Nature Reviews Molecular Cell Biology contents October 2015 Volume 16 Number 10 pp 577-638

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TABLE OF CONTENTS
October 2015 Volume 16 Number 10
Impact Factor 37.806 *	In this issue Research Highlights Progress Reviews Also this month  Featured article: Centrosome function and assembly in animal cells Paul T. Conduit, Alan Wainman & Jordan W. Raff
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RESEARCH HIGHLIGHTS Top Cell signalling: Ciliary phosphoinositides regulate Hedgehog signalling p577 | doi:10.1038/nrm4064 Shows that the distribution of phosphoinositides in cilia regulates ciliary trafficking to control Hedgehog (Hh) signalling. PDF Chromosome biology: CTCF-binding site orientation shapes the genome p578 | doi:10.1038/nrm4057 The orientation of CCCTC-binding factor (CTCF)-binding sites located in enhancers and promoters dictates the directionality of CTCF binding and thus chromatin topology and gene expression. PDF Cell adhesion: Myosin anchors junctional signalling p578 | doi:10.1038/nrm4065 A feedback loop involving non-muscle myosin II and Rho-associated protein kinase I provides a robust mechanism for stabilizing epithelial junctions. PDF Autophagy: Mitophagy receptors unravelled p580 | doi:10.1038/nrm4058 Optineurin and NDP52 are primary mitophagy receptors that are recruited to damaged mitochondria by PINK1-dependent phospho-ubiquitin. PDF In the news: The Lasker Prize 2015: DNA damage response p580 | doi:10.1038/nrm4066 The 2015 Lasker Award for Basic Medical Research goes to E. Witkin and S. Elledge for their studies on DNA damage response pathways. PDF IN BRIEF Cell signalling: Antagonizing and amplifying EGF signalling | Gene expression: Integrator enhances enhancers | Translation: Regulating the proteome in and out of mitosis PDF Molecular Cell Biology JOBS of the week PhD student position in Molecular and Cell Biology Nanyang Technological University (NTU) Postdoctoral Associate Position in Cell and Molecular Biology NYU Abu Dhabi Postdoctoral Research Associate, Biochemistry / Immunology Benaroya Research Institute at Virginia Mason (BRI) More Science jobs from Molecular Cell Biology EVENT Transcriptional Regulation in Development and Disease 28.06.15 Chicago, USA More science events from
PROGRESS		Top
Transcriptome-wide dynamics of RNA pseudouridylation John Karijolich, Chengqi Yi & Yi-Tao Yu p581 | doi:10.1038/nrm4040 Pseudouridine is the most abundant internal post-transcriptional modification of spliceosomal small nuclear RNAs and ribosomal RNAs. Transcriptome-wide maps of RNA pseudouridylation have recently established that pseudouridines are also found in mRNAs, potentially representing a new mechanism of proteomic diversification. Abstract | Full Text | PDF
Integrating mitochondrial translation into the cellular context Ricarda Richter-Dennerlein, Sven Dennerlein & Peter Rehling p586 | doi:10.1038/nrm4051 Recent findings revealed the extent to which mitochondrial translation and other cellular processes are mutually controlled. Mitochondrial translation is coordinated with the assembly of respiratory chain complexes and is positively regulated by microRNAs imported from the cytoplasm. In turn, mitochondrial translation stress activates retrograde signalling pathways that suppress cell proliferation. Abstract | Full Text | PDF | Supplementary information
REVIEWS		Top
Epigenetic regulation of ageing: linking environmental inputs to genomic stability Bérénice A. Benayoun, Elizabeth A. Pollina & Anne Brunet p593 | doi:10.1038/nrm4048 The chromatin-based epigenetic changes that occur during ageing and the role of chromatin modifiers in lifespan have recently been highlighted. The importance of epigenome remodelling by environmental stimuli for transcriptional and genomic stability is emerging, and such remodelling could provide new targets to counter ageing or age-related diseases. Abstract | Full Text | PDF | Supplementary information
Centrosome function and assembly in animal cells Paul T. Conduit, Alan Wainman & Jordan W. Raff p611 | doi:10.1038/nrm4062 Centrosomes are important microtubule organizers. As many proteins are concentrated at centrosomes, including cell cycle and signalling regulators, centrosomes are also likely to coordinate important cell decisions. Recent findings have shed light on the functions of centrosomes in animal cells and on the mechanisms of centrosome assembly and maturation during mitosis. Abstract | Full Text | PDF
Ovary and fimbrial stem cells: biology, niche and cancer origins Annie Ng & Nick Barker p625 | doi:10.1038/nrm4056 At each ovulation cycle, the single-layer epithelia that encapsulate mammalian ovaries undergo rupture and rapid repair. Recent studies have identified stem cell pools that ensure ovarian epithelial homeostasis, thus providing insights into the regulation of stem cell function and the contribution of stem cells to ovarian tumorigenesis. Abstract | Full Text | PDF
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