Molecular Systems Biology - New articles published - 1 Dec 2016

November 2016 | Volume 12, Number 11 Submit Table of Contents Reports News & Views Articles Volume 12, Number 11 Reports Dynamical compensation in physiological circuits Physiological circuits must keep their output dynamics precise despite wide variation in circuit parameters. We present a design principle for this robustness, find that it explains experimental observations on glucose homeostasis, and show that it may apply to other physiological circuits. Omer Karin, Avital Swisa, Benjamin Glaser, Yuval Dor, and Uri Alon Published online 08.11.2016 News & Views Unlocking the chromatin code by deciphering protein–DNA interactions Characterizing the chromatin proteome is essential for understanding transcriptional regulation. To this end, Krijgsveld and colleagues (Rafiee et al, 2016) report ChIP‐SICAP, a method combining ChIP, isolation of chromatin‐associated proteins and mass spectrometry. Dalila Bensaddek and Angus I Lamond Published online 10.11.2016 Articles Single‐cell sequencing maps gene expression to mutational phylogenies in PDGF‐ and EGF‐driven gliomas An approach is presented for mapping single‐cell expression profiles to sequentially acquired mutations identified by exome sequencing. Phylogenies of EGF‐driven and PDGF‐driven gliomas are constructed, modeling transcriptional kinetics during tumor evolution. Sören Müller, Siyuan John Liu, Elizabeth Di Lullo, Martina Malatesta, Alex A Pollen, Tomasz J Nowakowski, Gary Kohanbash, Manish Aghi, Arnold R Kriegstein, Daniel A Lim, and Aaron Diaz Published online 25.11.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.