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Advertisement | | Nature Outlook: Lysosomal Storage Disorders
Lysosomal storage disorders are individually rare but collectively common. The study of these diseases is not only leading to better treatments, but also revealing many of the secrets of this underappreciated organelle.
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Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | | | Latest Articles | View all Articles | | | | | Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines OPEN | | | Lanying Du, Wanbo Tai, Yang Yang, Guangyu Zhao, Qing Zhu, Shihui Sun, Chang Liu, Xinrong Tao, Chien-Te K. Tseng, Stanley Perlman, Shibo Jiang, Yusen Zhou and Fang Li | | | Viral subunit vaccines contain epitopes that elicit non-neutralizing immune responses. Here, Du et al. mask an immunodominant non-neutralizing epitope on a MERS coronavirus subunit vaccine with a glycan probe, leading to significantly improved efficacy of the vaccine. | | | 22 November 2016 | doi: 10.1038/ncomms13473 | | |
| A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood OPEN | | | Justin Rebo, Melod Mehdipour, Ranveer Gathwala, Keith Causey, Yan Liu, Michael J. Conboy and Irina M. Conboy | | | Joining the circulatory system of an old with a young animal has been shown to rejuvenate old tissues. Here the authors describe a comparatively simple blood infusion system that allows for the controlled exchange of blood between two animals, and study the effects of a single exchange on various tissues. | | | 22 November 2016 | doi: 10.1038/ncomms13363 | | |
| Prompt gravity signal induced by the 2011 Tohoku-Oki earthquake OPEN | | | Jean-Paul Montagner, Kévin Juhel, Matteo Barsuglia, Jean Paul Ampuero, Eric Chassande-Mottin, Jan Harms, Bernard Whiting, Pascal Bernard, Eric Clévédé and Philippe Lognonné | | | Earthquakes have been theorised to produce gravity signals that may arrive before seismic waves, but until now they had not been detected. Montagner et al. have detected prompt gravity signals from the 2011 Tohoku-Oki earthquake thus allowing an early warning of earthquakes before seismic wave arrival. | | | 22 November 2016 | doi: 10.1038/ncomms13349 | | |
| Evidence from stable isotopes and 10Be for solar system formation triggered by a low-mass supernova OPEN | | | Projjwal Banerjee, Yong-Zhong Qian, Alexander Heger and W C Haxton | | | One hypothesis for solar system formation is gas compression by a nearby supernova, whose traces should be found in isotopic anomalies. Here the authors show that this mechanism is viable only if the triggering event was a low-mass supernova, looking at short-lived 10Be and lack of anomalies in stable isotopes. | | | 22 November 2016 | doi: 10.1038/ncomms13639 | | |
| Secondary migration and leakage of methane from a major tight-gas system OPEN | | | James M. Wood and Hamed Sanei | | | As shale and tight gas basins are increasingly used to extract natural gas, understanding how gas migrates is important. Wood and Sanei find that secondary migration in a tight-gas basin leads to up-dip transmission of enriched methane into surficial strata which may leak into groundwater and the atmosphere. | | | 22 November 2016 | doi: 10.1038/ncomms13614 | | |
| Nanomechanical electro-optical modulator based on atomic heterostructures OPEN | | | P. A. Thomas, O. P. Marshall, F. J. Rodriguez, G. H. Auton, V. G. Kravets, D. Kundys, Y. Su and A. N. Grigorenko | | | Van der Waals heterostructures can be combined with metallic nanostructures to enable enhanced light–matter interaction. Here, the authors fabricate a broadband mechanical electro-optical modulator using a graphene/hexagonal boron nitride vertical heterojunction, suspended over a gold nanostripe array. | | | 22 November 2016 | doi: 10.1038/ncomms13590 | | |
| Atomically resolved phase transition of fullerene cations solvated in helium droplets OPEN | | | M. Kuhn, M. Renzler, J. Postler, S. Ralser, S. Spieler, M. Simpson, H Linnartz, A. G. G. M. Tielens, J. Cami, A. Mauracher, Y. Wang, M. Alcamí, F. Martín, M. K. Beyer, R. Wester, A. Lindinger and P. Scheier | | | 'Atkins snowballs', solid layers of helium around an ion core in bulk superfluid He, have been investigated for simple ions but many properties remain unknown. Here, the authors show via photofragmentation experiments that a phase transition occurs in C60-doped He droplets depending on the number of He atoms. | | | 22 November 2016 | doi: 10.1038/ncomms13550 | | |
| Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease OPEN | | | Christian Dölle, Irene Flønes, Gonzalo S. Nido, Hrvoje Miletic, Nelson Osuagwu, Stine Kristoffersen, Peer K. Lilleng, Jan Petter Larsen, Ole-Bjørn Tysnes, Kristoffer Haugarvoll, Laurence A. Bindoff and Charalampos Tzoulis | | | Accumulated damage to mitochondrial DNA (mtDNA) occurs during the ageing process and neurodegenerative disease. Here, the authors show that mtDNA copy number increases in an age-dependent manner in substantia nigra of healthy individuals, but not in individuals with Parkinson disease. | | | 22 November 2016 | doi: 10.1038/ncomms13548 | | |
| Fission and fusion scenarios for magnetic microswimmer clusters OPEN | | | Francisca Guzmán-Lastra, Andreas Kaiser and Hartmut Löwen | | | The collective motion of microswimmers is determined by not only their direct interaction, but also the hydrodynamics forces mediated by the surrounding flow field. Here, the authors detail in simulation the spontaneous assembly and disassembly of magnetic microswimmers into various structures. | | | 22 November 2016 | doi: 10.1038/ncomms13519 | | |
| Spray printing of organic semiconducting single crystals OPEN | | | Grigorios-Panagiotis Rigas, Marcia M. Payne, John E. Anthony, Peter N. Horton, Fernando A. Castro and Maxim Shkunov | | | The development of organic electronics calls for low-cost printing techniques that can prepare high quality, large-area organic single crystals. Here, Rigas et al. achieve this goal by combining spray printing and antisolvent crystallization and test the method on various materials and substrates. | | | 22 November 2016 | doi: 10.1038/ncomms13531 | | |
| Spontaneous formation of structurally diverse membrane channel architectures from a single antimicrobial peptide OPEN | | | Yukun Wang, Charles H. Chen, Dan Hu, Martin B. Ulmschneider and Jakob P. Ulmschneider | | | Antimicrobial peptides (AMPs) selectively form pores in microbial membranes in process not fully understood. Here the authors use experimentally guided molecular dynamics to study maculatin pore formation, showing how this AMP assembles into transient and structurally diverse oligomeric pores in cell membranes. | | | 22 November 2016 | doi: 10.1038/ncomms13535 | | |
| Modified relaxation dynamics and coherent energy exchange in coupled vibration-cavity polaritons OPEN | | | A. D. Dunkelberger, B. T. Spann, K. P. Fears, B. S. Simpkins and J. C. Owrutsky | | | Vibration-cavity polaritons are mixed states produced by strong coupling between a vibrational mode and an optical cavity. Here, the authors show that these polaritons can coherently exchange energy and exhibit drastically altered transient spectra and dynamics compared to uncoupled vibrations. | | | 22 November 2016 | doi: 10.1038/ncomms13504 | | |
| Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity OPEN | | | Jessica T. Y. Yue, Mona A. Abraham, Paige V. Bauer, Mary P. LaPierre, Peili Wang, Frank A. Duca, Beatrice M. Filippi, Owen Chan and Tony K. T. Lam | | | Glycine sensing in the dorsal vagal complex (DVC) regulates hepatic glucose production in rodents. Here the authors show that pharmacological and molecular inhibition of glycine reuptake in the DVC potentiates NMDA receptors, and improves metabolic homeostasis in animal models of obesity and diabetes. | | | 22 November 2016 | doi: 10.1038/ncomms13501 | | |
| Phase transformation strengthening of high-temperature superalloys OPEN | | | T. M. Smith, B. D. Esser, N. Antolin, A. Carlsson, R. E. A. Williams, A. Wessman, T. Hanlon, H. L. Fraser, W. Windl, D. W. McComb and M. J. Mills | | | Nanoscale processes may directly impact macroscopic mechanical behaviour. Here authors describe a ‘phase-transformation strengthening’ mechanism in nickel-based high temperature alloys, allowing suppression of deleterious deformation processes at elevated temperatures by specific alloying elements. | | | 22 November 2016 | doi: 10.1038/ncomms13434 | | |
| The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch OPEN | | | Mashito Sakai, Tomoko Tujimura-Hayakawa, Takashi Yagi, Hiroyuki Yano, Masaru Mitsushima, Hiroyuki Unoki-Kubota, Yasushi Kaburagi, Hiroshi Inoue, Yoshiaki Kido, Masato Kasuga and Michihiro Matsumoto | | | GCN5 inhibits hepatic gluconeogenesis through acetylation of PGC-1α. Here the authors show that GCN5 also activates hepatic gluconeogenesis by acetylating histone H3K9, and that the affinity of GCN5 for its different substrates is regulated via phosphorylation at S275 by PKA in a CITED2-dependent manner. | | | 22 November 2016 | doi: 10.1038/ncomms13147 | | |
| Quantum memory with strong and controllable Rydberg-level interactions OPEN | | | Lin Li and A Kuzmich | | | Quantum information processing requires long-storage time of quantum states, but this typically comes at the expense of their addressability. Here the authors developed a method that exploits interaction between Rydberg and ground states of an atom reporting fast state generation and long-term storage. | | | 21 November 2016 | doi: 10.1038/ncomms13618 | | |
| T-cell stimuli independently sum to regulate an inherited clonal division fate OPEN | | | J. M. Marchingo, G. Prevedello, A. Kan, S. Heinzel, P. D. Hodgkin and K. R. Duffy | | | Why do populations of highly similar T cells have heterogeneous division destinies in response to antigenic stimulus? Here the authors develop a multiplex-dye assay and a mathematical framework to test clonal heterogeneity and show distinction in division destiny is a result of inter-clonal variability as lineage imprinting ensures clones share similar proliferation fates. | | | 21 November 2016 | doi: 10.1038/ncomms13540 | | |
| Polarization bandgaps and fluid-like elasticity in fully solid elastic metamaterials OPEN | | | Guancong Ma, Caixing Fu, Guanghao Wang, Philipp del Hougne, Johan Christensen, Yun Lai and Ping Sheng | | | Controlling elastic waves in medium is essential to many applications in mechanical to earthquake engineering. Ma et al. demonstrate selective suppression of different vibrational modes in a three-dimensional rod-shape structure, which shows fluid-like elasticity with only longitudinal waves propagating. | | | 21 November 2016 | doi: 10.1038/ncomms13536 | | |
| A radial map of multi-whisker correlation selectivity in the rat barrel cortex OPEN | | | Luc Estebanez, Julien Bertherat, Daniel E. Shulz, Laurent Bourdieu and Jean- François Léger | | | Barrel cortex contains a functional map of whiskers but how neuronal activity maps multi-whisker inputs has not been studied. Here the authors show that while uncorrelated multi-whisker stimuli activate barrel neurons, correlated multi-whisker inputs activate neurons in a ring at the barrel-septa boundary | | | 21 November 2016 | doi: 10.1038/ncomms13528 | | |
| Cerebral vascular amyloid seeds drive amyloid β-protein fibril assembly with a distinct anti-parallel structure OPEN | | | Feng Xu, Ziao Fu, Sharmila Dass, AnnMarie E. Kotarba, Judianne Davis, Steven O. Smith and William E. Van Nostrand | | | Cerebrovascular accumulation of Aβ is a common feature of Alzheimer’s disease, though it is unclear whether mutant vascular amyloid is capable of Aβ seeding. Here, the authors show microvascular amyloid seeds are capable of driving wild-type Aβ to assemble into distinctive anti-parallel fibrillary structures. | | | 21 November 2016 | doi: 10.1038/ncomms13527 | | |
| Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells OPEN | | | Jan R. Kraehling, John H. Chidlow, Chitra Rajagopal, Michael G. Sugiyama, Joseph W. Fowler, Monica Y. Lee, Xinbo Zhang, Cristina M. Ramírez, Eon Joo Park, Bo Tao, Keyang Chen, Leena Kuruvilla, Bruno Larriveé, Ewa Folta-Stogniew, Roxana Ola, Noemi Rotllan, Wenping Zhou, Michael W. Nagle, Joachim Herz, Kevin Jon Williams et al. | | | Atherosclerosis is caused by low-density lipoprotein (LDL) buildup in the vessel wall, a process thought to be mediated by LDL receptor alone. Here, the authors show that the endothelium can uptake LDL via ALK1, a TGFβ signalling receptor, suggesting new therapies for blocking LDL accumulation in the vessel wall. | | | 21 November 2016 | doi: 10.1038/ncomms13516 | | |
| Autophagy controls centrosome number by degrading Cep63 OPEN | | | Yuichiro Watanabe, Shinya Honda, Akimitsu Konishi, Satoko Arakawa, Michiko Murohashi, Hirofumi Yamaguchi, Satoru Torii, Minoru Tanabe, Shinji Tanaka, Eiji Warabi and Shigeomi Shimizu | | | The ubiquitin-proteasome system is thought to be the primary regulator of centrosome number. Here, Watanabe et al. show that selective autophagy also plays a role in regulating centrosome number via p62-dependent recruitment of centrosomal protein 63 to autophagosomes. | | | 21 November 2016 | doi: 10.1038/ncomms13508 | | |
| Dynamic structure of active nematic shells OPEN | | | Rui Zhang, Ye Zhou, Mohammad Rahimi and Juan J. de Pablo | | | In active matter, chemical energy is transformed into mechanical motion; theoretical descriptions of nematic liquids are useful in understanding such phenomena. Here, Zhang et al. model the dynamics of active nematic liquid crystals confined onto a spherical shell in systems that mimic cell motion. | | | 21 November 2016 | doi: 10.1038/ncomms13483 | | |
| Bisguanidinium dinuclear oxodiperoxomolybdosulfate ion pair-catalyzed enantioselective sulfoxidation OPEN | | | Lili Zong, Chao Wang, Adhitya Mangala Putra Moeljadi, Xinyi Ye, Rakesh Ganguly, Yongxin Li, Hajime Hirao and Choon-Hong Tan | | | Peroxomolybdates can be used as catalysts, but to date have not been employed in catalytic asymmetric transformations. Here the authors report that peroxomolybdates with a chiral bisguanidinium salts are active catalysts for asymmetric sulfoxidation, and furthermore identify the catalytic species. | | | 21 November 2016 | doi: 10.1038/ncomms13455 | | |
| De-novo protein function prediction using DNA binding and RNA binding proteins as a test case OPEN | | | Sapir Peled, Olga Leiderman, Rotem Charar, Gilat Efroni, Yaron Shav-Tal and Yanay Ofran | | | Identification of the function of proteins is difficult when there are no structurally or biochemically characterized homologs. Here, the authors present an approach that allows the prediction of nucleic-acid binding proteins based on sequence alone, and they are able to experimentally validate their method. | | | 21 November 2016 | doi: 10.1038/ncomms13424 | | |
| Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry OPEN | | | Michal Bassani-Sternberg, Eva Bräunlein, Richard Klar, Thomas Engleitner, Pavel Sinitcyn, Stefan Audehm, Melanie Straub, Julia Weber, Julia Slotta-Huspenina, Katja Specht, Marc E. Martignoni, Angelika Werner, Rüdiger Hein, Dirk H. Busch, Christian Peschel, Roland Rad, Jürgen Cox, Matthias Mann and Angela M. Krackhardt | | | Neoantigens determine anti-cancer immunoreactivity and are important functional targets for immunotherapy. Here, the authors use deep mass spectrometry to characterize neoepitopes from human melanoma tissue and show the presence of tumour-reactive T cells with specificity for selected neoantigens. | | | 21 November 2016 | doi: 10.1038/ncomms13404 | | |
| Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors OPEN | | | Hui Cheng, Heather Yin-Kuan Ang, Chadi A. EL Farran, Pin Li, Hai Tong Fang, Tong Ming Liu, Say Li Kong, Michael Lingzi Chin, Wei Yin Ling, Edwin Kok Hao Lim, Hu Li, Tara Huber, Kyle M. Loh, Yuin-Han Loh and Bing Lim | | | Direct reprogramming of closely-related lineages can generate hematopoietic stem cells. Here, the authors show hematopoietic transcription factors Scl, Lmo2, Runx1 and Bmi1 can reprogram fibroblasts into induced hematopoietic progenitors (iHPs), which are engraftable blood progenitors. | | | 21 November 2016 | doi: 10.1038/ncomms13396 | | |
| Mid-infrared ultra-high-Q resonators based on fluoride crystalline materials OPEN | | | C. Lecaplain, C. Javerzac-Galy, M. L. Gorodetsky and T. J. Kippenberg | | | Highly sensitive trace-gas detection is possible in the mid-infrared range with transparent microresonators. Here, the authors directly measure the necessary ultra-high quality factors of microresonators made from fluoride crystal materials using a tapered chalcogenide fibre. | | | 21 November 2016 | doi: 10.1038/ncomms13383 | | |
| The influence of large cations on the electrochemical properties of tunnel-structured metal oxides OPEN | | | Yifei Yuan, Chun Zhan, Kun He, Hungru Chen, Wentao Yao, Soroosh Sharifi-Asl, Boao Song, Zhenzhen Yang, Anmin Nie, Xiangyi Luo, Hao Wang, Stephen M. Wood, Khalil Amine, M. Saiful Islam, Jun Lu and Reza Shahbazian-Yassar | | | Metal oxides with a tunnelled structure are attractive as charge storage materials for rechargeable batteries and supercapacitors. Here, the authors investigate the role of tunnel cations in governing and enhancing the electrochemical properties of electrode materials. | | | 21 November 2016 | doi: 10.1038/ncomms13374 | | |
| CELF1 is a central node in post-transcriptional regulatory programmes underlying EMT OPEN | | | Arindam Chaudhury, Shebna Cheema, Joseph M. Fachini, Natee Kongchan, Guojun Lu, Lukas M. Simon, Tao Wang, Sufeng Mao, Daniel G. Rosen, Michael M. Ittmann, Susan G. Hilsenbeck, Chad A. Shaw and Joel R. Neilson | | | Epithelial-to-mesenchymal transition is a key process in tumorigenesis but little is known about the molecular mechanism regulating such process at the translational level. Here, the authors identify a subset of mRNAs important for this process that are specifically modulated by the RNA-binding protein CELF1. | | | 21 November 2016 | doi: 10.1038/ncomms13362 | | |
| A systems study reveals concurrent activation of AMPK and mTOR by amino acids OPEN | | | Piero Dalle Pezze, Stefanie Ruf, Annika G. Sonntag, Miriam Langelaar-Makkinje, Philip Hall, Alexander M. Heberle, Patricia Razquin Navas, Karen van Eunen, Regine C. Tölle, Jennifer J. Schwarz, Heike Wiese, Bettina Warscheid, Jana Deitersen, Björn Stork, Erik Fäßler, Sascha Schäuble, Udo Hahn, Peter Horvatovich, Daryl P. Shanley and Kathrin Thedieck et al. | | | mTORC1 is known to mediate the signalling activity of amino acids. Here, the authors combine modelling with experiments and find that amino acids acutely stimulate mTORC2, IRS/PI3K and AMPK, independently of mTORC1. AMPK activation through CaMKKβ sustains autophagy under non-starvation conditions. | | | 21 November 2016 | doi: 10.1038/ncomms13254 | | |
| Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire OPEN | | | Yik Andy Yeung, Davide Foletti, Xiaodi Deng, Yasmina Abdiche, Pavel Strop, Jacob Glanville, Steven Pitts, Kevin Lindquist, Purnima D. Sundar, Marina Sirota, Adela Hasa-Moreno, Amber Pham, Jody Melton Witt, Irene Ni, Jaume Pons, David Shelton, Arvind Rajpal and Javier Chaparro-Riggers | | | Staphylococcus aureus can both cause disease in humans and be present with no discernible effect. Here, the authors look in detail at the memory immune response against a protein involved in iron acquisition. | | | 18 November 2016 | doi: 10.1038/ncomms13376 | | |
| Phase retrieval by coherent modulation imaging OPEN | | | Fucai Zhang, Bo Chen, Graeme R. Morrison, Joan Vila-Comamala, Manuel Guizar-Sicairos and Ian K. Robinson | | | Robust coherent diffractive imaging generally requires many exposures that may damage samples. Here, the authors develop a single-shot X-ray imaging method applicable to general samples for materials and biological sciences, also enabling imaging of dynamic processes, using a pulsed X-ray laser. | | | 18 November 2016 | doi: 10.1038/ncomms13367 | | |
| Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism OPEN | | | Tatsuya Tamura, Hiroshi Noda, Eri Joyashiki, Maiko Hoshino, Tomoyuki Watanabe, Masahiko Kinosaki, Yoshikazu Nishimura, Tohru Esaki, Kotaro Ogawa, Taiji Miyake, Shinichi Arai, Masaru Shimizu, Hidetomo Kitamura, Haruhiko Sato and Yoshiki Kawabe | | | Hypoparathyroidism and osteoporosis can be treated with parathyroid hormone, but frequent injections are required. Here the authors develop a small-molecule agonist for the parathyroid hormone type I receptor that can be administered orally, and demonstrate its efficacy in rats. | | | 18 November 2016 | doi: 10.1038/ncomms13384 | | |
| An archaeal ADP-dependent serine kinase involved in cysteine biosynthesis and serine metabolism OPEN | | | Yuki Makino, Takaaki Sato, Hiroki Kawamura, Shin-ichi Hachisuka, Ryo Takeno, Tadayuki Imanaka and Haruyuki Atomi | | | Archaea metabolism has unique adaptations to hostile environments. Here Makino et al. describe an unusual ADP-dependent kinase that phosphorylates free serine to O-phosphoserine and participates in an additional cysteine biosynthetic pathway in the archaeon Thermococcus kodakarensis. | | | 18 November 2016 | doi: 10.1038/ncomms13446 | | |
| One-volt-driven superfast polymer actuators based on single-ion conductors OPEN | | | Onnuri Kim, Hoon Kim, U. Hyeok Choi and Moon Jeong Park | | | Achieving a balance of desirable mechanical properties with low power consumption is important for developing soft actuator technologies. Here, the authors report single-ion-conducting polymers that function as fast, durable actuators at low voltages. | | | 18 November 2016 | doi: 10.1038/ncomms13576 | | |
| Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration OPEN | | | Wenjuan Pu, Hui Zhang, Xiuzhen Huang, Xueying Tian, Lingjuan He, Yue Wang, Libo Zhang, Qiaozhen Liu, Yan Li, Yi Li, Huan Zhao, Kuo Liu, Jie Lu, Yingqun Zhou, Pengyu Huang, Yu Nie, Yan Yan, Lijian Hui, Kathy O. Lui and Bin Zhou et al. | | | Hepatocytes are highly specialized cells and their fate is determined by their position in the liver as either periportal or perivenous hepatocytes. Here, Pu et al. show through genetic lineage tracing for Mfsd2 that periportal hepatocytes proliferate and reprogram into pericentral hepatocytes during liver regeneration and injury. | | | 18 November 2016 | doi: 10.1038/ncomms13369 | | |
| USP21 prevents the generation of T-helper-1-like Treg cells OPEN | | | Yangyang Li, Yue Lu, Shuaiwei Wang, Zhijun Han, Fuxiang Zhu, Yingmeng Ni, Rui Liang, Yan Zhang, Qibin Leng, Gang Wei, Guochao Shi, Ruihong Zhu, Dan Li, Haikun Wang, Song Guo Zheng, Hongxi Xu, Andy Tsun and Bin Li | | | The immunosuppressive role of regulatory T (Treg) cells largely depends on their virtue of expressing the transcription factor FOXP3. Here the authors show that the E3 deubiquitinase USP21 stabilizes FOXP3 by mediating its deubiquitination and helps to maintain the expression of Treg signature genes and Treg lineage stability in mice. | | | 18 November 2016 | doi: 10.1038/ncomms13559 | | |
| Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis OPEN | | | Charis E. Teh, Najoua Lalaoui, Reema Jain, Antonia N. Policheni, Melanie Heinlein, Silvia Alvarez-Diaz, Julie M. Sheridan, Eva Rieser, Stefanie Deuser, Maurice Darding, Hui-Fern Koay, Yifang Hu, Fiona Kupresanin, Lorraine A. O’Reilly, Dale I. Godfrey, Gordon K. Smyth, Philippe Bouillet, Andreas Strasser, Henning Walczak, John Silke et al. | | | LUBAC is a ubiquitin ligase complex of HOIL-1, HOIP and SHARPIN important for signal transduction of a range of stimuli. Here the authors define the function of all three LUBAC components in T cell development and homeostasis. | | | 18 November 2016 | doi: 10.1038/ncomms13353 | | |
| Self-assembly of diphenylalanine peptide with controlled polarization for power generation OPEN | | | Vu Nguyen, Ren Zhu, Kory Jenkins and Rusen Yang | | | Piezoelectricity in diphenylalanine peptide nanotubes (PNTs) suggests an avenue towards green piezoelectric devices. Here the authors show ‘smart’ PNTs whose polarization can be controlled with an electric field, and a resultant power generator which harvests biomechanical energy with high power density. | | | 18 November 2016 | doi: 10.1038/ncomms13566 | | |
| Positive and strongly relaxed purifying selection drive the evolution of repeats in proteins OPEN | | | Erez Persi, Yuri I. Wolf and Eugene V Koonin | | | Protein repeats may be considered a paradox, being evolutionarily conserved yet also hotspots of protein evolution associated with innovation. Here, the authors use a novel method to show that new repeats undergo rapid divergence within species, but are then fixed and conserved between species. | | | 18 November 2016 | doi: 10.1038/ncomms13570 | | |
| 3D visualization of additive occlusion and tunable full-spectrum fluorescence in calcite OPEN | | | David C. Green, Johannes Ihli, Paul D. Thornton, Mark A. Holden, Bartosz Marzec, Yi-Yeoun Kim, Alex N. Kulak, Mark A. Levenstein, Chiu Tang, Christophe Lynch, Stephen E. D. Webb, Christopher J. Tynan and Fiona C. Meldrum | | | Introducing organic guests to a crystal is a convenient way to tailor its properties. Here, the authors occlude fluorescent dyes within calcite to reveal that additives can occupy distinct zones of a crystal, and strategically embed green, blue, and red dyes to create white fluorescent calcite. | | | 18 November 2016 | doi: 10.1038/ncomms13524 | | |
| Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers OPEN | | | Eva Pérez-Guijarro, Panagiotis Karras, Metehan Cifdaloz, Raúl Martínez-Herranz, Estela Cañón, Osvaldo Graña, Celia Horcajada-Reales, Direna Alonso-Curbelo, Tonantzin G. Calvo, Gonzalo Gómez-López, Nicolas Bellora, Erica Riveiro-Falkenbach, Pablo L. Ortiz-Romero, José L. Rodríguez-Peralto, Lorena Maestre, Giovanna Roncador, Juan C. de Agustín Asensio, Colin R. Goding, Eduardo Eyras, Diego Megías et al. | | | Cytoplasmic polyadenylated transcripts have been poorly characterized, particularly in cancer. Here the authors identify a lineage-specific requirement of the cytoplasmic polyadenylation binding protein 4 (CPEB4) in malignant melanoma and show that it controls melanoma drivers MITF and RAB27A. | | | 18 November 2016 | doi: 10.1038/ncomms13418 | | |
| An elastic element in the protocadherin-15 tip link of the inner ear OPEN | | | Raul Araya-Secchi, Brandon L. Neel and Marcos Sotomayor | | | Tip-link filaments convey force to activate hair cells, important sensory receptors. Here the authors solve a partial structure of human protocadherin-15, a tip-link component with an unusual Ca2+–free linker that bends and is predicted to confer flexibility to this filament during inner-ear mechanotransduction. | | | 18 November 2016 | doi: 10.1038/ncomms13458 | | |
| Selectively tunable optical Stark effect of anisotropic excitons in atomically thin ReS2 OPEN | | | Sangwan Sim, Doeon Lee, Minji Noh, Soonyoung Cha, Chan Ho Soh, Ji Ho Sung, Moon-Ho Jo and Hyunyong Choi | | | The optical Stark effect is a light-matter interaction phenomenon that can be used to address and control exciton states in semiconductors. Here, the authors achieve optical tuning of the Stark effect of an individual exciton state in few-layer ReS2 with varying light polarization. | | | 18 November 2016 | doi: 10.1038/ncomms13569 | | |
| Silica deposits on Mars with features resembling hot spring biosignatures at El Tatio in Chile OPEN | | | Steven W. Ruff and Jack D. Farmer | | | Hydrothermal deposits on Mars may provide the best opportunity to find Martian biosignatures. Ruff and Farmer report that silica structures created by biotic and abiotic process in hot springs at El Tatio, Chile resemble those found in Gusev crater, thus making it an ideal location for future missions. | | | 17 November 2016 | doi: 10.1038/ncomms13554 | | |
| Field warming experiments shed light on the wheat yield response to temperature in China OPEN | | | Chuang Zhao, Shilong Piao, Yao Huang, Xuhui Wang, Philippe Ciais, Mengtian Huang, Zhenzhong Zeng and Shushi Peng | | | The degree to which wheat yield in China will respond to future warming remains uncertain. These authors compile data from warming experiments and process-based statistical models and show that warming increases yield only in regions where growing season mean temperature is low and water supply is not limiting. | | | 17 November 2016 | doi: 10.1038/ncomms13530 | | |
| CUG-binding protein 1 regulates HSC activation and liver fibrogenesis OPEN | | | Xingxin Wu, Xudong Wu, Yuxiang Ma, Fenli Shao, Yang Tan, Tao Tan, Liyun Gu, Yang Zhou, Beicheng Sun, Yang Sun, Xuefeng Wu and Qiang Xu | | | Activation of hepatic stellate cells is a critical event in the development of fibrosis, which is driven by TGF-beta and inhibited by IFN-gamma. Here Wu et al. show that the RNA binding protein CUGBP1 is increased by TGF-beta signalling and promotes IFN-gamma mRNA degradation. | | | 17 November 2016 | doi: 10.1038/ncomms13498 | | |
| Cl-out is a novel cooperative optogenetic tool for extruding chloride from neurons OPEN | | | Hannah Alfonsa, Jeremy H. Lakey, Robert N. Lightowlers and Andrew J. Trevelyan | | | Chloride regulation is important for setting GABAergic reversal potential, though tools to manipulate chloride levels are limited. Here, the authors combine Archaerhodopsin with a chloride channel opsin to generate an optogenetic chloride extrusion strategy, ‘Cl-out’, which they demonstrate in hippocampal slices. | | | 17 November 2016 | doi: 10.1038/ncomms13495 | | |
| Formation of bacterial pilus-like nanofibres by designed minimalistic self-assembling peptides OPEN | | | Tom Guterman, Micha Kornreich, Avigail Stern, Lihi Adler-Abramovich, Danny Porath, Roy Beck, Linda J. W. Shimon and Ehud Gazit | | | The application of nanofibres formed from monomers of bacterial type IV pili in vitro has proven to be complex. Here, the authors have overcome this limitation by using a reductionist approach to design a self-assembling pilin-based 20-mer peptide capable of forming a supramolecular beta sheet. | | | 17 November 2016 | doi: 10.1038/ncomms13482 | | |
| The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes OPEN | | | Tania Quesada-López, Rubén Cereijo, Jean-Valery Turatsinze, Anna Planavila, Montserrat Cairó, Aleix Gavaldà-Navarro, Marion Peyrou, Ricardo Moure, Roser Iglesias, Marta Giralt, Decio L. Eizirik and Francesc Villarroya | | | GPR120 is a G-protein-coupled receptor that binds polyunsaturated fatty acids. Here, the authors show that GPR120 is upregulated in brown fat in cold-exposed mice, and mediates thermogenic activation of brown fat via a mechanism that, at least in part, depends on the release of the adipokine FGF21. | | | 17 November 2016 | doi: 10.1038/ncomms13479 | | |
| Dendritic cell-elicited B-cell activation fosters immune privilege via IL-10 signals in hepatocellular carcinoma OPEN | | | Fang-Zhu Ouyang, Rui-Qi Wu, Yuan Wei, Rui-Xian Liu, Dong Yang, Xiao Xiao, Limin Zheng, Bo Li, Xiang-Ming Lao and Dong-Ming Kuang | | | Activation and biological function of B cells in cancer are still unclear. Here, the authors show that hepatocarcinoma cells drive the formation of semimature dendritic cells that in turn activate FcγRIIlow/− tumour B cells through the CD95L/CD95 axis, leading to the production of IL-10 and suppression of CD8 T cells. | | | 17 November 2016 | doi: 10.1038/ncomms13453 | | |
| A hyperaccumulation pathway to three-dimensional hierarchical porous nanocomposites for highly robust high-power electrodes OPEN | | | Jian Zhu, Yu Shan, Tao Wang, Hongtao Sun, Zipeng Zhao, Lin Mei, Zheng Fan, Zhi Xu, Imran Shakir, Yu Huang, Bingan Lu and Xiangfeng Duan | | | Hyperaccumulation can allow facile enrichment of metal ions in halophytic plants. Here, the authors use the effect to convert plant structures into hierarchical carbon/metal-oxide nanocomposites and demonstrate the structures as battery electrodes combining high power density and excellent cycling stability. | | | 17 November 2016 | doi: 10.1038/ncomms13432 | | |
| A natural light-driven inward proton pump OPEN | | | Keiichi Inoue, Shota Ito, Yoshitaka Kato, Yurika Nomura, Mikihiro Shibata, Takayuki Uchihashi, Satoshi P. Tsunoda and Hideki Kandori | | | Proton pumps that are driven by light to pump protons out of the cell are involved in the conversion of sunlight into proton motive force; pumps to drive protons in the other direction have been engineered. Here, the authors report the identification and characterisation of a naturally occurring inward-driven protein pump. | | | 17 November 2016 | doi: 10.1038/ncomms13415 | | |
| Near-infrared uncaging or photosensitizing dictated by oxygen tension OPEN | | | Erin D. Anderson, Alexander P. Gorka and Martin J. Schnermann | | | The generation of reactive oxygen species (ROS) in photodynamic cancer treatments is limited by low intraturmoural oxygen availability. Here the authors show that irradiation of a silicon phthalocyanine leads to uncaging of a biologically active molecule or to ROS formation in an oxygen-dependent manner. | | | 17 November 2016 | doi: 10.1038/ncomms13378 | | |
| Salinity tolerance loci revealed in rice using high-throughput non-invasive phenotyping OPEN | | | Nadia Al-Tamimi, Chris Brien, Helena Oakey, Bettina Berger, Stephanie Saade, Yung Shwen Ho, Sandra M. Schmöckel, Mark Tester and Sónia Negrão | | | Image-based plant phenotyping can be used to collect data with high temporal and spatial resolution. Here, the authors develop a computationally efficient method using smoothing splines and a new marker-by-trait association model to identify loci in a diverse rice population associated with early response to salinity. | | | 17 November 2016 | doi: 10.1038/ncomms13342 | | |
| Universal domain wall dynamics under electric field in Ta/CoFeB/MgO devices with perpendicular anisotropy OPEN | | | Weiwei Lin, Nicolas Vernier, Guillaume Agnus, Karin Garcia, Berthold Ocker, Weisheng Zhao, Eric E. Fullerton and Dafiné Ravelosona | | | Domain walls in ferromagnetic–oxide structures can be moved using an electric field, which could be useful for low-power electronic devices. Here, the authors demonstrate the modulation of the velocity of these domain walls between a creep and a flow regime. | | | 16 November 2016 | doi: 10.1038/ncomms13532 | | |
| Jahn-Teller-induced femtosecond electronic depolarization dynamics of the nitrogen-vacancy defect in diamond OPEN | | | Ronald Ulbricht, Shuo Dong, I-Ya Chang, Bala Murali Krishna Mariserla, Keshav M. Dani, Kim Hyeon-Deuk and Zhi-Heng Loh | | | Understanding ultrafast dynamics of excited states of nitrogen-vacancy helps its manipulation for technological applications. Here the authors use polarization anisotropy spectroscopy and molecular dynamics to investigate sub-picosecond dephasing dynamics, identifying the origin of orbital averaging effects. | | | 16 November 2016 | doi: 10.1038/ncomms13510 | | |
| Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors OPEN | | | Devid Damiani, André M. Goffinet, Arthur Alberts and Fadel Tissir | | | Molecular mechanisms that control the division of neural progenitor cells are only partially understood. Here the authors show that Diaph3 is critical for spindle checkpoint activity in cortical progenitor cells as the loss of Diaph3 leads to apoptosis of progenitor cells and eventually results in microcephaly in mice. | | | 16 November 2016 | doi: 10.1038/ncomms13509 | | |
| Magnetofermionic condensate in two dimensions OPEN | | | L. V. Kulik, A. S. Zhuravlev, S. Dickmann, A. V. Gorbunov, V. B. Timofeev, I. V. Kukushkin and S. Schmult | | | The motion of particles in a quantum condensate state are described by a single macroscopic wave function, leading to a host of unusual properties. Here, the authors generate such a condensation of magnetically induced excitons, known as cyclotron magnetoexcitons, in a high-mobility quantum well. | | | 16 November 2016 | doi: 10.1038/ncomms13499 | | |
| Epigenetic and genetic components of height regulation OPEN | | | Stefania Benonisdottir, Asmundur Oddsson, Agnar Helgason, Ragnar P. Kristjansson, Gardar Sveinbjornsson, Arna Oskarsdottir, Gudmar Thorleifsson, Olafur B. Davidsson, Gudny A. Arnadottir, Gerald Sulem, Brynjar O. Jensson, Hilma Holm, Kristjan F. Alexandersson, Laufey Tryggvadottir, G. Bragi Walters, Sigurjon A. Gudjonsson, Lucas D. Ward, Jon K. Sigurdsson, Paul D. Iordache, Michael L. Frigge et al. | | | Adult height has a strong genetic component and is highly heritable. Here the authors whole-genome sequence 8,453 Icelanders and find novel parent-of-origin derived associations in IGF2-H19 and DLK1-MEG3. | | | 16 November 2016 | doi: 10.1038/ncomms13490 | | |
| Polarization curling and flux closures in multiferroic tunnel junctions OPEN | | | Jonathan J. P. Peters, Geanina Apachitei, Richard Beanland, Marin Alexe and Ana M. Sanchez | | | Ferroelectric vortex-type structures have only been seen in isolated films, leaving electrode effects unexplored. Here, Peters et al. show that the polarisation curling and formation of vortex and flux-closure structures is a generic effect appearing in ultrathin ferroelectric films. | | | 16 November 2016 | doi: 10.1038/ncomms13484 | | |
| Contributions of distinct gold species to catalytic reactivity for carbon monoxide oxidation OPEN | | | Li-Wen Guo, Pei-Pei Du, Xin-Pu Fu, Chao Ma, Jie Zeng, Rui Si, Yu-Ying Huang, Chun-Jiang Jia, Ya-Wen Zhang and Chun-Hua Yan | | | Nanoscale supported gold clusters are common redox catalysts but in many cases the nature of the active sites remains unclear. Here, the authors use X-ray absorption to determine the contribution of single gold atoms, clusters and particles on the reactivity of room-temperature carbon monoxide oxidation. | | | 16 November 2016 | doi: 10.1038/ncomms13481 | | |
| Dendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells OPEN | | | Federico Brandalise, Stefano Carta, Fritjof Helmchen, John Lisman and Urs Gerber | | | Back-propagating action potentials (bAP) and NMDA dendritic spikes have both been linked to long-term plasticity (LTP) induction, though it is unclear which factors are essential. Here, using electrophysiology and Ca2+ imaging, the authors find NMDA spikes are a key initiator of LTP, and that bAP contribution occurs via NMDA spike triggering. | | | 16 November 2016 | doi: 10.1038/ncomms13480 | | |
| Wafer-sized multifunctional polyimine-based two-dimensional conjugated polymers with high mechanical stiffness OPEN | | | Hafeesudeen Sahabudeen, Haoyuan Qi, Bernhard Alexander Glatz, Diana Tranca, Renhao Dong, Yang Hou, Tao Zhang, Christian Kuttner, Tibor Lehnert, Gotthard Seifert, Ute Kaiser, Andreas Fery, Zhikun Zheng and Xinliang Feng | | | Forming 2D polymers in a controlled manner on the atomic and molecular level is difficult. Here, Feng and others have used Schiff-base polycondensation reactions at an air-water or liquid-liquid interface to form porphyrin containing monolayer and multilayer 2D polymers. | | | 16 November 2016 | doi: 10.1038/ncomms13461 | | |
| Direct observation of ultrafast many-body electron dynamics in an ultracold Rydberg gas OPEN | | | Nobuyuki Takei, Christian Sommer, Claudiu Genes, Guido Pupillo, Haruka Goto, Kuniaki Koyasu, Hisashi Chiba, Matthias Weidemüller and Kenji Ohmori | | | Studying long-range interactions in the controlled environment of trapped ultracold gases can help our understanding of fundamental many-body physics. Here the authors excite a gas of Rydberg atoms with a ps laser pulse, demonstrating behaviour consistent with many-body correlations beyond mean-field. | | | 16 November 2016 | doi: 10.1038/ncomms13449 | | |
| Deconvoluting complex structural histories archived in brittle fault zones OPEN | | | G. Viola, T. Scheiber, O. Fredin, H. Zwingmann, A. Margreth and J. Knies | | | Understanding when brittle rock faulting took place can help unravel the history of deformation in the Earth’s crust. The authors here develop a new approach to date faults using a combination of K-Ar isotopic dating of illite and structural analysis to provide high resolution dates of the faults. | | | 16 November 2016 | doi: 10.1038/ncomms13448 | | |
| Mechanical gating of a mechanochemical reaction cascade OPEN | | | Junpeng Wang, Tatiana B. Kouznetsova, Roman Boulatov and Stephen L. Craig | | | Polymer mechanochemistry offers opportunities to control and engineer desired chemical transformations. Here, Craig and co-workers present a mechanical gating system whereby one mechanophore modulates the reactivity of another, resulting in a mechanochemical cascade reaction. | | | 16 November 2016 | doi: 10.1038/ncomms13433 | | |
| In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development OPEN | | | Ivan V. Ozerov, Ksenia V. Lezhnina, Evgeny Izumchenko, Artem V. Artemov, Sergey Medintsev, Quentin Vanhaelen, Alexander Aliper, Jan Vijg, Andreyan N. Osipov, Ivan Labat, Michael D. West, Anton Buzdin, Charles R. Cantor, Yuri Nikolsky, Nikolay Borisov, Irina Irincheeva, Edward Khokhlovich, David Sidransky, Miguel Luiz Camargo and Alex Zhavoronkov et al. | | | Pathway analysis aids interpretation of large-scale gene expression data, but existing algorithms fall short of providing robust pathway identification. The method introduced here includes coexpression analysis and gene importance estimation to robustly identify relevant pathways and biomarkers for patient stratification. | | | 16 November 2016 | doi: 10.1038/ncomms13427 | | |
| 17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells OPEN | | | Benjamin Joachim Schmiedel, Grégory Seumois, Daniela Samaniego-Castruita, Justin Cayford, Veronique Schulten, Lukas Chavez, Ferhat Ay, Alessandro Sette, Bjoern Peters and Pandurangan Vijayanand | | | Variations in the 17q21 locus are linked to asthma susceptibility and other autoimmune diseases. Here, the authors perform cell type-specific functional genomic analyses of asthma-risk SNPs, and show a genotype specific mechanism of differential gene regulation relevant to immune function. | | | 16 November 2016 | doi: 10.1038/ncomms13426 | | |
| Sulfheme formation during homocysteine S-oxygenation by catalase in cancers and neurodegenerative diseases OPEN | | | Dominique Padovani, Assia Hessani, Francine T. Castillo, Géraldine Liot, Mireille Andriamihaja, Annaïg Lan, Camilla Pilati, François Blachier, Suvajit Sen, Erwan Galardon and Isabelle Artaud | | | High levels of homocysteine in cells are linked to pathological states. Here, the authors report that homocysteine inactivates catalase by modifying the heme group, impairing cellular redox homeostasis, and show that this modification occurs in cancer cells and in a cellular model of Parkinson’s disease. | | | 16 November 2016 | doi: 10.1038/ncomms13386 | | |
| Carbene footprinting accurately maps binding sites in protein–ligand and protein–protein interactions OPEN | | | Lucio Manzi, Andrew S. Barrow, Daniel Scott, Robert Layfield, Timothy G. Wright, John E. Moses and Neil J. Oldham | | | Mapping protein-ligand interactions is fundamental to advance the understanding of cellular processes and to develop drug discovery strategies. Here, the authors present a photo-activated probe that allows highly efficient labelling and identification of protein binding sites using mass spectrometry. | | | 16 November 2016 | doi: 10.1038/ncomms13288 | | |
| Genome editing in maize directed by CRISPR–Cas9 ribonucleoprotein complexes OPEN | | | Sergei Svitashev, Christine Schwartz, Brian Lenderts, Joshua K. Young and A. Mark Cigan | | | Genome editing in plants typically requires the expression of Cas9 and guide RNA from stably transformed plasmid DNA. Here, the authors show that successful editing can be achieved after delivery of the Cas9-guide RNA complex as a ribonucleoprotein to maize embryos via biolistics. | | | 16 November 2016 | doi: 10.1038/ncomms13274 | | |
| Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model OPEN | | | Elisa Romanelli, Doron Merkler, Aleksandra Mezydlo, Marie-Theres Weil, Martin S. Weber, Ivana Nikić, Stephanie Potz, Edgar Meinl, Florian E. H. Matznick, Mario Kreutzfeldt, Alexander Ghanem, Karl-Klaus Conzelmann, Imke Metz, Wolfgang Brück, Matthew Routh, Mikael Simons, Derron Bishop, Thomas Misgeld and Martin Kerschensteiner | | | Oligodendrocyte damage is a key component of demyelinating diseases. Here, the authors use in vivo light and correlated electron microscopy in EAE mouse models, and find early damage occurs at the myelin sheath before spreading to the oligodendrocyte cell body. | | | 16 November 2016 | doi: 10.1038/ncomms13275 | | |
| Fast ensemble representations for abstract visual impressions OPEN | | | Allison Yamanashi Leib, Anna Kosovicheva and David Whitney | | | Perceiving objects as lifelike is an inferential process but whether it occurs quickly and how it applies to groups of objects is not well understood. Here the authors show that observers’ percepts of crowd lifelikeness are fast and represent the average of the individual objects comprising that crowd. | | | 16 November 2016 | doi: 10.1038/ncomms13186 | | | | | | | | | | | | | | |
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