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January 2017 Volume 18 Number 1 | |||||||||||||||||||||||||||||||||||||
In this issue Comment Research Highlights Reviews Perspectives
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Article series: Scaling up neuroscience Comment: The contribution of neuroethics to international brain research initiatives Kathinka Evers p1 | doi:10.1038/nrn.2016.143 Kathinka Evers discusses the important role of neuroethics research in the planning and implementation of large-scale brain research initiatives. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
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REVIEWS | Top | ||||||||||||||||||||||||||||||||||||
Stress, glucocorticoids and memory: implications for treating fear-related disorders Dominique de Quervain, Lars Schwabe & Benno Roozendaal p7 | doi:10.1038/nrn.2016.155 Glucocorticoids, which are released in response to stress, modulate the consolidation, retrieval and extinction of memories. In this Review, de Quervain et al. suggest that, in fear-related disorders such as post-traumatic stress disorder, targeting glucocorticoid signalling to attenuate fear memories has therapeutic potential. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
Structural plasticity and reorganisation in chronic pain Rohini Kuner & Herta Flor p20 | doi:10.1038/nrn.2016.162 The mechanisms that underlie the transition of acute pain to a chronic intractable disorder are not well understood. In this Review, Kuner and Flor discuss how structural plasticity and reorganisation in somatosensory and emotional networks can contribute to chronic pain, integrating information available from animal models and human patients. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
Functional diversity of astrocytes in neural circuit regulation Lucile Ben Haim & David H. Rowitch p31 | doi:10.1038/nrn.2016.159 Emerging evidence suggests that astrocytes may be as diverse in their physiological and functional characteristics as neurons. Ben Haim and Rowitch describe astrocyte heterogeneity, consider the mechanisms by which such diversity may arise and discuss the consequences of its disruption in disease. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
The neural and computational bases of semantic cognition Matthew A. Lambon Ralph, Elizabeth Jefferies, Karalyn Patterson & Timothy T. Rogers p42 | doi:10.1038/nrn.2016.150 Our ability to use conceptual knowledge to support various behaviours is termed semantic cognition. In this Review, Lambon Ralph et al. argue that this ability arises from two interacting neural systems, one for representation and one for control. Abstract | Full Text | PDF | Supplementary information | |||||||||||||||||||||||||||||||||||||
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Towards a mechanistic understanding of the human subcortex Birte U. Forstmann, Gilles de Hollander, Leendert van Maanen, Anneke Alkemade & Max C. Keuken p57 | doi:10.1038/nrn.2016.163 The anatomical complexity and location of the human subcortex render it difficult to study by MRI in vivo. Here, Forstmann et al. argue that understanding subcortex function may be facilitated by combining in vivo and post-mortem ultra-high field MRI, post-mortem histology and modelling approaches. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
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