Nature Reviews Microbiology contents November 2016 Volume 14 Number 11 pp 663-723

Advertisement
nature.com webcasts Springer Nature presents a custom webcast on: Optimizing sensitivity and specificity in the RT-QuIC assay using BMG plate readers Date: Wednesday October 19, 2016 Time: 8AM PDT, 11AM EDT, 4PM BST, 5PM CEST  Register for FREE at   And learn how the RT-QuIC assay is currently being used as a diagnostic in the clinical setting for CJD and has the potential to be a valuable screening tool. Sponsored by: BMG LABTECH
TABLE OF CONTENTS
November 2016 Volume 14 Number 11
2015 2-year Impact Factor 24.727 Journal Metrics 2-year Median 19.5	In this issue Research Highlights Progress Reviews Perspectives Also this month Article series: Vector-borne diseases  Featured article: Zika virus — reigniting the TORCH Carolyn B. Coyne & Helen M. Lazear
Subscribe   Facebook   RSS   Recommend to library   Twitter
RESEARCH HIGHLIGHTS Top Virus Infection: HIV-1 weighs up risks and benefits p663 | doi:10.1038/nrmicro.2016.148 This study investigated the role of IFITM proteins in the restriction of HIV-1 strains that have different receptor tropism and identified IFITM proteins as major effectors of the innate immune response. PDF Archaeal biology: Archaeal virus escapology p664 | doi:10.1038/nrmicro.2016.147 Visualization of the morphogenesis and egress of a prototypical archaeal virus reveals some key similarities with eukaryotic viruses. PDF Bacterial physiology: A new chaperone for regulatory sRNAs p664 | doi:10.1038/nrmicro.2016.150 ProQ is revealed to be a global post-transcriptional regulator that stabilizes structured RNAs. PDF Bacterial secretion: Reusing injected proteins p666 | doi:10.1038/nrmicro.2016.143 This study shows that T6SS components that are transferred between cells can be reused to assemble a fucntional T6SS system in the recipient. PDF Bacterial toxins: TcdB aims for Frizzled p666 | doi:10.1038/nrmicro.2016.152 This study reveals that TcdB binds to two different receptors, CSPG4 and FZD, in a cell type-dependent manner. PDF IN BRIEF Marine microbiology: UCYN-A fixes N2 in the sea | Structural biology: Zooming in on F pili | Antimicrobials: Hitting malaria on several levels | Antimicrobials: Pump it out | Bacterial pathogenesis: Spirochete spreading | Archaeal genomics: Divergent methanogenic archaea PDF
PROGRESS		Top
Article series: Vector-borne diseases Sending a message: extracellular vesicles of pathogenic protozoan parasites Anthony J. Szempruch, Lauren Dennison, Rudo Kieft, John M. Harrington & Stephen L. Hajduk p669 | doi:10.1038/nrmicro.2016.110 Protozoan parasites produce extracellular vesicles to communicate with the host and within the parasite population. In this Progress article, Hajduk and colleagues review the production and effects of extracellular vesicles from parasites, including Plasmodium spp., Trichomonas vaginalis and kinetoplastids. Abstract | Full Text | PDF
Advertisement
Nature Insight: The Protein World This Insight highlights four exciting topics in contemporary protein science: de novo designed proteins; how cells monitor and regulate the proteome; the rise of cryo-electron microscopy; and proteome analysis through high-resolution mass spectrometry.
REVIEWS		Top
ESX secretion systems: mycobacterial evolution to counter host immunity Matthias I. Gröschel, Fadel Sayes, Roxane Simeone, Laleh Majlessi & Roland Brosch p677 | doi:10.1038/nrmicro.2016.131 Mycobacteria use ESX systems to secrete substrates across their cell envelopes. In this Review, Brosch and colleagues describe the roles of ESX systems in host-pathogen interactions and consider how studies of ESX systems might inform vaccine design and therapy development. Abstract | Full Text | PDF
Harnessing the power of microbial autotrophy Nico J. Claassens, Diana Z. Sousa, Vitor A. P. Martins dos Santos, Willem M. de Vos & John van der Oost p692 | doi:10.1038/nrmicro.2016.130 In this Review, Claassens et al. discuss recent advances in microbial autotrophic production platforms, in particular the genetic engineering of autotrophic systems in autotrophic microorganisms, the transplantation of partial or complete CO2 fixation pathways and autotrophic energy-harvesting systems into heterotrophs, and the large potential of hybrid systems as autotrophic production platforms. They also explore strategies for the design, quantitative analysis and modular experimental implementation of autotrophic cell factories. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
OPINION Article series: Vector-borne diseases Zika virus — reigniting the TORCH Carolyn B. Coyne & Helen M. Lazear p707 | doi:10.1038/nrmicro.2016.125 The placenta forms the foremost barrier that protects the developing fetus during pregnancy in eutherian organisms. However, diverse pathogens such as Toxoplasma gondii, rubella virus and cytomegalovirus can breach this barrier. In this Opinion article, Coyne and Lazear review mechanisms of vertical transmission, with a focus on the current Zika virus epidemic. Abstract | Full Text | PDF
OPINION Division of labour in microorganisms: an evolutionary perspective Stuart A. West & Guy A. Cooper p716 | doi:10.1038/nrmicro.2016.111 The division of labour is an important strategy in microbial species. In this Perspective, Cooper and West propose a set of conditions that define division of labour, describe recent examples according to these conditions and discuss how clarifying what constitutes division of labour highlights key evolutionary questions. Abstract | Full Text | PDF | Supplementary information
Advertisement
nature.com webcasts Join us for our upcoming webcast with live Q&A:  INNOVATING FOR OPHTHALMIC DISEASES Presented by BioPharma Dealmakers Date: Thursday, October 20, 2016 Time: 7am PDT / 10am EDT / 3pm BST / 4pm CEST  REGISTER FOR FREE   Sponsored by: HEALIOS K.K. | Apellis | Mannin Research
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our feedback department Nature Publishing Group | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW. © 2016 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.