Thursday, December 15, 2016

Nature Reviews Neuroscience contents January 2017 Volume 18 Number 1 pp 1 - 65

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Nature Reviews Neuroscience

January 2017 Volume 18 Number 1
Nature Reviews Neuroscience cover
2015 2-year Impact Factor 29.298 Journal Metrics 2-year Median 22
In this issue
Research Highlights

Also this month
Article series:
Scaling up neuroscience

Also this month
 Featured article:
Functional diversity of astrocytes in neural circuit regulation
Lucile Ben Haim & David H. Rowitch

Recommend to library
Article series: Scaling up neuroscience
Comment: The contribution of neuroethics to international brain research initiatives
Kathinka Evers
p1 | doi:10.1038/nrn.2016.143
Kathinka Evers discusses the important role of neuroethics research in the planning and implementation of large-scale brain research initiatives.

Abstract | Full Text | PDF


Psychiatric disorders: Age-dependent auditory abnormalities
p3 | doi:10.1038/nrn.2016.168
Deletion of Dgcr8 in 22q11.2 deletion syndrome leads to decreased processing of miR-338-3p, leading to an upregulation of thalamic dopamine D2 receptors and auditory thalamocortical deficits that might be associated with antipsychotic-sensitive auditory hallucinations.


Systems neuroscience: Opening the gait
p4 | doi:10.1038/nrn.2016.166
A brain-spine interface that uses decoded neural activity from motor cortex delivered to an electrical stimulation system in the spine was used to restore locomotor function in a monkey whose leg was paralyzed by spinal injury.


Neural development: Balancing the pruning programmes
p4 | doi:10.1038/nrn.2016.169
The genetic programmes involved in axonal pruning during development are poorly elucidated but are shown to involve a balance between the anti-apoptotic protein DUSP16 and the pro-degenerative protein PUMA.



Glia: Glial messenging | Learning and memory: The cannabinoid connection | Cell biology of the neuron: Endocytic mediators | Glia: An astrocytic influence | Neurodegenerative disease: Probing prions | Metabolism: A rapid satiety circuit | Synaptic transmission: Separating transmission modes | Perception: Coding for choice

Nature Reviews Neuroscience
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Stress, glucocorticoids and memory: implications for treating fear-related disorders
Dominique de Quervain, Lars Schwabe & Benno Roozendaal
p7 | doi:10.1038/nrn.2016.155
Glucocorticoids, which are released in response to stress, modulate the consolidation, retrieval and extinction of memories. In this Review, de Quervain et al. suggest that, in fear-related disorders such as post-traumatic stress disorder, targeting glucocorticoid signalling to attenuate fear memories has therapeutic potential.
Abstract | Full Text | PDF

Structural plasticity and reorganisation in chronic pain
Rohini Kuner & Herta Flor
p20 | doi:10.1038/nrn.2016.162
The mechanisms that underlie the transition of acute pain to a chronic intractable disorder are not well understood. In this Review, Kuner and Flor discuss how structural plasticity and reorganisation in somatosensory and emotional networks can contribute to chronic pain, integrating information available from animal models and human patients.
Abstract | Full Text | PDF

Functional diversity of astrocytes in neural circuit regulation
Lucile Ben Haim & David H. Rowitch
p31 | doi:10.1038/nrn.2016.159
Emerging evidence suggests that astrocytes may be as diverse in their physiological and functional characteristics as neurons. Ben Haim and Rowitch describe astrocyte heterogeneity, consider the mechanisms by which such diversity may arise and discuss the consequences of its disruption in disease.
Abstract | Full Text | PDF

The neural and computational bases of semantic cognition
Matthew A. Lambon Ralph, Elizabeth Jefferies, Karalyn Patterson & Timothy T. Rogers
p42 | doi:10.1038/nrn.2016.150
Our ability to use conceptual knowledge to support various behaviours is termed semantic cognition. In this Review, Lambon Ralph et al. argue that this ability arises from two interacting neural systems, one for representation and one for control.
Abstract | Full Text | PDF | Supplementary information

Towards a mechanistic understanding of the human subcortex
Birte U. Forstmann, Gilles de Hollander, Leendert van Maanen, Anneke Alkemade & Max C. Keuken
p57 | doi:10.1038/nrn.2016.163
The anatomical complexity and location of the human subcortex render it difficult to study by MRI in vivo. Here, Forstmann et al. argue that understanding subcortex function may be facilitated by combining in vivo and post-mortem ultra-high field MRI, post-mortem histology and modelling approaches.
Abstract | Full Text | PDF

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