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An open access, online-only journal providing researchers, policy makers and the public with the latest research on weather and climate, publishing high-quality papers that focus on topics including climate dynamics, climate variability, weather and climate prediction, climate change, weather extremes, atmospheric composition including aerosols, the hydrological cycle and atmosphere-ocean interactions.
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As of January 2016, the journal only publishes open access content, and legacy subscription content published in Nature Communications prior to 2016 has been made freely accessible. For more information visit our website.
Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | | | Latest Articles | View all Articles | | | | | Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors OPEN | | | Andrea M. Zuhl, Charles E. Nolan, Michael A. Brodney, Sherry Niessen, Kevin Atchison, Christopher Houle, David A. Karanian, Claude Ambroise, Jeffrey W. Brulet, Elizabeth M. Beck, Shawn D. Doran, Brian T. O’Neill, Christopher W. am Ende, Cheng Chang, Kieran F. Geoghegan, Graham M. West, Joshua C. Judkins, Xinjun Hou, David R. Riddell and Douglas S. Johnson et al. | | | Several β-secretase (BACE) inhibitors exhibit unexplained ocular toxicity in preclinical studies. Here the authors generate a clickable photoaffinity probe to interrogate off-targets in cells and animals, and identify inhibition of cathepsin D as a driver of ocular toxicity. | | | 11 October 2016 | doi: 10.1038/ncomms13042 | | |
| Eukaryotic association module in phage WO genomes from Wolbachia OPEN | | | Sarah R. Bordenstein and Seth R. Bordenstein | | | Viruses commonly exchange genetic material with their hosts, but not with species from other domains of life. Here, the authors find that the bacteriophage WO of Wolbachia contains eukaryotic-like genes, implicating lateral genetic transfer between eukaryotes and viruses infecting bacteria. | | | 11 October 2016 | doi: 10.1038/ncomms13155 | | |
| Circumpolar distribution and carbon storage of thermokarst landscapes OPEN | | | D. Olefeldt, S. Goswami, G. Grosse, D. Hayes, G. Hugelius, P. Kuhry, A. D. McGuire, V. E. Romanovsky, A.B.K. Sannel, E.A.G. Schuur and M. R. Turetsky | | | In thermokarst landscapes, permafrost thaw causes land subsidence with impacts on hydrology, ecology and biogeochemistry. Here, Olefeldt et al. produce circumpolar maps of thermokarst distribution, identifying that they cover 20% of the northern permafrost region, but store half the below-ground organic carbon. | | | 11 October 2016 | doi: 10.1038/ncomms13043 | | |
| NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells OPEN | | | Joanna Ratajczak, Magali Joffraud, Samuel A. J. Trammell, Rosa Ras, Núria Canela, Marie Boutant, Sameer S. Kulkarni, Marcelo Rodrigues, Philip Redpath, Marie E. Migaud, Johan Auwerx, Oscar Yanes, Charles Brenner and Carles Cantó | | | Raising cellular levels of the metabolic cofactor NAD+ reverses key indicators of aging. Here, Ratajczak et al. show that cellular levels of NAD+ depend on the extracellular catalytic activity of NRK1, which processes two NAD+ precursors, nicotinamide mononucleotide and nicotinamide riboside, in mice. | | | 11 October 2016 | doi: 10.1038/ncomms13103 | | |
| Increased global transcription activity as a mechanism of replication stress in cancer OPEN | | | Panagiotis Kotsantis, Lara Marques Silva, Sarah Irmscher, Rebecca M. Jones, Lisa Folkes, Natalia Gromak and Eva Petermann | | | Cancer cells proliferate at high rates and incur replication stress. Here, the authors show that this can be the consequence of oncogene-induced higher transcriptional activity, which, through increased RNA synthesis and R-loop accumulation, results in replication fork slowing and DNA damage. | | | 11 October 2016 | doi: 10.1038/ncomms13087 | | |
| Giant piezoelectric voltage coefficient in grain-oriented modified PbTiO3 material OPEN | | | Yongke Yan, Jie E. Zhou, Deepam Maurya, Yu U. Wang and Shashank Priya | | | High piezoelectric voltage coefficients drive the sensitivity of piezoelectric sensors. Here, the authors synthesized textured Sm- and Mn-doped PbTiO3 ceramics and demonstrate significant enhancement in voltage coefficient. | | | 11 October 2016 | doi: 10.1038/ncomms13089 | | |
| Imaging and controlling plasmonic interference fields at buried interfaces OPEN | | | Tom T. A. Lummen, Raymond J. Lamb, Gabriele Berruto, Thomas LaGrange, Luca Dal Negro, F. Javier García de Abajo, Damien McGrouther, B. Barwick and F. Carbone | | | Visualizing surface plasmon polaritons at buried interfaces has remained elusive. Here, the authors develop a methodology to study the spatiotemporal evolution of buried near-fields within complex heterostructures, enabling the characterization of the next generation of plasmonic devices. | | | 11 October 2016 | doi: 10.1038/ncomms13156 | | |
| Gate-tunable negative longitudinal magnetoresistance in the predicted type-II Weyl semimetal WTe2 OPEN | | | Yaojia Wang, Erfu Liu, Huimei Liu, Yiming Pan, Longqiang Zhang, Junwen Zeng, Yajun Fu, Miao Wang, Kang Xu, Zhong Huang, Zhenlin Wang, Hai-Zhou Lu, Dingyu Xing, Baigeng Wang, Xiangang Wan and Feng Miao | | | Controllable electric transport of topological particles in solid state systems hold the key towards novel electronic applications. Here, Wang et al. demonstrate gate-tunable negative longitudinal magnetoresistance in WTe2, featuring controllable transport of Type-II Weyl fermions. | | | 11 October 2016 | doi: 10.1038/ncomms13142 | | |
| Fabrication of fibrillosomes from droplets stabilized by protein nanofibrils at all-aqueous interfaces OPEN | | | Yang Song, Ulyana Shimanovich, Thomas C. T. Michaels, Qingming Ma, Jingmei Li, Tuomas P. J. Knowles and Ho Cheung Shum | | | All-aqueous emulsions are useful for delivering and processing biomolecules, but their stability is constrained by low interfacial adsorption energy. Song et al. solve this problem using protein nanofibrils that form a crosslinked network, whose stability is superior to conventional colloidal capsules. | | | 11 October 2016 | doi: 10.1038/ncomms12934 | | |
| Salicylic acid receptors activate jasmonic acid signalling through a non-canonical pathway to promote effector-triggered immunity OPEN | | | Lijing Liu, Fathi-Mohamed Sonbol, Bethany Huot, Yangnan Gu, John Withers, Musoki Mwimba, Jian Yao, Sheng Yang He and Xinnian Dong | | | Salicylic acid (SA) and jasmonic acid (JA) often act antagonistically in plant defence. Here, Liu et al. show that during effector-triggered immunity (ETI) against Pseudomonas syringae, JA signalling is activated via a non-canonical pathway involving the SA receptors, NPR3 and NPR4, to positively regulate ETI. | | | 11 October 2016 | doi: 10.1038/ncomms13099 | | |
| The solution structure of an anti-CRISPR protein OPEN | | | Karen L. Maxwell, Bianca Garcia, Joseph Bondy-Denomy, Diane Bona, Yurima Hidalgo-Reyes and Alan R. Davidson | | | Recently, anti-CRISPR proteins have been identified. Here, the authors report the solution structure of one of these proteins, and use mutational analysis to provide some insight into its function. | | | 11 October 2016 | doi: 10.1038/ncomms13134 | | |
| Human acid sphingomyelinase structures provide insight to molecular basis of Niemann–Pick disease OPEN | | | Yan-Feng Zhou, Matthew C. Metcalf, Scott C. Garman, Tim Edmunds, Huawei Qiu and Ronnie R. Wei | | | Genetic alterations in the protein acid sphingomyelinase (ASM) lead to ASM deficiency and have been associated with Niemann–Pick disease. Here, the authors report the crystal structures of ASM alone and bound to its product, and discuss the catalytic mechanism and its possible significance for patients with ASM deficiency. | | | 11 October 2016 | doi: 10.1038/ncomms13082 | | |
| Spin–torque generator engineered by natural oxidation of Cu OPEN | | | Hongyu An, Yuito Kageyama, Yusuke Kanno, Nagisa Enishi and Kazuya Ando | | | In thin film spintronic devices, heavy metals with strong spin-orbit coupling are required to achieve a sizeable spin Hall effect. Here, the authors demonstrate an enhancement of the spin Hall effect in Cu, a material with weak spin-orbit coupling, via natural oxidation. | | | 11 October 2016 | doi: 10.1038/ncomms13069 | | |
| Colossal magnetic phase transition asymmetry in mesoscale FeRh stripes OPEN | | | V. Uhlíř, J. A. Arregi and E. E. Fullerton | | | FeRh possesses a unique hysteretic metamagnetic phase transition between antiferromagnetic and ferromagnetic order close to room temperature. Here, the authors demonstrate a strong enhancement of the asymmetry of this transition in mesoscale stripes of FeRh. | | | 11 October 2016 | doi: 10.1038/ncomms13113 | | |
| Theory of highly efficient multiexciton generation in type-II nanorods OPEN | | | Hagai Eshet, Roi Baer, Daniel Neuhauser and Eran Rabani | | | Multiple exciton generation could help limit thermalization losses in solar cells, but the efficiency of the process is still limited. Here, the authors show by atomistic calculations that type-II interfaces in nanostructures along with a change in exciton cooling rate favour multiple exciton generation. | | | 11 October 2016 | doi: 10.1038/ncomms13178 | | |
| A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome OPEN | | | Rasika Ann Mathias, Margaret A. Taub, Christopher R. Gignoux, Wenqing Fu, Shaila Musharoff, Timothy D. O'Connor, Candelaria Vergara, Dara G. Torgerson, Maria Pino-Yanes, Suyash S. Shringarpure, Lili Huang, Nicholas Rafaels, Meher Preethi Boorgula, Henry Richard Johnston, Victor E. Ortega, Albert M. Levin, Wei Song, Raul Torres, Badri Padhukasahasram, Celeste Eng et al. | | | The Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) aims to better understand population genetics of the African diaspora. Here, it uses deeply sequenced whole-genomes to describe the impact of admixture and potential disease burden of deleterious variants. | | | 11 October 2016 | doi: 10.1038/ncomms12522 | | |
| Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers OPEN | | | Roni Allaoui, Caroline Bergenfelz, Sofie Mohlin, Catharina Hagerling, Kiarash Salari, Zena Werb, Robin L. Anderson, Stephen P. Ethier, Karin Jirström, Sven Påhlman, Daniel Bexell, Balázs Tahin, Martin E. Johansson, Christer Larsson and Karin Leandersson | | | A reactive tumour stroma is associated with poor prognosis. Here, the authors show that in patients with triple negative breast cancer resident monocytes activate cancer-associated fibroblasts and induce production of CXCL16, which acts as a monocyte chemoattractant, resulting in an amplificatory feedback loop. | | | 11 October 2016 | doi: 10.1038/ncomms13050 | | |
| Tiam1/Rac1 complex controls Il17a transcription and autoimmunity OPEN | | | Ahmed T. Kurdi, Ribal Bassil, Marta Olah, Chuan Wu, Sheng Xiao, Mariko Taga, Michael Frangieh, Thomas Buttrick, William Orent, Elizabeth M. Bradshaw, Samia J. Khoury and Wassim Elyaman | | | Tiam1 is a guanine nucleotide exchange factor for the Rho-family GTPase Rac1. Here, the authors show that nuclear Tiam1 and Rac1 bind to RORγt on the IL-17 promoter, activating its transcription, and that inhibiting Tiam1/Rac1 is beneficial in a mouse model of autoimmunity. | | | 11 October 2016 | doi: 10.1038/ncomms13048 | | |
| Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry OPEN | | | Michael D. Kessler, Laura Yerges-Armstrong, Margaret A. Taub, Amol C. Shetty, Kristin Maloney, Linda Jo Bone Jeng, Ingo Ruczinski, Albert M. Levin, L. Keoki Williams, Terri H. Beaty, Rasika A. Mathias, Kathleen C. Barnes, Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA), Meher Preethi Boorgula, Monica Campbell, Sameer Chavan, Jean G. Ford, Cassandra Foster, Li Gao, Nadia N. Hansel et al. | | | Personalized medicine requires accurate and ethnicity-optimized reference genome panels. Here, the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) evaluates typical variant filters and existing genome databases against newly sequenced African-ancestry populations. | | | 11 October 2016 | doi: 10.1038/ncomms12521 | | |
| Nop9 is a PUF-like protein that prevents premature cleavage to correctly process pre-18S rRNA OPEN | | | Jun Zhang, Kathleen L. McCann, Chen Qiu, Lauren E. Gonzalez, Susan J. Baserga and Traci M. Tanaka Hall | | | Nop9 is a conserved small ribosomal subunit biogenesis factor. Here, Zhang et al. show that Nop9, in complex with RNA, adopts a C-shaped fold formed from 11 Pumillo repeats and propose that Nop9 inhibits premature cleavage of 20S pre-rRNA by inhibiting the Nob1 nuclease. | | | 11 October 2016 | doi: 10.1038/ncomms13085 | | |
| A quantum spin-probe molecular microscope OPEN | | | V. S. Perunicic, C. D. Hill, L. T. Hall and L.C.L. Hollenberg | | | Single spin defects can allow high-resolution sensing of molecules under an applied magnetic field. Here, the authors propose a protocol for three-dimensional magnetic resonance imaging with angstrom-level resolution exploiting the dipolar field of a spin qubit, such as a diamond nitrogen-vacancy. | | | 11 October 2016 | doi: 10.1038/ncomms12667 | | |
| Land-use choices follow profitability at the expense of ecological functions in Indonesian smallholder landscapes OPEN | | | Yann Clough, Vijesh V. Krishna, Marife D. Corre, Kevin Darras, Lisa H. Denmead, Ana Meijide, Stefan Moser, Oliver Musshoff, Stefanie Steinebach, Edzo Veldkamp, Kara Allen, Andrew D. Barnes, Natalie Breidenbach, Ulrich Brose, Damayanti Buchori, Rolf Daniel, Reiner Finkeldey, Idham Harahap, Dietrich Hertel, A. Mareike Holtkamp et al. | | | Small-scale farmers in Southeast Asia are increasingly turning to monocultures of oil palm and rubber to maximize income. Clough and colleagues demonstrate that this land-use change in Indonesia comes at a cost to a wide array of ecosystem functions and biodiversity. | | | 11 October 2016 | doi: 10.1038/ncomms13137 | | |
| Ground-state oxygen holes and the metal–insulator transition in the negative charge-transfer rare-earth nickelates OPEN | | | Valentina Bisogni, Sara Catalano, Robert J. Green, Marta Gibert, Raoul Scherwitzl, Yaobo Huang, Vladimir N. Strocov, Pavlo Zubko, Shadi Balandeh, Jean-Marc Triscone, George Sawatzky and Thorsten Schmitt | | | Rare-earth perovskite nickelates show intriguing metal–insulator transitions, whose mechanism remains elusive. Here, Bisogni et al. evidenced a 3d8 Ni configuration together with abundance of oxygen 2p holes in the ground state of a NdNiO3 thin film, suggesting a negative charge-transfer scenario. | | | 11 October 2016 | doi: 10.1038/ncomms13017 | | |
| Exploiting endogenous fibrocartilage stem cells to regenerate cartilage and repair joint injury OPEN | | | Mildred C. Embree, Mo Chen, Serhiy Pylawka, Danielle Kong, George M. Iwaoka, Ivo Kalajzic, Hai Yao, Chancheng Shi, Dongming Sun, Tzong-Jen Sheu, David A. Koslovsky, Alia Koch and Jeremy J. Mao | | | A potentially superior tissue regenerative strategy to stem cell transplantation is modulation of endogenous stem cells. Here the authors show fibrocartilage stem cells exist in the temporomandibular joint that contribute to cartilage regeneration and can be manipulated to enhance regeneration through canonical Wnt signalling. | | | 10 October 2016 | doi: 10.1038/ncomms13073 | | |
| Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10 OPEN | | | Lars Ellenrieder, Łukasz Opaliński, Lars Becker, Vivien Krüger, Oliver Mirus, Sebastian P. Straub, Katharina Ebell, Nadine Flinner, Sebastian B. Stiller, Bernard Guiard, Chris Meisinger, Nils Wiedemann, Enrico Schleiff, Richard Wagner, Nikolaus Pfanner and Thomas Becker | | | The protein Mdm10 is known to be present in the endoplasmic reticulum-mitochondria encounter structure (ERMES) and in mitochondrial sorting and assembly machinery (SAM). Here, the authors examine how this protein interacts with SAM and EMRES, showing that the SAM-mediated protein machinery is independent of ERMES. | | | 10 October 2016 | doi: 10.1038/ncomms13021 | | |
| All-optical materials design of chiral edge modes in transition-metal dichalcogenides OPEN | | | Martin Claassen, Chunjing Jia, Brian Moritz and Thomas P. Devereaux | | | Transition metal dichalcogenides offer a platform to study light-matter interaction in atomically thin semiconductors. Here, the authors perform ab initio calculations to illustrate the possibility of optical control of chiral edge modes, outlining a strategy to manipulate topological states. | | | 10 October 2016 | doi: 10.1038/ncomms13074 | | |
| Coordinated integrin activation by actin-dependent force during T-cell migration OPEN | | | Pontus Nordenfelt, Hunter L. Elliott and Timothy A. Springer | | | The role of force in activating integrin cell adhesion receptors is not known. Here the authors develop fluorescent tension sensors for αL and β2 integrins and show that in migrating T cells force is transduced across the β2 integrin, and that this correlates with an active conformational state. | | | 10 October 2016 | doi: 10.1038/ncomms13119 | | |
| Global and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis OPEN | | | Xiaoyue Pan, Christopher A. Bradfield and M. Mahmood Hussain | | | Bmal1 is a key transcription factor that controls rhythmicity of diverse biological functions. Here, Pan et al. show that Bmal1 deficiency in mice increases lipoprotein secretion and reduces cholesterol excretion to bile, and decipher the molecular mechanisms underlying hyperlipidaemia and atherosclerosis promoted by the lack of Bmal1. | | | 10 October 2016 | doi: 10.1038/ncomms13011 | | |
| Near-infrared exciton-polaritons in strongly coupled single-walled carbon nanotube microcavities OPEN | | | Arko Graf, Laura Tropf, Yuriy Zakharko, Jana Zaumseil and Malte C. Gather | | | The formation of exciton-polaritons in organic semiconductors by strong coupling to a cavity is a promising route towards electrically pumped organic lasers. Here, Graf et al. demonstrate strong coupling from semiconducting single-walled carbon nanotubes in the near infrared frequency range. | | | 10 October 2016 | doi: 10.1038/ncomms13078 | | |
| Nicotinamide riboside is uniquely and orally bioavailable in mice and humans OPEN | | | Samuel A. J. Trammell, Mark S. Schmidt, Benjamin J. Weidemann, Philip Redpath, Frank Jaksch, Ryan W. Dellinger, Zhonggang Li, E. Dale Abel, Marie E. Migaud and Charles Brenner | | | NAD+ is an important coenzyme that mediates cellular metabolism and defends against stresses due to age and overnutrition. Here the authors demonstrate unique bioavailability of the NAD+ precursor vitamin nicotinamide riboside (NR) in mice and humans, and show that NR safely elevates human NAD+. | | | 10 October 2016 | doi: 10.1038/ncomms12948 | | |
| Quantum spin transistor with a Heisenberg spin chain OPEN | | | O. V. Marchukov, A. G. Volosniev, M. Valiente, D. Petrosyan and N. T. Zinner | | | Systems of interacting quantum spins provide a basis for quantum computation devices. Here, the authors demonstrate a quantum spin transistor in a Heisenberg spin chain, which may be realized in a system of trapped cold atoms. | | | 10 October 2016 | doi: 10.1038/ncomms13070 | | |
| Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch OPEN | | | Sara L. Morales-Lázaro, Itzel Llorente, Félix Sierra-Ramírez, Ana E. López-Romero, Miguel Ortíz-Rentería, Barbara Serrano-Flores, Sidney A. Simon, León D. Islas and Tamara Rosenbaum | | | TRPV1 channels are known to mediate pathological pain and itch. Here, the authors find a naturally occurring fatty acid, oleic acid, acts as a TRPV1 antagonist and can modulate capsaicin and histamine-mediated pain and itch response in mouse models. | | | 10 October 2016 | doi: 10.1038/ncomms13092 | | |
| Identification of a common mesenchymal stromal progenitor for the adult haematopoietic niche OPEN | | | Xingbin Hu, Mayra Garcia, Lihong Weng, Xiaoman Jung, Jodi L. Murakami, Bijender Kumar, Charles D. Warden, Ivan Todorov and Ching-Cheng Chen | | | How the environment of the niche regulates haematopoietic stem cells (HSC) is unclear. Here, the authors identify a mesenchymal stromal progenitor hierarchy and identify Sca1+ cells as common progenitors for mesenchymal stromal cells in the adult niche that provide a supportive environment for hematopoiesis. | | | 10 October 2016 | doi: 10.1038/ncomms13095 | | |
| Distinct gene expression patterns correlate with developmental and functional traits of iNKT subsets OPEN | | | Hristo Georgiev, Inga Ravens, Charaf Benarafa, Reinhold Förster and Günter Bernhardt | | | A recent advance in invariant natural killer T cell (iNKT) cell biology is their classification into iNKT1, iNKT2 and iNKT17 subsets. Here the authors provide a transcriptomic analysis of these thymic subsets from Balb/c and C57Bl/6 mice that supports and extends the categorization. | | | 10 October 2016 | doi: 10.1038/ncomms13116 | | |
| Probing the spinor nature of electronic states in nanosize non-collinear magnets OPEN | | | Jeison A. Fischer, Leonid M. Sandratskii, Soo-Hyon Phark, Safia Ouazi, André A. Pasa, Dirk Sander and Stuart S. P. Parkin | | | Non-collinear magnetization textures which are established by chiral exchange interactions have recently provided a route to novel phenomena and device concepts. Here, the authors demonstrate the effects of symmetry breaking on non-collinear magnetization by lateral confinement. | | | 10 October 2016 | doi: 10.1038/ncomms13000 | | |
| Flare differentially rotates sunspot on Sun’s surface OPEN | | | Chang Liu, Yan Xu, Wenda Cao, Na Deng, Jeongwoo Lee, Hugh S. Hudson, Dale E. Gary, Jiasheng Wang, Ju Jing and Haimin Wang | | | Sunspots are concentration of magnetic field visible on the solar surface, which were thought to be unaffected by solar flares that take place in the solar corona. Here the authors report evidence of a flare-induced rotation of a sunspot, showing nonuniform acceleration following the peaks of X-ray emissions. | | | 10 October 2016 | doi: 10.1038/ncomms13104 | | |
| EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance OPEN | | | Lingling Jiang, Yingying Shen, Danfeng Guo, Diya Yang, Jiajun Liu, Xuefeng Fei, Yunshan Yang, Buyi Zhang, Zhendong Lin, Fei Yang, Xiaojian Wang, Keyi Wang, Jianli Wang and Zhijian Cai | | | The intestinal tract is continually exposed to foreign material and gut homeostasis is dependent on tolerance. Here, the authors show that extracellular vesicles released from intestinal epithelial cells stimulate T regulatory cells and immunosuppressive dendritic cells. | | | 10 October 2016 | doi: 10.1038/ncomms13045 | | |
| Thermoelectric signature of the chiral anomaly in Cd3As2 OPEN | | | Zhenzhao Jia, Caizhen Li, Xinqi Li, Junren Shi, Zhimin Liao, Dapeng Yu and Xiaosong Wu | | | The thermoelectric effect can be used to explore electronic properties. Here, the authors show experimentally that Cd3As2 exhibits a negative magnetic thermopower which reverses sign at high field, and relate it to the chiral anomaly, a signature of Weyl fermions. | | | 10 October 2016 | doi: 10.1038/ncomms13013 | | |
| Actomyosin-dependent dynamic spatial patterns of cytoskeletal components drive mesoscale podosome organization OPEN | | | Marjolein B. M. Meddens, Elvis Pandzic, Johan A. Slotman, Dominique Guillet, Ben Joosten, Svenja Mennens, Laurent M. Paardekooper, Adriaan B. Houtsmuller, Koen van den Dries, Paul W. Wiseman and Alessandra Cambi | | | Podosomes are adhesive cytoskeletal structures found in several cell types, but whether or how they are interconnected is not known. Here the authors demonstrate mesoscale connectivity of podosome clusters by imaging directional flow patterns of podosome components vinculin, talin and F-actin. | | | 10 October 2016 | doi: 10.1038/ncomms13127 | | |
| Isotope analysis in the transmission electron microscope OPEN | | | Toma Susi, Christoph Hofer, Giacomo Argentero, Gregor T. Leuthner, Timothy J. Pennycook, Clemens Mangler, Jannik C. Meyer and Jani Kotakoski | | | Electron microscopy can reveal a material’s chemical structure down to the atomic level, but has so far been blind to isotopic differences. Here the authors are able to map isotope concentrations in graphene by measuring the probability of ejecting atoms, demonstrating a ‘mass spectrometer in the microscope’. | | | 10 October 2016 | doi: 10.1038/ncomms13040 | | |
| Giant Kerr response of ultrathin gold films from quantum size effect OPEN | | | Haoliang Qian, Yuzhe Xiao and Zhaowei Liu | | | When plasmonic structures reach the nanoscale, quantum size effects become important for their optical properties. Here, Qian et al. find a giant third-order nonlinear Kerr response from nanometre thick gold quantum wells, which they attribute to quantum size effects. | | | 10 October 2016 | doi: 10.1038/ncomms13153 | | |
| Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria OPEN | | | Pierre-Yves Mantel, Daisy Hjelmqvist, Michael Walch, Solange Kharoubi-Hess, Sandra Nilsson, Deepali Ravel, Marina Ribeiro, Christof Grüring, Siyuan Ma, Prasad Padmanabhan, Alexander Trachtenberg, Johan Ankarklev, Nicolas M. Brancucci, Curtis Huttenhower, Manoj T. Duraisingh, Ionita Ghiran, Winston P. Kuo, Luis Filgueira, Roberta Martinelli and Matthias Marti et al. | | | Inflammatory response to malaria pathogen Plasmodium falciparum can be triggered by infected red blood cell-derived extracellular vesicles (EVs). This study shows these EVs contain functional microRNA-Argonaute 2 complex that modulates gene expression and alter vascular barrier properties. | | | 10 October 2016 | doi: 10.1038/ncomms12727 | | |
| High-harmonic generation by field enhanced femtosecond pulses in metal-sapphire nanostructure OPEN | | | Seunghwoi Han, Hyunwoong Kim, Yong Woo Kim, Young-Jin Kim, Seungchul Kim, In-Yong Park and Seung-Woo Kim | | | It has been suggested that strong field enhancement for high harmonic generation may be achievable with nano-antennas. Here, the authors show relevant field enhancement using a metal-sapphire nanostructure that provides a solid tip as the high harmonic emitter, replacing commonly used gaseous atoms. | | | 10 October 2016 | doi: 10.1038/ncomms13105 | | |
| Striatal prediction errors support dynamic control of declarative memory decisions OPEN | | | Jason M. Scimeca, Perri L. Katzman and David Badre | | | The human brain can efficiently retrieve information from long-term memory and use it to guide action but how the brain selects the most useful information in each case is unclear. Here the authors show that reinforcement learning mechanisms, based on expected value and prediction error fMRI signals in striatum, play a role in memory control processes guiding behavior. | | | 07 October 2016 | doi: 10.1038/ncomms13061 | |
| Experimental creation of quantum Zeno subspaces by repeated multi-spin projections in diamond OPEN | | | N. Kalb, J. Cramer, D. J. Twitchen, M. Markham, R. Hanson and T. H. Taminiau | | | Repeated observations of quantum states inhibit coherent evolution through the Zeno effect, providing opportunities for controlling multi-qubit systems. Here the authors demonstrate that projecting joint observables of three spins in diamond creates quantum Zeno subspaces that suppress dephasing. | | | 07 October 2016 | doi: 10.1038/ncomms13111 | | |
| Endoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2 OPEN | | | June Baik, Alessandro Magli, Naoyuki Tahara, Scott A. Swanson, Naoko Koyano-Nakagawa, Luciene Borges, Ron Stewart, Daniel J. Garry, Yasuhiko Kawakami, James A. Thomson and Rita C. R. Perlingeiro | | | How both BMP and Wnt signalling pathways regulate lineage specification early in development is unclear. Here, the authors show that endoglin via Jdp2, an AP-1 family member, modulates BMP and Wnt signalling to commit mesodermal progenitors to a haematopoietic fate at the expense of the cardiac lineage. | | | 07 October 2016 | doi: 10.1038/ncomms13101 | | |
| N-type organic electrochemical transistors with stability in water OPEN | | | Alexander Giovannitti, Christian B. Nielsen, Dan-Tiberiu Sbircea, Sahika Inal, Mary Donahue, Muhammad R. Niazi, David A. Hanifi, Aram Amassian, George G. Malliaras, Jonathan Rivnay and Iain McCulloch | | | Organic electrochemical transistors transduce ionic to electronic signals in aqueous solutions, holding promise for biological sensing applications. Here, Giovannitti et al. report an ambipolar organic electrochemical transistor, based on a conjugated copolymer, which has a high stability in water. | | | 07 October 2016 | doi: 10.1038/ncomms13066 | | |
| Disaggregating the evidence linking biodiversity and ecosystem services OPEN | | | Taylor H. Ricketts, Keri B. Watson, Insu Koh, Alicia M. Ellis, Charles C. Nicholson, Stephen Posner, Leif L. Richardson and Laura J. Sonter | | | Biodiversity can enhance ecosystem services such as crop pollination. Here, Ricketts et al. synthesize 14 years of literature to show that biodiversity-ecosystem services relationships depend on the service, how services and biodiversity are each measured, and the approach used to link them. | | | 07 October 2016 | doi: 10.1038/ncomms13106 | | |
| Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets OPEN | | | Ying-Bei Chen, Jianing Xu, Anders Jacobsen Skanderup, Yiyu Dong, A. Rose Brannon, Lu Wang, Helen H. Won, Patricia I. Wang, Gouri J. Nanjangud, Achim A. Jungbluth, Wei Li, Virginia Ojeda, A. Ari Hakimi, Martin H. Voss, Nikolaus Schultz, Robert J. Motzer, Paul Russo, Emily H. Cheng, Filippo G. Giancotti, William Lee et al. | | | A subset of renal cell carcinomas have uncertain histology and are aggressive in nature. Here, the authors examine this group of unclassified renal cancers using genomics techniques and identify further subclasses of the tumours that have differing prognoses. | | | 07 October 2016 | doi: 10.1038/ncomms13131 | | |
| Formation of metastable phases by spinodal decomposition OPEN | | | Ricard Alert, Pietro Tierno and Jaume Casademunt | | | Metastable phases are usually formed through nucleation, upon overcoming an energy barrier. Here, Alert et al. theoretically predict and experimentally verify the unexpected formation of a metastable phase by spinodal decomposition through direct phase separation from an unstable phase. | | | 07 October 2016 | doi: 10.1038/ncomms13067 | | |
| Motor cortex activity predicts response alternation during sensorimotor decisions OPEN | | | Anna-Antonia Pape and Markus Siegel | | | The motor cortex executes responses based on sensory choices, but it is unknown whether it also impacts response selection. Here, Pape and Siegel show that motor cortex activity present before decision making predicts responses and that this activity is influenced by previous button-presses. | | | 07 October 2016 | doi: 10.1038/ncomms13098 | | |
| Social learning strategies modify the effect of network structure on group performance OPEN | | | Daniel Barkoczi and Mirta Galesic | | | Previous studies have disagreed over whether efficient or inefficient network structures should be more effective in promoting group performance. Here, Barkoczi and Galesic demonstrate that which structure is superior depends on the social learning strategy used by individuals in the network. | | | 07 October 2016 | doi: 10.1038/ncomms13109 | | |
| Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids OPEN | | | Yijun Yan, Jing Yang, Zhiyin Yu, Mingming Yu, Ya-Tuan Ma, Li Wang, Can Su, Jianying Luo, Geoffrey P. Horsman and Sheng-Xiong Huang | | | The biosynthesis of pyridine rings is still poorly understood. Here the authors propose a biosynthetic pathway for pyridine-containing rubrolones, which is characterized by a non-enzymatic condensation and cyclization of the pyridine moiety. | | | 07 October 2016 | doi: 10.1038/ncomms13083 | | |
| Polymer-dispersed liquid crystal elastomers OPEN | | | Andraž Rešetič, Jerneja Milavec, Blaž Zupančič, Valentina Domenici and Boštjan Zalar | | | Liquid crystal elastomers are promising for building actuators due to excellent thermomechanical response, but it is challenging to prepare them at macroscale with arbitrary shape. Here, the authors overcome this restriction by doping microparticles to the polymer matrix without employing mechanical stressing. | | | 07 October 2016 | doi: 10.1038/ncomms13140 | | |
| Orbital disproportionation of electronic density is a universal feature of alkali-doped fullerides OPEN | | | Naoya Iwahara and Liviu F. Chibotaru | | | Understanding the electronic phases of alkali-doped fullerides is a long-standing and challenging task for material scientists. Here the authors show that Jahn-Teller instability and orbital disproportionation of electronic density in the lowest unoccupied molecular orbital band is universal in these systems. | | | 07 October 2016 | doi: 10.1038/ncomms13093 | | |
| Nanoscale probing of electron-regulated structural transitions in silk proteins by near-field IR imaging and nano-spectroscopy OPEN | | | Nan Qin, Shaoqing Zhang, Jianjuan Jiang, Stephanie Gilbert Corder, Zhigang Qian, Zhitao Zhou, Woonsoo Lee, Keyin Liu, Xiaohan Wang, Xinxin Li, Zhifeng Shi, Ying Mao, Hans A. Bechtel, Michael C. Martin, Xiaoxia Xia, Benedetto Marelli, David L. Kaplan, Fiorenzo G. Omenetto, Mengkun Liu and Tiger H. Tao et al. | | | Silk protein fibres are exceptionally strong, owing to their high β-sheet nanocrystal content. Here, the authors use an electron beam to guide silk β-sheet crystals through structural transitions, and visualize the changes by infrared near-field optics, achieving close to molecular-level resolution. | | | 07 October 2016 | doi: 10.1038/ncomms13079 | | |
| Scaled laboratory experiments explain the kink behaviour of the Crab Nebula jet OPEN | | | C. K. Li, P. Tzeferacos, D. Lamb, G. Gregori, P. A. Norreys, M. J. Rosenberg, R. K. Follett, D. H. Froula, M. Koenig, F. H. Seguin, J. A. Frenje, H. G. Rinderknecht, H. Sio, A. B. Zylstra, R. D. Petrasso, P. A. Amendt, H. S. Park, B. A. Remington, D. D. Ryutov, S. C. Wilks et al. | | | The periodical change of the Crab nebula’s jet direction challenges our understanding of astrophysical jet dynamics. Here the authors use high-power lasers to create a jet that can be directly compared to the Crab nebula’s, and report the detection of plasma instabilities that mimic kink behaviour. | | | 07 October 2016 | doi: 10.1038/ncomms13081 | | |
| Single-shot observation of optical rogue waves in integrable turbulence using time microscopy OPEN | | | Pierre Suret, Rebecca El Koussaifi, Alexey Tikan, Clément Evain, Stéphane Randoux, Christophe Szwaj and Serge Bielawski | | | A rogue wave is an unexpected oscillation of large amplitude and is an example of the spontaneous formation of a coherent structure out of disorder. Here, the authors develop an experimental strategy that can provide snapshots in time and thus record the real shape of optical rogue waves emerging from random noise. | | | 07 October 2016 | doi: 10.1038/ncomms13136 | | |
| Thermally-nucleated self-assembly of water and alcohol into stable structures at hydrophobic interfaces OPEN | | | Kislon Voïtchovsky, Daniele Giofrè, Juan José Segura, Francesco Stellacci and Michele Ceriotti | | | Alcohol-water mixtures are characterized by the existence of segregated clusters, whose dynamics are too fast to be investigated in bulk solution. Here, Voïtchovsky et al. show the formation of stable two-dimensional water-alcohol wire-like structures via H-bonds on graphite surface at room temperature. | | | 07 October 2016 | doi: 10.1038/ncomms13064 | | |
| An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5′Hoxd–Gli3 antagonism OPEN | | | Bau-Lin Huang, Anna Trofka, Aki Furusawa, Jacqueline L. Norrie, Adam H. Rabinowitz, Steven A. Vokes, M. Mark Taketo, Jozsef Zakany and Susan Mackem | | | The molecular mechanisms governing digit joint specification are poorly understood. Here, the authors identify the 5′Hoxd–Gli3 balance as a key regulator of the net interdigital Bmp signalling level in mouse, which in turn regulates phalanx and joint formation. | | | 07 October 2016 | doi: 10.1038/ncomms12903 | | |
| Electronic control of H+ current in a bioprotonic device with Gramicidin A and Alamethicin OPEN | | | Zahra Hemmatian, Scott Keene, Erik Josberger, Takeo Miyake, Carina Arboleda, Jessica Soto-Rodríguez, François Baneyx and Marco Rolandi | | | Conventional electronics use electrons as charge carriers whereas biological systems use ions, confounding integration of electronics with biology. Here the authors show voltage-regulated flow of protons across a supported lipid bilayer using the ion channel Gramicidin A and the voltage-gated ion channel Alamethicin. | | | 07 October 2016 | doi: 10.1038/ncomms12981 | | |
| Sensory feedback synchronizes motor and sensory neuronal networks in the neonatal rat spinal cord OPEN | | | Ana R. Inácio, Azat Nasretdinov, Julia Lebedeva and Roustem Khazipov | | | Spontaneous movements are important for mammalian development but how network activity underlies the generation of these actions remains unclear. Here the authors show that both spontaneous twitches and complex movements enable correlated activity in motor and sensory networks of the rat spinal cord in vivo, and that sensory feedback is instrumental in this synchronization. | | | 07 October 2016 | doi: 10.1038/ncomms13060 | | |
| Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig OPEN | | | Jianzhao Liu, Yuanxiang Zhu, Guan-Zheng Luo, Xinxia Wang, Yanan Yue, Xiaona Wang, Xin Zong, Kai Chen, Hang Yin, Ye Fu, Dali Han, Yizhen Wang, Dahua Chen and Chuan He | | | DNA 6mA is a poorly understood epigenetic mark present at a low abundance in eukaryotic genomes. Here the authors observe high levels in zebrafish and pig during early embryogenesis enriched to repetitive regions of the genome and followed by attenuation during development. | | | 07 October 2016 | doi: 10.1038/ncomms13052 | | |
| Insulin and TOR signal in parallel through FOXO and S6K to promote epithelial wound healing OPEN | | | Parisa Kakanj, Bernard Moussian, Sebastian Grönke, Victor Bustos, Sabine A. Eming, Linda Partridge and Maria Leptin | | | The TOR and insulin/IGF signalling (IIS) network are central responses to wound healing. Here the authors develop a technique of live imaging of laser-induced epidermal wounds to flies and show that TOR and IIS are independently required for wound healing, which may have implications for diabetic wound healing and its treatment. | | | 07 October 2016 | doi: 10.1038/ncomms12972 | | |
| Evolutionary interplay between sister cytochrome P450 genes shapes plasticity in plant metabolism OPEN | | | Zhenhua Liu, Raquel Tavares, Evan S. Forsythe, François André, Raphaël Lugan, Gabriella Jonasson, Stéphanie Boutet-Mercey, Takayuki Tohge, Mark A. Beilstein, Danièle Werck-Reichhart and Hugues Renault | | | Genes in the cytochrome P450 family have evolved a wide range of functions. Here, Liu et al. reconstruct the evolution of the P450 genes CYP98A8 and CYP98A9 in the Brassicales, revealing a complex history of retrotransposition, tandem duplication and neofunctionalization, followed by subfunctionalization or gene loss in specific lineages. | | | 07 October 2016 | doi: 10.1038/ncomms13026 | | |
| Structural characterization of antibiotic self-immunity tRNA synthetase in plant tumour biocontrol agent OPEN | | | Shaileja Chopra, Andrés Palencia, Cornelia Virus, Sarah Schulwitz, Brenda R. Temple, Stephen Cusack and John Reader | | | The bacterium Agrobacterium radiobacter K84 secretes an antibiotic that is transported into the plant pathogen A. tumefaciens and processed into the toxin TM84. Here, the authors identify a mechanism whereby the antibiotic-producing microbe resists its own toxin. | | | 07 October 2016 | doi: 10.1038/ncomms12928 | | |
| Bimodal antagonism of PKA signalling by ARHGAP36 OPEN | | | Rebecca L. Eccles, Maciej T. Czajkowski, Carolin Barth, Paul Markus Müller, Erik McShane, Stephan Grunwald, Patrick Beaudette, Nora Mecklenburg, Rudolf Volkmer, Kerstin Zühlke, Gunnar Dittmar, Matthias Selbach, Annette Hammes, Oliver Daumke, Enno Klussmann, Sylvie Urbé and Oliver Rocks | | | Protein kinase A (PKA) is a key mediator of cyclic AMP signalling. Here, Eccles et al. show that ARHGAP36 antagonizes PKA by acting as a kinase inhibitor and targeting the catalytic subunit for endolysosomal degradation, thus reducing sensitivity of cells to cAMP and promoting Hedgehog signalling. | | | 07 October 2016 | doi: 10.1038/ncomms12963 | | |
| Unveiling the pentagonal nature of perfectly aligned single-and double-strand Si nano-ribbons on Ag(110) OPEN | | | Jorge I. Cerdá, Jagoda Sławińska, Guy Le Lay, Antonela C. Marele, José M. Gómez-Rodríguez and María E. Dávila | | | The atomic structure of Si nanoribbons on metallic surfaces has been disputed for years and yet remained elusive. Here, the authors unveil the nature of aligned Si nanoribbons on Ag(110), shifting the focus from a hexagonal silicene-like arrangement to a 1D phase solely comprising Si pentagons. | | | 06 October 2016 | doi: 10.1038/ncomms13076 | | |
| Evolutionary trajectories of snake genes and genomes revealed by comparative analyses of five-pacer viper OPEN | | | Wei Yin, Zong-ji Wang, Qi-ye Li, Jin-ming Lian, Yang Zhou, Bing-zheng Lu, Li-jun Jin, Peng-xin Qiu, Pei Zhang, Wen-bo Zhu, Bo Wen, Yi-jun Huang, Zhi-long Lin, Bi-tao Qiu, Xing-wen Su, Huan-ming Yang, Guo-jie Zhang, Guang-mei Yan and Qi Zhou | | | Snakes have many characteristics that distinguish them from their relatives. Here, Yin et al. sequence the genome of the five-pacer viper, Deinagkistrodon acutus, and use comparative genomic analyses to elucidate the evolution of transposable elements, developmental genes and sex chromosomes in snakes. | | | 06 October 2016 | doi: 10.1038/ncomms13107 | | |
| Spatiotemporal control of cell–cell reversible interactions using molecular engineering OPEN | | | Peng Shi, Enguo Ju, Zhengqing Yan, Nan Gao, Jiasi Wang, Jianwen Hou, Yan Zhang, Jinsong Ren and Xiaogang Qu | | | Reversible manipulation of cell-cell interactions has potential applications in basic research and cell-based therapy. Here the authors control cell-cell adhesion in vitro with light, by modifying the surface sugars of cells to display β-cyclodextrin, which recognises one isoform of light-isomerizable azobenzene linkers. | | | 06 October 2016 | doi: 10.1038/ncomms13088 | | |
| Spontaneous assembly of chemically encoded two-dimensional coacervate droplet arrays by acoustic wave patterning OPEN | | | Liangfei Tian, Nicolas Martin, Philip G. Bassindale, Avinash J. Patil, Mei Li, Adrian Barnes, Bruce W. Drinkwater and Stephen Mann | | | Isolated droplets can be used as micro-reactors, yet it is challenging to operate them functionally in solution and observe chemical exchanges between droplets. Here, Tian et al. use an acoustic trap to assemble water-based micro-droplets into periodic arrays, spontaneously separated from solution media. | | | 06 October 2016 | doi: 10.1038/ncomms13068 | | |
| Direct X-ray photoconversion in flexible organic thin film devices operated below 1 V OPEN | | | Laura Basiricò, Andrea Ciavatti, Tobias Cramer, Piero Cosseddu, Annalisa Bonfiglio and Beatrice Fraboni | | | Organic electronics show advantages in easy processing, mechanical flexibility and low costs compared to their inorganic counterparts, yet there are not many proofs for the sake of X-ray detection. Here, Basiricò et al. build a flexible X-ray detector operated at sub-1 V using pentacene-based thin films. | | | 06 October 2016 | doi: 10.1038/ncomms13063 | | |
| Spiral magnetic order and pressure-induced superconductivity in transition metal compounds OPEN | | | Yishu Wang, Yejun Feng, J.-G. Cheng, W. Wu, J. L. Luo and T. F. Rosenbaum | | | The relationship between magnetic order and superconductivity is one of the central issues in unconventional superconductors. Here, Wang et al. report a spiral spin order in MnP and trace its pressure evolution towards superconducting order, suggesting variable spiral pitch as a mechanism to tune spin-fluctuation-induced superconductivity. | | | 06 October 2016 | doi: 10.1038/ncomms13037 | | |
| A route for a strong increase of critical current in nanostrained iron-based superconductors OPEN | | | Toshinori Ozaki, Lijun Wu, Cheng Zhang, Jan Jaroszynski, Weidong Si, Juan Zhou, Yimei Zhu and Qiang Li | | | Simultaneous increase of critical temperature and critical current in superconductors is desirable for application purpose, but very difficult to realize. Here, Ozaki et al. report a simultaneous enhancement of Tc and Jc in FeSe0.5Te0.5 films with cascade defects produced by low-energy proton irradiation. | | | 06 October 2016 | doi: 10.1038/ncomms13036 | | |
| Loss of immune tolerance to IL-2 in type 1 diabetes OPEN | | | Louis Pérol, John M. Lindner, Pamela Caudana, Nicolas Gonzalo Nunez, Audrey Baeyens, Andrea Valle, Christine Sedlik, Delphine Loirat, Olivier Boyer, Alain Créange, José Laurent Cohen, Ute Christine Rogner, Jun Yamanouchi, Martine Marchant, Xavier Charles Leber, Meike Scharenberg, Marie-Claude Gagnerault, Roberto Mallone, Manuela Battaglia, Pere Santamaria et al. | | | Type 1 diabetes is driven by T-cell autoimmunity to pancreatic islet cells. Here the authors show that autoreactive anti-IL-2 T and B cells are present in type 1 diabetes patients, and that anti-IL-2 antibodies precede diabetes onset in mice, suggesting their potential as a diagnostic marker. | | | 06 October 2016 | doi: 10.1038/ncomms13027 | | |
| Sensing the quantum limit in scanning tunnelling spectroscopy OPEN | | | Christian R. Ast, Berthold Jäck, Jacob Senkpiel, Matthias Eltschka, Markus Etzkorn, Joachim Ankerhold and Klaus Kern | | | The tunnelling current in scanning tunnelling spectroscopy has often been treated by a continuous charge flow, which lacks proper treatment of charge quantization. Here, Ast et al. unveil the effects of granularity in the tunnelling current at extremely low temperatures by including P(E) theory, thereby reaching the quantum limit in scanning tunnelling spectroscopy. | | | 06 October 2016 | doi: 10.1038/ncomms13009 | | |
| Obesity-associated NLRC4 inflammasome activation drives breast cancer progression OPEN | | | Ryan Kolb, Liem Phan, Nicholas Borcherding, Yinghong Liu, Fang Yuan, Ann M. Janowski, Qing Xie, Kathleen R. Markan, Wei Li, Matthew J. Potthoff, Enrique Fuentes-Mattei, Lesley G. Ellies, C. Michael Knudson, Mong-Hong Lee, Sai-Ching J. Yeung, Suzanne L. Cassel, Fayyaz S. Sutterwala and Weizhou Zhang | | | Obesity is associated with higher breast cancer risk and poor prognosis. Here, the authors show that obesity promotes breast cancer through the recruitment of macrophages with activated NLRC4 inflammasome, which activate IL-1β production, resulting in VEGFA expression in adipocytes and angiogenesis. | | | 06 October 2016 | doi: 10.1038/ncomms13007 | | |
| A high-quality human reference panel reveals the complexity and distribution of genomic structural variants OPEN | | | Jayne Y. Hehir-Kwa, Tobias Marschall, Wigard P. Kloosterman, Laurent C. Francioli, Jasmijn A. Baaijens, Louis J. Dijkstra, Abdel Abdellaoui, Vyacheslav Koval, Djie Tjwan Thung, René Wardenaar, Ivo Renkens, Bradley P. Coe, Patrick Deelen, Joep de Ligt, Eric-Wubbo Lameijer, Freerk van Dijk, Fereydoun Hormozdiari, The Genome of the Netherlands Consortium, Jasper A. Bovenberg, Anton J. M. de Craen et al. | | | Structural variants (SVs) are prevalent in genomes of the general population. Here, Guryev and The Genome of the Netherlands Consortium describe the reference panel of haplotype-resolved SVs from 769 individuals from 250 Dutch families and show its utility for studying heritable traits. | | | 06 October 2016 | doi: 10.1038/ncomms12989 | | |
| Genome sequence of the basal haplorrhine primate Tarsius syrichta reveals unusual insertions OPEN | | | Jürgen Schmitz, Angela Noll, Carsten A. Raabe, Gennady Churakov, Reinhard Voss, Martin Kiefmann, Timofey Rozhdestvensky, Jürgen Brosius, Robert Baertsch, Hiram Clawson, Christian Roos, Aleksey Zimin, Patrick Minx, Michael J. Montague, Richard K. Wilson and Wesley C. Warren | | | Tarsiers occupy a key node between strepsirrhines and anthropoids in the primate phylogeny. Here, Warren and colleagues present the genome of Tarsius syrichta, including a survey of transposable elements, an unusual mitochondrial insertion, and evidence for positive gene selection. | | | 06 October 2016 | doi: 10.1038/ncomms12997 | | |
| Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity OPEN | | | Naoto Kubota, Tetsuya Kubota, Eiji Kajiwara, Tomokatsu Iwamura, Hiroki Kumagai, Taku Watanabe, Mariko Inoue, Iseki Takamoto, Takayoshi Sasako, Katsuyoshi Kumagai, Motoyuki Kohjima, Makoto Nakamuta, Masao Moroi, Kaoru Sugi, Tetsuo Noda, Yasuo Terauchi, Kohjiro Ueki and Takashi Kadowaki | | | Type 2 diabetes and obesity are associated with increased hepatic gluconeogenesis and lipogenesis, known as selective insulin resistance. Here Kubota et al. explain selective insulin resistance in the liver with the zonal distribution and selective insulin-mediated regulation of Irs1 and Irs2. | | | 06 October 2016 | doi: 10.1038/ncomms12977 | | |
| Competitive solvent-molecule interactions govern primary processes of diphenylcarbene in solvent mixtures OPEN | | | Johannes Knorr, Pandian Sokkar, Sebastian Schott, Paolo Costa, Walter Thiel, Wolfram Sander, Elsa Sanchez-Garcia and Patrick Nuernberger | | | Photochemistry in solution often involves coexisting reaction channels that may comprise intermediates capturing a solvent molecule. Here, the authors show for one of the most reactive species, diphenylcarbene, that the decision-maker is not the nearest solvent molecule but its neighbour. | | | 06 October 2016 | doi: 10.1038/ncomms12968 | | |
| Modelling proteins’ hidden conformations to predict antibiotic resistance OPEN | | | Kathryn M. Hart, Chris M. W. Ho, Supratik Dutta, Michael L. Gross and Gregory R. Bowman | | | Expression of TEM β-lactamase is a predominant mechanism underlying antibiotic resistance in pathogenic Gram-negative bacteria. Here, the authors use Markov state models to reveal and experimentally confirm hidden conformations that determine TEM substrate specificity. | | | 06 October 2016 | doi: 10.1038/ncomms12965 | | |
| Metal-free photochemical silylations and transfer hydrogenations of benzenoid hydrocarbons and graphene OPEN | | | Raffaello Papadakis, Hu Li, Joakim Bergman, Anna Lundstedt, Kjell Jorner, Rabia Ayub, Soumyajyoti Haldar, Burkhard O. Jahn, Aleksandra Denisova, Burkhard Zietz, Roland Lindh, Biplab Sanyal, Helena Grennberg, Klaus Leifer and Henrik Ottosson | | | Baird’s rules say that the first triplet state of benzene displays antiaromatic character. Here, the authors exploit this to show that aromatic molecules can undergo rapid transfer hydrogenation or silylations without the need for metal catalysts when photochemcially excited into this state. | | | 06 October 2016 | doi: 10.1038/ncomms12962 | | |
| Mechanism of pH-dependent activation of the sodium-proton antiporter NhaA OPEN | | | Yandong Huang, Wei Chen, David L. Dotson, Oliver Beckstein and Jana Shen | | | The pH dependence of the activity of Escherichia coli main sodium-proton antiporter NhaA is still not fully understood. Here, the authors use continuous constant pH molecular dynamics simulations to identify NhaA proton carrier residues and elucidate its gating and ion transport processes. | | | 06 October 2016 | doi: 10.1038/ncomms12940 | | |
| Interplay between evanescence and disorder in deep subwavelength photonic structures OPEN | | | Hanan Herzig Sheinfux, Ido Kaminer, Azriel Z. Genack and Mordechai Segev | | | Features much smaller than the wavelength are not expected to have a significant impact on the transport of a wave. Here, the authors show that Anderson localization can dominate light transport in a one-dimensional disordered system, even when the disordered features are a thousand times smaller than the wavelength. | | | 06 October 2016 | doi: 10.1038/ncomms12927 | | |
| ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation OPEN | | | Ji Hae Seo, Ji-Hyeon Park, Eun Ji Lee, Tam Thuy Lu Vo, Hoon Choi, Jun Yong Kim, Jae Kyung Jang, Hee-Jun Wee, Hye Shin Lee, Se Hwan Jang, Zee Yong Park, Jaeho Jeong, Kong-Joo Lee, Seung-Hyeon Seok, Jin Young Park, Bong Jin Lee, Mi-Ni Lee, Goo Taeg Oh and Kyu-Won Kim | | | The chaperone Hsp70 has a dual role, promoting both protein refolding and protein degradation. Seo and Park et al. show that Hsp70 acetylation enhances protein refolding after stress, and that subsequent deacetylation progressively promotes ubiquitin ligase binding and protein degradation. | | | 06 October 2016 | doi: 10.1038/ncomms12882 | | |
| A distinct holoenzyme organization for two-subunit pyruvate carboxylase OPEN | | | Philip H. Choi, Jeanyoung Jo, Yu-Cheng Lin, Min-Han Lin, Chi-Yuan Chou, Lars E. P. Dietrich and Liang Tong | | | Pyruvate carboxylases are homotetrameric enzymes in eukaryotes and most bacteria. Here, the authors report the structure of an unusual two-subunit form of the enzyme from the Gram-negative bacterium Methylobacillus flagellates, revealing an unexpected α2β4 stoichiometry. | | | 06 October 2016 | doi: 10.1038/ncomms12713 | | |
| Efficient and selective N-alkylation of amines with alcohols catalysed by manganese pincer complexes OPEN | | | Saravanakumar Elangovan, Jacob Neumann, Jean-Baptiste Sortais, Kathrin Junge, Christophe Darcel and Matthias Beller | | | Hydrogen borrowing is an attractive method for C-N bond formation - avoiding multiple alkylation products and reducing waste - but often is carried out with noble metals. Here the authors show that a manganese catalyst allows the selective N-alkylation of amines with alcohols. | | | 06 October 2016 | doi: 10.1038/ncomms12641 | | |
| Analogue modulation of back-propagating action potentials enables dendritic hybrid signalling OPEN | | | János Brunner and János Szabadics | | | ‘Analogue’ modulation by somatic membrane potentials can modify ‘digital’ axonal action potentials. Here, the authors show that analogue modulation can occur in back-propagating dendritic action potentials and calcium signals, leading to signal enhancement or attenuation in a location-dependent manner. | | | 05 October 2016 | doi: 10.1038/ncomms13033 | | |
| Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor OPEN | | | Kavya Ramkumar, Soma Samanta, Anahita Kyani, Suhui Yang, Shuzo Tamura, Elizabeth Ziemke, Jeanne A. Stuckey, Si Li, Krishnapriya Chinnaswamy, Hiroyuki Otake, Bikash Debnath, Vladimir Yarovenko, Judith S. Sebolt-Leopold, Mats Ljungman and Nouri Neamati | | | Glutathione S-transferase omega 1 (GSTO1) is an atypical GST isoform overexpressed in several cancers that has been implicated in drug resistance. Here the authors identify a small molecule inhibitor of GSTO1 that effectively inhibits tumor growth in colon cancer models, and establish its mechanism of action. | | | 05 October 2016 | doi: 10.1038/ncomms13084 | | |
| The origin of efficient triplet state population in sulfur-substituted nucleobases OPEN | | | Sebastian Mai, Marvin Pollum, Lara Martínez-Fernández, Nicholas Dunn, Philipp Marquetand, Inés Corral, Carlos E. Crespo-Hernández and Leticia González | | | Sulfur-substituted nucleobases are promising photo- and chemotherapeutic drugs. Here, the authors unravel the electronic and structural aspects that lead to the ultrafast population of triplet states in these molecules, providing an explanation for their efficiency as photosensitizers. | | | 05 October 2016 | doi: 10.1038/ncomms13077 | | |
| Structure sensitivity of Cu and CuZn catalysts relevant to industrial methanol synthesis OPEN | | | Roy van den Berg, Gonzalo Prieto, Gerda Korpershoek, Lars I. van der Wal, Arnoldus J. van Bunningen, Susanne Lægsgaard-Jørgensen, Petra E. de Jongh and Krijn P. de Jong | | | The dependence of the Cu-catalysed methanol synthesis on the structure of the Cu surface is a matter of debate. Here the authors show that activity falls for Cu and Cu-Zn particles below 8 nm and propose this is due to the absence of certain atomic configurations on the smaller particle surfaces. | | | 05 October 2016 | doi: 10.1038/ncomms13057 | | |
| Determinants of carbon release from the active layer and permafrost deposits on the Tibetan Plateau OPEN | | | Leiyi Chen, Junyi Liang, Shuqi Qin, Li Liu, Kai Fang, Yunping Xu, Jinzhi Ding, Fei Li, Yiqi Luo and Yuanhe Yang | | | Permafrost stores large quantities of carbon (C), but uncertainty surrounds decomposability differences between active and permafrost layers. Here, Chen et al. use incubation experiments and a 3-pool model to find permafrost layers are equally or more labile, contributing to C vulnerability in Tibetan permafrost. | | | 05 October 2016 | doi: 10.1038/ncomms13046 | | |
| Repeating microearthquake sequences interact predominantly through postseismic slip OPEN | | | Semechah K. Y. Lui and Nadia Lapusta | | | Small repeating earthquakes can be used to understand fault properties such as friction. Here, Lui et al. model the interaction between repeating earthquakes and find that postseismic creep dominates as the mechanism, which may help constrain the frictional properties of creeping fault segments. | | | 05 October 2016 | doi: 10.1038/ncomms13020 | | |
| Boosted output performance of triboelectric nanogenerator via electric double layer effect OPEN | | | Jinsung Chun, Byeong Uk Ye, Jae Won Lee, Dukhyun Choi, Chong-Yun Kang, Sang-Woo Kim, Zhong Lin Wang and Jeong Min Baik | | | The energy harvesting potential of triboelectric nanogenerators is currently limited by their output power. Here, the authors design a triboelectric nanogenerator inspired by lightning generation, featuring an electric double layer that delivers impressive charge separation and electric potential. | | | 05 October 2016 | doi: 10.1038/ncomms12985 | | |
| Thermopile detector of light ellipticity OPEN | | | Feng Lu, Jongwon Lee, Aiting Jiang, Seungyong Jung and Mikhail A. Belkin | | | Differences in the intensity of the left- and right-circularly polarized components of light can provide useful information about the chirality of electromagnetic radiation. Here, the authors demonstrate a monolithic photodetector that translates this difference in incident radiation directly into a voltage | | | 05 October 2016 | doi: 10.1038/ncomms12994 | | |
| Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma OPEN | | | Ling-Hao Zhao, Xiao Liu, He-Xin Yan, Wei-Yang Li, Xi Zeng, Yuan Yang, Jie Zhao, Shi-Ping Liu, Xue-Han Zhuang, Chuan Lin, Chen-Jie Qin, Yi Zhao, Ze-Ya Pan, Gang Huang, Hui Liu, Jin Zhang, Ruo-Yu Wang, Yun Yang, Wen Wen, Gui-Shuai Lv et al. | | | Hepatitis B infection is a risk factor for hepatocellular carcinoma. Here, the authors characterise viral infection in a cohort of hepatocellular carcinoma patients and find viral integration is more frequent in males than females. | | | 05 October 2016 | doi: 10.1038/ncomms12992 | | |
| Pre-eruptive magmatic processes re-timed using a non-isothermal approach to magma chamber dynamics OPEN | | | Chiara Maria Petrone, Giuseppe Bugatti, Eleonora Braschi and Simone Tommasini | | | Zoned crystals may reflect magma chamber dynamics, where changes in temperature, pressure and timescale before volcanic eruption may be measured. Petrone et al. develop a new Non-Isothermal Diffusion Incremental Step model to reconstruct crystal lifetime histories to constrain pre-eruptive magmatic processes. | | | 05 October 2016 | doi: 10.1038/ncomms12946 | | |
| Environmental fatty acids enable emergence of infectious Staphylococcus aureus resistant to FASII-targeted antimicrobials OPEN | | | Claire Morvan, David Halpern, Gérald Kénanian, Constantin Hays, Jamila Anba-Mondoloni, Sophie Brinster, Sean Kennedy, Patrick Trieu-Cuot, Claire Poyart, Gilles Lamberet, Karine Gloux and Alexandra Gruss | | | The bacterial pathway for fatty acid biosynthesis, FASII, is a target for development of new anti-staphylococcal drugs. Here, Morvan et al. show that exogenous fatty acids can favour the emergence of staphylococcal strains displaying resistance to multiple FASII inhibitors. | | | 05 October 2016 | doi: 10.1038/ncomms12944 | | |
| Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration OPEN | | | Richard Gordon, Matthew L. Neal, Jie Luo, Monica R. Langley, Dilshan S. Harischandra, Nikhil Panicker, Adhithiya Charli, Huajun Jin, Vellareddy Anantharam, Trent M. Woodruff, Qun-Yong Zhou, Anumantha G. Kanthasamy and Arthi Kanthasamy | | | Prokineticin-2 (PK2) is a secreted protein involved in a number of physiological functions. Here, the authors find that PK2 expression increases in surviving DA neurons from Parkinson's disease patients, and show it protects against dopaminergic degeneration in PD mouse models. | | | 05 October 2016 | doi: 10.1038/ncomms12932 | | |
| Elucidation of the biosynthesis of carnosic acid and its reconstitution in yeast OPEN | | | Ulschan Scheler, Wolfgang Brandt, Andrea Porzel, Kathleen Rothe, David Manzano, Dragana Božić, Dimitra Papaefthimiou, Gerd Ulrich Balcke, Anja Henning, Swanhild Lohse, Sylvestre Marillonnet, Angelos K. Kanellis, Albert Ferrer and Alain Tissier | | | Diterpenes are plant products with high antioxidant properties and potential application as food additives and therapeutics. Here, the authors describe the complete biosynthetic pathway of carnosic acid and reconstruct it in yeast, opening the way to metabolic engineering of phenolic diterpenes. | | | 05 October 2016 | doi: 10.1038/ncomms12942 | | |
| Genome-wide compendium and functional assessment of in vivo heart enhancers OPEN | | | Diane E. Dickel, Iros Barozzi, Yiwen Zhu, Yoko Fukuda-Yuzawa, Marco Osterwalder, Brandon J. Mannion, Dalit May, Cailyn H. Spurrell, Ingrid Plajzer-Frick, Catherine S. Pickle, Elizabeth Lee, Tyler H. Garvin, Momoe Kato, Jennifer A. Akiyama, Veena Afzal, Ah Young Lee, David U. Gorkin, Bing Ren, Edward M. Rubin, Axel Visel et al. | | | Identification of non-coding variants has outstripped our ability to annotate and interpret them. Dickel et al. present a compendium of over 80,000 putative human heart enhancers and demonstrate that two conserved enhancers are required for proper cardiac function in mice. | | | 05 October 2016 | doi: 10.1038/ncomms12923 | | |
| An extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid OPEN | | | Vanessa K. Wong, Stephen Baker, Thomas R. Connor, Derek Pickard, Andrew J. Page, Jayshree Dave, Niamh Murphy, Richard Holliman, Armine Sefton, Michael Millar, Zoe A. Dyson, Gordon Dougan, Kathryn E. Holt, International Typhoid Consortium, Julian Parkhill, Nicholas A. Feasey, Robert A. Kingsley, Nicholas R. Thomson, Jacqueline A. Keane, François- Xavier Weill et al. | | | Typhoid fever is caused by Salmonella enterica serovar Typhi (S. Typhi). This study examines ∼2,000 clinical isolates of S. Typhi to show highly structured/geographically restricted genomes except rapidly disseminating H58 subclade, and design a genotyping framework for tracking the disease. | | | 05 October 2016 | doi: 10.1038/ncomms12827 | | |
| Animal diversity and ecosystem functioning in dynamic food webs OPEN | | | Florian D. Schneider, Ulrich Brose, Björn C. Rall and Christian Guill | | | Losing animals from food webs could reduce ecosystem function, but drivers of this pattern are difficult to disentangle. With food web simulations, Schneider et al. show that high animal diversity does not release plants from top-down control owing to a balancing effect of increased animal body size. | | | 05 October 2016 | doi: 10.1038/ncomms12718 | | |
| Observation of pendular butterfly Rydberg molecules OPEN | | | Thomas Niederprüm, Oliver Thomas, Tanita Eichert, Carsten Lippe, Jesús Pérez-Ríos, Chris H. Greene and Herwig Ott | | | Rydberg molecules have potential for ultracold chemistry applications in light of their unconventional binding mechanism that provides high tunability. Here the authors observe and control butterfly Rydberg molecules, which are bound by a shape resonance in the electron-perturber scattering. | | | 05 October 2016 | doi: 10.1038/ncomms12820 | | |
| | | | | | | | | | Latest Corrigenda | | | | | | Corrigendum: Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety OPEN | | | Guo-Qiang Wang, Cheng Cen, Chong Li, Shuai Cao, Ning Wang, Zheng Zhou, Xue-Mei Liu, Yu Xu, Na-Xi Tian, Ying Zhang, Jun Wang, Li-Ping Wang and Yun Wang | | | 10 October 2016 | doi: 10.1038/ncomms12705 | | | Biological Sciences Neuroscience |
| | | | | | | | | | | Latest Errata | | | | | | Erratum: Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis OPEN | | | Solveig K. Sieberts, Fan Zhu, Javier García-García, Eli Stahl, Abhishek Pratap, Gaurav Pandey, Dimitrios Pappas, Daniel Aguilar, Bernat Anton, Jaume Bonet, Ridvan Eksi, Oriol Fornés, Emre Guney, Hongdong Li, Manuel Alejandro Marín, Bharat Panwar, Joan Planas-Iglesias, Daniel Poglayen, Jing Cui, Andre O. Falcao et al. | | | 10 October 2016 | doi: 10.1038/ncomms13205 | | |
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1 comment:
APP is cleaved by three types of proteases, called α-,β-and γ-secretase. Proteolytic cleavage of amyloid from amyloid precursor (APP) by APP secretase is a key event in the pathogenesis of Alzheimer’s disease (AD). β Secretase Inhibitors
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