and temperature‐sensitive deafness in humans carrying this mutation. Nicola Strenzke, Rituparna Chakrabarti, Hanan Al‐Moyed, Alexandra Müller, Gerhard Hoch, Tina Pangrsic, Gulnara Yamanbaeva, Christof Lenz, Kuan‐Ting Pan, Elisabeth Auge, Ruth Geiss‐Friedlander, Henning Urlaub, Nils Brose, Carolin Wichmann, and Ellen Reisinger Published online 11.10.2016 Tryptophan‐rich basic protein (WRB) mediates insertion of the tail‐anchored protein otoferlin and is required for hair cell exocytosis and hearing ER membrane insertion of the sensory hair cell component otoferlin depends on the tail‐anchored protein insertion TRC40 pathway, whose disruption impairs synaptic vesicle replenishment and hearing. Christian Vogl, Iliana Panou, Gulnara Yamanbaeva, Carolin Wichmann, Sara J Mangosing, Fabio Vilardi, Artur A Indzhykulian, Tina Pangršič, Rosamaria Santarelli, Montserrat Rodriguez‐Ballesteros, Thomas Weber, Sangyong Jung, Elena Cardenas, Xudong Wu, Sonja M Wojcik, Kelvin Y Kwan, Ignacio del Castillo, Blanche Schwappach, Nicola Strenzke, David P Corey, Shuh‐Yow Lin, and Tobias Moser Published online 25.07.2016 RKIP and TBK1 form a positive feedback loop to promote type I interferon production in innate immunity A positive feedback loop involving TBK1 and its substrate RKIP (Raf kinase inhibitory protein) is essential for interferon responses in virus‐infected mice. Meidi Gu, Zhiyong Liu, Rongrong Lai, Si Liu, Wenlong Lin, Chuan Ouyang, Sheng Ye, He Huang, and Xiaojian Wang Published online 17.10.2016 CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels A combination of proteomics and mouse knockout approaches identifies substrates of the mammalian ClpXP protease, showing that it controls mitochondrial homeostasis by ensuring assembly and function of mitochondrial ribosomes. Karolina Szczepanowska, Priyanka Maiti, Alexandra Kukat, Eduard Hofsetz, Hendrik Nolte, Katharina Senft, Christina Becker, Benedetta Ruzzenente, Hue‐Tran Hornig‐Do, Rolf Wibom, Rudolf J Wiesner, Marcus Krüger, and Aleksandra Trifunovic Published online 20.10.2016 The MMS22L–TONSL heterodimer directly promotes RAD51‐dependent recombination upon replication stress RAD51‐mediated DNA strand exchange at stalled replication forks requires RPA‐dependent fork recruitment of MMS22L–TONSL, explaining how this homologous recombination mediator facilitates fork restart. Wojciech Piwko, Lucie J Mlejnkova, Karun Mutreja, Lepakshi Ranjha, Diana Stafa, Alexander Smirnov, Mia ML Brodersen, Ralph Zellweger, Andreas Sturzenegger, Pavel Janscak, Massimo Lopes, Matthias Peter, and Petr Cejka Published online 26.10.2016 Resource A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit β5i Engineering of chimeric yeast/mammalian proteasomes allows crystallographic elucidation of the binding modes and specificities of immunoproteasome inhibitors, which are promising anti‐inflammatory drug candidates. Eva M Huber, Wolfgang Heinemeyer, Gerjan de Bruin, Herman S Overkleeft, and Michael Groll Published online 27.10.2016 Corrigendum Sulfatase modifying factor 1 trafficking through the cells: from endoplasmic reticulum to the endoplasmic reticulum Ester Zito, Mario Buono, Stefano Pepe, Carmine Settembre, Ida Annunziata, Enrico Maria Surace, Thomas Dierks, Maria Monti, Marianna Cozzolino, Piero Pucci, Andrea Ballabio, and Maria Pia Cosma Published online 01.12.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.