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Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | |  | | | Latest Articles | View all Articles | | | Inducing amnesia through systemic suppression OPEN |  | Justin C. Hulbert, Richard N. Henson and Michael C. Anderson |  | Suppressing an unwanted memory reduces hippocampal activity and makes people more likely to forget the experience. Here, the authors show that suppressing past events induces an "amnesic shadow" for experiences near in time to suppression, consistent with a global disruption to hippocampal function. |  | 15 March 2016 | doi: 10.1038/ncomms11003 |  | Biological Sciences Neuroscience | 
Understanding congested travel in urban areas OPEN |  | Serdar Çolak, Antonio Lima and Marta C. González |  | Rapid urbanization burdens urban road infrastructures, but understanding the interplay of road infrastructure and travel patterns is a complex challenge. Here, authors use mobile phone traces during morning peak hours to evaluate the effect of a congestion relief approach under a centralized routing scheme. |  | 15 March 2016 | doi: 10.1038/ncomms10793 |  | Physical Sciences Theoretical physics | 


Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments OPEN |  | Hawa-Racine Thiam, Pablo Vargas, Nicolas Carpi, Carolina Lage Crespo, Matthew Raab, Emmanuel Terriac, Megan C. King, Jordan Jacobelli, Arthur S. Alberts, Theresia Stradal, Ana-Maria Lennon-Dumenil and Matthieu Piel |  | Cell migration through micrometric constraints is limited by low deformability of the nucleus. Here the authors show that in dendritic cells a perinuclear actin network nucleated by Arp2/3 increases nuclear deformation and allows the cells to pass through narrow constrictions, likely by rupturing the nuclear lamina. |  | 15 March 2016 | doi: 10.1038/ncomms10997 |  | Biological Sciences Cell biology | 


Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice OPEN |  | Isabelle Serr, Rainer W. Fürst, Peter Achenbach, Martin G. Scherm, Füsun Gökmen, Florian Haupt, Eva-Maria Sedlmeier, Annette Knopff, Leonard Shultz, Richard A. Willis, Anette-Gabriele Ziegler and Carolin Daniel |  | Type 1 diabetes is associated with the loss of self-tolerance to the insulin-producing β-cells in the pancreas. Here the authors show that vaccination with insulin mimetopes can induce human insulin-specific regulatory T cells to mediate tolerance in a humanized mouse model. |  | 15 March 2016 | doi: 10.1038/ncomms10991 |  | Biological Sciences Immunology Medical research | 
Nesting-driven multipolar order in CeB6 from photoemission tomography OPEN |  | A. Koitzsch, N. Heming, M. Knupfer, B. Büchner, P. Y. Portnichenko, A. V Dukhnenko, N. Y. Shitsevalova, V. B. Filipov, L. L. Lev, V. N. Strocov, J. Ollivier and D. S. Inosov |  | In compounds containing 4f and 5f elements, hidden-order phases exist which are undetectable by many methods, the origins of which are debated. Here, the authors use photoemission and neutron scattering methods to show how such a multipolar-ordered phase emerges due to Fermi surface instability in CeB6. |  | 15 March 2016 | doi: 10.1038/ncomms10876 |  | Physical Sciences Condensed matter | 
G6PD protects from oxidative damage and improves healthspan in mice OPEN |  | Sandrina Nóbrega-Pereira, Pablo J. Fernandez-Marcos, Thomas Brioche, Mari Carmen Gomez-Cabrera, Andrea Salvador-Pascual, Juana M. Flores, Jose Viña and Manuel Serrano |  | The enzyme G6PD generates the reductive metabolite NADPH, which has antioxidant effects, but has also been linked to tumour growth. Here the authors generate mice that modestly overexpress G6PD and report increased lifespan in females, and no negative effects on tumour formation in various genetic models. |  | 15 March 2016 | doi: 10.1038/ncomms10894 |  | Biological Sciences Cancer Medical research | 

IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis OPEN |  | Rossana G. Iannitti, Valerio Napolioni, Vasilis Oikonomou, Antonella De Luca, Claudia Galosi, Marilena Pariano, Cristina Massi-Benedetti, Monica Borghi, Matteo Puccetti, Vincenzina Lucidi, Carla Colombo, Ersilia Fiscarelli, Cornelia Lass-Flörl, Fabio Majo, Lisa Cariani, Maria Russo, Luigi Porcaro, Gabriella Ricciotti, Helmut Ellemunter, Luigi Ratclif et al. |  | IL-1-mediated inflammation contributes to the pathogenesis of cystic fibrosis. Here the authors show that this is largely due to NLRP3 activation, whereas NLRP4 induces IL-1Ra, limiting the overall inflammasome activity and providing a therapeutic angle to ameliorate the disease. |  | 14 March 2016 | doi: 10.1038/ncomms10791 |  | Biological Sciences Immunology Medical research | 
Nanosecond formation of diamond and lonsdaleite by shock compression of graphite OPEN |  | D. Kraus, A. Ravasio, M. Gauthier, D. O. Gericke, J. Vorberger, S. Frydrych, J. Helfrich, L. B. Fletcher, G. Schaumann, B. Nagler, B. Barbrel, B. Bachmann, E. J. Gamboa, S. Göde, E. Granados, G. Gregori, H. J. Lee, P. Neumayer, W. Schumaker, T. Döppner et al. |  | Shock synthesis of diamond and even harder carbon polymorphs from graphite is of great interest for science and technology. Here, the authors present unprecedented in situ measurements of the structural changes, showing ultrafast formation of diamond and, at higher pressures, evidence for a pure lonsdaleite structure. |  | 14 March 2016 | doi: 10.1038/ncomms10970 |  | Earth Sciences Geology and geophysics | 

Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium OPEN |  | Bethany A. Kerr, Xiaoxia Z. West, Young-Woong Kim, Yongzhong Zhao, Miroslava Tischenko, Rebecca M. Cull, Timothy W. Phares, Xiao-Ding Peng, Jeremiah Bernier-Latmani, Tatiana V. Petrova, Ralf H. Adams, Nissim Hay, Sathyamangla V. Naga Prasad and Tatiana V. Byzova |  | The Akt pathway integrates multiple signals, but whether it affects vasculature function is debatable. Here the authors show that Akt pathway shutdown in adult mouse endothelium causes destabilization of vasculature leading to cardiac and retinal dysfunction, due to decreased levels of Jagged1 and impaired Notch signaling. |  | 14 March 2016 | doi: 10.1038/ncomms10960 |  | Biological Sciences Cell biology Medical research | 

Superconductivity in Weyl semimetal candidate MoTe2 OPEN |  | Yanpeng Qi, Pavel G. Naumov, Mazhar N. Ali, Catherine R. Rajamathi, Walter Schnelle, Oleg Barkalov, Michael Hanfland, Shu-Chun Wu, Chandra Shekhar, Yan Sun, Vicky Süß, Marcus Schmidt, Ulrich Schwarz, Eckhard Pippel, Peter Werner, Reinald Hillebrand, Tobias Förster, Erik Kampert, Stuart Parkin, R. J. Cava et al. |  | Materials which simultaneously exhibit superconductivity and topologically non-trivial electronic band structure possess potential applications in quantum computing but have yet to be found. Here, the authors find superconductivity in MoTe2, a material predicted to be topologically non-trivial. |  | 14 March 2016 | doi: 10.1038/ncomms11038 |  | Physical Sciences Condensed matter | 
Coexistence of charge and ferromagnetic order in fcc Fe OPEN |  | Pin-Jui Hsu, Jens Kügel, Jeannette Kemmer, Francesco Parisen Toldin, Tobias Mauerer, Matthias Vogt, Fakher Assaad and Matthias Bode |  | The coexistence of different magnetic and electronic phases often occurs in materials with complex chemical compositions, allowing for the study of competitive, collaborative, or emergent phenomena. Here, the authors demonstrate such behaviour in ultrathin Fe films on a Rh(001) substrate. |  | 14 March 2016 | doi: 10.1038/ncomms10949 |  | Physical Sciences Condensed matter | 





Surface Landau levels and spin states in bismuth (111) ultrathin films OPEN |  | Hongjian Du, Xia Sun, Xiaogang Liu, Xiaojun Wu, Jufeng Wang, Mingyang Tian, Aidi Zhao, Yi Luo, Jinlong Yang, Bing Wang and J. G. Hou |  | The electronic surface states of bismuth present promise for applications exploiting spin and valley degrees of freedom however their study is inhibited by bulk states. Here, the authors directly access the surface-state Landau levels of ultrathin bismuth films under a perpendicular magnetic field. |  | 11 March 2016 | doi: 10.1038/ncomms10814 |  | Physical Sciences Condensed matter | 
Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis OPEN |  | Christoph Weigel, Marlon R. Veldwijk, Christopher C. Oakes, Petra Seibold, Alla Slynko, David B. Liesenfeld, Mariona Rabionet, Sabrina A. Hanke, Frederik Wenz, Elena Sperk, Axel Benner, Christoph Rösli, Roger Sandhoff, Yassen Assenov, Christoph Plass, Carsten Herskind, Jenny Chang-Claude, Peter Schmezer and Odilia Popanda |  | Radiotherapy can induce fibrosis in cancer patients, limiting its use in clinical settings. Here, the authors identify a differentially methylated enhancer of the lipid kinase DGKA in fibroblasts from breast cancer patients developing fibrosis after radiotherapy and they show that DGKA inhibition affects lipid homeostasis and reduces pro-fibrotic fibroblast activation. |  | 11 March 2016 | doi: 10.1038/ncomms10893 |  | Biological Sciences Cancer Cell biology Medical research | 
CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL OPEN |  | Paulina Bartuzi, Daniel D. Billadeau, Robert Favier, Shunxing Rong, Daphne Dekker, Alina Fedoseienko, Hille Fieten, Melinde Wijers, Johannes H. Levels, Nicolette Huijkman, Niels Kloosterhuis, Henk van der Molen, Gemma Brufau, Albert K. Groen, Alison M. Elliott, Jan Albert Kuivenhoven, Barbara Plecko, Gernot Grangl, Julie McGaughran, Jay D. Horton et al. |  | Low density lipoprotein receptor (LDLR) is crucial for cholesterol homeostasis. Here, the authors show that components of the CCC-protein complex, CCDC22 and COMMD1, facilitate the endosomal sorting of LDLR and that mutations in these genes cause hypercholesterolemia in dogs and mice, providing new insights into regulation of cholesterol homeostasis. |  | 11 March 2016 | doi: 10.1038/ncomms10961 |  | Biological Sciences Cell biology Genetics Medical research | 
Thermal selectivity of intermolecular versus intramolecular reactions on surfaces OPEN |  | Borja Cirera, Nelson Giménez-Agulló, Jonas Björk, Francisco Martínez-Peña, Alberto Martin-Jimenez, Jonathan Rodriguez-Fernandez, Ana M. Pizarro, Roberto Otero, José M. Gallego, Pablo Ballester, José R. Galan-Mascaros and David Ecija |  | Surface-mediated synthesis of low-dimensional polymers is a promising approach to design materials for targeted applications. Here, the authors introduce surface-confined thermally tunable pathways to select intra- or intermolecular reactions yielding monomeric or lowdimensional polymeric phthalocyanines. |  | 11 March 2016 | doi: 10.1038/ncomms11002 |  | Chemical Sciences Nanotechnology Physical chemistry | 
The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model OPEN |  | Kiyohito Murai, Guoqiang Sun, Peng Ye, E. Tian, Su Yang, Qi Cui, Guihua Sun, Daniel Trinh, Olivia Sun, Teresa Hong, Zhexing Wen, Markus Kalkum, Arthur D. Riggs, Hongjun Song, Guo-li Ming and Yanhong Shi |  | Dysregulation of microRNAs has been implicated in neurodevelopmental disorders, including schizophrenia. Here the authors show that the TLX-miR-219 cascade regulates the proliferation of neural stem cells during normal development, and this pathway is dysregulated in a schizophrenia iPSC model. |  | 11 March 2016 | doi: 10.1038/ncomms10965 |  | Biological Sciences Cell biology Neuroscience | 
IL-17-producing γδ T cells enhance bone regeneration OPEN |  | Takehito Ono, Kazuo Okamoto, Tomoki Nakashima, Takeshi Nitta, Shohei Hori, Yoichiro Iwakura and Hiroshi Takayanagi |  | γδ T cells are innate-like lymphocytes that regulate immune responses by producing IL-17A or IFN-γ, but have no known role in bone healing. Here the authors show a nonimmune bone-regenerative function of IL-17A produced by the Vγ6+ subset in mice. |  | 11 March 2016 | doi: 10.1038/ncomms10928 |  | Biological Sciences Immunology Medical research | 

Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis OPEN |  | Moritz Leppkes, Christian Maueröder, Sebastian Hirth, Stefanie Nowecki, Claudia Günther, Ulrike Billmeier, Susanne Paulus, Mona Biermann, Luis E. Munoz, Markus Hoffmann, Dane Wildner, Andrew L. Croxford, Ari Waisman, Kerri Mowen, Dieter E. Jenne, Veit Krenn, Julia Mayerle, Markus M. Lerch, Georg Schett, Stefan Wirtz et al. |  | Pancreatitis often develops as a consequence of ductal obstruction. Here, the authors show that bicarbonate ions initiate the release of neutrophil extracellular traps (NETs) that form pancreatic ductal aggregates and occlude the ducts, thereby driving pancreatitis in mice and humans. |  | 11 March 2016 | doi: 10.1038/ncomms10973 |  | Biological Sciences Medical research | 

αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells OPEN |  | Mridu Acharya, Anna Sokolovska, Jenny M. Tam, Kara L. Conway, Caroline Stefani, Fiona Raso, Subhankar Mukhopadhyay, Marianela Feliu, Elahna Paul, John Savill, Richard O. Hynes, Ramnik J. Xavier, Jatin M. Vyas, Lynda M. Stuart and Adam Lacy-Hulbert |  | Integrins can regulate antigen-specific and innate immune receptor signalling, thereby affecting immune cell function. Here the authors show that avß3 integrin controls Toll-like receptor (TLR) signalling by regulating its trafficking to limit TLR-mediated B-cell proliferation and antibody production. |  | 11 March 2016 | doi: 10.1038/ncomms10917 |  | Biological Sciences Immunology | 
Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA OPEN |  | David Albesa-Jové, Zuzana Svetlíková, Montse Tersa, Enea Sancho-Vaello, Ana Carreras-González, Pascal Bonnet, Pedro Arrasate, Ander Eguskiza, Shiva K. Angala, Javier O. Cifuente, Jana Korduláková, Mary Jackson, Katarína Mikušová and Marcelo E. Guerin |  | PatA is a membrane-associated acyltransferase that is essential for the biosynthesis of mycobacterial glycolipids. Here, Albesa-Jové et al. describe structures of PatA from Mycobacterium smegmatis in complex with acyl donors and show that catalysis occurs by an unusual charge-relay mechanism. |  | 11 March 2016 | doi: 10.1038/ncomms10906 |  | Biological Sciences Biochemistry Microbiology | 


The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles OPEN |  | Mariam H. Orme, Gianmaria Liccardi, Nina Moderau, Rebecca Feltham, Sidonie Wicky-John, Tencho Tenev, Lior Aram, Rebecca Wilson, Katiuscia Bianchi, Otto Morris, Celia Monteiro Domingues, David Robertson, Meghana Tare, Alexander Wepf, David Williams, Andreas Bergmann, Matthias Gstaiger, Eli Arama, Paulo S. Ribeiro and Pascal Meier et al. |  | In addition to their role in apoptosis, caspases are also involved in mediating non-apoptotic events. Here the authors show that the Drosophila myosin family member CRINKLED and its mammalian counterpart act as substrate adaptor that facilitate caspase-mediated cleavage and localised kinase activity. |  | 10 March 2016 | doi: 10.1038/ncomms10972 |  | Biological Sciences Biochemistry Cell biology | 
Damage-free vibrational spectroscopy of biological materials in the electron microscope OPEN |  | Peter Rez, Toshihiro Aoki, Katia March, Dvir Gur, Ondrej L. Krivanek, Niklas Dellby, Tracy C. Lovejoy, Sharon G. Wolf and Hagai Cohen |  | Use of electron microscopy to determine morphology, or find where functionally significant biomolecules are located with high spatial resolution is of great interest. Here, Rez, Cohen et al. use aloof electron beam vibrational spectroscopy to probe different bonds in biological samples with no significant radiation damage. |  | 10 March 2016 | doi: 10.1038/ncomms10945 |  | Physical Sciences Optical physics | 
Acoustic trapping of active matter OPEN |  | Sho C. Takatori, Raf De Dier, Jan Vermant and John F. Brady |  | Active matter, such as swimming bacteria, show unique behaviors under confinement, but it is experimentally challenging to measure them. Takatori et al. show the use of acoustic tweezers to trap self-propelled Janus particles as an enabling tool to investigate collective motions in living systems. |  | 10 March 2016 | doi: 10.1038/ncomms10694 |  | Physical Sciences Applied physics Biophysics | 
Spatial control of chemical processes on nanostructures through nano-localized water heating OPEN |  | Calum Jack, Affar S. Karimullah, Ryan Tullius, Larousse Khosravi Khorashad, Marion Rodier, Brian Fitzpatrick, Laurence D. Barron, Nikolaj Gadegaard, Adrian J. Lapthorn, Vincent M. Rotello, Graeme Cooke, Alexander O. Govorov and Malcolm Kadodwala |  | It is generally believed that rapid dissipation means that spatially precise heating is not feasible via thermoplasmonic means. Here, the authors induce highly localized heating around plasmonic nanostructures by pulsed laser irradiation, which effects chemical modification of surface bound molecules. |  | 10 March 2016 | doi: 10.1038/ncomms10946 |  | Physical Sciences Materials science Nanotechnology Optical physics | 

Constructing 3D interaction maps from 1D epigenomes OPEN |  | Yun Zhu, Zhao Chen, Kai Zhang, Mengchi Wang, David Medovoy, John W. Whitaker, Bo Ding, Nan Li, Lina Zheng and Wei Wang |  | The human genome is highly organized, with one-dimensional chromatin states packaged into higher level three-dimensional architecture. Here, the authors present EpiTensor that can identify 3D spatial associations from 1D epigenetic information. |  | 10 March 2016 | doi: 10.1038/ncomms10812 |  | Biological Sciences Bioinformatics Molecular biology | 

Screen-printed flexible MRI receive coils OPEN |  | Joseph R. Corea, Anita M. Flynn, Balthazar Lechêne, Greig Scott, Galen D. Reed, Peter J. Shin, Michael Lustig and Ana C. Arias |  | Signal-to-noise ratio is one of the key factors that currently limit the diagnostic image quality and patient conditions of magnetic resonance imaging. Here, Corea et al. use fully printed flexible receive coils, conforming to patient bodies, to improve signals and patient comfort in clinical scanners. |  | 10 March 2016 | doi: 10.1038/ncomms10839 |  | Physical Sciences Applied physics Bioengineering Medical research | 
Stable topological insulators achieved using high energy electron beams OPEN |  | Lukas Zhao, Marcin Konczykowski, Haiming Deng, Inna Korzhovska, Milan Begliarbekov, Zhiyi Chen, Evangelos Papalazarou, Marino Marsi, Luca Perfetti, Andrzej Hruban, Agnieszka Wołoś and Lia Krusin-Elbaum |  | Defects in solids may introduce additional charges that influence the overall charge transport behaviour. Here, Zhao et al. use swift electron beams to compensate charge defects, which effectively tune Bi2Te3 and Bi2Se3 from p-type to n-type while preserving their topological properties. |  | 10 March 2016 | doi: 10.1038/ncomms10957 |  | Physical Sciences Condensed matter Materials science | 
Three mechanisms control E-cadherin localization to the zonula adherens OPEN |  | Innokenty Woichansky, Carlo Antonio Beretta, Nicola Berns and Veit Riechmann |  | E-cadherin is an adhesion molecule mediating cell-cell adhesion; correct localization is important but how localization is controlled is not clear. Here the authors use Drosophila as a model system to distinguish three distinct trafficking pathways that direct E-cadherin to the zonula adherens. |  | 10 March 2016 | doi: 10.1038/ncomms10834 |  | Biological Sciences Cell biology | 
G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression OPEN |  | Xi Zhang, Danni Peng, Yuanxin Xi, Chao Yuan, Cari A. Sagum, Brianna J. Klein, Kaori Tanaka, Hong Wen, Tatiana G. Kutateladze, Wei Li, Mark T. Bedford and Xiaobing Shi |  | The histone methyltransferase G9a methylates histone H3K9 to repress gene expression, but it also acts as a coactivator for some nuclear receptors. Here, Zhang et al. show that methylation of ERα by G9a recruits the PHF20/MOF complex that deposits histone H4K16 acetylation promoting active transcription. |  | 10 March 2016 | doi: 10.1038/ncomms10810 |  | Biological Sciences Cell biology Molecular biology | 
Macroscopic self-reorientation of interacting two-dimensional crystals OPEN |  | C. R. Woods, F. Withers, M. J. Zhu, Y. Cao, G. Yu, A. Kozikov, M. Ben Shalom, S. V. Morozov, M. M. van Wijk, A. Fasolino, M. I. Katsnelson, K. Watanabe, T. Taniguchi, A. K. Geim, A. Mishchenko and K. S. Novoselov |  | Precise control of the relative orientation of two two-dimensional layers enables reproducible fabrication of heterostructure devices. Here, the authors show that graphene rotates towards the crystallographic direction of a boron-nitride substrate due to the interplay between van der Waals and elastic energies. |  | 10 March 2016 | doi: 10.1038/ncomms10800 |  | Physical Sciences Materials science Nanotechnology | 
A metallic mosaic phase and the origin of Mott-insulating state in 1T-TaS2 OPEN |  | Liguo Ma, Cun Ye, Yijun Yu, Xiu Fang Lu, Xiaohai Niu, Sejoong Kim, Donglai Feng, David Tománek, Young-Woo Son, Xian Hui Chen and Yuanbo Zhang |  | In correlated materials, new phases emerge when the balance between many-body interactions is perturbed. Here, Ma et al. induce a mosaic charge-density-wave phase out of Mott insulating state in layered 1T-TaS2 by voltage pulses, which reveals a dominating role of interlayer stacking order. |  | 10 March 2016 | doi: 10.1038/ncomms10956 |  | Physical Sciences Condensed matter Materials science Nanotechnology | 


Spacer-free BODIPY fluorogens in antimicrobial peptides for direct imaging of fungal infection in human tissue OPEN |  | Lorena Mendive-Tapia, Can Zhao, Ahsan R. Akram, Sara Preciado, Fernando Albericio, Martin Lee, Alan Serrels, Nicola Kielland, Nick D Read, Rodolfo Lavilla and Marc Vendrell |  | Functionalizing antimicrobial peptides with fluorescent groups is a useful strategy for imaging infection, but the tag can alter the performance of the probe. Here, the authors report a spacer-free method to directly functionalise an amino acid with a fluorogenic group and prepare peptide-based imaging agents for fungal infection. |  | 09 March 2016 | doi: 10.1038/ncomms10940 |  | Chemical Sciences Chemical biology Microbiology Organic chemistry | 
Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank OPEN |  | Jacqueline M. Lane, Irma Vlasac, Simon G. Anderson, Simon D. Kyle, William G. Dixon, David A. Bechtold, Shubhroz Gill, Max A. Little, Annemarie Luik, Andrew Loudon, Richard Emsley, Frank A. J. L. Scheer, Deborah A. Lawlor, Susan Redline, David W. Ray, Martin K. Rutter and Richa Saxena |  | Here, Richa Saxena and colleagues perform a genome-wide association study (GWAS) of self-reported morningness/eveningness preference in the UKBiobank cohort, and identify new genetic loci that contribute to a person's chronotype. |  | 09 March 2016 | doi: 10.1038/ncomms10889 |  | Biological Sciences Genetics | 

Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia OPEN |  | Sonja I. Berndt, Nicola J. Camp, Christine F. Skibola, Joseph Vijai, Zhaoming Wang, Jian Gu, Alexandra Nieters, Rachel S. Kelly, Karin E. Smedby, Alain Monnereau, Wendy Cozen, Angela Cox, Sophia S. Wang, Qing Lan, Lauren R. Teras, Moara Machado, Meredith Yeager, Angela R. Brooks-Wilson, Patricia Hartge, Mark P. Purdue et al. |  | Chronic lymphocytic leukemia is a highly inheritable cancer. Here the authors conduct a metaanalysis of four genome-wide association studies and identify three novel loci located near EOMES, SERPINB6 and LPP associated with risk of this disease. |  | 09 March 2016 | doi: 10.1038/ncomms10933 |  | Biological Sciences Cancer Genetics | 
MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration OPEN |  | Anil Noronha Antony, Melanie Paillard, Cynthia Moffat, Egle Juskeviciute, Jason Correnti, Brad Bolon, Emanuel Rubin, György Csordás, Erin L. Seifert, Jan B. Hoek and György Hajnóczky |  | Mitochondrial calcium uptake is a highly regulated process, and calcium overload can lead to cell death. Here, using knockout mouse model, the authors show that the mitochondrial calcium uniporter (MCU) regulator MICU1 is needed to prevent calcium overload and promotes survival under liver regeneration and postnatal adaptation-associated stress. |  | 09 March 2016 | doi: 10.1038/ncomms10955 |  | Biological Sciences Cell biology | 
Bcl-2 is a critical mediator of intestinal transformation OPEN |  | Maartje van der Heijden, Cheryl D. Zimberlin, Anna M. Nicholson, Selcuk Colak, Richard Kemp, Sybren L. Meijer, Jan Paul Medema, Florian R. Greten, Marnix Jansen, Douglas J. Winton and Louis Vermeulen |  | The anti-apoptotic protein Bcl-2 is selectively expressed in intestinal stem cells (ISCs). Here, the authors show that, in intestinal stem cells, Bcl-2 alleviates apoptotic priming induced by the loss of the tumour suppressor Apc in ISCs and that the absence of Bcl-2 or pharmacological blockade of Bcl-2 can inhibit the intestinal tumorigenesis driven by the Apc-loss. |  | 09 March 2016 | doi: 10.1038/ncomms10916 |  | Biological Sciences Cancer Cell biology | 

The Gq signalling pathway inhibits brown and beige adipose tissue OPEN |  | Katarina Klepac, Ana Kilić, Thorsten Gnad, Loren M. Brown, Beate Herrmann, Andrea Wilderman, Aileen Balkow, Anja Glöde, Katharina Simon, Martin E. Lidell, Matthias J. Betz, Sven Enerbäck, Jürgen Wess, Marc Freichel, Matthias Blüher, Gabi König, Evi Kostenis, Paul A. Insel and Alexander Pfeifer |  | Brown and beige adipose tissues contribute to organismal energy expenditure by generating heat. Here, Klepac et al. survey G protein-coupled receptors in brown fat and show that Gq-coupled receptors inhibit expression of thermogenic proteins in mice and in human adipocytes. |  | 09 March 2016 | doi: 10.1038/ncomms10895 |  | Biological Sciences Medical research | 
Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation OPEN |  | Chuntao Zhao, Yaqi Deng, Lei Liu, Kun Yu, Liguo Zhang, Haibo Wang, Xuelian He, Jincheng Wang, Changqing Lu, Laiman N Wu, Qinjie Weng, Meng Mao, Jianrong Li, Johan H van Es, Mei Xin, Lee Parry, Steven A Goldman, Hans Clevers and Q. Richard Lu |  | Wnt/β-catenin signaling regulates oligodendrocyte (OL) development. Here the authors show that Tcf7l2, a β-catenin transcriptional partner,sequentially interacts with stage-specific partners to coordinate the transitions of differentiation initiation and maturation during OL development. |  | 09 March 2016 | doi: 10.1038/ncomms10883 |  | Biological Sciences Cell biology Neuroscience | 
Disorder-mediated crowd control in an active matter system OPEN |  | Erçağ Pinçe, Sabareesh K. P. Velu, Agnese Callegari, Parviz Elahi, Sylvain Gigan, Giovanni Volpe and Giorgio Volpe |  | Many living systems, such as bacterial colonies, exhibit collective and dynamic behaviours that are sensitive to the change in environmental conditions. Here, the authors show that a colloidal active matter system switches between gathering and dispersal of individuals in response to a disordered potential. |  | 09 March 2016 | doi: 10.1038/ncomms10907 |  | Physical Sciences Fluids and plasma physics Materials science | 
| | | | |  | | | Latest Corrigendum | | | | Corrigendum: Elucidating the role of disorder and free-carrier recombination kinetics in CH3NH3PbI3 perovskite films OPEN |  | Chan La-o-vorakiat, Teddy Salim, Jeannette Kadro, Mai-Thu Khuc, Reinhard Haselsberger, Liang Cheng, Huanxin Xia, Gagik G. Gurzadyan, Haibin Su, Yeng Ming Lam, Rudolph A. Marcus, Maria-Elisabeth Michel-Beyerle and Elbert E. M. Chia |  | 10 March 2016 | doi: 10.1038/ncomms11054 |  | Physical Sciences Applied physics Materials science | | |  | | | Latest Errata | | | | 
 | | | Erratum: RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection OPEN |  | Agnieszka Jozwik, Maximillian S. Habibi, Allan Paras, Jie Zhu, Aleks Guvenel, Jaideep Dhariwal, Mark Almond, Ernie H. C. Wong, Annemarie Sykes, Matthew Maybeno, Jerico Del Rosario, Maria-Belen Trujillo-Torralbo, Patrick Mallia, John Sidney, Bjoern Peters, Onn Min Kon, Alessandro Sette, Sebastian L. Johnston, Peter J. Openshaw and Christopher Chiu et al. |  | 09 March 2016 | doi: 10.1038/ncomms11011 |  | Biological Sciences Immunology Virology | 
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