Nature Communications - 16 March 2016

Weekly Content Alert Nature Communications is now fully open access. Read more. 16 March 2016  Featured image: Müller et al. identify a subunit of the oligosaccharyltransferase complex required for interspecific, but not intraspecific, gametophytic recognition in Arabidopsis. Latest content: Correspondence Articles Corrigendum Errata Advertisement   Need help with DNA cloning?   Free Molecular Cloning Handbook  —with troubleshooting & protocols guide Download Now Journal homepage Recommend to library Web feed   Advertisement A new open access journal dedicated to publishing the most important scientific advances in all aspects of genomics and its application in the practice of medicine. Part of the Nature Partner Journals series, the journal is published in partnership with the Center of Excellence in Genomic Medicine Research.  Open for submissions   Advertisement Nature Publishing Group offers a free open access funding support service to enable authors to discover and apply for article processing charge funding available to them. Visit our website for further advice on the funding options available, and guidance in approaching funders and institutions, or email openaccess@nature.com for more information.        Nature Communications - now fully open access All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Correspondence     Correspondence: SEMA4A variation and risk of colorectal cancer OPEN 10 March 2016 | doi: 10.1038/ncomms10611     Correspondence: Reply to ‘SEMA4A variation and risk of colorectal cancer’ OPEN 10 March 2016 | doi: 10.1038/ncomms10695       Latest Articles View all Articles     Inducing amnesia through systemic suppression OPEN Justin C. Hulbert, Richard N. Henson and Michael C. Anderson Suppressing an unwanted memory reduces hippocampal activity and makes people more likely to forget the experience. Here, the authors show that suppressing past events induces an "amnesic shadow" for experiences near in time to suppression, consistent with a global disruption to hippocampal function. 15 March 2016 | doi: 10.1038/ncomms11003 Biological Sciences  Neuroscience  Understanding congested travel in urban areas OPEN Serdar Çolak, Antonio Lima and Marta C. González Rapid urbanization burdens urban road infrastructures, but understanding the interplay of road infrastructure and travel patterns is a complex challenge. Here, authors use mobile phone traces during morning peak hours to evaluate the effect of a congestion relief approach under a centralized routing scheme. 15 March 2016 | doi: 10.1038/ncomms10793 Physical Sciences  Theoretical physics  Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist OPEN Benjamin Cao, Zhen Zhang, Jochen Grassinger, Brenda Williams, Chad K. Heazlewood, Quentin I. Churches, Simon A. James, Songhui Li, Thalia Papayannopoulou and Susan K. Nilsson Mobilizing haematopoietic stem cells to the peripheral blood has largely replaced bone marrow transplants as a strategy in the clinic. Here, Cao et al. report the use of an α9β1/α4β1 integrin antagonist to induce rapid mobilization of blood stem cells from the bone marrow in a humanized mouse model. 15 March 2016 | doi: 10.1038/ncomms11007 Biological Sciences  Cell biology  Medical research  Metal-free intermolecular formal cycloadditions enable an orthogonal access to nitrogen heterocycles OPEN Lan-Gui Xie, Supaporn Niyomchon, Antonio J. Mota, Leticia González and Nuno Maulide Nitrogen containing heterocycles play key roles as both bioactive compounds and synthetic building blocks in organic chemistry. Here, the authors report the synthesis of a range of heterocyclic structures via metal free cycloadditions and provide mechanistic analyses for the transformations. 15 March 2016 | doi: 10.1038/ncomms10914 Chemical Sciences  Organic chemistry  Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments OPEN Hawa-Racine Thiam, Pablo Vargas, Nicolas Carpi, Carolina Lage Crespo, Matthew Raab, Emmanuel Terriac, Megan C. King, Jordan Jacobelli, Arthur S. Alberts, Theresia Stradal, Ana-Maria Lennon-Dumenil and Matthieu Piel Cell migration through micrometric constraints is limited by low deformability of the nucleus. Here the authors show that in dendritic cells a perinuclear actin network nucleated by Arp2/3 increases nuclear deformation and allows the cells to pass through narrow constrictions, likely by rupturing the nuclear lamina. 15 March 2016 | doi: 10.1038/ncomms10997 Biological Sciences  Cell biology  Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer OPEN Zhou Du, Tong Sun, Ezgi Hacisuleyman, Teng Fei, Xiaodong Wang, Myles Brown, John L. Rinn, Mary Gwo-Shu Lee, Yiwen Chen, Philip W. Kantoff and X. Shirley Liu Long non-coding RNAs (lncRNA; >200 base pair nucleic acids with little protein-coding capacity) are emerging as potentially important regulators of oncogenesis. Here the authors show tumour suppressive lncRNA sponge function for the protein products of prostate cancer driver genes. 15 March 2016 | doi: 10.1038/ncomms10982 Biological Sciences  Cancer  Medical research  The absence of an Atlantic imprint on the multidecadal variability of wintertime European temperature OPEN Ayako Yamamoto and Jaime B. Palter The conspicuous absence of a North Atlantic sea surface temperature signature from western European temperature records remains an anomaly. Here, the authors show that this is due to a dynamic atmospheric circulation anomaly that suppresses the expected thermodynamic response. 15 March 2016 | doi: 10.1038/ncomms10930 Earth Sciences  Atmospheric science  Climate science  Oceanography  Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice OPEN Isabelle Serr, Rainer W. Fürst, Peter Achenbach, Martin G. Scherm, Füsun Gökmen, Florian Haupt, Eva-Maria Sedlmeier, Annette Knopff, Leonard Shultz, Richard A. Willis, Anette-Gabriele Ziegler and Carolin Daniel Type 1 diabetes is associated with the loss of self-tolerance to the insulin-producing β-cells in the pancreas. Here the authors show that vaccination with insulin mimetopes can induce human insulin-specific regulatory T cells to mediate tolerance in a humanized mouse model. 15 March 2016 | doi: 10.1038/ncomms10991 Biological Sciences  Immunology  Medical research  Nesting-driven multipolar order in CeB6 from photoemission tomography OPEN A. Koitzsch, N. Heming, M. Knupfer, B. Büchner, P. Y. Portnichenko, A. V Dukhnenko, N. Y. Shitsevalova, V. B. Filipov, L. L. Lev, V. N. Strocov, J. Ollivier and D. S. Inosov In compounds containing 4f and 5f elements, hidden-order phases exist which are undetectable by many methods, the origins of which are debated. Here, the authors use photoemission and neutron scattering methods to show how such a multipolar-ordered phase emerges due to Fermi surface instability in CeB6. 15 March 2016 | doi: 10.1038/ncomms10876 Physical Sciences  Condensed matter  G6PD protects from oxidative damage and improves healthspan in mice OPEN Sandrina Nóbrega-Pereira, Pablo J. Fernandez-Marcos, Thomas Brioche, Mari Carmen Gomez-Cabrera, Andrea Salvador-Pascual, Juana M. Flores, Jose Viña and Manuel Serrano The enzyme G6PD generates the reductive metabolite NADPH, which has antioxidant effects, but has also been linked to tumour growth. Here the authors generate mice that modestly overexpress G6PD and report increased lifespan in females, and no negative effects on tumour formation in various genetic models. 15 March 2016 | doi: 10.1038/ncomms10894 Biological Sciences  Cancer  Medical research  Nitrogenase FeMoco investigated by spatially resolved anomalous dispersion refinement OPEN Thomas Spatzal, Julia Schlesier, Eva-Maria Burger, Daniel Sippel, Limei Zhang, Susana L.A. Andrade, Douglas C. Rees and Oliver Einsle The [Mo:7Fe:9S:C] iron-molybdenum cofactor (FeMoco) of nitrogenase is a large metal cluster with an important role in biological nitrogen fixation. Here, the authors use spatially resolved refinement of the anomalous scattering contributions of the iron atoms to determine the resting-state electron distribution of FeMoco. 14 March 2016 | doi: 10.1038/ncomms10902 Biological Sciences  Biochemistry  Microbiology  IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis OPEN Rossana G. Iannitti, Valerio Napolioni, Vasilis Oikonomou, Antonella De Luca, Claudia Galosi, Marilena Pariano, Cristina Massi-Benedetti, Monica Borghi, Matteo Puccetti, Vincenzina Lucidi, Carla Colombo, Ersilia Fiscarelli, Cornelia Lass-Flörl, Fabio Majo, Lisa Cariani, Maria Russo, Luigi Porcaro, Gabriella Ricciotti, Helmut Ellemunter, Luigi Ratclif et al. IL-1-mediated inflammation contributes to the pathogenesis of cystic fibrosis. Here the authors show that this is largely due to NLRP3 activation, whereas NLRP4 induces IL-1Ra, limiting the overall inflammasome activity and providing a therapeutic angle to ameliorate the disease. 14 March 2016 | doi: 10.1038/ncomms10791 Biological Sciences  Immunology  Medical research  Nanosecond formation of diamond and lonsdaleite by shock compression of graphite OPEN D. Kraus, A. Ravasio, M. Gauthier, D. O. Gericke, J. Vorberger, S. Frydrych, J. Helfrich, L. B. Fletcher, G. Schaumann, B. Nagler, B. Barbrel, B. Bachmann, E. J. Gamboa, S. Göde, E. Granados, G. Gregori, H. J. Lee, P. Neumayer, W. Schumaker, T. Döppner et al. Shock synthesis of diamond and even harder carbon polymorphs from graphite is of great interest for science and technology. Here, the authors present unprecedented in situ measurements of the structural changes, showing ultrafast formation of diamond and, at higher pressures, evidence for a pure lonsdaleite structure. 14 March 2016 | doi: 10.1038/ncomms10970 Earth Sciences  Geology and geophysics  Targeting neurotransmitter receptors with nanoparticles in vivo allows single-molecule tracking in acute brain slices OPEN Juan A. Varela, Julien P. Dupuis, Laetitia Etchepare, Agnès Espana, Laurent Cognet and Laurent Groc Single quantum dot tracking is an established technique used in cultured neurons and organotypic brain slices. Here, the authors demonstrate in vivo targeting of dopamine receptors via ventricular injection of functionalized quantum dots and track single nanoparticle-receptors in acute rat brain slices. 14 March 2016 | doi: 10.1038/ncomms10947 Biological Sciences  Nanotechnology  Neuroscience  Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium OPEN Bethany A. Kerr, Xiaoxia Z. West, Young-Woong Kim, Yongzhong Zhao, Miroslava Tischenko, Rebecca M. Cull, Timothy W. Phares, Xiao-Ding Peng, Jeremiah Bernier-Latmani, Tatiana V. Petrova, Ralf H. Adams, Nissim Hay, Sathyamangla V. Naga Prasad and Tatiana V. Byzova The Akt pathway integrates multiple signals, but whether it affects vasculature function is debatable. Here the authors show that Akt pathway shutdown in adult mouse endothelium causes destabilization of vasculature leading to cardiac and retinal dysfunction, due to decreased levels of Jagged1 and impaired Notch signaling. 14 March 2016 | doi: 10.1038/ncomms10960 Biological Sciences  Cell biology  Medical research  Stabilin-2 modulates the efficiency of myoblast fusion during myogenic differentiation and muscle regeneration OPEN Seung-Yoon Park, Youngeun Yun, Jung-Suk Lim, Mi-Jin Kim, Sang-Yeob Kim, Jung-Eun Kim and In-San Kim Phosphatidylserine and its receptors are associated with cell-cell fusion. Here, the authors show the phosphatidylserine receptor stabilin-2 is expressed by muscle cells and plays a vital role in myoblast fusion and post-injury muscle regeneration in mice. 14 March 2016 | doi: 10.1038/ncomms10871 Biological Sciences  Medical research  Superconductivity in Weyl semimetal candidate MoTe2 OPEN Yanpeng Qi, Pavel G. Naumov, Mazhar N. Ali, Catherine R. Rajamathi, Walter Schnelle, Oleg Barkalov, Michael Hanfland, Shu-Chun Wu, Chandra Shekhar, Yan Sun, Vicky Süß, Marcus Schmidt, Ulrich Schwarz, Eckhard Pippel, Peter Werner, Reinald Hillebrand, Tobias Förster, Erik Kampert, Stuart Parkin, R. J. Cava et al. Materials which simultaneously exhibit superconductivity and topologically non-trivial electronic band structure possess potential applications in quantum computing but have yet to be found. Here, the authors find superconductivity in MoTe2, a material predicted to be topologically non-trivial. 14 March 2016 | doi: 10.1038/ncomms11038 Physical Sciences  Condensed matter  Coexistence of charge and ferromagnetic order in fcc Fe OPEN Pin-Jui Hsu, Jens Kügel, Jeannette Kemmer, Francesco Parisen Toldin, Tobias Mauerer, Matthias Vogt, Fakher Assaad and Matthias Bode The coexistence of different magnetic and electronic phases often occurs in materials with complex chemical compositions, allowing for the study of competitive, collaborative, or emergent phenomena. Here, the authors demonstrate such behaviour in ultrathin Fe films on a Rh(001) substrate. 14 March 2016 | doi: 10.1038/ncomms10949 Physical Sciences  Condensed matter  Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults OPEN Koichi Hasegawa, Toru Yasuda, Chinatsu Shiraishi, Kazushiro Fujiwara, Serge Przedborski, Hideki Mochizuki and Kazuaki Yoshikawa Mitochondrial dysfunction occurs in Parkinson's disease, although the underlying mechanisms are unclear. Here, the authors find necdin works to stabilise the mitochondrial regulator PGC-1α, and that overexpression of necdin protects against MPTP-mediated neurodegeneration both in vitro and in vivo. 14 March 2016 | doi: 10.1038/ncomms10943 Biological Sciences  Neuroscience  A subunit of the oligosaccharyltransferase complex is required for interspecific gametophyte recognition in Arabidopsis OPEN Lena M. Müller, Heike Lindner, Nuno D. Pires, Valeria Gagliardini and Ueli Grossniklaus Species-specific gamete recognition is needed to maintain species boundaries. Here, Müller et al. show that ARTUMES regulates pollen tube recognition between different Arabidopsis species, representing the first gene known to exclusively influence inter- but not intraspecific gamete interaction in plants. 11 March 2016 | doi: 10.1038/ncomms10826 Biological Sciences  Genetics  Plant sciences  A three-dimensional actuated origami-inspired transformable metamaterial with multiple degrees of freedom OPEN Johannes T.B. Overvelde, Twan A. de Jong, Yanina Shevchenko, Sergio A. Becerra, George M. Whitesides, James C. Weaver, Chuck Hoberman and Katia Bertoldi Typically, most structures and devices that can be reconfigured are designed with application specific requirements. Inspired by modular origami ideas, Overvelde et al. present a mechanical metamaterial enabling the design of three-dimensional structures of arbitrary architecture with tunable shape, volume and stiffness. 11 March 2016 | doi: 10.1038/ncomms10929 Physical Sciences  Applied physics  Materials science  IL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease OPEN Milena J. Tosiek, Laurence Fiette, Sary El Daker, Gérard Eberl and Antonio A. Freitas Transcription factors directing T cell fate are induced by instructive signals such as cytokines. Here the authors show that IL-15 promotes Foxp3 and inhibits RORγt expression in CD4 T cells, and that IL-15 is critical to suppress colitis by maintaining the Treg to Th1/Th17 ratio in a mouse model. 11 March 2016 | doi: 10.1038/ncomms10888 Biological Sciences  Immunology  Effective energy storage from a triboelectric nanogenerator OPEN Yunlong Zi, Jie Wang, Sihong Wang, Shengming Li, Zhen Wen, Hengyu Guo and Zhong Lin Wang Self-charging systems based on the connection of a nanogenerator and an energy storage unit through a rectifier can have low energy storage efficiencies. Here, the authors design the charging cycle to maximize the energy storage efficiency of a triboelectric nanogenerator by introducing a motion-induced switch. 11 March 2016 | doi: 10.1038/ncomms10987 Physical Sciences  Applied physics  Materials science  Nanotechnology  Surface Landau levels and spin states in bismuth (111) ultrathin films OPEN Hongjian Du, Xia Sun, Xiaogang Liu, Xiaojun Wu, Jufeng Wang, Mingyang Tian, Aidi Zhao, Yi Luo, Jinlong Yang, Bing Wang and J. G. Hou The electronic surface states of bismuth present promise for applications exploiting spin and valley degrees of freedom however their study is inhibited by bulk states. Here, the authors directly access the surface-state Landau levels of ultrathin bismuth films under a perpendicular magnetic field. 11 March 2016 | doi: 10.1038/ncomms10814 Physical Sciences  Condensed matter  Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis OPEN Christoph Weigel, Marlon R. Veldwijk, Christopher C. Oakes, Petra Seibold, Alla Slynko, David B. Liesenfeld, Mariona Rabionet, Sabrina A. Hanke, Frederik Wenz, Elena Sperk, Axel Benner, Christoph Rösli, Roger Sandhoff, Yassen Assenov, Christoph Plass, Carsten Herskind, Jenny Chang-Claude, Peter Schmezer and Odilia Popanda Radiotherapy can induce fibrosis in cancer patients, limiting its use in clinical settings. Here, the authors identify a differentially methylated enhancer of the lipid kinase DGKA in fibroblasts from breast cancer patients developing fibrosis after radiotherapy and they show that DGKA inhibition affects lipid homeostasis and reduces pro-fibrotic fibroblast activation. 11 March 2016 | doi: 10.1038/ncomms10893 Biological Sciences  Cancer  Cell biology  Medical research  CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL OPEN Paulina Bartuzi, Daniel D. Billadeau, Robert Favier, Shunxing Rong, Daphne Dekker, Alina Fedoseienko, Hille Fieten, Melinde Wijers, Johannes H. Levels, Nicolette Huijkman, Niels Kloosterhuis, Henk van der Molen, Gemma Brufau, Albert K. Groen, Alison M. Elliott, Jan Albert Kuivenhoven, Barbara Plecko, Gernot Grangl, Julie McGaughran, Jay D. Horton et al. Low density lipoprotein receptor (LDLR) is crucial for cholesterol homeostasis. Here, the authors show that components of the CCC-protein complex, CCDC22 and COMMD1, facilitate the endosomal sorting of LDLR and that mutations in these genes cause hypercholesterolemia in dogs and mice, providing new insights into regulation of cholesterol homeostasis. 11 March 2016 | doi: 10.1038/ncomms10961 Biological Sciences  Cell biology  Genetics  Medical research  Thermal selectivity of intermolecular versus intramolecular reactions on surfaces OPEN Borja Cirera, Nelson Giménez-Agulló, Jonas Björk, Francisco Martínez-Peña, Alberto Martin-Jimenez, Jonathan Rodriguez-Fernandez, Ana M. Pizarro, Roberto Otero, José M. Gallego, Pablo Ballester, José R. Galan-Mascaros and David Ecija Surface-mediated synthesis of low-dimensional polymers is a promising approach to design materials for targeted applications. Here, the authors introduce surface-confined thermally tunable pathways to select intra- or intermolecular reactions yielding monomeric or lowdimensional polymeric phthalocyanines. 11 March 2016 | doi: 10.1038/ncomms11002 Chemical Sciences  Nanotechnology  Physical chemistry  The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model OPEN Kiyohito Murai, Guoqiang Sun, Peng Ye, E. Tian, Su Yang, Qi Cui, Guihua Sun, Daniel Trinh, Olivia Sun, Teresa Hong, Zhexing Wen, Markus Kalkum, Arthur D. Riggs, Hongjun Song, Guo-li Ming and Yanhong Shi Dysregulation of microRNAs has been implicated in neurodevelopmental disorders, including schizophrenia. Here the authors show that the TLX-miR-219 cascade regulates the proliferation of neural stem cells during normal development, and this pathway is dysregulated in a schizophrenia iPSC model. 11 March 2016 | doi: 10.1038/ncomms10965 Biological Sciences  Cell biology  Neuroscience  IL-17-producing γδ T cells enhance bone regeneration OPEN Takehito Ono, Kazuo Okamoto, Tomoki Nakashima, Takeshi Nitta, Shohei Hori, Yoichiro Iwakura and Hiroshi Takayanagi γδ T cells are innate-like lymphocytes that regulate immune responses by producing IL-17A or IFN-γ, but have no known role in bone healing. Here the authors show a nonimmune bone-regenerative function of IL-17A produced by the Vγ6+ subset in mice. 11 March 2016 | doi: 10.1038/ncomms10928 Biological Sciences  Immunology  Medical research  Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice OPEN Gang Han, Ben Gu, Limin Cao, Xianjun Gao, Qingsong Wang, Yiqi Seow, Ning Zhang, Matthew J. A. Wood and HaiFang Yin Exon-skipping therapies such as systemic i.v. administration of morpholino are being explored as a means of treating Duchenne muscular dystrophy. Here the authors show that adding a glucose-fructose mix can enhance uptake of phosphorodiamidate morpholino oligomer and its therapeutic effect in mdx mice. 11 March 2016 | doi: 10.1038/ncomms10981 Biological Sciences  Medical research  Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis OPEN Moritz Leppkes, Christian Maueröder, Sebastian Hirth, Stefanie Nowecki, Claudia Günther, Ulrike Billmeier, Susanne Paulus, Mona Biermann, Luis E. Munoz, Markus Hoffmann, Dane Wildner, Andrew L. Croxford, Ari Waisman, Kerri Mowen, Dieter E. Jenne, Veit Krenn, Julia Mayerle, Markus M. Lerch, Georg Schett, Stefan Wirtz et al. Pancreatitis often develops as a consequence of ductal obstruction. Here, the authors show that bicarbonate ions initiate the release of neutrophil extracellular traps (NETs) that form pancreatic ductal aggregates and occlude the ducts, thereby driving pancreatitis in mice and humans. 11 March 2016 | doi: 10.1038/ncomms10973 Biological Sciences  Medical research  A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome OPEN Eva M. Huber, Wolfgang Heinemeyer, Xia Li, Cassandra S. Arendt, Mark Hochstrasser and Michael Groll The proteasome, an essential molecular machine, is a threonine protease, but the evolution and the components of its proteolytic centre are unclear. Here, the authors use structural biology and biochemistry to investigate the role of proteasome active site residues on maturation and activity. 11 March 2016 | doi: 10.1038/ncomms10900 Biological Sciences  Biochemistry  αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells OPEN Mridu Acharya, Anna Sokolovska, Jenny M. Tam, Kara L. Conway, Caroline Stefani, Fiona Raso, Subhankar Mukhopadhyay, Marianela Feliu, Elahna Paul, John Savill, Richard O. Hynes, Ramnik J. Xavier, Jatin M. Vyas, Lynda M. Stuart and Adam Lacy-Hulbert Integrins can regulate antigen-specific and innate immune receptor signalling, thereby affecting immune cell function. Here the authors show that avß3 integrin controls Toll-like receptor (TLR) signalling by regulating its trafficking to limit TLR-mediated B-cell proliferation and antibody production. 11 March 2016 | doi: 10.1038/ncomms10917 Biological Sciences  Immunology  Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA OPEN David Albesa-Jové, Zuzana Svetlíková, Montse Tersa, Enea Sancho-Vaello, Ana Carreras-González, Pascal Bonnet, Pedro Arrasate, Ander Eguskiza, Shiva K. Angala, Javier O. Cifuente, Jana Korduláková, Mary Jackson, Katarína Mikušová and Marcelo E. Guerin PatA is a membrane-associated acyltransferase that is essential for the biosynthesis of mycobacterial glycolipids. Here, Albesa-Jové et al. describe structures of PatA from Mycobacterium smegmatis in complex with acyl donors and show that catalysis occurs by an unusual charge-relay mechanism. 11 March 2016 | doi: 10.1038/ncomms10906 Biological Sciences  Biochemistry  Microbiology  Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation OPEN Jose Antonio Escudero, Celine Loot, Vincent Parissi, Aleksandra Nivina, Christiane Bouchier and Didier Mazel The integron integrases have evolved to perform recombination of single and double stranded DNA. Here the authors show that the ancestral pathway is still functional at double stranded sites, revealing the evolution towards the modern resolution pathway. 10 March 2016 | doi: 10.1038/ncomms10937 Biological Sciences  Molecular biology  Making the hydrogen evolution reaction in polymer electrolyte membrane electrolysers even faster OPEN Jakub Tymoczko, Federico Calle-Vallejo, Wolfgang Schuhmann and Aliaksandr S. Bandarenka There is substantial research into minimizing platinum use in polymer electrolyte membrane electrolyzers. Here, the authors report that the hydrogen evolution activity of platinum(111) electrodes can be significantly enhanced by monolayer amounts of copper, which weaken the binding of hydrogen intermediates. 10 March 2016 | doi: 10.1038/ncomms10990 Chemical Sciences  Catalysis  Materials science  Physical chemistry  The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles OPEN Mariam H. Orme, Gianmaria Liccardi, Nina Moderau, Rebecca Feltham, Sidonie Wicky-John, Tencho Tenev, Lior Aram, Rebecca Wilson, Katiuscia Bianchi, Otto Morris, Celia Monteiro Domingues, David Robertson, Meghana Tare, Alexander Wepf, David Williams, Andreas Bergmann, Matthias Gstaiger, Eli Arama, Paulo S. Ribeiro and Pascal Meier et al. In addition to their role in apoptosis, caspases are also involved in mediating non-apoptotic events. Here the authors show that the Drosophila myosin family member CRINKLED and its mammalian counterpart act as substrate adaptor that facilitate caspase-mediated cleavage and localised kinase activity. 10 March 2016 | doi: 10.1038/ncomms10972 Biological Sciences  Biochemistry  Cell biology  Damage-free vibrational spectroscopy of biological materials in the electron microscope OPEN Peter Rez, Toshihiro Aoki, Katia March, Dvir Gur, Ondrej L. Krivanek, Niklas Dellby, Tracy C. Lovejoy, Sharon G. Wolf and Hagai Cohen Use of electron microscopy to determine morphology, or find where functionally significant biomolecules are located with high spatial resolution is of great interest. Here, Rez, Cohen et al. use aloof electron beam vibrational spectroscopy to probe different bonds in biological samples with no significant radiation damage. 10 March 2016 | doi: 10.1038/ncomms10945 Physical Sciences  Optical physics  Acoustic trapping of active matter OPEN Sho C. Takatori, Raf De Dier, Jan Vermant and John F. Brady Active matter, such as swimming bacteria, show unique behaviors under confinement, but it is experimentally challenging to measure them. Takatori et al. show the use of acoustic tweezers to trap self-propelled Janus particles as an enabling tool to investigate collective motions in living systems. 10 March 2016 | doi: 10.1038/ncomms10694 Physical Sciences  Applied physics  Biophysics  Spatial control of chemical processes on nanostructures through nano-localized water heating OPEN Calum Jack, Affar S. Karimullah, Ryan Tullius, Larousse Khosravi Khorashad, Marion Rodier, Brian Fitzpatrick, Laurence D. Barron, Nikolaj Gadegaard, Adrian J. Lapthorn, Vincent M. Rotello, Graeme Cooke, Alexander O. Govorov and Malcolm Kadodwala It is generally believed that rapid dissipation means that spatially precise heating is not feasible via thermoplasmonic means. Here, the authors induce highly localized heating around plasmonic nanostructures by pulsed laser irradiation, which effects chemical modification of surface bound molecules. 10 March 2016 | doi: 10.1038/ncomms10946 Physical Sciences  Materials science  Nanotechnology  Optical physics  Interphase APC/C–Cdc20 inhibition by cyclin A2–Cdk2 ensures efficient mitotic entry OPEN Jamin B. Hein and Jakob Nilsson The Anaphase Promoting Complex/Cyclosome (APC/C) and its co-activator Cdc20 regulate mitotic progression, but both are also present in interphase. Here Hein and Nilsson show that Cyclin A2–CDK2 phosphorylates Cdc20 to inhibit APC/C–Cdc20 activity during this cell cycle phase to promote mitotic entry. 10 March 2016 | doi: 10.1038/ncomms10975 Biological Sciences  Cell biology  Constructing 3D interaction maps from 1D epigenomes OPEN Yun Zhu, Zhao Chen, Kai Zhang, Mengchi Wang, David Medovoy, John W. Whitaker, Bo Ding, Nan Li, Lina Zheng and Wei Wang The human genome is highly organized, with one-dimensional chromatin states packaged into higher level three-dimensional architecture. Here, the authors present EpiTensor that can identify 3D spatial associations from 1D epigenetic information. 10 March 2016 | doi: 10.1038/ncomms10812 Biological Sciences  Bioinformatics  Molecular biology  Mobility overestimation due to gated contacts in organic field-effect transistors OPEN Emily G. Bittle, James I. Basham, Thomas N. Jackson, Oana D. Jurchescu and David J. Gundlach Charge mobility, extracted from current–voltage curves, is an important parameter for evaluating the performance of organic field-effect transistors. Bittle et al. show that charge mobility can be overestimated by one order of magnitude due to the gate bias dependence of the charge injection process. 10 March 2016 | doi: 10.1038/ncomms10908 Physical Sciences  Applied physics  Screen-printed flexible MRI receive coils OPEN Joseph R. Corea, Anita M. Flynn, Balthazar Lechêne, Greig Scott, Galen D. Reed, Peter J. Shin, Michael Lustig and Ana C. Arias Signal-to-noise ratio is one of the key factors that currently limit the diagnostic image quality and patient conditions of magnetic resonance imaging. Here, Corea et al. use fully printed flexible receive coils, conforming to patient bodies, to improve signals and patient comfort in clinical scanners. 10 March 2016 | doi: 10.1038/ncomms10839 Physical Sciences  Applied physics  Bioengineering  Medical research  Stable topological insulators achieved using high energy electron beams OPEN Lukas Zhao, Marcin Konczykowski, Haiming Deng, Inna Korzhovska, Milan Begliarbekov, Zhiyi Chen, Evangelos Papalazarou, Marino Marsi, Luca Perfetti, Andrzej Hruban, Agnieszka Wołoś and Lia Krusin-Elbaum Defects in solids may introduce additional charges that influence the overall charge transport behaviour. Here, Zhao et al. use swift electron beams to compensate charge defects, which effectively tune Bi2Te3 and Bi2Se3 from p-type to n-type while preserving their topological properties. 10 March 2016 | doi: 10.1038/ncomms10957 Physical Sciences  Condensed matter  Materials science  Three mechanisms control E-cadherin localization to the zonula adherens OPEN Innokenty Woichansky, Carlo Antonio Beretta, Nicola Berns and Veit Riechmann E-cadherin is an adhesion molecule mediating cell-cell adhesion; correct localization is important but how localization is controlled is not clear. Here the authors use Drosophila as a model system to distinguish three distinct trafficking pathways that direct E-cadherin to the zonula adherens. 10 March 2016 | doi: 10.1038/ncomms10834 Biological Sciences  Cell biology  G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression OPEN Xi Zhang, Danni Peng, Yuanxin Xi, Chao Yuan, Cari A. Sagum, Brianna J. Klein, Kaori Tanaka, Hong Wen, Tatiana G. Kutateladze, Wei Li, Mark T. Bedford and Xiaobing Shi The histone methyltransferase G9a methylates histone H3K9 to repress gene expression, but it also acts as a coactivator for some nuclear receptors. Here, Zhang et al. show that methylation of ERα by G9a recruits the PHF20/MOF complex that deposits histone H4K16 acetylation promoting active transcription. 10 March 2016 | doi: 10.1038/ncomms10810 Biological Sciences  Cell biology  Molecular biology  Macroscopic self-reorientation of interacting two-dimensional crystals OPEN C. R. Woods, F. Withers, M. J. Zhu, Y. Cao, G. Yu, A. Kozikov, M. Ben Shalom, S. V. Morozov, M. M. van Wijk, A. Fasolino, M. I. Katsnelson, K. Watanabe, T. Taniguchi, A. K. Geim, A. Mishchenko and K. S. Novoselov Precise control of the relative orientation of two two-dimensional layers enables reproducible fabrication of heterostructure devices. Here, the authors show that graphene rotates towards the crystallographic direction of a boron-nitride substrate due to the interplay between van der Waals and elastic energies. 10 March 2016 | doi: 10.1038/ncomms10800 Physical Sciences  Materials science  Nanotechnology  A metallic mosaic phase and the origin of Mott-insulating state in 1T-TaS2 OPEN Liguo Ma, Cun Ye, Yijun Yu, Xiu Fang Lu, Xiaohai Niu, Sejoong Kim, Donglai Feng, David Tománek, Young-Woo Son, Xian Hui Chen and Yuanbo Zhang In correlated materials, new phases emerge when the balance between many-body interactions is perturbed. Here, Ma et al. induce a mosaic charge-density-wave phase out of Mott insulating state in layered 1T-TaS2 by voltage pulses, which reveals a dominating role of interlayer stacking order. 10 March 2016 | doi: 10.1038/ncomms10956 Physical Sciences  Condensed matter  Materials science  Nanotechnology  G protein-coupled receptor 37 is a negative regulator of oligodendrocyte differentiation and myelination OPEN Hyun-Jeong Yang, Anna Vainshtein, Galia Maik-Rachline and Elior Peles The molecular mechanism controlling oligodendrocyte differentiation is not fully understood. Here the authors show that G protein coupled receptor 37 acts as a negative regulator of CNS myelination, and this effect is mediated by suppression of ERK signalling. 10 March 2016 | doi: 10.1038/ncomms10884 Biological Sciences  Cell biology  Neuroscience  Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation OPEN Won Hoon Choi, Stefanie A. H. de Poot, Jung Hoon Lee, Ji Hyeon Kim, Dong Hoon Han, Yun Kyung Kim, Daniel Finley and Min Jae Lee The proteasome plays a key role in proteostasis by mediating the degradation of ubiquitinated substrates. Here the authors show that an open-gate mutant of the proteasome is hyperactive towards a subset of substrates and can effectively delay the accumulation of toxic protein aggregates. 09 March 2016 | doi: 10.1038/ncomms10963 Biological Sciences  Biochemistry  Cell biology  Spacer-free BODIPY fluorogens in antimicrobial peptides for direct imaging of fungal infection in human tissue OPEN Lorena Mendive-Tapia, Can Zhao, Ahsan R. Akram, Sara Preciado, Fernando Albericio, Martin Lee, Alan Serrels, Nicola Kielland, Nick D Read, Rodolfo Lavilla and Marc Vendrell Functionalizing antimicrobial peptides with fluorescent groups is a useful strategy for imaging infection, but the tag can alter the performance of the probe. Here, the authors report a spacer-free method to directly functionalise an amino acid with a fluorogenic group and prepare peptide-based imaging agents for fungal infection. 09 March 2016 | doi: 10.1038/ncomms10940 Chemical Sciences  Chemical biology  Microbiology  Organic chemistry  Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank OPEN Jacqueline M. Lane, Irma Vlasac, Simon G. Anderson, Simon D. Kyle, William G. Dixon, David A. Bechtold, Shubhroz Gill, Max A. Little, Annemarie Luik, Andrew Loudon, Richard Emsley, Frank A. J. L. Scheer, Deborah A. Lawlor, Susan Redline, David W. Ray, Martin K. Rutter and Richa Saxena Here, Richa Saxena and colleagues perform a genome-wide association study (GWAS) of self-reported morningness/eveningness preference in the UKBiobank cohort, and identify new genetic loci that contribute to a person's chronotype. 09 March 2016 | doi: 10.1038/ncomms10889 Biological Sciences  Genetics  FAM21 directs SNX27–retromer cargoes to the plasma membrane by preventing transport to the Golgi apparatus OPEN Seongju Lee, Jaerak Chang and Craig Blackstone Endosomes maintain cellular homeostasis by sorting, recycling and degrading endocytosed cargoes. Here the authors show that the SNX27-retromer-WASH complex acts as a hub to direct cargoes to the plasma membrane by blocking their transport to lysosomes and Golgi apparatus. 09 March 2016 | doi: 10.1038/ncomms10939 Biological Sciences  Cell biology  Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia OPEN Sonja I. Berndt, Nicola J. Camp, Christine F. Skibola, Joseph Vijai, Zhaoming Wang, Jian Gu, Alexandra Nieters, Rachel S. Kelly, Karin E. Smedby, Alain Monnereau, Wendy Cozen, Angela Cox, Sophia S. Wang, Qing Lan, Lauren R. Teras, Moara Machado, Meredith Yeager, Angela R. Brooks-Wilson, Patricia Hartge, Mark P. Purdue et al. Chronic lymphocytic leukemia is a highly inheritable cancer. Here the authors conduct a metaanalysis of four genome-wide association studies and identify three novel loci located near EOMES, SERPINB6 and LPP associated with risk of this disease. 09 March 2016 | doi: 10.1038/ncomms10933 Biological Sciences  Cancer  Genetics  MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration OPEN Anil Noronha Antony, Melanie Paillard, Cynthia Moffat, Egle Juskeviciute, Jason Correnti, Brad Bolon, Emanuel Rubin, György Csordás, Erin L. Seifert, Jan B. Hoek and György Hajnóczky Mitochondrial calcium uptake is a highly regulated process, and calcium overload can lead to cell death. Here, using knockout mouse model, the authors show that the mitochondrial calcium uniporter (MCU) regulator MICU1 is needed to prevent calcium overload and promotes survival under liver regeneration and postnatal adaptation-associated stress. 09 March 2016 | doi: 10.1038/ncomms10955 Biological Sciences  Cell biology  Bcl-2 is a critical mediator of intestinal transformation OPEN Maartje van der Heijden, Cheryl D. Zimberlin, Anna M. Nicholson, Selcuk Colak, Richard Kemp, Sybren L. Meijer, Jan Paul Medema, Florian R. Greten, Marnix Jansen, Douglas J. Winton and Louis Vermeulen The anti-apoptotic protein Bcl-2 is selectively expressed in intestinal stem cells (ISCs). Here, the authors show that, in intestinal stem cells, Bcl-2 alleviates apoptotic priming induced by the loss of the tumour suppressor Apc in ISCs and that the absence of Bcl-2 or pharmacological blockade of Bcl-2 can inhibit the intestinal tumorigenesis driven by the Apc-loss. 09 March 2016 | doi: 10.1038/ncomms10916 Biological Sciences  Cancer  Cell biology  Tracking the shape-dependent sintering of platinum–rhodium model catalysts under operando conditions OPEN Uta Hejral, Patrick Müller, Olivier Balmes, Diego Pontoni and Andreas Stierle Understanding nanoparticle sintering is crucial for designing stable catalysts. Here, the authors use high energy grazing incidence X-ray diffraction as an in situ probe to track the composition dependent three-dimensional restructuring of supported alloy nanoparticles during carbon monoxide oxidation. 09 March 2016 | doi: 10.1038/ncomms10964 Chemical Sciences  Catalysis  Condensed matter  Physical chemistry  The Gq signalling pathway inhibits brown and beige adipose tissue OPEN Katarina Klepac, Ana Kilić, Thorsten Gnad, Loren M. Brown, Beate Herrmann, Andrea Wilderman, Aileen Balkow, Anja Glöde, Katharina Simon, Martin E. Lidell, Matthias J. Betz, Sven Enerbäck, Jürgen Wess, Marc Freichel, Matthias Blüher, Gabi König, Evi Kostenis, Paul A. Insel and Alexander Pfeifer Brown and beige adipose tissues contribute to organismal energy expenditure by generating heat. Here, Klepac et al. survey G protein-coupled receptors in brown fat and show that Gq-coupled receptors inhibit expression of thermogenic proteins in mice and in human adipocytes. 09 March 2016 | doi: 10.1038/ncomms10895 Biological Sciences  Medical research  Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation OPEN Chuntao Zhao, Yaqi Deng, Lei Liu, Kun Yu, Liguo Zhang, Haibo Wang, Xuelian He, Jincheng Wang, Changqing Lu, Laiman N Wu, Qinjie Weng, Meng Mao, Jianrong Li, Johan H van Es, Mei Xin, Lee Parry, Steven A Goldman, Hans Clevers and Q. Richard Lu Wnt/β-catenin signaling regulates oligodendrocyte (OL) development. Here the authors show that Tcf7l2, a β-catenin transcriptional partner,sequentially interacts with stage-specific partners to coordinate the transitions of differentiation initiation and maturation during OL development. 09 March 2016 | doi: 10.1038/ncomms10883 Biological Sciences  Cell biology  Neuroscience  Disorder-mediated crowd control in an active matter system OPEN Erçağ Pinçe, Sabareesh K. P. Velu, Agnese Callegari, Parviz Elahi, Sylvain Gigan, Giovanni Volpe and Giorgio Volpe Many living systems, such as bacterial colonies, exhibit collective and dynamic behaviours that are sensitive to the change in environmental conditions. Here, the authors show that a colloidal active matter system switches between gathering and dispersal of individuals in response to a disordered potential. 09 March 2016 | doi: 10.1038/ncomms10907 Physical Sciences  Fluids and plasma physics  Materials science  Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system OPEN Taek-Chin Cheong, Mara Compagno and Roberto Chiarle CRISPR-Cas9 has been used to generate a range of genetic modifications including gene knock-outs and chromosomal rearrangements. Here the authors target the immunogloblin genes and demonstrate the induction of class switch recombination, opening up possibilities for research and antibody production. 09 March 2016 | doi: 10.1038/ncomms10934 Biological Sciences  Molecular biology    Nature Communications JOBS of the week Postdoc / Bioinformatician German Cancer Research Center (DKFZ). Postgraduate Research Associate (M / F) Universitat fur Bodenkultur Wien Postdoctoral Researcher University of California, San Diego ( UCSD ) Postdoctoral Fellowship in Neuroscience University of Oslo Research Associate University College London (UCL) Marie Curie Early Stage Researchers University of Birmingham Laboratory Technician Philip Morris International (PMI) Plant Science Faculty King Abdullah University of science & Technology ( KAUST ) Postdoctoral Research Fellow Beth Israel Deaconess Medical Center - Harvard Medical School Research Fellow TU Dresden More Science jobs from Nature Communications EVENT 14th Annual Meeting of Association for Cancer Immunotherapy 10.05.16 Mainz, Germany More science events from       Latest Corrigendum     Corrigendum: Elucidating the role of disorder and free-carrier recombination kinetics in CH3NH3PbI3 perovskite films OPEN Chan La-o-vorakiat, Teddy Salim, Jeannette Kadro, Mai-Thu Khuc, Reinhard Haselsberger, Liang Cheng, Huanxin Xia, Gagik G. Gurzadyan, Haibin Su, Yeng Ming Lam, Rudolph A. Marcus, Maria-Elisabeth Michel-Beyerle and Elbert E. M. Chia 10 March 2016 | doi: 10.1038/ncomms11054 Physical Sciences  Applied physics  Materials science        Latest Errata     Erratum: Multimodal stimulus coding by a gustatory sensory neuron in Drosophila larvae OPEN Lena van Giesen, Luis Hernandez-Nunez, Sophie Delasoie-Baranek, Martino Colombo, Philippe Renaud, Rémy Bruggmann, Richard Benton, Aravinthan D. T. Samuel and Simon G. Sprecher 14 March 2016 | doi: 10.1038/ncomms11028 Biological Sciences  Neuroscience      Erratum: RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection OPEN Agnieszka Jozwik, Maximillian S. Habibi, Allan Paras, Jie Zhu, Aleks Guvenel, Jaideep Dhariwal, Mark Almond, Ernie H. C. Wong, Annemarie Sykes, Matthew Maybeno, Jerico Del Rosario, Maria-Belen Trujillo-Torralbo, Patrick Mallia, John Sidney, Bjoern Peters, Onn Min Kon, Alessandro Sette, Sebastian L. Johnston, Peter J. Openshaw and Christopher Chiu et al. 09 March 2016 | doi: 10.1038/ncomms11011 Biological Sciences  Immunology  Virology      Erratum: Pure-quartic solitons OPEN Andrea Blanco-Redondo, C. Martijn de Sterke, J. E. Sipe, Thomas F. Krauss, Benjamin J. Eggleton and Chad Husko 09 March 2016 | doi: 10.1038/ncomms11048 Physical Sciences  Optical physics      Advertisement npj Science of Learning is a new online-only, open access, peer-reviewed journal dedicated to publishing high-quality research into the mechanisms that underpin learning in experimental conditions and educational environments. 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