Nature Reviews Genetics Contents January 2017 Volume 18 Number 1 pp1-66

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TABLE OF CONTENTS
January 2017 Volume 18 Number 1
2015 2-year Impact Factor 35.898 Journal Metrics 2-year Median 32	In this issue Research Highlights Reviews Also this month Article series: Study designs Article series: Epigenetics  Featured article: From profiles to function in epigenomics Stefan H. Stricker, Anna Köferle & Stephan Beck
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CRISPR Calendar 2017 To celebrate the continuing rise to fame of the CRISPR system, the Nature Reviews Genetics 2017 CRISPR calendar highlights the underlying biology of CRISPR, as well as its diverse range of exciting potential applications in genetic research, biotechnology and therapeutics. Download the calendar free online Produced with support from  OriGene
RESEARCH HIGHLIGHTS Top Gene therapy: In vivo gene editing in non-dividing cells p1 | doi:10.1038/nrg.2016.158 PDF Cancer genomics: Single-cell RNA-seq to decipher tumour architecture p2 | doi:10.1038/nrg.2016.151 PDF DNA elements: The ins and outs of enhancer validation p2 | doi:10.1038/nrg.2016.155 PDF DNA repair: RNA-DNA hybrids: double-edged swords p3 | doi:10.1038/nrg.2016.153 PDF Epigenomics: Deciphering non-coding variation with 3D epigenomics p4 | doi:10.1038/nrg.2016.161 PDF
REVIEWS		Top
Paramutation and related phenomena in diverse species Jay B. Hollick p5 | doi:10.1038/nrg.2016.115 In this Review, the author discusses current knowledge on the paramutations that occur in maize and contrasts these behaviours with potentially parallel examples in metazoans. He highlights the key role of small RNAs (sRNAs) in diverse paramutation mechanisms across eukaryotes and considers the evolutionary importance of these regulatory systems. Abstract | Full Text | PDF | Supplementary information
Article series: Study designs Loss-of-function genetic tools for animal models: cross-species and cross-platform differences Benjamin E. Housden et al. p24 | doi:10.1038/nrg.2016.118 Loss-of-function (LOF) approaches are powerful experimental tools for characterizing gene functions. However, emerging discrepancies when genes are investigated using different tools or organisms has triggered debate about how such LOF results should be biologically interpreted. In this Review, experts from varied fields discuss how understanding the underlying features of each LOF approach can provide explanations for different experimental outcomes and can guide their optimal and reliable application. Abstract | Full Text | PDF
Microbial genome-wide association studies: lessons from human GWAS Robert A. Power, Julian Parkhill & Tulio de Oliveira p41 | doi:10.1038/nrg.2016.132 With the increasing availability of microbial whole genomes, researchers are beginning to carry out genome-wide association studies (GWAS) in bacteria, viruses and protozoa. In this Review, the authors discuss the specific challenges and considerations associated with the application of GWAS methods to microorganisms and consider the future of microbial GWAS in the light of lessons learned from human studies. Abstract | Full Text | PDF
Article series: Epigenetics From profiles to function in epigenomics Stefan H. Stricker, Anna Köferle & Stephan Beck p51 | doi:10.1038/nrg.2016.138 A wealth of data is emerging from diverse studies of epigenomics, including genome-scale profiles of DNA methylation, histone modifications and higher-order chromatin features. In this Review, the authors discuss how, despite all this information, many challenges remain for inferring and proving the physiological and pathological functions of chromatin states. They describe the degrees of 'functionality' that are revealed by different experimental approaches, the value of integrative strategies and visions for the future. Abstract | Full Text | PDF | Supplementary information
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*2015 Journal Citation Report (Thomson Reuters, 2016)

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