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npj Precision Oncology is a new open access, online-only, peer-reviewed journal committed to publishing cutting-edge scientific research in all aspects of precision oncology from basic science to translational applications, to clinical medicine. The journal is part of the Nature Partner Journals series and published in partnership with The Hormel Institute, University of Minnesota.
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All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website.
Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | | | | | | | | | | | Latest Articles | View all Articles | | | | | The suppression of Antarctic bottom water formation by melting ice shelves in Prydz Bay OPEN | | | G. D. Williams, L. Herraiz-Borreguero, F. Roquet, T. Tamura, K. I. Ohshima, Y. Fukamachi, A. D. Fraser, L. Gao, H. Chen, C. R. McMahon, R. Harcourt and M. Hindell | | | Antarctic bottom water (AABW) production is critical to the global ocean overturning circulation. Here, the authors show new observations of AABW formation from seal CTD data in Prydz Bay, East Antarctica that highlights its susceptibility to increased freshwater input from the melting of ice shelves. | | | 23 August 2016 | doi: 10.1038/ncomms12577 | | |
| Sixteen years of change in the global terrestrial human footprint and implications for biodiversity conservation OPEN | | | Oscar Venter, Eric W. Sanderson, Ainhoa Magrach, James R. Allan, Jutta Beher, Kendall R. Jones, Hugh P. Possingham, William F. Laurance, Peter Wood, Balázs M. Fekete, Marc A. Levy and James E. M. Watson | | | Habitat loss and urbanization are primary components of human impact on the environment. Here, Venter et al. use global data on infrastructure, agriculture, and urbanization to show that the human footprint is growing slower than the human population, but footprints are increasing in biodiverse regions. | | | 23 August 2016 | doi: 10.1038/ncomms12558 | | |
| Sources of black carbon to the Himalayan–Tibetan Plateau glaciers OPEN | | | Chaoliu Li, Carme Bosch, Shichang Kang, August Andersson, Pengfei Chen, Qianggong Zhang, Zhiyuan Cong, Bing Chen, Dahe Qin and Örjan Gustafsson | | | Black carbon accelerates melting of glaciers in the Himalayas and Tibet, yet the source of these aerosols remains enigmatic. Here, the authors use isotope fingerprinting techniques to determine the origin of black carbon preserved in glacier ice cores recovered from the Himalayas and Tibetan Plateau. | | | 23 August 2016 | doi: 10.1038/ncomms12574 | | |
| Sleep recalibrates homeostatic and associative synaptic plasticity in the human cortex OPEN | | | Marion Kuhn, Elias Wolf, Jonathan G. Maier, Florian Mainberger, Bernd Feige, Hanna Schmid, Jan Bürklin, Sarah Maywald, Volker Mall, Nikolai H. Jung, Janine Reis, Kai Spiegelhalder, Stefan Klöppel, Annette Sterr, Anne Eckert, Dieter Riemann, Claus Normann and Christoph Nissen | | | Sleep deprivation is believed to lead to homeostatic increases in synaptic strength and reduced inducibility of associative LTP, based mainly on findings from animal studies. Here, Kuhn et al. demonstrate similar sleep-dependent synaptic plasticity changes in humans along with altered plasma BDNF levels. | | | 23 August 2016 | doi: 10.1038/ncomms12455 | | |
| Urban heat islands in China enhanced by haze pollution OPEN | | | Chang Cao, Xuhui Lee, Shoudong Liu, Natalie Schultz, Wei Xiao, Mi Zhang and Lei Zhao | | | The impact of locally-sourced aerosols on the Urban Heat Island (UHI) effect has been difficult to quantify due to opposing long and shortwave radiation effects. Here, using satellite observations and climate model simulations, the authors reveal that urban haze pollution intensifies the nighttime UHI in China. | | | 23 August 2016 | doi: 10.1038/ncomms12509 | | |
| El Niño and coral larval dispersal across the eastern Pacific marine barrier OPEN | | | S. Wood, I. B. Baums, C. B. Paris, A. Ridgwell, W. S. Kessler and E. J. Hendy | | | Over 5,000 km of open ocean separate central and eastern Pacific coral reefs. Here, the authors combine a biophysical dispersal model with genetic data to show that eastern Pacific coral populations have been isolated from western sources of larval recruitment since the 1997-98 El Niño-induced bleaching event. | | | 23 August 2016 | doi: 10.1038/ncomms12571 | | |
| A MUB E2 structure reveals E1 selectivity between cognate ubiquitin E2s in eukaryotes OPEN | | | Xiaolong Lu, Konstantin R. Malley, Caitlin C. Brenner, Olga Koroleva, Sergey Korolev and Brian P. Downes | | | Regulators of the important ubiquitylation cascade are not well studied. Here, the authors report the crystal structure of a prenylated membrane-anchored ubiquitin-fold protein from Arabidopsis bound to an E2 protein and conclude that it is an example of selective activation between E2 enzymes. | | | 23 August 2016 | doi: 10.1038/ncomms12580 | | |
| Heterogeneous reduction of carbon dioxide by hydride-terminated silicon nanocrystals OPEN | | | Wei Sun, Chenxi Qian, Le He, Kulbir Kaur Ghuman, Annabelle P. Y. Wong, Jia Jia, Abdinoor A. Jelle, Paul G. O’Brien, Laura M. Reyes, Thomas E. Wood, Amr S. Helmy, Charles A. Mims, Chandra Veer Singh and Geoffrey A. Ozin | | | Elemental silicon is widely studied for photovoltaic applications. Here, the authors report that hydride-terminated silicon nanocrystals can also function as single component heterogeneous reducing agent for converting gaseous carbon dioxide selectively to carbon monoxide. | | | 23 August 2016 | doi: 10.1038/ncomms12553 | | |
| Hybrid bio-photo-electro-chemical cells for solar water splitting OPEN | | | Roy I. Pinhassi, Dan Kallmann, Gadiel Saper, Hen Dotan, Artyom Linkov, Asaf Kay, Varda Liveanu, Gadi Schuster, Noam Adir and Avner Rothschild | | | Photoelectrochemical water splitting uses solar power to decompose water to hydrogen and oxygen. Here, the authors integrate thylakoid membranes extracted from spinach into a bio-photo-electro-chemical cell capable of overall water splitting without the need for any sacrificial reagents. | | | 23 August 2016 | doi: 10.1038/ncomms12552 | | |
| Topology and structure of an engineered human cohesin complex bound to Pds5B OPEN | | | Michael T. Hons, Pim J. Huis in ‘t Veld, Jan Kaesler, Pascaline Rombaut, Alexander Schleiffer, Franz Herzog, Holger Stark and Jan-Michael Peters | | | Cohesin is a ring-shaped protein complex that structures chromatin and mediates sister chromatid cohesion. Here the authors rigidify cohesin using engineered Smc1 and Smc3 and generated 3D models showing how Pds5B forms an integral part of the cohesin ring. | | | 23 August 2016 | doi: 10.1038/ncomms12523 | | |
| Global threats from invasive alien species in the twenty-first century and national response capacities OPEN | | | Regan Early, Bethany A. Bradley, Jeffrey S. Dukes, Joshua J. Lawler, Julian D. Olden, Dana M. Blumenthal, Patrick Gonzalez, Edwin D. Grosholz, Ines Ibañez, Luke P. Miller, Cascade J. B. Sorte and Andrew J. Tatem | | | Globalization facilitates the spread of invasive alien species, while environmental change can ease invasion. Here, Early et al. identify vulnerable regions globally and evaluate capacity in vulnerable countries to prevent invasions arising from sources such as air travel, horticulture, and pet trade. | | | 23 August 2016 | doi: 10.1038/ncomms12485 | | |
| Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis OPEN | | | Solveig K. Sieberts, Fan Zhu, Javier García-García, Eli Stahl, Abhishek Pratap, Gaurav Pandey, Dimitrios Pappas, Daniel Aguilar, Bernat Anton, Jaume Bonet, Ridvan Eksi, Oriol Fornés, Emre Guney, Hongdong Li, Manuel Alejandro Marín, Bharat Panwar, Joan Planas-Iglesias, Daniel Poglayen, Jing Cui, Andre O. Falcao et al. | | | Rheumatoid arthritis patients respond differently to anti-TNF treatment. Using community-based challenge, the authors show that currently available data does not reveal meaningful genetic predictors of response to anti-TNF therapy, thus confirming clinical observations. | | | 23 August 2016 | doi: 10.1038/ncomms12460 | | |
| Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma OPEN | | | Ugur Eskiocak, Vijayashree Ramesh, Jennifer G. Gill, Zhiyu Zhao, Stacy W. Yuan, Meng Wang, Travis Vandergriff, Mark Shackleton, Elsa Quintana, Timothy M. Johnson, Ralph J. DeBerardinis and Sean J. Morrison | | | Treatment responses of melanoma patients to MAPK pathway inhibitors are often limited. Here, the authors show that combining cardiac glycosides with MAPK inhibitors improves tumor regression by inducing intracellular acidification, mitochondrial calcium dysregulation, ATP depletion, and cell death. | | | 22 August 2016 | doi: 10.1038/ncomms12336 | | |
| MURC deficiency in smooth muscle attenuates pulmonary hypertension OPEN | | | Naohiko Nakanishi, Takehiro Ogata, Daisuke Naito, Kotaro Miyagawa, Takuya Taniguchi, Tetsuro Hamaoka, Naoki Maruyama, Takeru Kasahara, Masahiro Nishi, Satoaki Matoba and Tomomi Ueyama | | | MURC protein regulates the function of caveolae, the small invaginations of the plasma membrane in muscle cells. Here the authors show that by interacting with caveolin proteins, MURC affects RhoA/ROCK signalling and regulates proliferation and migration of pulmonary artery smooth muscle cells, suggesting a new target in therapy of pulmonary hypertension. | | | 22 August 2016 | doi: 10.1038/ncomms12417 | | |
| Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification OPEN | | | Jong Ho Park, Seung Wook Yang, Jung Mi Park, Seung Hyeun Ka, Ji-Hoon Kim, Young-Yun Kong, Young Joo Jeon, Jae Hong Seol and Chin Ha Chung | | | The ‘genome guardian’ p53 has a well-established role in suppressing tumour development after DNA damage. Here the authors show that expression of the ubiquitin-like protein ISG15 is regulated by p53 which in turn is modified by ISG15 to enhance binding to target gene promoters. | | | 22 August 2016 | doi: 10.1038/ncomms12513 | | |
| Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults OPEN | | | Andrew L. Young, Grant A. Challen, Brenda M. Birmann and Todd E. Druley | | | Clonal haematopoiesis has been thought to occur in less than 10% of individuals younger than 70 years old. Here, the authors use an error corrected next-generation sequencing method to find clonal haematopoiesis in the peripheral blood of 19 of 20 healthy 50–70 year old individuals. | | | 22 August 2016 | doi: 10.1038/ncomms12484 | | |
| Mid-Holocene pulse of thinning in the Weddell Sea sector of the West Antarctic ice sheet OPEN | | | Andrew S. Hein, Shasta M. Marrero, John Woodward, Stuart A. Dunning, Kate Winter, Matthew J. Westoby, Stewart P. H. T. Freeman, Richard P. Shanks and David E. Sugden | | | The precise contribution of the West Antarctic Ice Sheet (WAIS) melt to global sea-level rise remains enigmatic. Here, the authors generate an ice sheet thinning history for the Weddell Sea embayment and propose that this sector of the WAIS contributed to mid-Holocene, rather than late-glacial sea-level rise. | | | 22 August 2016 | doi: 10.1038/ncomms12511 | | |
| Characterization of a recently evolved flavonol-phenylacyltransferase gene provides signatures of natural light selection in Brassicaceae OPEN | | | Takayuki Tohge, Regina Wendenburg, Hirofumi Ishihara, Ryo Nakabayashi, Mutsumi Watanabe, Ronan Sulpice, Rainer Hoefgen, Hiromitsu Takayama, Kazuki Saito, Mark Stitt and Alisdair R. Fernie | | | Protection from UV-B is critical for land plant survival. Here Tohge et al. show that saiginols, a novel class of flavonols that efficiently absorb UV-B, accumulate in Arabidopsis accessions collected from high irradiance regions and identify a flavonol phenylacyltransferase gene required for saiginol production. | | | 22 August 2016 | doi: 10.1038/ncomms12399 | | |
| Magnetic torque anomaly in the quantum limit of Weyl semimetals OPEN | | | Philip J. W. Moll, Andrew C. Potter, Nityan L. Nair, B. J. Ramshaw, K. A. Modic, Scott Riggs, Bin Zeng, Nirmal J. Ghimire, Eric D. Bauer, Robert Kealhofer, Filip Ronning and James G. Analytis | | | The topological character of electrons in semimetals subtly influences their bulk properties, leading typically to weak experimental signatures. Here, Moll et al. report a distinctive anomaly in the magnetic torque upon entering quantum limit state in the Weyl semimetal NbAs, which only appears due to the presence of Weyl fermions. | | | 22 August 2016 | doi: 10.1038/ncomms12492 | | |
| Tuneable on-demand single-photon source in the microwave range OPEN | | | Z. H. Peng, S. E. de Graaf, J. S. Tsai and O. V. Astafiev | | | Microwave single photon sources are important for quantum applications, but their design often incorporates a resonator that fixes the frequency of the emitted photon. Here, the authors demonstrate a tuneable on-demand photon source based on an artificial atom asymmetrically coupled to two transmission lines. | | | 22 August 2016 | doi: 10.1038/ncomms12588 | | |
| Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation OPEN | | | Zhaoting Liu, Guozhu Ning, Ranran Xu, Yu Cao, Anming Meng and Qiang Wang | | | It is unclear how the cytoskeleton acts to assist in TGF-β signalling downstream of the receptor. Here, in zebrafish, the authors show that the actin-bundling protein FSCN1 interacts with TGF-β type I receptors ALK 4 and 5, enabling actin filament mediated vesicle trafficking and endoderm formation. | | | 22 August 2016 | doi: 10.1038/ncomms12603 | | |
| Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair OPEN | | | Yanhao Lai, Helen Budworth, Jill M. Beaver, Nelson L. S. Chan, Zunzhen Zhang, Cynthia T. McMurray and Yuan Liu | | | The expansion of trinucleotide repeats can have detrimental effects and give rise to a range of human diseases. Here the authors report that the mismatch repair and the base excision repair machinery can operate together to promote expansion during lesion removal. | | | 22 August 2016 | doi: 10.1038/ncomms12465 | | |
| Nonlinear metamaterials for holography OPEN | | | Euclides Almeida, Ora Bitton and Yehiam Prior | | | Phased metasurfaces have been extended to the nonlinear regime, enabling coherent generation, beam steering and lensing of light beams in one thin element. Here, Almeida et al. demonstrate a nonlinear multilayer metamaterial hologram generating images at the third harmonic frequency of the illuminating beam. | | | 22 August 2016 | doi: 10.1038/ncomms12533 | | |
| Rapid α-oligomer formation mediated by the Aβ C terminus initiates an amyloid assembly pathway OPEN | | | Pinaki Misra, Ravindra Kodali, Saketh Chemuru, Karunakar Kar and Ronald Wetzel | | | The elucidation of amyloid nucleation mechanisms remains challenging as early oligomeric intermediates are transient and difficult to distinguish. Here the authors use Aβ- polyglutamine hybrid peptides designed to slow and limit amyloid maturation to provide insights into the structures of Aβ self-assembly intermediates. | | | 22 August 2016 | doi: 10.1038/ncomms12419 | | |
| Lipidic cubic phase injector is a viable crystal delivery system for time-resolved serial crystallography OPEN | | | Przemyslaw Nogly, Valerie Panneels, Garrett Nelson, Cornelius Gati, Tetsunari Kimura, Christopher Milne, Despina Milathianaki, Minoru Kubo, Wenting Wu, Chelsie Conrad, Jesse Coe, Richard Bean, Yun Zhao, Petra Båth, Robert Dods, Rajiv Harimoorthy, Kenneth R. Beyerlein, Jan Rheinberger, Daniel James, Daniel DePonte et al. | | | Serial femtosecond crystallography using X-ray free-electron lasers has huge potential for time-resolved structural experiments. Here, the authors present a structure of the light-driven proton pump bacteriorhodopsin using these techniques. | | | 22 August 2016 | doi: 10.1038/ncomms12314 | | |
| Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma OPEN | | | Harvind S. Chahal, Wenting Wu, Katherine J. Ransohoff, Lingyao Yang, Haley Hedlin, Manisha Desai, Yuan Lin, Hong-Ji Dai, Abrar A. Qureshi, Wen-Qing Li, Peter Kraft, David A. Hinds, Jean Y. Tang, Jiali Han and Kavita Y. Sarin | | | Basal cell carcinoma is a common skin lesion and the risk loci for this cancer are beginning to be understood. In this study, the authors conduct a two-stage genome-wide association study and confirm known risk loci and identify an additional 14 loci. | | | 19 August 2016 | doi: 10.1038/ncomms12510 | | |
| Dynamic clonal equilibrium and predetermined cancer risk in Barrett’s oesophagus OPEN | | | Pierre Martinez, Margriet R. Timmer, Chiu T. Lau, Silvia Calpe, Maria del Carmen Sancho-Serra, Danielle Straub, Ann-Marie Baker, Sybren L. Meijer, Fiebo J. W. ten Kate, Rosalie C. Mallant-Hent, Anton H. J. Naber, Arnoud H. A. M. van Oijen, Lubbertus C. Baak, Pieter Scholten, Clarisse J. M. Böhmer, Paul Fockens, Jacques J. G. H. M. Bergman, Carlo C. Maley, Trevor A. Graham and Kausilia K Krishnadath et al. | | | Barrett’s oesophagus is thought to be a precursor lesion for oesophageal cancer, and predicting the benign lesions that progress to cancer is clinically important. Here, the authors use FISH to study the clonal evolution of Barrett’s oesophagus and show that genetic diversity and somatic mutations are present early in the benign disease. | | | 19 August 2016 | doi: 10.1038/ncomms12158 | | |
| Quantifying redox-induced Schottky barrier variations in memristive devices via in operando spectromicroscopy with graphene electrodes OPEN | | | Christoph Baeumer, Christoph Schmitz, Astrid Marchewka, David N. Mueller, Richard Valenta, Johanna Hackl, Nicolas Raab, Steven P. Rogers, M. Imtiaz Khan, Slavomir Nemsak, Moonsub Shim, Stephan Menzel, Claus Michael Schneider, Rainer Waser and Regina Dittmann | | | Resistive switching in metal oxides is related to the migration of donor defects. Here Baeumer et al. use in operando X-ray spectromicroscopy to quantify the doping locally and show that small local variations in the donor concentration result in large variations in the device resistance. | | | 19 August 2016 | doi: 10.1038/ncomms12398 | | |
| Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia OPEN | | | Ralph Klose, Ewelina Krzywinska, Magali Castells, Dagmar Gotthardt, Eva Maria Putz, Chahrazade Kantari-Mimoun, Naima Chikdene, Anna-Katharina Meinecke, Katrin Schrödter, Iris Helfrich, Joachim Fandrey, Veronika Sexl and Christian Stockmann | | | Chemerin is an adipokine often downregulated in tumours. Here the authors show that chemotherapy induces chemerin production by endothelial cells, leading to cachexia, and that VEGF ablation in myeloid cells prevents cachexia in a chemerin-dependent manner, and improves chemotherapeutic effects. | | | 19 August 2016 | doi: 10.1038/ncomms12528 | | |
| Identification of carbon-encapsulated iron nanoparticles as active species in non-precious metal oxygen reduction catalysts OPEN | | | Jason A. Varnell, Edmund C. M. Tse, Charles E. Schulz, Tim T. Fister, Richard T. Haasch, Janis Timoshenko, Anatoly I. Frenkel and Andrew A. Gewirth | | | Determining active species in non-precious metal catalysts for the oxygen reduction reaction remains a challenge due to catalyst heterogeneity. Here the authors perform gas-phase treatments on an iron-based catalyst to allow the identification of carbon-encapsulated iron nanoparticles as the active species. | | | 19 August 2016 | doi: 10.1038/ncomms12582 | | |
| Bright monomeric near-infrared fluorescent proteins as tags and biosensors for multiscale imaging OPEN | | | Daria M. Shcherbakova, Mikhail Baloban, Alexander V. Emelyanov, Michael Brenowitz, Peng Guo and Vladislav V. Verkhusha | | | Near-infrared fluorescent proteins are non-invasive probes for deep tissue imaging, but because of the dimeric state they perform poorly in protein labelling. Here, the authors engineered three spectrally resolvable monomeric near-infrared probes with improved brightness for multiscale imaging. | | | 19 August 2016 | doi: 10.1038/ncomms12405 | | |
| Divergent synthesis and identification of the cellular targets of deoxyelephantopins OPEN | | | Roman Lagoutte, Christelle Serba, Daniel Abegg, Dominic G. Hoch, Alexander Adibekian and Nicolas Winssinger | | | Deoxyelephantopin is a naturally occurring sesquiterpene lactone with known anticancer properties. Here, the authors synthesize deoxyelephantopins and a range of analogues including alkyne-tagged probes, using them to identify its cellular targets. | | | 19 August 2016 | doi: 10.1038/ncomms12470 | | |
| β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain OPEN | | | Gang Chen, Rou-Gang Xie, Yong-Jing Gao, Zhen-Zhong Xu, Lin-Xia Zhao, Sangsu Bang, Temugin Berta, Chul-Kyu Park, Mark Lay, Wei Chen and Ru-Rong Ji | | | The cellular mechanisms underlying acute pain transitions to chronic pain are poorly understood. Here the authors show that the scaffolding protein β-arrestin 2 contributes to these processes via desensitization of NMDA receptors in spinal neurons. | | | 19 August 2016 | doi: 10.1038/ncomms12531 | | |
| Néel-like domain walls in ferroelectric Pb(Zr,Ti)O3 single crystals OPEN | | | Xian-Kui Wei, Chun-Lin Jia, Tomas Sluka, Bi-Xia Wang, Zuo-Guang Ye and Nava Setter | | | Flexible rotation of spontaneous polarization at ferroelectric domain walls is predicted in theory but lacks evidence from experiment. Here, Wei et al. image a Néel-like domain wall in Ti-rich ferroelectric Pb(Zr1−x Ti x )O3 crystals, providing insight in exploring chiral domain walls in ferroelectrics. | | | 19 August 2016 | doi: 10.1038/ncomms12385 | | |
| Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans OPEN | | | Lesca M. Holdt, Anika Stahringer, Kristina Sass, Garwin Pichler, Nils A. Kulak, Wolfgang Wilfert, Alexander Kohlmaier, Andreas Herbst, Bernd H. Northoff, Alexandros Nicolaou, Gabor Gäbel, Frank Beutner, Markus Scholz, Joachim Thiery, Kiran Musunuru, Knut Krohn, Matthias Mann and Daniel Teupser | | | Circular RNAs are widely expressed in eukaryotic cells but their functions and mechanisms of action are still being elucidated. Here the authors show that circANRIL modulates rRNA maturation and confers protection again atherosclerosis. | | | 19 August 2016 | doi: 10.1038/ncomms12429 | | |
| Ultrafast formation of interlayer hot excitons in atomically thin MoS2/WS2 heterostructures OPEN | | | Hailong Chen, Xiewen Wen, Jing Zhang, Tianmin Wu, Yongji Gong, Xiang Zhang, Jiangtan Yuan, Chongyue Yi, Jun Lou, Pulickel M. Ajayan, Wei Zhuang, Guangyu Zhang and Junrong Zheng | | | Van der Waals heterostructures, fabricated via vertical stacking of two-dimensional materials, hold promise for opto-electronic applications. Here, the authors study the exciton-assisted charge transfer mechanisms occurring in a WS2/MoS2 heterojunction via ultrafast microspectroscopy. | | | 19 August 2016 | doi: 10.1038/ncomms12512 | | |
| Microfibres and macroscopic films from the coordination-driven hierarchical self-assembly of cylindrical micelles OPEN | | | David J. Lunn, Oliver E. C. Gould, George R. Whittell, Daniel P. Armstrong, Kenneth P. Mineart, Mitchell A. Winnik, Richard J. Spontak, Paul G. Pringle and Ian Manners | | | Anisotropic nanoparticles made from block copolymers are important building blocks for synthetic hierarchical materials. Here, the authors report a reversible coordination-driven self-assembly strategy for the preparation of micron-scale fibres and macroscopic films based on monodisperse cylindrical micelles. | | | 19 August 2016 | doi: 10.1038/ncomms12371 | | |
| Coevolution of parental investment and sexually selected traits drives sex-role divergence OPEN | | | Lutz Fromhage and Michael D. Jennions | | | Females tend to invest more than males in caring for offspring, which has been argued to be a consequence of the small initial difference in investment in eggs versus sperm. Here, Fromhage and Jennions formalize this argument mathematically in a model of the evolution of sex roles in parental care. | | | 18 August 2016 | doi: 10.1038/ncomms12517 | | |
| Entrainment dominates the interaction of microalgae with micron-sized objects OPEN | | | Raphaël Jeanneret, Dmitri O. Pushkin, Vasily Kantsler and Marco Polin | | | Passive particles surrounded by swimming protists diffuse tens of times faster than their thermal motion, which might have an impact on microscopic predator-prey interaction in nature. Here, Jeanneret et al. investigate its physical origin and identify direct particle entrainment as the dominant feature. | | | 18 August 2016 | doi: 10.1038/ncomms12518 | | |
| Mechanosensing by the α6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis OPEN | | | Huaping Chen, Jing Qu, Xiangwei Huang, Ashish Kurundkar, Lanyan Zhu, Naiheng Yang, Aida Venado, Qiang Ding, Gang Liu, Veena B. Antony, Victor J. Thannickal and Yong Zhou | | | Matrix stiffening is a feature of pulmonary fibrosis, and is amplified by lung myofibroblasts. Here the authors find that a6 integrin expression is upregulated on lung myofibroblasts in response to matrix stiffness, and this integrin is required for myofibroblast invasion, and fibrosis in an experimental disease model. | | | 18 August 2016 | doi: 10.1038/ncomms12564 | | |
| PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis OPEN | | | Katherine Martin, James Pritchett, Jessica Llewellyn, Aoibheann F. Mullan, Varinder S. Athwal, Ross Dobie, Emma Harvey, Leo Zeef, Stuart Farrow, Charles Streuli, Neil C. Henderson, Scott L. Friedman, Neil A. Hanley and Karen Piper Hanley | | | Antifibrotic therapies that target myofibroblast activation are needed to treat chronic liver disease. Here the authors identify an axis of integrin beta-1 expression and Yap-1 and Pak protein signalling that can be interfered with to inhibit myofibroblast function and liver fibrosis in vivo. | | | 18 August 2016 | doi: 10.1038/ncomms12502 | | |
| Responses of sequential and hierarchical phenological events to warming and cooling in alpine meadows OPEN | | | Xine Li, Lili Jiang, Fandong Meng, Shiping Wang, Haishan Niu, Amy M. Iler, Jichuan Duan, Zhenhua Zhang, Caiyun Luo, Shujuan Cui, Lirong Zhang, Yaoming Li, Qi Wang, Yang Zhou, Xiaoying Bao, Tsechoe Dorji, Yingnian Li, Josep Peñuelas, Mingyuan Du, Xinquan Zhao et al. | | | Describing changes in the timing of life history events is critical to understanding effects of climate change. Wang et al. relocated plant communities up and down elevation gradients and found that warming lengthened the reproductive and activity phases, while cooling reduced the vegetative and reproductive phases. | | | 18 August 2016 | doi: 10.1038/ncomms12489 | | |
| Past and estimated future impact of invasive alien mammals on insular threatened vertebrate populations OPEN | | | Erin E. McCreless, David D. Huff, Donald A. Croll, Bernie R. Tershy, Dena R. Spatz, Nick D. Holmes, Stuart H. M. Butchart and Chris Wilcox | | | Invasive vertebrates can decimate native species living on islands. Using a model of global extirpation patterns, McCreless et al. identify the types of invasive species most harmful to natives and predict when controlling or eradicating the invasive species is likely to succeed as a conservation strategy. | | | 18 August 2016 | doi: 10.1038/ncomms12488 | | |
| Optimal policy for value-based decision-making OPEN | | | Satohiro Tajima, Jan Drugowitsch and Alexandre Pouget | | | Drift diffusion models (DDM) are fundamental to our understanding of perceptual decision-making. Here, the authors show that DDM can implement optimal choice strategies in value-based decisions but require sufficient knowledge of reward contingencies and collapsing decision boundaries with time. | | | 18 August 2016 | doi: 10.1038/ncomms12400 | | |
| Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia OPEN | | | Pierre Hirsch, Yanyan Zhang, Ruoping Tang, Virginie Joulin, Hélène Boutroux, Elodie Pronier, Hannah Moatti, Pascale Flandrin, Christophe Marzac, Dominique Bories, Fanny Fava, Hayat Mokrani, Aline Betems, Florence Lorre, Rémi Favier, Frédéric Féger, Mohamad Mohty, Luc Douay, Ollivier Legrand, Chrystèle Bilhou-Nabera et al. | | | Pre-leukaemic clones, together with the propensity to cause disease in mice, are characterized by appearing early in myeloid leukaemia and being found at relapse. Here, the authors identify clones in human samples and find that they are characterized by hierarchically organized genetic lesions, which can be used to track evolution of the disease. | | | 18 August 2016 | doi: 10.1038/ncomms12475 | | |
| A keystone mutualism underpins resilience of a coastal ecosystem to drought OPEN | | | Christine Angelini, John N. Griffin, Johan van de Koppel, Leon P. M. Lamers, Alfons J. P. Smolders, Marlous Derksen-Hooijberg, Tjisse van der Heide and Brian R. Silliman | | | Intensifying drought has caused massive die-offs in ecosystems worldwide. Here, Angelini et al. use observations, experiments, and models in US salt marshes to show that a key mutualism increases ecosystem resilience by maintaining stress-resistant habitat patches that aid post-drought recovery. | | | 18 August 2016 | doi: 10.1038/ncomms12473 | | |
| In situ high-resolution structure of the baseplate antenna complex in Chlorobaculum tepidum OPEN | | | Jakob Toudahl Nielsen, Natalia V. Kulminskaya, Morten Bjerring, Juha M. Linnanto, Margus Rätsep, Marie Østergaard Pedersen, Petar H. Lambrev, Márta Dorogi, Győző Garab, Karen Thomsen, Caroline Jegerschöld, Niels-Ulrik Frigaard, Martin Lindahl and Niels Chr. Nielsen | | | The chlorosome of the photosynthetic bacterium C. tepidum harvests light and transfers the energy to the photosynthetic reaction centre. Here the authors determine the structure of the baseplate, a scaffolding super-structure, to show that the baseplate consists of rods of repeated CsmA dimers containing pigment molecules. | | | 18 August 2016 | doi: 10.1038/ncomms12454 | | |
| Defective TiO2 with high photoconductive gain for efficient and stable planar heterojunction perovskite solar cells OPEN | | | Yanbo Li, Jason K. Cooper, Wenjun Liu, Carolin M. Sutter-Fella, Matin Amani, Jeffrey W. Beeman, Ali Javey, Joel W. Ager, Yi Liu, Francesca M. Toma and Ian D. Sharp | | | Perovskite-based photovoltaics have already reached high efficiency levels but their stability under operating conditions remains a challenge. Here, Li et al. use defective TiO2 with reduced photocatalytic efficiency to increase the stability of high efficiency solar cells under illumination | | | 18 August 2016 | doi: 10.1038/ncomms12446 | | |
| Novel gene function revealed by mouse mutagenesis screens for models of age-related disease OPEN | | | Paul K. Potter, Michael R. Bowl, Prashanthini Jeyarajan, Laura Wisby, Andrew Blease, Michelle E. Goldsworthy, Michelle M. Simon, Simon Greenaway, Vincent Michel, Alun Barnard, Carlos Aguilar, Thomas Agnew, Gareth Banks, Andrew Blake, Lauren Chessum, Joanne Dorning, Sara Falcone, Laurence Goosey, Shelley Harris, Andy Haynes et al. | | | Random mutagenesis can uncover novel genes involved in phenotypic traits. Here the authors perform a large-scale phenotypic screen on over 100 mouse strains generated by ENU mutagenesis to identify mice with age-related diseases, which they attribute to specific mutations revealed by whole-genome sequencing. | | | 18 August 2016 | doi: 10.1038/ncomms12444 | | |
| The hydrolethalus syndrome protein HYLS-1 regulates formation of the ciliary gate OPEN | | | Qing Wei, Yingyi Zhang, Clementine Schouteden, Yuxia Zhang, Qing Zhang, Jinhong Dong, Veronika Wonesch, Kun Ling, Alexander Dammermann and Jinghua Hu | | | Transition fibres (TFs) and the transition zone (TZ) are basal ciliary structures thought to act as a gate to regulate protein transport. Here the authors show that the C. elegans orthologue of hydrolethalus protein 1, HYLS-1, disrupts both structures and compromises the trafficking of cargo through the ciliary gate. | | | 18 August 2016 | doi: 10.1038/ncomms12437 | | |
| Local dynamics of topological magnetic defects in the itinerant helimagnet FeGe OPEN | | | A. Dussaux, P. Schoenherr, K. Koumpouras, J. Chico, K. Chang, L. Lorenzelli, N. Kanazawa, Y. Tokura, M. Garst, A. Bergman, C. L. Degen and D. Meier | | | Topological defects may strongly influence the evolution of a materials' micromagnetic structure whilst their manipulation forms the basis for emerging technological concepts. Here, the authors study the depinning and motion of magnetic edge dislocations in the domain structure of helimagnetic FeGe. | | | 18 August 2016 | doi: 10.1038/ncomms12430 | | |
| Neural processes mediating contextual influences on human choice behaviour OPEN | | | Francesco Rigoli, Karl J. Friston and Raymond J. Dolan | | | The influence of context on value-based choice is well established but the neural correlates associated with this remain poorly understood. Here the authors perform fMRI in human subjects and find that the hippocampus and ventral tegmental area/substantia nigra are associated with the degree of influence of context on choice behaviour. | | | 18 August 2016 | doi: 10.1038/ncomms12416 | | |
| Thermodynamics of freezing and melting OPEN | | | Ulf R. Pedersen, Lorenzo Costigliola, Nicholas P. Bailey, Thomas B. Schrøder and Jeppe C. Dyre | | | Melting is a classic first-order phase transition, but an accurate thermodynamic description is still lacking. Here, Pedersen et al. develop a theory, validated by simulations of the Lennard-Jones system, for the melting thermodynamics applicable to all systems characterized by hidden scale invariance. | | | 17 August 2016 | doi: 10.1038/ncomms12386 | | |
| Volume-wise destruction of the antiferromagnetic Mott insulating state through quantum tuning OPEN | | | Benjamin A. Frandsen, Lian Liu, Sky C. Cheung, Zurab Guguchia, Rustem Khasanov, Elvezio Morenzoni, Timothy J. S. Munsie, Alannah M. Hallas, Murray N. Wilson, Yipeng Cai, Graeme M. Luke, Bijuan Chen, Wenmin Li, Changqing Jin, Cui Ding, Shengli Guo, Fanlong Ning, Takashi U. Ito, Wataru Higemoto, Simon J. L. Billinge et al. | | | Knowing whether a quantum phase transition is first- or second-order is crucial for understanding any associated exotic phenomena, but direct experimental evidence has been scarce. Here, Frandsen et al. report first-order magnetic quantum phase transitions in archetypal Mott systems, providing insight into the underlying quantum fluctuations. | | | 17 August 2016 | doi: 10.1038/ncomms12519 | | |
| Asymmetric counteranion-directed Lewis acid organocatalysis for the scalable cyanosilylation of aldehydes OPEN | | | Zhipeng Zhang, Han Yong Bae, Joyram Guin, Constantinos Rabalakos, Manuel van Gemmeren, Markus Leutzsch, Martin Klussmann and Benjamin List | | | Asymmetric cyanosilyation is a powerful method to convert carbonyls to chiral, configurationally stable cyanohydrins. Here, the authors report a catalyst capable of carrying out this reaction on large scales with extremely low catalyst loading, and also identify and explain a dormant period in the cycle. | | | 17 August 2016 | doi: 10.1038/ncomms12478 | | |
| Telomeric RNAs are essential to maintain telomeres OPEN | | | Juan José Montero, Isabel López de Silanes, Osvaldo Graña and Maria A. Blasco | | | The telomeric long-non coding RNA, TERRA, has been proposed in the past to modulate different telomeric functions based on in vitro studies. Here the authors show, using a genetic deletion approach, that TERRA is transcribed from the 20q subtelomere and that it is essential for telomere maintenance. | | | 17 August 2016 | doi: 10.1038/ncomms12534 | | |
| reChIP-seq reveals widespread bivalency of H3K4me3 and H3K27me3 in CD4+ memory T cells OPEN | | | Sarah Kinkley, Johannes Helmuth, Julia K. Polansky, Ilona Dunkel, Gilles Gasparoni, Sebastian Fröhler, Wei Chen, Jörn Walter, Alf Hamann and Ho-Ryun Chung | | | Co-localizing chromatin modifications and regulators can exert a combinatorial effect on chromatin structure and function. Here the authors describe reChIP-seq and normR to identify co-localizing proteins in an unbiased genome-wide manner. | | | 17 August 2016 | doi: 10.1038/ncomms12514 | | |
| Extension of human lncRNA transcripts by RACE coupled with long-read high-throughput sequencing (RACE-Seq) OPEN | | | Julien Lagarde, Barbara Uszczynska-Ratajczak, Javier Santoyo-Lopez, Jose Manuel Gonzalez, Electra Tapanari, Jonathan M. Mudge, Charles A. Steward, Laurens Wilming, Andrea Tanzer, Cédric Howald, Jacqueline Chrast, Alicia Vela-Boza, Antonio Rueda, Francisco J. Lopez-Domingo, Joaquin Dopazo, Alexandre Reymond, Roderic Guigó and Jennifer Harrow | | | Long non-coding RNAs are increasingly recognised to be important factors in regulating cellular processes and comprise a large faction of the transcriptome, however most are uncharacterised. Here the authors present RACE-Seq, a tool to improve and extend the annotation of low-expression transcripts. | | | 17 August 2016 | doi: 10.1038/ncomms12339 | | |
| Ubiquity and impact of thin mid-level clouds in the tropics OPEN | | | Quentin Bourgeois, Annica M. L. Ekman, Matthew R. Igel and Radovan Krejci | | | Clouds play a pivotal role in the Earth’s climate, yet little is known about those at mid-levels. Here, using satellite observations and high-resolution modeling, the authors find thin mid-level clouds, formed by detrainment during deep convection, occur across the tropics with a cooling effect on the climate. | | | 17 August 2016 | doi: 10.1038/ncomms12432 | | |
| Neural correlates of two different types of extinction learning in the amygdala central nucleus OPEN | | | Mihaela D. Iordanova, Mickael L. D. Deroche, Guillem R. Esber and Geoffrey Schoenbaum | | | There are two forms of extinction learning, which are vital for adaptive behaviour: simple extinction, when an expected outcome fails to occur, and overexpectation, when an exaggerated expectation is in conflict with the actual outcome. Iordanova et al. show that both forms of extinction learning have a common neural substrate in the amygdala. | | | 17 August 2016 | doi: 10.1038/ncomms12330 | | |
| Phototriggered protein syntheses by using (7-diethylaminocoumarin-4-yl)methoxycarbonyl-caged aminoacyl tRNAs OPEN | | | Takashi Ohtsuki, Shigeto Kanzaki, Sae Nishimura, Yoshio Kunihiro, Masahiko Sisido and Kazunori Watanabe | | | Spatiotemporal regulation of protein synthesis would advance studies into the consequences of localised protein translation in cells and tissues. Here, Ohtsuki et al. improve on an earlier caged-tRNA design to provide caged aminoacyl-tRNAs that are rapidly uncaged by visible light. | | | 17 August 2016 | doi: 10.1038/ncomms12501 | | |
| Non-homologous DNA increases gene disruption efficiency by altering DNA repair outcomes OPEN | | | C. D. Richardson, G. J. Ray, N. L. Bray and J. E. Corn | | | CRISPR-Cas9 mediated gene editing has begun to revolutionize molecular biology, but editing efficiencies can vary greatly between reagents. The authors show that the addition of single-stranded non-homologous DNA stimulates gene disruption by favouring error-prone DNA repair. | | | 17 August 2016 | doi: 10.1038/ncomms12463 | | |
| PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2 OPEN | | | Gabrielle J. Grundy, Luis M. Polo, Zhihong Zeng, Stuart L. Rulten, Nicolas C. Hoch, Pathompong Paomephan, Yingqi Xu, Steve M. Sweet, Alan W. Thorne, Antony W. Oliver, Steve J. Matthews, Laurence H. Pearl and Keith W. Caldecott | | | Chromosomal single-strand DNA breaks occur frequently and require repair to avoid disease outcomes. Here, the authors show that in bird cells, PARP3 accelerates this repair, and use structural biology and cell biology techniques to reveal details of the mechanism of action. | | | 17 August 2016 | doi: 10.1038/ncomms12404 | | |
| Immunogenomic engineering of a plug-and-(dis)play hybridoma platform OPEN | | | Mark Pogson, Cristina Parola, William J. Kelton, Paul Heuberger and Sai T. Reddy | | | Hybridomas are widely used for antibody screening and production due to their genetic stability and rapid proliferation. Here the authors demonstrate the rapid reprogramming of antibody specificity in hybridomas using CRISPR-Cas9. | | | 17 August 2016 | doi: 10.1038/ncomms12535 | | |
| Spectroscopic and computational investigation of actinium coordination chemistry OPEN | | | Maryline G. Ferrier, Enrique R. Batista, John M. Berg, Eva R. Birnbaum, Justin N. Cross, Jonathan W. Engle, Henry S. La Pierre, Stosh A. Kozimor, Juan S. Lezama Pacheco, Benjamin W. Stein, S. Chantal E. Stieber and Justin J. Wilson | | | Actinium-225 is a promising isotope for α-therapy but progress in developing its chemistry is hindered by its high radioactivity and short supply. Here, the authors characterize actinium coordination in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. | | | 17 August 2016 | doi: 10.1038/ncomms12312 | | | | | | | | | | |
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