EMBO reports Table of Contents for October 2015; Vol. 16, No. 10

October 2015 | Volume 16, Number 10 Submit Table of Contents Correspondence Opinion Science & Society Reviews Scientific Reports Articles Volume 16, Number 10 Correspondence Beclin 1 is dispensable for chromosome congression and proper outer kinetochore assembly This is a correspondence about “Beclin‐1 is required for chromosome congression and proper outer kinetochore assembly”. Luca L Fava, Johannes Rainer, Manuel D Haschka, Stephan Geley, and Andreas Villunger Published online 20.08.2015 Response to Luca L Fava and colleagues The original authors' response. Stéphane Frémont, Annabelle Gérard, Marie Galloux, Katy Janvier, Roger E Karess, and Clarisse Berlioz‐Torrent Published online 20.08.2015 Opinion A holo'ome approach in colon cancer: we change as we age Pinpointing multi‐faceted, longitudinally‐changing factors that drive colorectal cancer is laborious and expensive, but doing so is necessary for more accurate CRC prognosis and therapy. Yiorgos Apidianakis and Aristides G Eliopoulos Published online 09.09.2015 Science & Society The sociality of bioremediation: Hijacking the social lives of microbial populations to clean up heavy metal contamination Bioremediation to remove toxic heavy metals from the environment relies on metal‐tolerant plants or microbes to do the job, but with varying degrees of success. Understanding the ecology and evolution of metal‐resistant bacterial societies could drastically improve the efficiency of microbial bioremediation. Siobhan O'Brien and Angus Buckling Published online 16.09.2015 Next generation partnerships in translational science and medicine: Partnerships between academics, big pharma, biotech firms, philanthropists and patients look set to change the way science advances Academic biomedical research and clinical studies are increasingly funded by and conducted in collaboration with partners from industry, patient organizations, charities, and philanthropists. These new partnerships are a much‐needed source of funds and expertise to advance translational medical research. Hans‐Gustaf Ljunggren and Kenneth R Chien Published online 10.09.2015 Could Big Data be the end of theory in science?: A few remarks on the epistemology of data‐driven science The era of Big Data is claimed to herald the end of hypothesis‐driven research in favour of sophisticated algorithms uncovering information from huge data sets. But a closer look reveals that Big Data actually enhances the testing of hypothesis and experimentation, rather than replaces them. Fulvio Mazzocchi Published online 10.09.2015 Phoning in sick—telehealth in the iPhone age: As mobile devices become ubiquitous, can health care finally be delivered effectively over the Internet? A convergence of communications and IT technology, rising costs for health care and the growing market for personal fitness and well‐being are driving projects to implement telehealth care on increasingly large scales. Philip Hunter Published online 10.09.2015 Reviews Plasticity of gene‐regulatory networks controlling sex determination: of masters, slaves, usual suspects, newcomers, and usurpators This review assesses recent insight into the molecular mechanisms and plasticity of sex determination and their evolution across a wide range of species. Amaury Herpin and Manfred Schartl Published online 09.09.2015 New frontiers: discovering cilia‐independent functions of cilia proteins Various cilia proteins are crucial for other cellular processes, such as regulation of the cell cycle, polarized membrane trafficking and the DNA damage response. Thus, so called “ciliopathies” may be caused not only—or not at all—by faulty cilia. Anastassiia Vertii, Alison Bright, Benedicte Delaval, Heidi Hehnly, and Stephen Doxsey Published online 09.09.2015 Scientific Reports UTX inhibits EMT‐induced breast CSC properties by epigenetic repression of EMT genes in cooperation with LSD1 and HDAC1 UTX, a histone H3K27 demethylase, epigenetically silences EMT genes by facilitating LSD1‐dependent H3K4 demethylation and HDAC‐dependent histone deacetylation to inhibit EMT‐induced breast CSC properties. Hee‐Joo Choi, Ji‐Hye Park, Mikyung Park, Hee‐Young Won, Hyeong‐seok Joo, Chang Hoon Lee, Jeong‐Yeon Lee, and Gu Kong Published online 24.08.2015 Glucagon signalling in the dorsal vagal complex is sufficient and necessary for high‐protein feeding to regulate glucose homeostasis in vivo This study introduces a physiological role for brain glucagon action in regulating postprandial glucose homeostasis. Glucagon acts in the DVC to suppress glucose production and to mediate the lowering of plasma glucose after high‐protein feeding. Mary P LaPierre, Mona A Abraham, Jessica TY Yue, Beatrice M Filippi, and Tony KT Lam Published online 19.08.2015 Evolutionary conservation of complexins: from choanoflagellates to mice Complexins play roles in regulated exocytosis in mice, Drosophila, and C. elegans. It is shown here that complexins are not only conserved in all metazoans but are also present in some unicellular organisms. Complexin from the cnidarian Nematostella vectensis can functionally rescue the impairment in neurotransmitter release in mouse neurons that is induced by loss of complexins. Xiaofei Yang, Jimin Pei, Yea Jin Kaeser‐Woo, Taulant Bacaj, Nick V Grishin, and Thomas C Südhof Published online 03.09.2015 Articles Structure and function of the N‐terminal domain of the human mitochondrial calcium uniporter This study reports the crystal structures of the N‐terminal domain (NTD) of wild‐type and a S92A mutant form of MCU. Functional analyses suggest that the N‐terminal domain of MCU is essential for the modulation of MCU activity. Youngjin Lee, Choon Kee Min, Tae Gyun Kim, Hong Ki Song, Yunki Lim, Dongwook Kim, Kahee Shin, Moonkyung Kang, Jung Youn Kang, Hyung‐Seop Youn, Jung‐Gyu Lee, Jun Yop An, Kyoung Ryoung Park, Jia Jia Lim, Ji Hun Kim, Ji Hye Kim, Zee Yong Park, Yeon‐Soo Kim, Jimin Wang, Do Han Kim, and Soo Hyun Eom Published online 03.09.2015 Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network An unbiased integrative genomics approach identified proteins associated with the E3 ubiquitin ligase MKRN1 and its associated mRNAs in ESCs, indicating that MKRN1 is a RNA‐binding protein involved in the modulation of cellular stress and apoptosis. Paul A Cassar, Richard L Carpenedo, Payman Samavarchi‐Tehrani, Jonathan B Olsen, Chang Jun Park, Wing Y Chang, Zhaoyi Chen, Chandarong Choey, Sean Delaney, Huishan Guo, Hongbo Guo, R Matthew Tanner, Theodore J Perkins, Scott A Tenenbaum, Andrew Emili, Jeffrey L Wrana, Derrick Gibbings, and William L Stanford Published online 11.08.2015 miR‐9‐5p suppresses pro‐fibrogenic transformation of fibroblasts and prevents organ fibrosis by targeting NOX4 and TGFBR2 miR‐9‐5p is discovered as an anti‐fibrotic miRNA that targets TGBR2 and NOX4 to inhibit the transformation of fibroblasts into myofibroblasts. TGF‐β1 itself is pro‐fibrogenic, but promotes miR‐9‐5p expression, thus inducing inhibition of its own pro‐fibrogenic role. Marta Fierro‐Fernández, Óscar Busnadiego, Pilar Sandoval, Cristina Espinosa‐Díez, Eva Blanco‐Ruiz, Macarena Rodríguez, Héctor Pian, Ricardo Ramos, Manuel López‐Cabrera, Maria Laura García‐Bermejo, and Santiago Lamas Published online 27.08.2015 MicroRNA‐455 regulates brown adipogenesis via a novel HIF1an‐AMPK‐PGC1α signaling network miR‐455 promotes brown adipocyte differentiation and thermogenesis by targeting the key adipogenic inhibitors Necdin and Runx1t1 and by inducing a HIF1an‐AMPK‐PGC1α signaling cascade stimulating mitochondria biogenesis. Hongbin Zhang, Meiping Guan, Kristy L Townsend, Tian Lian Huang, Ding An, Xu Yan, Ruidan Xue, Tim J Schulz, Jonathon Winnay, Marcelo Mori, Michael F Hirshman, Karsten Kristiansen, John S Tsang, Andrew P White, Aaron M Cypess, Laurie J Goodyear, and Yu‐Hua Tseng Published online 24.08.2015 Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis Cancer‐associated fibroblasts induce cancer growth and spread. Here, chronic hypoxia and HIF‐1α stabilization are shown to deactivate CAFs, leading to impaired ECM remodelling and decreased metastasis in vivo. Chris D Madsen, Jesper T Pedersen, Freja A Venning, Lukram Babloo Singh, Emad Moeendarbary, Guillaume Charras, Thomas R Cox, Erik Sahai, and Janine T Erler Published online 31.08.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.