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| Nature Outlook: Kidney Cancer Kidney cancer has long flown under the radar despite being one of the top-ten cancer killers worldwide. It remains hard to detect, difficult to treat and poorly understood. But that is starting to change as researchers dig into the mysteries surrounding the disease.
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 RESEARCH HIGHLIGHTS
| Top | Angiogenesis: Going with the flow
p751 | doi:10.1038/nrc.2016.127
Two studies have revealed two possible mechanisms that might explain why VEGF inhibition can be rendered ineffective
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Tumorigenesis: Networking: a survival guide
p752 | doi:10.1038/nrc.2016.125
A subset of cancer cells is dependent on a large, stable multi-protein complex called the epichaperome for survival under conditions of stress.
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Cancer risk: Generating tumours: it's all in the balance
p753 | doi:10.1038/nrc.2016.137
Two papers examine the influence of different stem cell characteristics on tumorigenesis in an organ-specific and age-associated manner, continuing the debate on the influence of intrinsic and extrinsic factors on cancer risk.
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Tumour metabolism: RED(D1) or dead
p754 | doi:10.1038/nrc.2016.132
Mathias Wenes and colleagues have studied metabolic changes in tumour associated macrophages (TAMs) and found that specific alterations of mTOR regulation through regulated in development and DNA damage response 1 (REDD1) results in defective blood vessel formation and increased metastasis.
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Anticancer drugs: Breaking up a pro-survival interaction
p754 | doi:10.1038/nrc.2016.139
A paper in Nature describes a highly specific and potent small molecule inhibitor of MCL1 that has single-agent activity and good tolerability in several cancer models.
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Pancreatic cancer: Fast or slow?
p755 | doi:10.1038/nrc.2016.128
An analysis of pancreatic ductal adenocarcinoma genomes indicates that many of these tumours undergo polyploidization and chromothripsis, leading to rapid acquisition of genetic changes required for tumour progression.
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Lymphoma: Customized therapeutic delivery
p756 | doi:10.1038/nrc.2016.121
Boice, Salloum, Mourcin et al. show that HVEM is an important tumour suppressor in lymphomas and that direct delivery of a soluble HVEM peptide using engineered T cells might be therapeutically beneficial.
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Tumour microenvironment: That gut feeling
p756 | doi:10.1038/nrc.2016.122
Daillère et al. have identified two bacterial species that mediate systemic and tumour-infiltrating T cell responses associated with the antitumour efficacy of the chemotherapy drug cyclophosphamide.
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IN BRIEF
| Metastasis: Caught in a trap | Tumour metabolism: When metabolic and epigenetic states converge | Tumour immunology: The consequences of concomitant challenges | Immunotherapy: Powerful combinations
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| Top | Mouse models in oncoimmunology
Laurence Zitvogel, Jonathan M. Pitt, Romain Daillère, Mark J. Smyth & Guido Kroemer
p759 | doi:10.1038/nrc.2016.91
In this Review, Zitvogel et al. describe the mouse models of transplantable, carcinogen-induced and genetically engineered tumours that have laid the foundations of oncoimmunology.
Abstract | Full Text | PDF
| | | | PERSPECTIVES
| Top | TIMELINE
Gap junctions and cancer: communicating for 50 years
Trond Aasen, Marc Mesnil, Christian C. Naus, Paul D. Lampe & Dale W. Laird
p775 | doi:10.1038/nrc.2016.105
In this Timeline article, Aasen et al. look back over 50 years of research linking gap junctions and connexins to cancer, highlighting the conditional nature of their role in cancer progression, future challenges and therapeutic strategies.
Abstract | Full Text | PDF | Supplementary information
| TIMELINE
Epstein–Barr virus: more than 50 years old and still providing surprises
Lawrence S. Young, Lee Fah Yap & Paul G. Murray
p789 | doi:10.1038/nrc.2016.92
This Timeline article describes the discovery of the Epstein–Barr virus and summarizes the key advances in the field that have led to our current understanding of the role this virus plays in a number of different lymphoid and epithelial malignancies.
Abstract | Full Text | PDF
| OPINION
Maintaining cell identity: PRC2-mediated regulation of transcription and cancer
Itys Comet, Eva M. Riising, Benjamin Leblanc & Kristian Helin
p803 | doi:10.1038/nrc.2016.83
In this Opinion article, the authors propose that the function of Polycomb repressive complex 2 (PRC2) in maintaining, rather than specifying, transcriptional repression can explain its seemingly contradictory roles in cancer.
Abstract | Full Text | PDF | Supplementary information
| Corrigendum: From Krebs to clinic: glutamine metabolism to cancer therapy
Brian J. Altman, Zachary E. Stine & Chi V. Dang
p773 | doi:10.1038/nrc.2016.131
Full Text | PDF
| Correction: Obesity promotes prostate cancer invasion
p773 | doi:10.1038/nrc.2016.130
Full Text | PDF
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