Nature Reviews Genetics Contents April 2016 Volume 17 Number 4 pp 189-250

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TABLE OF CONTENTS
April 2016 Volume 17 Number 4		Advertisement
Impact Factor 36.978 *	In this issue Comment Research Highlights Reviews Also this month Article series: Regulatory elements Article series: Disease mechanisms  Featured article: Enhancers as non-coding RNA transcription units: recent insights and future perspectives Wenbo Li, Dimple Notani & Michael G. Rosenfeld	This special Focus highlights the unprecedented insights gained into the regulatory mechanisms underlying nuclear reprogramming, pluripotency and cell identity, and looks at the progress and challenges in using embryonic stem (ES) cells and iPSCs for therapeutic applications. Available free online.    Produced with support from:  Thermo Fisher Scientific
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Comment: Mitchochondrial replacement therapy: the IOM report and its aftermath I. Glenn Cohen & Eli Y. Adashi p189 | doi:10.1038/nrg.2016.21 Glenn Cohen and Eli Adashi comment on the recommendations and limitations of the Institute of Medicine (IOM) report on mitochondrial replacement therapies in light of recent legislative changes in the United States. Full Text | PDF
RESEARCH HIGHLIGHTS Top Evolutionary genetics: Haunted by the past — modern consequences of Neanderthal DNA p191 | doi:10.1038/nrg.2016.26 PDF Epigenetics: A three-state model for epigenetic silencing p192 | doi:10.1038/nrg.2016.19 PDF Microbial genetics: CRISPR memories of RNA p192 | doi:10.1038/nrg.2016.31 PDF Gene regulation: A gene-centric analysis of transcriptional cascades p193 | doi:10.1038/nrg.2016.30 PDF Complex traits: Integrating gene variation and expression to understand complex traits p194 | doi:10.1038/nrg.2016.18 PDF Plant genomics: Under the sea flowering plants adapt and thrive p195 | doi:10.1038/nrg.2016.17 PDF DNA methylation: A SMRT analysis of prokaryotic epigenomes p195 | doi:10.1038/nrg.2016.22 PDF IN BRIEF Technique: Chicago HighRise for genome scaffolding | Genetic screens: CombiGEM-CRISPR: a creative combination | Bioinformatics: Sequence searches blossom PDF Genetics JOBS of the week Tenure-Track / Tenured Faculty Position, Translational and Clinical Pharmacology Washington University in St. Louis Postdoctoral Fellowship in Biomedical Science (Cancer Research) Institute for Cancer Genetics Columbia University Medical Center Junior Group Leader in the systems biology programme CRG – Centre for Genomic Regulation Postdoctoral Fellow The University of Tennessee Health Science Center Postdoctoral Research Associate University of Illinois Chicago College of Medicine More Science jobs from Genetics EVENT Drosophila Genetics and Genomics 07.07.16 Hinxton, UK More science events from
REVIEWS		Top
The genetics of drug efficacy: opportunities and challenges Matthew R. Nelson, Toby Johnson, Liling Warren, Arlene R. Hughes, Stephanie L. Chissoe, Chun-Fang Xu & Dawn M. Waterworth p197 | doi:10.1038/nrg.2016.12 In this Review, the authors highlight the potential for efficacy genetics to drive drug development and guide treatment options. They argue for the integration of routine pharmacogenetic screening into clinical development and propose strategies for identifying efficacy loci for marketed drugs. Abstract | Full Text | PDF | Supplementary information
Article series: Regulatory elements Enhancers as non-coding RNA transcription units: recent insights and future perspectives Wenbo Li, Dimple Notani & Michael G. Rosenfeld p207 | doi:10.1038/nrg.2016.4 The observation that many, if not all, functional enhancers generate non-coding enhancer RNAs (eRNAs) has raised critical questions regarding the potential biological roles of the enhancer transcription process and, indeed, of eRNAs. This article reviews fundamental insights into the inter-regulation of enhancers and promoters and discusses unresolved questions regarding the functional role of enhancers as transcription units in genome regulation. Abstract | Full Text | PDF
Article series: Disease mechanisms Mechanisms underlying structural variant formation in genomic disorders Claudia M. B. Carvalho & James R. Lupski p224 | doi:10.1038/nrg.2015.25 Recent studies have revealed a ubiquitous role for genome architecture in the formation of structural variants at a given locus, both in DNA recombination-based and in DNA replication-based processes. These reports showcase the influence of repeat sequences on genomic stability and structural variant complexity and the tremendous plasticity and dynamic nature of our genome. Abstract | Full Text | PDF
Causes of molecular convergence and parallelism in protein evolution Jay F. Storz p239 | doi:10.1038/nrg.2016.11 In this Review, the author discusses the extent to which adaptive convergence in protein function is caused by convergent or parallel changes at the amino acid level, and addresses questions about the repeatability and predictability of molecular evolution. Abstract | Full Text | PDF
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