Nature Reviews Genetics Contents November 2015 Volume 16 Number 11 pp 623-681

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TABLE OF CONTENTS
November 2015 Volume 16 Number 11
Impact Factor 36.978 *	In this issue Research Highlights Reviews Also this month Article series: Applications of next-generation sequencing Modes of transcriptional regulation  Featured article: Genetic variation and the de novo assembly of human genomes Mark J. P. Chaisson, Richard K. Wilson & Evan E. Eichler
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Celebrating 15 years of high-quality Reviews October 2015 marks the 15th anniversary of the launch of Nature Reviews Genetics, Nature Reviews Neuroscience, and Nature Reviews Molecular Cell Biology. See what each journal is publishing in 2015. Visit the current issues to see what each journal is publishing in 2015. Nature Reviews Genetics, Nature Reviews Neuroscience and Nature Reviews Molecular Cell Biology.
RESEARCH HIGHLIGHTS Top Human genetics: Strength in numbers in the low-frequency spectrum p623 | doi:10.1038/nrg4024 PDF Gene expression: Environmental noise control p624 | doi:10.1038/nrg4021 PDF Epigenetics: Bad Karma reduces palm oil yields p624 | doi:10.1038/nrg4022 PDF Evolution: Regulatory evolution of human craniofacial morphology p625 | doi:10.1038/nrg4026 PDF Microbial genetics: Phages' box of tricks for CRISPR p626 | doi:10.1038/nrg4030 PDF IN BRIEF Viral evolution: Hypermutation of HIV-1 in vivo | Genomics: Identification of sORFs | Microbial genetics: Single-locus changes perturb community structure PDF Genetics JOBS of the week Postdoctoral Positions - Developing Artificial Nucleases Influencing Genome Architecture University of Massachusetts Post-Doctoral Fellow in Genome Editing for Retinal Diseases Mass Eye and Ear and Harvard Medical School Postdoctoral Scientist for Computational Genomics and Epigenomics Helmholtz Association Assistant Professor, Evolutionary Genomics Princeton University Faculty Position in Genomics Wake Forest University More Science jobs from Genetics EVENT Plant Genetics and Breeding Technologies II 01.02.16 Vienna, Austria More science events from
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REVIEWS		Top
Article series: Applications of next-generation sequencing Genetic variation and the de novo assembly of human genomes Mark J. P. Chaisson, Richard K. Wilson & Evan E. Eichler p627 | doi:10.1038/nrg3933 The wealth of existing and emerging DNA-sequencing data provides an opportunity for a comprehensive understanding of human genetic variation, including the discovery of disease-causing variants. This Review describes how the limitations of current reference-genome assemblies confound the characterization of genetic variation and how this can be mitigated by important advances in algorithms and sequencing technology that facilitate the de novo assembly of genomes. Abstract | Full Text | PDF
Molecular insights into transgenerational non-genetic inheritance of acquired behaviours Johannes Bohacek & Isabelle M. Mansuy p641 | doi:10.1038/nrg3964 In this Review, the authors discuss the concept, and possible mechanisms, of non-genetic transgenerational inheritance. They outline the evidence to date that environmental factors can influence behaviour across generations in mammals through the modification of epigenetic marks and/or non-coding RNAs. Abstract | Full Text | PDF
Article series: Modes of transcriptional regulation Random monoallelic expression of autosomal genes: stochastic transcription and allele-level regulation Björn Reinius & Rickard Sandberg p653 | doi:10.1038/nrg3888 In diploid organisms, expression from only one allele is frequently observed. This Review focuses on the widespread random monoallelic expression (RME) of autosomal genes, highlighting both the mitotically stable form observed in bulk analyses of cell populations and the recently discovered dynamic form identified through single-cell studies. The article also addresses the implications of different experimental criteria for calling monoallelic expression and potential biological roles in disease manifestations. Abstract | Full Text | PDF
Article series: Modes of transcriptional regulation Exploring the emerging complexity in transcriptional regulation of energy homeostasis Adelheid Lempradl, J. Andrew Pospisilik & Josef M. Penninger p665 | doi:10.1038/nrg3941 The recent rise in obesity and its associated diseases has sparked intensive research into the transcriptional control of metabolic processes, collectively termed energy homeostasis. The authors review our current understanding of transcriptional and epigenetic regulators of energy homeostasis and crosstalk between pathways, and provide insights into emerging developments and challenges in this field. Abstract | Full Text | PDF
Corrigendum: Integrating circadian dynamics with physiological processes in plants Kathleen Greenham & C. Robertson McClung p681 | doi:10.1038/nrg4031 Full Text | PDF
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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