Nature Reviews Immunology Contents January 2017 Volume 17 Number 1 pp 1-75

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TABLE OF CONTENTS
January 2017 Volume 17 Number 1		Advertisement
2015 2-year Impact Factor 39.416 Journal Metrics 2-year Median 31	In this issue Research Highlights Reviews Also this month  Featured article: Human immune system variation Petter Brodin & Mark M. Davis	January 2017 marks the 2nd anniversary of Nature Plants! Visit the journal to see what’s been publishing and submit your research.
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RESEARCH HIGHLIGHTS Top Allergy: Pollutants drive atopic dermatitis p1 | doi:10.1038/nri.2016.141 Pollutants activate the aryl hydrocarbon receptor to upregulate type 2 cytokines and neurotrophic factors that drive atopic dermatitis. PDF Reproductive immunology: B cells, be shells? p2 | doi:10.1038/nri.2016.145 B cells may protect against pre-term labour by responding to IL-33. PDF T cells: Sorting memories p2 | doi:10.1038/nri.2016.146 Expression of CX3CR1 defines a new memory T cell subset that surveys peripheral tissues. PDF JOURNAL CLUB Correlates of protection against Neisseria Meningitidis p3 | doi:10.1038/nri.2016.135 Andrew Pollard describes a 1921 study by George Heist and colleagues that pointed to antibody as a correlate of protection against meningococcal disease. PDF Tumour immunology: Interrogating intratumoral Treg cells p4 | doi:10.1038/nri.2016.137 Two studies have characterized a distinct molecular signature of intratumoral CD4+ regulatory T cells from various tumours that correlates with cancer prognosis. PDF Infection: TSLP complements neutrophil killing of bacteria p4 | doi:10.1038/nri.2016.139 Thymic stromal lymphopoietin increases the killing of methicillin-resistant Staphylococcus aureus in a neutrophil- and complement-dependent manner. PDF Haematopoiesis: HSC function determined by epigenetic memory p5 | doi:10.1038/nri.2016.140 The functional behaviour of haematopoietic stem cells is determined in a cell-autonomous manner by clone-specific epigenetic modifications. PDF Immunology JOBS of the week Postdoc with focus on pre-clinical in vivo studies and immunology German Cancer Research Center (DKFZ). Postdoctoral fellow University of Toronto Postdoctoral Fellows University of Massachusetts Post-doctoral Fellowship University of Georgia, College of Veterinary Medicine Two Junior Group Leader Positions Centre for Genomic Regulation More Science jobs from Immunology EVENT Fundamental Immunology Its Therapeutic Potential 25.04.17 Cold Spring Harbor, USA More science events from   REVIEWS Top Early local immune defences in the respiratory tract Akiko Iwasaki, Ellen F. Foxman & Ryan D. Molony p7 | doi:10.1038/nri.2016.117 This Review provides a comprehensive overview of the early airway immune responses to infections. The authors discuss the stepwise engagement of distinct tiers of effector functions and how early airway immune responses are influenced by factors such as the environment, obesity and ageing. Abstract | Full Text | PDF Human immune system variation Petter Brodin & Mark M. Davis p21 | doi:10.1038/nri.2016.125 This Review provides a comprehensive overview of the influences on human immune system variation. Systems immunology analyses have revealed that variations between individuals are mainly due to non-heritable influences such as age, sex, microbiota and the environment. Abstract | Full Text | PDF Dendritic cell migration in health and disease Tim Worbs, Swantje I. Hammerschmidt & Reinhold Förster p30 | doi:10.1038/nri.2016.116 Dendritic cells (DCs) shape tolerogenic and pro-inflammatory immune responses by presenting antigens to T cells; their ability to localize in peripheral tissues and secondary lymphoid organs is crucial for these functions. This Review describes the different migratory pathways employed by subsets of DCs from distinct tissue sites, detailing their mechanistic basis and importance for maintaining health. Abstract | Full Text | PDF Cytokine networks in neuroinflammation Burkhard Becher, Sabine Spath & Joan Goverman p49 | doi:10.1038/nri.2016.123 This Review discusses the contribution of different cytokine networks to inflammation in the central nervous system (CNS). In neuroinflammatory diseases such as multiple sclerosis, CNS-invading leukocytes produce many of the cytokines that are associated with disease. By contrast, in Alzheimer disease and other neurodegenerative diseases, tissue-resident cells are the main source of pathological cytokines. Abstract | Full Text | PDF The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting Vivianne Malmstrom, Anca I. Catrina & Lars Klareskog p60 | doi:10.1038/nri.2016.124 Understanding the gradual development of disease in patients with seropositive rheumatoid arthritis offers new opportunities for prevention and early therapy. Abstract | Full Text | PDF Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events *2014 Journal Citation Report (Thomson Reuters, 2015) You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant). 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