Nature Reviews Cancer contents May 2016 Volume 16 Number 5 pp271-339

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TABLE OF CONTENTS
May 2016 Volume 16 Number 5		Advertisement
Impact Factor 37.4 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy Suzanne L. Topalian, Janis M. Taube, Robert A. Anders & Drew M. Pardoll	Determine the Metabolic Phenotype of Your Cells The XF Cell Energy Phenotype Test from Seahorse Bioscience (a part of Agilent Technologies). Using as few as 15,000 cells and an XF Extracellular Flux Analyzer, the XF Cell Energy Phenotype Test identifies your cells' metabolic phenotype as well as their metabolic potential - the utilization of mitochondrial respiration and glycolysis.  bit.ly/1GIZs4D
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An online-only, open access, multidisciplinary journal dedicated to publishing high-quality original research articles, reviews, editorials, commentaries, and hypothesis generating observations on all areas of breast cancer research. Part of the Nature Partner Journals series, published in partnership with the Breast Cancer Research Foundation.  Now open for submissions
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Don't miss the latest focus issues from Laboratory Investigation and Modern Pathology  Focus on Breast Highlighting recent advances in breast cancer diagnosis and treatment.  Focus on Soft Tissue Advancing understanding of the pathogenesis of soft tissue sarcomas, and describing advances that may lead to the development of new diagnostic tests and targeted therapies.
RESEARCH HIGHLIGHTS Top Tumour immunology: Metastasis in action p271 | doi:10.1038/nrc.2016.43 Circulating tumour cells fragment as they metastasize, providing 'information' to immune cells that promote or inhibit metastasis. PDF Tumour suppressors: Turning a negative into a positive p272 | doi:10.1038/nrc.2016.39 A recent publication in Nature Medicine in which Seyedmehdi Shojaee, Markus Muschen and colleagues show that deletion of the tumour suppressor PTEN in pre-B cell acute lymphoblastic leukaemia (pre-B ALL) cells results in cell death. PDF Cell migration: Nuclear envelope ruptures as cells squeeze through tight spaces p272 | doi:10.1038/nrc.2016.42 Two studies report that the nuclear envelope undergoes rupture and resealing when migrating cells pass through tight spaces. PDF IN BRIEF Genetics: p53 variant increases cancer risk | Prostate cancer: Connecting androgen receptor and immunity | Tumour immunology: Another string to the MYC bow | Translocations: Circular RNAs from translocations PDF Cancer JOBS of the week Postdoctoral Fellowships in Prostate Cancer Cleveland Clinic Postdoctoral Fellow in Cancer Biology Johns Hopkins University Shcool of Medicine Post-doctoral fellow in cancer signaling and therapeutics Memorial Sloan Kettering Cancer Center (MSKCC) Post-doctoral Fellow – Cancer Research Memorial Sloan Kettering Cancer Center (MSKCC) Faculty Positions in Cancer Immunology University of New Mexico More Science jobs from Cancer EVENT Horizons of Cancer Biology and Therapy Inaugural Symposium 07.09.16 Lausanne, Switzerland More science events from
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BJC collections: Cancer Immunotherapy Immunotherapies have revolutionised therapy for some cancers. In parallel with therapeutic trials, many other mechanisms and pathways are being investigated in optimising these treatments.  Access this collection from British Journal of Cancer - free online for six months Produced with support from: EMD Serono
REVIEWS		Top
Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy Suzanne L. Topalian, Janis M. Taube, Robert A. Anders & Drew M. Pardoll p275 | doi:10.1038/nrc.2016.36 This Review assesses the mechanism-based biomarkers in use and in development for immune checkpoint inhibition, identifying cancer types and cancer phenotypes that are most likely to respond to immune checkpoint blockade, and considerations for future biomarkers of immune checkpoint response. Abstract | Full Text | PDF
New frontiers in translational control of the cancer genome Morgan L. Truitt & Davide Ruggero p288 | doi:10.1038/nrc.2016.27 This Review summarizes our current understanding of the molecular mechanisms that regulate translation in cancer cells. The authors highlight the technological advances that have fuelled progress in this field and discuss how cancer cells tailor translation to adapt to oncogenic stress. Abstract | Full Text | PDF
Oesophageal adenocarcinoma and gastric cancer: should we mind the gap? Yoku Hayakawa, Nilay Sethi, Antonia R. Sepulveda, Adam J. Bass & Timothy C. Wang p305 | doi:10.1038/nrc.2016.24 This Review discusses our current understanding of oesophageal adenocarcinoma and intestinal-type gastric cancer, integrating advances from cell-of-origin studies and comprehensive genomic alteration analyses, with the goal of providing insight into the relationships between these two cancers. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Defining actionable mutations for oncology therapeutic development T. Hedley Carr, Robert McEwen, Brian Dougherty, Justin H. Johnson, Jonathan R. Dry, Zhongwu Lai, Zara Ghazoui, Naomi M. Laing, Darren R. Hodgson, Francisco Cruzalegui, Simon J. Hollingsworth & J. Carl Barrett p319 | doi:10.1038/nrc.2016.35 This Opinion article discusses the challenges in determining which genomic events in tumours are actionable and thus expected to affect treatment response. The authors summarize published classification approaches and propose a new framework to classify mutation actionability in early-phase clinical trials. Abstract | Full Text | PDF
OPINION Sexual dimorphism in cancer Andrea Clocchiatti, Elisa Cora, Yosra Zhang & G. Paolo Dotto p330 | doi:10.1038/nrc.2016.30 The incidence of many cancer types in non-reproductive tissues is higher in males than in females. This Opinion article discusses the cellular and molecular differences between the two sexes that might contribute to this discrepancy. Abstract | Full Text | PDF | Supplementary information
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*2014 Journal Citation Report (Thomson Reuters, 2015)

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