Scientific Reports Biology Table of Contents e-alert: 15 March 2016

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15 March 2016      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports               Open for Submissions  A new open access, multi-and interdisciplinary journal dedicated to publishing the finest research on both microbial biofilms and microbiomes, the journal is now open for submissions.   Explore the benefits of submitting your next research article.                 Biological Sciences               Atomic visualization of a flipped-back conformation of bisected glycans bound to specific lectins ▶     Masamichi Nagae, Mayumi Kanagawa, Kana Morita-Matsumoto et al.     Glycans normally exist as a dynamic equilibrium of several conformations. A fundamental question concerns how such molecules bind lectins despite disadvantageous entropic loss …             Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer ▶     Xiaojia Guo, Lindsay Hollander, Douglas MacPherson et al.     An essential feature of cancer is dysregulation of cell senescence and death. Renalase, a recently discovered secreted flavoprotein, provides cytoprotection against ischemic and …             hTERT promotes cell adhesion and migration independent of telomerase activity ▶     Haiying Liu, Qianqian Liu, Yuanlong Ge et al.     hTERT, a catalytic component of human telomerase, is undetectable in normal somatic cells but up-regulated in cancer and stem cells where telomere length is maintained by …             Ecosystem function decays by fungal outbreaks in Antarctic microbial mats ▶     David Velázquez, Alberto López-Bueno, Daniel Aguirre de Cárcer et al.     Antarctica harbours a remarkably diverse range of freshwater bodies and terrestrial ecosystems, where microbial mats are considered the most important systems in terms of biomass …             Metagenomic and functional analyses of the consequences of reduction of bacterial diversity on soil functions and bioremediation in diesel-contaminated microcosms ▶     Jaejoon Jung, Laurent Philippot, Woojun Park     The relationship between microbial biodiversity and soil function is an important issue in ecology, yet most studies have been performed in pristine ecosystems. Here, we assess …             Guiding migration of transplanted glial progenitor cells in the injured spinal cord ▶     Xiao-bing Yuan, Ying Jin, Christopher Haas et al.     Transplantation of glial-restricted progenitors (GRPs) is a promising strategy for generating a supportive environment for axon growth in the injured spinal cord. Here we …             Metabolic Reprogramming by Hexosamine Biosynthetic and Golgi N-Glycan Branching Pathways ▶     Michael C. Ryczko, Judy Pawling, Rui Chen et al.     De novo uridine-diphosphate-N-acetylglucosamine (UDP-GlcNAc) biosynthesis requires glucose, glutamine, acetyl-CoA and uridine, however GlcNAc salvaged from glycoconjugate …             Polymorphisms of the IL27 gene in a Chinese Han population complicated with pre-eclampsia ▶     Bin Liu, Yuan Li, Yuan Yao et al.     IL-27 could inhibit the development of Th17 cells, and the Th17/regulatory T-cell imbalance may reverse maternal tolerance in pre-eclampsia (PE). The aim of this study was to …             Influence of cell physiological state on gene delivery to T lymphocytes by chimeric adenovirus Ad5F35 ▶     Wen-feng Zhang, Hong-wei Shao, Feng-lin Wu et al.     Adoptive transfer of genetically-modified T cells is a promising approach for treatment of both human malignancies and viral infections. Due to its ability to efficiently infect …             A genistein-enriched diet neither improves skeletal muscle oxidative capacity nor prevents the transition towards advanced insulin resistance in ZDF rats ▶     Bianca W. J. van Bree, Ellen Lenaers, Miranda Nabben et al.     Genistein, a natural food compound mainly present in soybeans, is considered a potent antioxidant and to improve glucose homeostasis. However, its mechanism of action remains …             Intraguild predation between Amblyseius swirskii and two native Chinese predatory mite species and their development on intraguild prey ▶     Yingwei Guo, Jiale Lv, Xiaohuan Jiang et al.     Amblyseius swirskii, native to the east and southeast Mediterranean region, is a successful biological control agent of whiteflies. In this study, we investigated intraguild …             Functional characterization of ent-copalyl diphosphate synthase, kaurene synthase and kaurene oxidase in the Salvia miltiorrhiza gibberellin biosynthetic pathway ▶     Ping Su, Yuru Tong, Qiqing Cheng et al.     Salvia miltiorrhiza Bunge is highly valued in traditional Chinese medicine for its roots and rhizomes. Its bioactive diterpenoid tanshinones have been reported to have many …             Characterization and comparison of post-natal rat Achilles tendon-derived stem cells at different development stages ▶     Jialin Chen, Wei Zhang, Zeyu Liu et al.     Tendon stem/progenitor cells (TSPCs) are a potential cell source for tendon tissue engineering. The striking morphological and structural changes of tendon tissue during …             Changes in neurotransmitter levels and expression of immediate early genes in brain of mice infected with Neospora caninum ▶     Fumiaki Ihara, Maki Nishimura, Yoshikage Muroi et al.     Neospora caninum is an obligate intracellular parasite that causes neurological disorders in dogs and cattle. The majority of host animals are asymptomatic at the chronic stage …             Inhibition of pancreatic oxidative damage by stilbene derivative dihydro-resveratrol: implication for treatment of acute pancreatitis ▶     Siu Wai Tsang, Yi-Fu Guan, Juan Wang et al.     Trans-resveratrol is a natural stilbenoid possessing multifarious pharmacological benefits; however, when orally consumed, it is rapidly metabolised by colonic microflora and …             hnRNPK inhibits GSK3β Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells ▶     Xuejuan Gao, Junxia Feng, Yujiao He et al.     c-FLIP (cellular FLICE-inhibitory protein) is the pivotal regulator of TRAIL resistance in cancer cells, It is a short-lived protein degraded through the ubiquitin/proteasome …             Candida albicans repetitive elements display epigenetic diversity and plasticity ▶     Verónica Freire-Benéitez, R. Jordan Price, Daniel Tarrant et al.     Transcriptionally silent heterochromatin is associated with repetitive DNA. It is poorly understood whether and how heterochromatin differs between different organisms and …             Structure of the fimbrial protein Mfa4 from Porphyromonas gingivalis in its precursor form: implications for a donor-strand complementation mechanism ▶     Patrik Kloppsteck, Michael Hall, Yoshiaki Hasegawa et al.     Gingivitis and periodontitis are chronic inflammatory diseases that can lead to tooth loss. One of the causes of these diseases is the Gram-negative Porphyromonas gingivalis. …             Shape perception enhances perceived contrast: evidence for excitatory predictive feedback? ▶     Biao Han, Rufin VanRullen     Predictive coding theory suggests that predictable responses are “explained away” (i.e., reduced) by feedback. Experimental evidence for feedback inhibition, however, is …             Efficient and simple generation of multiple unmarked gene deletions in Mycobacterium smegmatis ▶     Xu-Jian Mao, Mei-Yi Yan, Hui Zhu et al.     Research on mycobacterial genetics relies heavily on techniques for directed gene mutation, but genetic studies are often hampered by the difficulty of generating gene deletions …             Rationalising the role of Keratin 9 as a biomarker for Alzheimer’s disease ▶     Joanna L. Richens, Hannah L. Spencer, Molly Butler et al.     Keratin 9 was recently identified as an important component of a biomarker panel which demonstrated a high diagnostic accuracy (87%) for Alzheimer’s disease (AD). Understanding …             Selection of suitable reference genes for assessing gene expression in pearl millet under different abiotic stresses and their combinations ▶     Radha Shivhare, Charu Lata     Pearl millet [Pennisetum glaucum (L.) R. Br.] a widely used grain and forage crop, is grown in areas frequented with one or more abiotic stresses, has superior drought and heat …             Using AAV vectors expressing the β2-adrenoceptor or associated Gα proteins to modulate skeletal muscle mass and muscle fibre size ▶     Adam Hagg, Timothy D. Colgan, Rachel E. Thomson et al.     Anabolic β2-adrenoceptor (β2-AR) agonists have been proposed as therapeutics for treating muscle wasting but concerns regarding possible off-target effects have hampered their …             Hypoxia-induced nitric oxide production and tumour perfusion is inhibited by pegylated arginine deiminase (ADI-PEG20) ▶     Natalie Burrows, Gaelle Cane, Mathew Robson et al.     The hypoxic tumour microenvironment represents an aggressive, therapy-resistant compartment. As arginine is required for specific hypoxia-induced processes, we hypothesised that …             Differential network analysis reveals the genome-wide landscape of estrogen receptor modulation in hormonal cancers ▶     Tzu-Hung Hsiao, Yu-Chiao Chiu, Pei-Yin Hsu et al.     Several mutual information (MI)-based algorithms have been developed to identify dynamic gene-gene and function-function interactions governed by key modulators (genes, proteins, …             Regulation of cell polarity determinants by the Retinoblastoma tumor suppressor protein ▶     Sandhya Payankaulam, Kelvin Yeung, Helen McNeill et al.     In addition to their canonical roles in the cell cycle, RB family proteins regulate numerous developmental pathways, although the mechanisms remain obscure. We found that …             FADD regulates NF-κB activation and promotes ubiquitination of cFLIPL to induce apoptosis ▶     Kishu Ranjan, Chandramani Pathak     Tumor Necrosis Factor-α canonically induces the activation of NF-κB and associated gene product cellular FLICE-like inhibitory protein (cFLIPL) to promote cell survival. …             Noggin4 is a long-range inhibitor of Wnt8 signalling that regulates head development in Xenopus laevis ▶     Fedor M. Eroshkin, Alexey M. Nesterenko, Alexander V. Borodulin et al.     Noggin4 is a Noggin family secreted protein whose molecular and physiological functions remain unknown. In this study, we demonstrate that in contrast to other Noggins, Xenopus …             Decoding regulatory landscape of somatic embryogenesis reveals differential regulatory networks between japonica and indica rice subspecies ▶     Yuvraj Indoliya, Poonam Tiwari, Abhisekh Singh Chauhan et al.     Somatic embryogenesis is a unique process in plants and has considerable interest for biotechnological application. Compare to japonica, indica rice has been less responsive to …             Sustained PI3K Activation exacerbates BLM-induced Lung Fibrosis via activation of pro-inflammatory and pro-fibrotic pathways ▶     Julia Barbara Kral, Mario Kuttke, Waltraud Cornelia Schrottmaier et al.     Idiopathic pulmonary fibrosis (IPF) is a life-threatening disease with limited treatment options. Additionally, the lack of a complete understanding of underlying immunological …             Inverse regulation of two classic Hippo pathway target genes in Drosophila by the dimerization hub protein Ctp ▶     Daniel A. Barron, Kenneth Moberg     The LC8 family of small ~8 kD proteins are highly conserved and interact with multiple protein partners in eukaryotic cells. LC8-binding modulates target protein activity, often …             Identification of novel RNA secondary structures within the hepatitis C virus genome reveals a cooperative involvement in genome packaging ▶     H. Stewart, R.J. Bingham, S. J. White et al.     The specific packaging of the hepatitis C virus (HCV) genome is hypothesised to be driven by Core-RNA interactions. To identify the regions of the viral genome involved in this …             Bacteriophage application to control the contaminated water with Shigella ▶     Jin Woo Jun, Sib Sankar Giri, Hyoun Joong Kim et al.     Shigella is one of the most important waterborne and foodborne pathogens around the world. Emergence of antibiotic-resistant Shigella has made the development of alternatives to …             Configurational space discretization and free energy calculation in complex molecular systems ▶     Kai Wang, Shiyang Long, Pu Tian     We sought to design a free energy calculation scheme with the hope of saving cost for generating dynamical information that is inherent in trajectories. We demonstrated that …             The Empathizing-Systemizing Theory, Social Abilities, and Mathematical Achievement in Children ▶     Emily Escovar, Miriam Rosenberg-Lee, Lucina Q. Uddin et al.     The Empathizing-Systemizing (E-S) theory describes a profile of traits that have been linked to autism spectrum disorders, and are thought to encompass a continuum that includes …             Discovery of a Novel Seminal Fluid Microbiome and Influence of Estrogen Receptor Alpha Genetic Status ▶     Angela B. Javurek, William G. Spollen, Amber M. Mann Ali et al.     Bacteria harbored in the male reproductive system may influence reproductive function and health of the male and result in developmental origins of adult health and disease …             Holliday Junction Thermodynamics and Structure: Coarse-Grained Simulations and Experiments ▶     Wujie Wang, Laura M. Nocka, Brianne Z. Wiemann et al.     Holliday junctions play a central role in genetic recombination, DNA repair and other cellular processes. We combine simulations and experiments to evaluate the ability of the …             Peltaster fructicola genome reveals evolution from an invasive phytopathogen to an ectophytic parasite ▶     Chao Xu, Huan Chen, Mark L. Gleason et al.     Sooty blotch and flyspeck (SBFS) fungi are unconventional plant pathogens that cause economic losses by blemishing the surface appearance of infected fruit. Here, we introduce …             An exceptional fossil skull from South America and the origins of the archosauriform radiation ▶     Felipe L. Pinheiro, Marco A. G. França, Marcel B. Lacerda et al.     Birds, dinosaurs, crocodilians, pterosaurs and their close relatives form the highly diverse clade Archosauriformes. Archosauriforms have a deep evolutionary history, originating …             Pathways for Modulating Exosome Lipids Identified By High-Density Lipoprotein-Like Nanoparticle Binding to Scavenger Receptor Type B-1 ▶     Nicholas L. Angeloni, Kaylin M. McMahon, Suchitra Swaminathan et al.     Exosomes are produced by cells to mediate intercellular communication, and have been shown to perpetuate diseases, including cancer. New tools are needed to understand exosome …             Extensible Multiplex Real-time PCR of MicroRNA Using Microparticles ▶     Seungwon Jung, Junsun Kim, Dong Jin Lee et al.     Multiplex quantitative real-time PCR (qPCR), which measures multiple DNAs in a given sample, has received significant attention as a mean of verifying the rapidly increasing …             DTDP-rhamnosyl transferase RfbF, is a newfound receptor-related regulatory protein for phage phiYe-F10 specific for Yersinia enterocolitica serotype O:3 ▶     Junrong Liang, Xu Li, Tao Zha et al.     Bacteriophages and their hosts are continuously engaged in evolutionary competition. Here we isolated a lytic phage phiYe-F10 specific for Yersinia enterocolitica serotype O:3. …             Unique glycosignature for intervertebral disc and articular cartilage cells and tissues in immaturity and maturity ▶     E. C. Collin, M. Kilcoyne, S. J. White et al.     In this study, on/off markers for intervertebral disc (IVD) and articular cartilage (AC) cells (chondrocytes) and distinct glycoprofiles of cell and tissue-types were identified …             Determination of cyanidin 3-glucoside in rat brain, liver and kidneys by UPLC/MS-MS and its application to a short-term pharmacokinetic study ▶     Stefano Fornasaro, Lovro Ziberna, Mattia Gasperotti et al.     Anthocyanins exert neuroprotection in various in vitro and in vivo experimental models. However, no details regarding their brain-related pharmacokinetics are so far available to …             A New Acyl-homoserine Lactone Molecule Generated by Nitrobacter winogradskyi ▶     Qiuxuan Shen, Jie Gao, Jun Liu et al.     It is crucial to reveal the regulatory mechanism of nitrification to understand nitrogen conversion in agricultural systems and wastewater treatment. In this study, the nwiI gene …             Antioxidants inhibit advanced glycosylation end-product-induced apoptosis by downregulation of miR-223 in human adipose tissue-derived stem cells ▶     Zhe Wang, Hongqiu Li, Ran Guo et al.     Advanced glycosylation end products (AGEs) are endogenous inflammatory mediators that induce apoptosis of mesenchymal stem cells. A potential mechanism includes increased …             Chloroquine enhances TRAIL-mediated apoptosis through up-regulation of DR5 by stabilization of mRNA and protein in cancer cells ▶     Eun Jung Park, Kyoung-jin Min, Kyeong Sook Choi et al.     Chloroquine (CQ), an anti-malarial drug, has immune-modulating activity and lysosomotropic activity. In this study, we investigated CQ sensitizes TRAIL-mediated apoptosis in …             Secreted APE1/Ref-1 inhibits TNF-α-stimulated endothelial inflammation via thiol-disulfide exchange in TNF receptor ▶     Myoung Soo Park, Sunga Choi, Yu Ran Lee et al.     Apurinic apyrimidinic endonuclease 1/Redox factor-1 (APE1/Ref-1) is a multifunctional protein with redox activity and is proved to be secreted from stimulated cells. The aim of …             Identification of OCTN2 variants and their association with phenotypes of Crohn’s disease in a Korean population ▶     Hyo Jin Park, Eun Suk Jung, Kyoung Ae Kong et al.     Crohn’s disease (CD) is a chronic inflammatory bowel disease and a genetic variant in the OCTN2, g.-207G > C is significantly associated with CD susceptibility. This study was …             miR-434-3p and DNA hypomethylation co-regulate eIF5A1 to increase AChRs and to improve plasticity in SCT rat skeletal muscle ▶     Fei-Fei Shang, Qing-Jie Xia, Wei Liu et al.     Acetylcholine receptors (AChRs) serve as connections between motor neurons and skeletal muscle and are essential for recovery from spinal cord transection (SCT). Recently, …             Activation of c-Jun predicts a poor response to sorafenib in hepatocellular carcinoma: Preliminary Clinical Evidence ▶     Wei Chen, Weikai Xiao, Kunsong Zhang et al.     We determined the mitogen-activated protein kinase (MAPK) gene expression profile of acquired resistance in sorafenib-sensitive hepatocellular carcinoma (HCC) cells and aimed to …             Structure-Based Virtual Ligand Screening on the XRCC4/DNA Ligase IV Interface ▶     Grégory Menchon, Oriane Bombarde, Mansi Trivedi et al.     The association of DNA Ligase IV (Lig4) with XRCC4 is essential for repair of DNA double-strand breaks (DSBs) by Non-homologous end-joining (NHEJ) in humans. DSBs cytotoxicity is …             Masculinised Behaviour of XY Females in a Mammal with Naturally Occuring Sex Reversal ▶     Paul A. Saunders, Thomas Franco, Camille Sottas et al.     Most sex differences in phenotype are controlled by gonadal hormones, but recent work on laboratory strain mice that present discordant chromosomal and gonadal sex showed that …             The Wnt/β-catenin signaling/Id2 cascade mediates the effects of hypoxia on the hierarchy of colorectal-cancer stem cells ▶     Hye-Jin Dong, Gyu-Beom Jang, Hwa-Yong Lee et al.     Hypoxia, a feature common to most solid tumors, is known to regulate many aspects of tumorigenesis. Recently, it was suggested that hypoxia increased the size of the cancer …             Novel function of LHFPL2 in female and male distal reproductive tract development ▶     Fei Zhao, Jun Zhou, Rong Li et al.     Congenital reproductive tract anomalies could impair fertility. Female and male reproductive tracts are developed from Müllerian ducts and Wolffian ducts, respectively, involving …             A high-throughput peptidomic strategy to decipher the molecular diversity of cyclic cysteine-rich peptides ▶     Aida Serra, Xinya Hemu, Giang K. T. Nguyen et al.     Cyclotides are plant cyclic cysteine-rich peptides (CRPs). The cyclic nature is reported to be gene-determined with a precursor containing a cyclization-competent domain which …             Establishment of a cone photoreceptor transplantation platform based on a novel cone-GFP reporter mouse line ▶     Sheila Smiley, Philip E. Nickerson, Lacrimioara Comanita et al.     We report successful retinal cone enrichment and transplantation using a novel cone-GFP reporter mouse line. Using the putative cone photoreceptor-enriched transcript Coiled-Coil …             Diet of dingoes and other wild dogs in peri-urban areas of north-eastern Australia ▶     Benjamin L. Allen, Erin Carmelito, Matt Amos et al.     Knowledge of the resource requirements of urban predators can improve our understanding of their ecology and assist town planners and wildlife management agencies in developing …             ACEMg Diet Supplement Modifies Progression of Hereditary Deafness ▶     Kari L. Green, Donald L. Swiderski, Diane M. Prieskorn et al.     Dietary supplements consisting of beta-carotene (precursor to vitamin A), vitamins C and E and the mineral magnesium (ACEMg) can be beneficial for reducing hearing loss due to …             Study of individual erythrocyte deformability susceptibility to INFeD and ethanol using a microfluidic chip ▶     Lihong Liu, Sha Huang, Xiaoying Xu et al.     Human red blood cells (RBCs) deformability in vitro was assessed during iron dextran (INFeD) loading and/or ethanol co-administration using microfluidic deformability screening. …             Evolution of conditional cooperation under multilevel selection ▶     Huanren Zhang, Matjaž Perc     We study the emergence of conditional cooperation in the presence of both intra-group and inter-group selection. Individuals play public goods games within their groups using …             Preservation of ancestral Cretaceous microflora recovered from a hypersaline oil reservoir ▶     Grégoire Gales, Nicolas Tsesmetzis, Isabel Neria et al.     Microbiology of a hypersaline oil reservoir located in Central Africa was investigated with molecular and culture methods applied to preserved core samples. Here we show that the …             An implantable compound-releasing capsule triggered on demand by ultrasound ▶     Olga Ordeig, Sau Yin Chin, Sohyun Kim et al.     Implantable devices have a large potential to improve human health, but they are often made of biofouling materials that necessitate special coatings, rely on electrical …             Vaginal Fibroblastic Cells from Women with Pelvic Organ Prolapse Produce Matrices with Increased Stiffness and Collagen Content ▶     Alejandra M. Ruiz-Zapata, Manon H. Kerkhof, Samaneh Ghazanfari et al.     Pelvic organ prolapse (POP) is characterised by the weakening of the pelvic floor support tissues, and often by subsequent prolapse of the bladder outside the body, i.e. …             In silico assessment of primers for eDNA studies using PrimerTree and application to characterize the biodiversity surrounding the Cuyahoga River ▶     M. V. Cannon, J. Hester, A. Shalkhauser et al.     Analysis of environmental DNA (eDNA) enables the detection of species of interest from water and soil samples, typically using species-specific PCR. Here, we describe a method to …             Structure of ThiM from Vitamin B1 biosynthetic pathway of Staphylococcus aureus – Insights into a novel pro-drug approach addressing MRSA infections ▶     Julia Drebes, Madeleine Künz, Björn Windshügel et al.     Infections caused by the methicillin-resistant Staphylococcus aureus (MRSA) are today known to be a substantial threat for global health. Emerging multi-drug resistant bacteria …             Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases ▶     Valeria Crippa, Vito G. D’Agostino, Riccardo Cristofani et al.     Neurodegenerative diseases (NDs) are often associated with the presence of misfolded protein inclusions. The chaperone HSPB8 is upregulated in mice, the human brain and muscle …             Overcoming doxorubicin resistance of cancer cells by Cas9-mediated gene disruption ▶     Jong Seong Ha, Juyoung Byun, Dae-Ro Ahn     In this study, Cas9 system was employed to down-regulate mdr1 gene for overcoming multidrug resistance of cancer cells. Disruption of the MDR1 gene was achieved by delivery of …             A critical role of mevalonate for peptidoglycan synthesis in Staphylococcus aureus ▶     Yasuhiko Matsumoto, Jyunichiro Yasukawa, Masaki Ishii et al.     3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase, a mevalonate synthetase, is required for the growth of Staphylococcus aureus. However, the essential role of the enzyme in …             The three-dimensional structure of Clostridium absonum 7α-hydroxysteroid dehydrogenase: new insights into the conserved arginines for NADP(H) recognition ▶     Deshuai Lou, Bochu Wang, Jun Tan et al.     7α-hydroxysteroid dehydrogenase (7α-HSDH) can catalyse the oxidation of C7 α-OH of the steroid nucleus in the bile acid metabolism. In the paper we determined the crystal …             Intracellular nanoparticles mass quantification by near-edge absorption soft X-ray nanotomography ▶     Jose Javier Conesa, Joaquín Otón, Michele Chiappi et al.     We used soft X-ray three-dimensional imaging to quantify the mass of superparamagnetic iron oxide nanoparticles (SPION) within whole cells, by exploiting the iron oxide …             Corrigendum: Lovastatin blocks Kv1.3 channel in human T cells: a new mechanism to explain its immunomodulatory properties ▶     Ning Zhao, Qian Dong, Cheng Qian et al.                 Effects of Nosema apis, N. ceranae, and coinfections on honey bee (Apis mellifera) learning and memory ▶     Lise R. Charbonneau, Neil Kirk Hillier, Richard E. L. Rogers et al.     Western honey bees (Apis mellifera) face an increasing number of challenges that in recent years have led to significant economic effects on apiculture, with attendant …             Integrated analysis of mRNA-seq and miRNA-seq in the liver of Pelteobagrus vachelli in response to hypoxia ▶     Guosong Zhang, Shaowu Yin, Jianqiang Mao et al.     Pelteobagrus vachelli is a well-known commercial species in Asia. However, a sudden lack of oxygen will result in mortality and eventually to pond turnover. Studying the …             Large-scale production of functional human lysozyme from marker-free transgenic cloned cows ▶     Dan Lu, Shen Liu, Fangrong Ding et al.     Human lysozyme is an important natural non-specific immune protein that is highly expressed in breast milk and participates in the immune response of infants against bacterial …             Comparing the defence-related gene expression changes upon root-knot nematode attack in susceptible versus resistant cultivars of rice ▶     Chanchal Kumari, Tushar K. Dutta, Prakash Banakar et al.     Rice is one of the major staple food crops in the world and an excellent model system for studying monocotyledonous plants. Diseases caused by nematodes in rice are well …             Silicon moderated the K deficiency by improving the plant-water status in sorghum ▶     Daoqian Chen, Beibei Cao, Shiwen Wang et al.     Although silicon (Si) has been widely reported to alleviate plant nutrient deficiency, the underlying mechanism in potassium (K) deficiency is poorly understood. In this study, …             Brain mechanisms associated with internally directed attention and self-generated thought ▶     Mathias Benedek, Emanuel Jauk, Roger E. Beaty et al.     Internal cognition like imagination and prospection require sustained internally directed attention and involve self-generated thought. This fMRI study aimed to disentangle the …             Bacterial associations reveal spatial population dynamics in Anopheles gambiae mosquitoes ▶     Moritz Buck, Louise K. J. Nilsson, Carl Brunius et al.     The intolerable burden of malaria has for too long plagued humanity and the prospect of eradicating malaria is an optimistic, but reachable, target in the 21st century. However, …             Testis-specific serine/threonine protein kinase 4 (Tssk4) phosphorylates Odf2 at Ser-76 ▶     Xiaoli Wang, Han Li, Guolong Fu et al.     As a member of the testis-specific serine/threonine protein kinase (TSSK) family, Tssk4 is exclusively expressed in the testis and plays an essential role in male fertility. We …             A transducible nuclear/nucleolar protein, mLLP, regulates neuronal morphogenesis and synaptic transmission ▶     Nam-Kyung Yu, Hyoung F. Kim, Jaehoon Shim et al.     Cell-permeable proteins are emerging as unconventional regulators of signal transduction and providing a potential for therapeutic applications. However, only a few of them are …             Immunomodulation of Lactobacillus rhamnosus GG (LGG)-derived soluble factors on antigen-presenting cells of healthy blood donors ▶     Fiona Long Yan Fong, Pirkka V. Kirjavainen, Hani El-Nezami     Lactobacillus rhamnosus GG (LGG) cells have been shown to promote type-1 immune responsiveness; however knowledge of immunomodulation of soluble factors secreted by LGG is …             Intrinsic phenotypic stability of a bi-stable auto regulatory gene ▶     Azim-Berdy Besya, Andreas Grönlund     Even under homogenous conditions clonal cells can assume different distinct states for generations to follow, also known as epigenetic inheritance. Such long periods of different …             Sex-specific local life-history adaptation in surface- and cave-dwelling Atlantic mollies (Poecilia mexicana) ▶     Rüdiger Riesch, David N. Reznick, Martin Plath et al.     Cavefishes have long been used as model organisms showcasing adaptive diversification, but does adaptation to caves also facilitate the evolution of reproductive isolation from …             Antioxidant Lignans and Neolignans from Acorus tatarinowii ▶     Yuanyuan Lu, Yongbo Xue, Shenjie Chen et al.     Eleven new lignans and neolignans, named acortatarinowins G–N (1−8), including three pairs of enantiomers (1a/1b−3a/3b) and five optically pure lignans and neolignans (4−8), …             Phylogenetic evidence for intratypic recombinant events in a novel human adenovirus C that causes severe acute respiratory infection in children ▶     Yanqun Wang, Yamin Li, Roujian Lu et al.     Human adenoviruses (HAdVs) are prevalent in hospitalized children with severe acute respiratory infection (SARI). Here, we report a unique recombinant HAdV strain (CBJ113) …             Intracellular acidification is required for full activation of the sweet taste receptor by miraculin ▶     Keisuke Sanematsu, Masayuki Kitagawa, Ryusuke Yoshida et al.     Acidification of the glycoprotein, miraculin (MCL), induces sweet taste in humans, but not in mice. The sweet taste induced by MCL is more intense when acidification occurs with …             Comprehensive molecular portrait using next generation sequencing of resected intestinal-type gastric cancer patients dichotomized according to prognosis ▶     E. Bria, S. Pilotto, M. Simbolo et al.     In this study, we evaluated whether the presence of genetic alterations detected by next generation sequencing may define outcome in a prognostically-selected and …             Circulating human cytomegalovirus-encoded HCMV-miR-US4-1 as an indicator for predicting the efficacy of IFNα treatment in chronic hepatitis B patients ▶     Yi Pan, Nan Wang, Zhenxian Zhou et al.     The efficacy of interferon α (IFNα) therapy for chronic hepatitis B (CHB) patients is about 40% and often associates with adverse side-effects, thus identification of an easy …             Differences in Trait Impulsivity Indicate Diversification of Dog Breeds into Working and Show Lines ▶     Fernanda Ruiz Fadel, Patricia Driscoll, Malgorzata Pilot et al.     Impulsiveness describes the inability to inhibit behaviour in the presence of salient cues. Trait-level impulsivity exists on a continuum and individual differences can be …             NADPH oxidase promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in a cellular model of Parkinson’s disease ▶     Rituraj Pal, Lakshya Bajaj, Jaiprakash Sharma et al.     Oxidative stress and aberrant accumulation of misfolded proteins in the cytosol are key pathological features associated with Parkinson’s disease (PD). NADPH oxidase (Nox2) is …             Corrigendum: Studying biological membranes with extended range high-speed atomic force microscopy ▶     Adrian P. Nievergelt, Blake W. Erickson, Nahid Hosseini et al.                 Corrigendum: X-Linked Retinoschisis: Phenotypic Variability in a Chinese Family ▶     Yangyan Xiao, Xiao Liu, Luosheng Tang et al.                 Insight into determinants of substrate binding and transport in a multidrug efflux protein ▶     Kamela O. Alegre, Stephanie Paul, Paola Labarbuta et al.     Multidrug resistance arising from the activity of integral membrane transporter proteins presents a global public health threat. In bacteria such as Escherichia coli, transporter …             Illumina microRNA profiles reveal the involvement of miR397a in Citrus adaptation to long-term boron toxicity via modulating secondary cell-wall biosynthesis ▶     Jing-Hao Huang, Yi-Ping Qi, Shou-Xing Wen et al.     The mechanisms underlying tolerance to B-toxicity in plants are still controversial. Our previous studies indicated that B-toxicity is mainly limited to leaves in Citrus and that …             Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice ▶     Yuki Matsushita, Yasunari Sakai, Mitsunori Shimmura et al.     Epilepsy is a frequent comorbidity in patients with focal cortical dysplasia (FCD). Recent studies utilizing massive sequencing data identified subsets of genes that are …             Integrated mRNA and miRNA expression profiling in blood reveals candidate biomarkers associated with endurance exercise in the horse ▶     Núria Mach, Sandra Plancade, Alicja Pacholewska et al.     The adaptive response to extreme endurance exercise might involve transcriptional and translational regulation by microRNAs (miRNAs). Therefore, the objective of the present …             Generation of a novel, multi-stage, progressive, and transplantable model of plasma cell neoplasms ▶     Takashi Asai, Megan A. Hatlen, Chen Lossos et al.     Multiple myeloma is a plasma cell neoplasm with an extremely variable clinical course. Animal models are needed to better understand its pathophysiology and for preclinical …             In vivo visualization and quantification of collecting lymphatic vessel contractility using near-infrared imaging ▶     Chloé Chong, Felix Scholkmann, Samia B. Bachmann et al.     Techniques to image lymphatic vessel function in either animal models or in the clinic are limited. In particular, imaging methods that can provide robust outcome measures for …             Complement factor H binding of monomeric C-reactive protein downregulates proinflammatory activity and is impaired with at risk polymorphic CFH variants ▶     Blanca Molins, Pablo Fuentes-Prior, Alfredo Adán et al.     Inflammation and immune-mediated processes are pivotal to the pathogenic progression of age-related macular degeneration (AMD). Although plasma levels of C-reactive protein (CRP) …             A systematic study on drug-response associated genes using baseline gene expressions of the Cancer Cell Line Encyclopedia ▶     Xiaoming Liu, Jiasheng Yang, Yi Zhang et al.     We have studied drug-response associated (DRA) gene expressions by applying a systems biology framework to the Cancer Cell Line Encyclopedia data. More than 4,000 genes are …             Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells ▶     Rosanna Mezzapelle, Eltjona Rrapaj, Elena Gatti et al.     Malignant Mesothelioma is a highly aggressive cancer, which is difficult to diagnose and treat. Here we describe the molecular, cellular and morphological characterization of a …             FNDC5 is produced in the stomach and associated to body composition ▶     S. Barja-Fernández, C. Folgueira, C. Castelao et al.     The fibronectin type III domain-containing protein 5 (FNDC5) discovered in 2002 has recently gained attention due to its potential role in protecting against obesity. In rat, no …             Nitrogen acquisition by plants and microorganisms in a temperate grassland ▶     Qianyuan Liu, Na Qiao, Xingliang Xu et al.     Nitrogen (N) limitation is common in most terrestrial ecosystems, often leading to strong competition between microorganisms and plants. The mechanisms of niche differentiation …             Gradients in pore size enhance the osteogenic differentiation of human mesenchymal stromal cells in three-dimensional scaffolds ▶     Andrea Di Luca, Barbara Ostrowska, Ivan Lorenzo-Moldero et al.     Small fractures in bone tissue can heal by themselves, but in case of larger defects current therapies are not completely successful due to several drawbacks. A possible strategy …             Colorimetric method for rapid detection of Oxacillin resistance in Staphylococcus aureus and its comparison with PCR for mec A gene ▶     Niraj Ghanwate, Prashant Thakare, P. R. Bhise et al.     Rapid and accurate detection of Methicillin Resistant Staphylococcus aureus (MRSA) is an important role of clinical microbiology laboratories to avoid treatment failure. The …             Novel GRN Mutations in Patients with Corticobasal Syndrome ▶     Foad Taghdiri, Christine Sato, Mahdi Ghani et al.     Loss-of-function GRN mutations lead to GRN haploinsufficiency and consequently neurodegeneration with significant heterogeneity in clinical presentation of various syndromes. The …             New fossil insect order Permopsocida elucidates major radiation and evolution of suction feeding in hemimetabolous insects (Hexapoda: Acercaria) ▶     Di-Ying Huang, Günter Bechly, Patricia Nel et al.     With nearly 100,000 species, the Acercaria (lice, plant lices, thrips, bugs) including number of economically important species is one of the most successful insect lineages. …             Asymmetrical Deterministic Lateral Displacement Gaps for Dual Functions of Enhanced Separation and Throughput of Red Blood Cells ▶     Kerwin Kwek Zeming, Thoriq Salafi, Chia-Hung Chen et al.     Deterministic lateral displacement (DLD) method for particle separation in microfluidic devices has been extensively used for particle separation in recent years due to its high …             Castration influences intestinal microflora and induces abdominal obesity in high-fat diet-fed mice ▶     Naoki Harada, Ryo Hanaoka, Hiroko Horiuchi et al.     Late-onset hypogonadism (i.e. androgen deficiency) raises the risk for abdominal obesity in men. The mechanism for this obesity is unclear. Here, we demonstrated that …             Synthesis and Larvicidal Activity of Novel Thenoylhydrazide Derivatives ▶     Gao-Peng Song, De-Kun Hu, Hao Tian et al.     A pair of chemical isomeric structures of novel N-tert-butylphenyl thenoylhydrazide compounds I and II were designed and synthesized. Their structures were characterized by MS, …             Carnosic acid slows photoreceptor degeneration in the Pde6brd10 mouse model of retinitis pigmentosa ▶     Kai Kang, Matthew J. Tarchick, Xiaoshan Yu et al.     The photoreceptor cell death associated with the various genetic forms of retinitis pigmentosa (RP) is currently untreatable and leads to partial or complete vision loss. …             Preliminary analysis of salivary microbiome and their potential roles in oral lichen planus ▶     Kun Wang, Wenxin Lu, Qichao Tu et al.     Several studies have explored the origin and development mechanism of oral lichen planus (OLP) with limited attention to the role of bacteria in the progression of this common …             Estrogen ameliorates microglial activation by inhibiting the Kir2.1 inward-rectifier K+ channel ▶     Shih-Ying Wu, Yun-Wen Chen, Sheng-Feng Tsai et al.     Microglial activation is implicated in the pathogenesis of Parkinson’s disease (PD). Although the etiology of PD remains unclear, age and male gender are known PD risk factors. …             Dynamics of spinal microglia repopulation following an acute depletion ▶     Yao Yao, Stefania Echeverry, Xiang Qun Shi et al.     Our understanding on the function of microglia has been revolutionized in the recent 20 years. However, the process of maintaining microglia homeostasis has not been fully …             Reduction Impairs the Antibacterial Activity but Benefits the LPS Neutralization Ability of Human Enteric Defensin 5 ▶     Cheng Wang, Mingqiang Shen, Naixin Zhang et al.     Oxidized human defensin 5 (HD5OX), a Paneth cell-secreted antibacterial peptide with three characteristic disulfide bonds, protects the host from invasion by morbigenous microbes …             Plant Phenotyping using Probabilistic Topic Models: Uncovering the Hyperspectral Language of Plants ▶     Mirwaes Wahabzada, Anne-Katrin Mahlein, Christian Bauckhage et al.     Modern phenotyping and plant disease detection methods, based on optical sensors and information technology, provide promising approaches to plant research and precision farming. …             Object-based Encoding in Visual Working Memory: Evidence from Memory-driven Attentional Capture ▶     Zaifeng Gao, Shixian Yu, Chengfeng Zhu et al.     Visual working memory (VWM) adopts a specific manner of object-based encoding (OBE) to extract perceptual information: Whenever one feature-dimension is selected for entry into …             Epstein Barr Virus and Mycobacterium avium subsp. paratuberculosis peptides are recognized in sera and cerebrospinal fluid of MS patients ▶     Giuseppe Mameli, Eleonora Cocco, Jessica Frau et al.     Mycobacterium avium subsp. paratuberculosis (MAP) and Epstein-Barr virus (EBV) epitopes elicit a consistent humoral response in serum of multiple sclerosis patients, but the …             Silver nanoparticle-enriched diamond-like carbon implant modification as a mammalian cell compatible surface with antimicrobial properties ▶     Christian Gorzelanny, Ralf Kmeth, Andreas Obermeier et al.     The implant-bone interface is the scene of competition between microorganisms and distinct types of tissue cells. In the past, various strategies have been followed to support …             Trans-Atlantic exchanges have shaped the population structure of the Lyme disease agent Borrelia burgdorferi sensu stricto ▶     S. Castillo-Ramírez, V. Fingerle, S. Jungnick et al.     The origin and population structure of Borrelia burgdorferi sensu stricto (s.s.), the agent of Lyme disease, remain obscure. This tick-transmitted bacterial species occurs in …             Ultra–sensitive droplet digital PCR for detecting a low–prevalence somatic GNAQ mutation in Sturge–Weber syndrome ▶     Yuri Uchiyama, Mitsuko Nakashima, Satoshi Watanabe et al.     Droplet digital PCR (ddPCR), a method for measuring target nucleic acid sequence quantity, is useful for determining somatic mutation rates using TaqMan probes. In this study, …             A Targeted DNAzyme-Nanocomposite Probe Equipped with Built-in Zn2+ Arsenal for Combined Treatment of Gene Regulation and Drug Delivery ▶     Zhi-Mei He, Peng-Hui Zhang, Xin Li et al.     As catalytic nucleic acids, DNAzymes have been extensively used in the design of sensing platforms. However, their potentials as intelligent drug carriers for responsive drug …             The RecQ DNA helicase Rqh1 constrains Exonuclease 1-dependent recombination at stalled replication forks ▶     Fekret Osman, Jong Sook Ahn, Alexander Lorenz et al.     DNA double-strand break (DSB) repair by homologous recombination (HR) involves resection of the break to expose a 3′ single-stranded DNA tail. In budding yeast, resection occurs …             Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells ▶     Pengying Li, Dongyang Zhang, Lingxiao Shen et al.     Mitochondria are the powerhouses of eukaryotic cells and the main source of reactive oxygen species (ROS) in hypoxic cells, participating in regulating redox homeostasis. The …             Variations in SXT elements in epidemic Vibrio cholerae O1 El Tor strains in China ▶     Ruibai Wang, Dong Yu, Junjie Yue et al.     Vibrio cholerae O1 El Tor biotype strains are responsible for three multiyear epidemics of cholera in China during the seventh ongoing pandemic. The presence of the integrative …             Selective advantage of trisomic human cells cultured in non-standard conditions ▶     Samuel D. Rutledge, Temple A. Douglas, Joshua M. Nicholson et al.     An abnormal chromosome number, a condition known as aneuploidy, is a ubiquitous feature of cancer cells. A number of studies have shown that aneuploidy impairs cellular fitness. …             Adaptive bill morphology for enhanced tool manipulation in New Caledonian crows ▶     Hiroshi Matsui, Gavin R. Hunt, Katja Oberhofer et al.     Early increased sophistication of human tools is thought to be underpinned by adaptive morphology for efficient tool manipulation. Such adaptive specialisation is unknown in …             Response of Human Osteoblast to n-HA/PEEK—Quantitative Proteomic Study of Bio-effects of Nano-Hydroxyapatite Composite ▶     Minzhi Zhao, Haiyun Li, Xiaochen Liu et al.     Nano-sized hydroxyapatite (n-HA) is considered as a bio-active material, which is often mixed into bone implant material, polyetheretherketone (PEEK). To reveal the global …             A High-Throughput, Multi-Cell Phenotype Assay for the Identification of Novel Inhibitors of Chemotaxis/Migration ▶     Xin-Hua Liao, Netra Pal Meena, Noel Southall et al.     Chemotaxis and cell migration are fundamental, universal eukaryotic processes essential for biological functions such as embryogenesis, immunity, cell renewal, and wound healing, …             A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase ▶     Shuofeng Yuan, Hin Chu, Kailash Singh et al.     The RNA-dependent RNA polymerase of influenza A virus comprises conserved and independently-folded subdomains with defined functionalities. The N-terminal domain of the PA …             Two overlapping two-component systems in Xanthomonas oryzae pv. oryzae contribute to full fitness in rice by regulating virulence factors expression ▶     Dehong Zheng, Xiaoyan Yao, Meng Duan et al.     Two-component signal transduction systems (TCSs) are widely used by bacteria to adapt to the environment. In the present study, StoS (stress tolerance-related oxygen sensor) and …             Dependence of fluorescent protein brightness on protein concentration in solution and enhancement of it ▶     Takamitsu J. Morikawa, Hideaki Fujita, Akira Kitamura et al.     Fluorescent proteins have been widely used in biology because of their compatibility and varied applications in living specimens. Fluorescent proteins are often undesirably …             Nitrogen cycling in an extreme hyperarid environment inferred from δ15N analyses of plants, soils and herbivore diet ▶     Francisca P. Díaz, Matías Frugone, Rodrigo A. Gutiérrez et al.     Climate controls on the nitrogen cycle are suggested by the negative correlation between precipitation and δ15N values across different ecosystems. For arid ecosystems this is …             Mechanical oscillations enhance gene delivery into suspended cells ▶     Z. L. Zhou, X. X. Sun, J. Ma et al.     Suspended cells are difficult to be transfected by common biochemical methods which require cell attachment to a substrate. Mechanical oscillations of suspended cells at certain …             All together now: Analogies between chimera state collapses and epileptic seizures ▶     Ralph G. Andrzejak, Christian Rummel, Florian Mormann et al.     Conceptually and structurally simple mathematical models of coupled oscillator networks can show a rich variety of complex dynamics, providing fundamental insights into many …             E-selectin-targeting delivery of microRNAs by microparticles ameliorates endothelial inflammation and atherosclerosis ▶     Shuangtao Ma, Xiao Yu Tian, Yunrong Zhang et al.     E-selectin is a surface marker of endothelial cell (EC) inflammation, one of the hallmarks of atherogenesis. Thus, we tested the hypothesis that delivery of microRNA (miR)-146a …             Chronic Kidney Disease Impairs Bone Defect Healing in Rats ▶     Weiqing Liu, Ning Kang, Dutmanee Seriwatanachai et al.     Chronic kidney disease (CKD) has been regarded as a risk for bone health. The aim of this study was to evaluate the effect of CKD on bone defect repair in rats. Uremia was …             Inter-molecular β-sheet structure facilitates lung-targeting siRNA delivery ▶     Jihan Zhou, Dong Li, Hao Wen et al.     Size-dependent passive targeting based on the characteristics of tissues is a basic mechanism of drug delivery. While the nanometer-sized particles are efficiently captured by …             Novel EGFR-targeted strategy with hybrid peptide against oesophageal squamous cell carcinoma ▶     Osamu Kikuchi, Shinya Ohashi, Tomohisa Horibe et al.     Epidermal growth factor receptor (EGFR) is a key molecule in the pathophysiology of oesophageal squamous cell carcinoma (OSCC). However, EGFR-targeted agents such as anti-EGFR …             Immune Infertility Should Be Positively Diagnosed Using an Accurate Method by Monitoring the Level of Anti-ACTL7a Antibody ▶     Jun Fu, Rongyan Yao, Yanyun Luo et al.     Infertility is currently a major public health problem. Anti-sperm antibodies (ASAs) markedly reduce sperm quality, which can subsequently lead to male and/or female infertility. …             In vivo reprogramming reactive glia into iPSCs to produce new neurons in the cortex following traumatic brain injury ▶     Xiang Gao, Xiaoting Wang, Wenhui Xiong et al.     Traumatic brain injury (TBI) results in a significant amount of cell death in the brain. Unfortunately, the adult mammalian brain possesses little regenerative potential …             Distinctive Pattern of Serum Elements During the Progression of Alzheimer’s Disease ▶     Giuseppe Paglia, Oto Miedico, Adriana Cristofano et al.     Element profiling is an interesting approach for understanding neurodegenerative processes, considering that compelling evidences show that element toxicity might play a crucial …             Sepsis-induced elevation in plasma serotonin facilitates endothelial hyperpermeability ▶     Yicong Li, Coedy Hadden, Anthonya Cooper et al.     Hyperpermeability of the endothelial barrier and resulting microvascular leakage are a hallmark of sepsis. Our studies describe the mechanism by which serotonin (5-HT) regulates …             Towards population-level conservation in the critically endangered Antarctic blue whale: the number and distribution of their populations ▶     Catherine R. M. Attard, Luciano B. Beheregaray, Luciana M. Möller     Population-level conservation is required to prevent biodiversity loss within a species, but it first necessitates determining the number and distribution of populations. Many …             Evolutionary Dynamics of Homophily and Heterophily ▶     Pouria Ramazi, Ming Cao, Franz J. Weissing     Most social interactions do not take place at random. In many situations, individuals choose their interaction partners on the basis of phenotypic cues. When this happens, …             Quantitative proteomics study of the neuroprotective effects of B12 on hydrogen peroxide-induced apoptosis in SH-SY5Y cells ▶     Lijun Zhong, Juntuo Zhou, Xi Chen et al.     B12 belongs to the coumarin class of compounds that have been shown to have various physiological and pharmacological activities including anti-inflammatory, antibacterial, and …             Erratum: The role of dung beetles in reducing greenhouse gas emissions from cattle farming ▶     Eleanor M. Slade, Terhi Riutta, Tomas Roslin et al.                 A Web Server and Mobile App for Computing Hemolytic Potency of Peptides ▶     Kumardeep Chaudhary, Ritesh Kumar, Sandeep Singh et al.     Numerous therapeutic peptides do not enter the clinical trials just because of their high hemolytic activity. Recently, we developed a database, Hemolytik, for maintaining …             Corrigendum: Correlative in-resin super-resolution and electron microscopy using standard fluorescent proteins ▶     Errin Johnson, Elena Seiradake, E. Yvonne Jones et al.                 Environmental and Historical Determinants of Patterns of Genetic Differentiation in Wild Soybean (Glycine soja Sieb. et Zucc) ▶     Shui-Lian He, Yun-Sheng Wang, De-Zhu Li et al.     Wild soybean, the direct progenitor of cultivated soybean, inhabits a wide distribution range across the mainland of East Asia and the Japanese archipelago. A multidisciplinary …             Physical connections between different SSVEP neural networks ▶     Zhenghua Wu     This work investigates the mechanism of the Steady-State Visual Evoked Potential (SSVEP). One theory suggests that different SSVEP neural networks exist whose strongest response …             Neuronal activity controls transsynaptic geometry ▶     Oleg O. Glebov, Susan Cox, Lawrence Humphreys et al.     The neuronal synapse is comprised of several distinct zones, including presynaptic vesicle zone (SVZ), active zone (AZ) and postsynaptic density (PSD). While correct relative …             Delta-proteobacterial SAR324 group in hydrothermal plumes on the South Mid-Atlantic Ridge ▶     Huiluo Cao, Chunming Dong, Salim Bougouffa et al.     In the dark ocean, the SAR324 group of Delta-proteobacteria has been associated with a chemolithotrophic lifestyle. However, their electron transport chain for energy generation …             miR-155 Deletion in Female Mice Prevents Diet-Induced Obesity ▶     Andrew D. Gaudet, Laura K. Fonken, Liubov V. Gushchina et al.     Obesity is a growing epidemic in developed countries. Obese individuals are susceptible to comorbidities, including cardiovascular disease and metabolic disorder. Increasing the …             Occurrence and removal of phenolic endocrine disrupting chemicals in the water treatment processes ▶     Xuemin Lv, Sanhua Xiao, Gang Zhang et al.     This paper evaluated the occurrence and removal efficiency of four selected phenolic endocrine disrupting chemicals (bisphenol A (BPA), octylphenol (OP), nonylphenol (NP) and …             Herbivory in the soft coral Sinularia flexibilis (Alcyoniidae) ▶     Chiara C. Piccinetti, Roberta Ricci, Chiara Pennesi et al.     Our work provides strong support for the hypothesis that Sinularia flexibilis ingests diatoms such as Thalassiosira pseudonana. We assessed algal ingestion by S. flexibilis …             miR-429 regulates the transition between Hypoxia-Inducible Factor (HIF)1A and HIF3A expression in human endothelial cells ▶     Anna Janaszak-Jasiecka, Sylwia Bartoszewska, Kinga Kochan et al.     Hypoxia-inducible factors (HIF) are heterodimeric transcription factors that allow cells to adapt and survive during hypoxia. Regulation of HIF1A and HIF2A mRNA is well …             A “building block” approach to the new influenza A virus entry inhibitors with reduced cellular toxicities ▶     Dongguo Lin, Fangfang Li, Qiuyi Wu et al.     Influenza A virus (IAV) is a severe worldwide threat to public health and economic development that results in the emergence of drug-resistant or highly virulent strains. …             Notch Signaling Coordinates Progenitor Cell-Mediated Biliary Regeneration Following Partial Hepatectomy ▶     Jie Lu, Yingqun Zhou, Tianyuan Hu et al.     Aberrant transcriptional regulation contributes to the pathogenesis of both congenital and adult forms of liver disease. Although the transcription factor RBPJ is essential for …                       npj Systems Biology and Applications is a new online, open access, multi- and cross- disciplinary journal dedicated to publishing finest research on systems biology and all its approaches. 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