Nature Reviews Neuroscience contents November 2015 Volume 16 Number 11 pp 643-700

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TABLE OF CONTENTS
November 2015 Volume 16 Number 11		Advertisement
Impact Factor 31.427 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Genomic integrity and the ageing brain Hei-man Chow & Karl Herrup	Could your research provide a new therapy for dementia? Next deadline 17th November The Dementia Consortium unites academia, charities and industry by investing in collaborative drug discovery projects. We are looking for novel molecular targets in any neurodegenerative disease. We provide full funding, drug discovery resources and expertise.  Click here for more
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RESEARCH HIGHLIGHTS Top Interneurons: Neuronal tuning p643 | doi:10.1038/nrn4051 Neural activity may dynamically tune the properties of a group of fast-spiking interneurons in the adult mouse cortex through a transcription-mediated mechanism. PDF Neural development: Migration matters p644 | doi:10.1038/nrn4041 The cortical distribution of Cajal–Retzius cells is regulated by the vesicular trafficking protein VAMP3 and contributes to the specification of higher-order cortical areas. PDF Autonomic nervous system: Zapping fat in WAT p644 | doi:10.1038/nrn4050 Leptin promotes the activity of sympathetic neurons that directly innervate WAT and regulate local lipolysis. PDF Neuronal circuits: Looking after your own p645 | doi:10.1038/nrn4040 Parental care of offspring involves a complex array of innate behaviours and is influenced by a dopaminergic circuit within the hypothalamus that regulates circulating oxytocin levels. PDF Repair: Mobilizing stem cells p646 | doi:10.1038/nrn4052 Inhibition of GLI1 promotes the endogenous response to demyelination, including the recruitment and differentiation of neural stem cells. PDF IN BRIEF Neurodegenerative disorders: Tackling TAUxicity | Neuropharmacology: Old and young | Computational neuroscience: Mind over matter | Learning and memory: Neurotrophic memory PDF Neuroscience JOBS of the week PhD Student (F / M) in Neuroscience German Center for Neurodegenerative Deseases Assistant / Associate Professors in Neuroscience Virginia Tech (VT) Institute Assoc Scientist IV – Target Biology – Neuroscience The University of Texas MD Anderson Cancer Center More Science jobs from Neuroscience EVENT Microglia in the Brain 12.06.2016 Keystone, USA More science events from
REVIEWS		Top
Proliferation control in neural stem and progenitor cells Catarina C. F. Homem, Marko Repic & Jürgen A. Knoblich p647 | doi:10.1038/nrn4021 The brain is particularly sensitive to changes in cell number, which can acutely affect neural function. Here, Knoblich and colleagues describe the proliferation control mechanisms that exist in Drosophila melanogaster and mammals, and their regulation by developmental age and by metabolic and nutritional status. Abstract | Full Text | PDF
Hippocampal insulin resistance and cognitive dysfunction Geert Jan Biessels & Lawrence P. Reagan p660 | doi:10.1038/nrn4019 Type 2 diabetes mellitus is associated with an increased risk of cognitive dysfunction and Alzheimer disease. In this Review, Biessels and Reagan discuss findings from human studies and animal models which suggest that hippocampal insulin resistance is one of the mechanisms underlying the links between these disorders. Abstract | Full Text | PDF
Genomic integrity and the ageing brain Hei-man Chow & Karl Herrup p672 | doi:10.1038/nrn4020 Ageing leads to the gradual loss of brain function and is a key risk factor for most late-onset neurological disease. In this Review, Chow and Herrup explore how the loss of DNA integrity drives brain ageing and contributes to the pathogenesis of many seemingly unrelated conditions. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION The new nanophysiology: regulation of ionic flow in neuronal subcompartments David Holcman & Rafael Yuste p685 | doi:10.1038/nrn4022 Classical theories, such as cable theory, can only successfully model signal propagation in neurons on a macroscopic scale. Holcman and Yuste argue that, as the functional importance of neuronal compartments such as dendritic spines becomes apparent, it is important to develop models that can account for the effects of their size and geometry on electrical current flow. Abstract | Full Text | PDF
OPINION The neural bases of emotion regulation Amit Etkin, Christian Büchel & James J. Gross p693 | doi:10.1038/nrn4044 Various brain regions have been implicated in emotion regulation, although this process remains poorly understood. In this Opinion article, Etkin and colleagues bring together neuroimaging findings and ideas from value-based decision-making and reinforcement learning to propose a conceptual framework for emotion regulation. Abstract | Full Text | PDF
Erratum: Tinnitus: perspectives from human neuroimaging Ana Bélen Elgoyhen, Berthold Langguth, Dirk De Ridder & Sven Vanneste p700 | doi:10.1038/nrn4039 Full Text | PDF
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*2014 Journal Citation Report (Thomson Reuters, 2015)

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