Nature Cell Biology contents: January 2017 Volume 19 Number 1, pp 1 - 76

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Advertisement January 2017 marks the 1st anniversary of Nature Microbiology! Visit the journal to see what’s been publishing and submit your research. Interested in our forum to discuss and share opinions about microbiology? Join the Nature Microbiology Community! TABLE OF CONTENTS January 2017 Volume 19, Issue 1 Review News and Views Articles Letters Corrigendum Retraction Advertisement January 2017 marks the 2nd anniversary of Nature Plants! Visit the journal to see what’s been publishing and submit your research. Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement CRISPR Calendar 2017 To celebrate the continuing rise to fame of the CRISPR system, the Nature Reviews Genetics 2017 CRISPR calendar highlights the underlying biology of CRISPR, as well as its diverse range of exciting potential applications in genetic research, biotechnology and therapeutics. Download the calendar free online Produced with support from  OriGene   Review Top The control of DNA repair by the cell cycle   pp1 - 9 Nicole Hustedt and Daniel Durocher doi:10.1038/ncb3452 In this Review, Hustedt and Durocher discuss recent advances in our understanding of how different repair pathways, in particular double-strand break repair, are regulated across the cell cycle to ensure faithful segregation of the genome. News and Views Top Haematopoietic stem cells show their true colours   pp10 - 12 Trista E. North and Wolfram Goessling doi:10.1038/ncb3459 Delineating the behaviour of haematopoietic stem cells (HSCs) in vivo has thus far proven challenging. Two studies in zebrafish and mouse models now track HSCs in vivo using fate mapping with multicolour approaches to provide further insights into clonal events that regulate blood development, HSC function and differentiation during homeostasis and stress conditions. See also: Article by Henninger et al. Y chromothripsis?   pp12 - 14 Emily M. Hatch doi:10.1038/ncb3458 Micronucleation of missegregated chromatin can lead to substantial chromosome rearrangements via chromothripsis. However, the molecular details of micronucleus-based chromothripsis are still unclear. Now, an elegant system that specifically induces missegregation of the Y chromosome provides insight into this process, including a role for non-homologous end joining. See also: Letter by Ly et al. Resolving the cadherin–F-actin connection   pp14 - 16 Mitchell K. L. Han and Johan de Rooij doi:10.1038/ncb3457 Cadherin adhesion complexes have recently emerged as sensors of tissue tension that regulate key developmental processes. Super-resolution microscopy experiments now unravel the spatial organization of the interface between cadherins and the actin cytoskeleton and reveal how vinculin, a central component in cadherin mechanotransduction, is regulated by mechanical and biochemical signals. See also: Article by Bertocchi et al. Nature Cell Biology JOBS of the week Post-doctoral Research Assistant in Cell Biology St. George's University of London Post-doctoral Research Assistant in Cell Biology St. George's University of London Postdoctoral Fellow in Stem Cell Biology University of Maryland School of Medicine More Science jobs from Nature Cell Biology EVENT More science events from Articles Top Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development   pp17 - 27 Jonathan Henninger, Buyung Santoso, Stefan Hans, Ellen Durand, Jessica Moore et al. doi:10.1038/ncb3444 Henninger et al. analyse the early clonal events that underlie haematopoiesis and establish the number of stem cell clones that arise from the ventral dorsal aorta to maintain lifelong blood production. See also: News and Views by North & Goessling Nanoscale architecture of cadherin-based cell adhesions   pp28 - 37 Cristina Bertocchi, Yilin Wang, Andrea Ravasio, Yusuke Hara, Yao Wu et al. doi:10.1038/ncb3456 Bertocchi and colleagues describe the organization of cadherin-based adhesions using super-resolution microscopy. They find that [alpha]-catenin is important for vinculin localization and observe a conformational change in vinculin following its activation. See also: News and Views by Han & de Rooij A hypoxia-responsive TRAF6–ATM–H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis   pp38 - 51 Abdol-Hossein Rezaeian, Chien-Feng Li, Ching-Yuan Wu, Xian Zhang, Jorge Delacerda et al. doi:10.1038/ncb3445 Lin and colleagues report that hypoxia induces TRAF6-dependent mono-ubiquitylation of histone H2AX, which promotes binding and stabilization of HIF1α. Activated HIF1α signalling in turn promotes tumorigenesis and metastasis. Letters Top Tricellular junctions regulate intestinal stem cell behaviour to maintain homeostasis   pp52 - 59 Martin Resnik-Docampo, Christopher L. Koehler, Rebecca I. Clark, Joseph M. Schinaman, Vivien Sauer et al. doi:10.1038/ncb3454 Resnik-Docampo et al. demonstrate that depletion of the tricellular junction protein Gliotactin in young flies leads to hallmarks of ageing, including an increase in intestinal stem cell proliferation and a block in terminal differentiation. LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency   pp60 - 67 Kaloyan M. Tsanov, Daniel S. Pearson, Zhaoting Wu, Areum Han, Robinson Triboulet et al. doi:10.1038/ncb3453 Daley and colleagues report that MAPK signalling controls pluripotency in embryonic stem cells and during somatic cell reprogramming by enhancing the stability and effects of LIN28 on direct mRNA targets through its phosphorylation by ERK. Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining   pp68 - 75 Peter Ly, Levi S. Teitz, Dong H. Kim, Ofer Shoshani, Helen Skaletsky et al. doi:10.1038/ncb3450 Ly et al. establish a method to selectively inactivate the centromere of the Y chromosome to follow chromosome shattering and micronuclei formation through several cell cycles, and suggest re-ligation of chromosome fragments is dependent on non-homologous end joining. See also: News and Views by Hatch Corrigendum Top Corrigendum: Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery   p76 Fiorenza Fumagalli, Julia Noack, Timothy J. Bergmann, Eduardo Cebollero, Giorgia Brambilla Pisoni et al. doi:10.1038/ncb3451 Retraction Top Retraction: G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/β-catenin pathway   p76 Shih-Ting Cha, Ching-Ting Tan, Cheng-Chi Chang, Chia-Yu Chu, Wei-Jiunn Lee et al. doi:10.1038/ncb3455 See also: Article by Cha et al. Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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