Nature Reviews Genetics Contents October 2015 Volume 16 Number 10 pp 561-622

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TABLE OF CONTENTS
October 2015 Volume 16 Number 10
Impact Factor 39.794 *	In this issue Comment Research Highlights Reviews Also this month Article series: Applications of next-generation sequencing  Featured article: R loops: new modulators of genome dynamics and function José M. Santos-Pereira & Andrés Aguilera
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Comment: Using human genetics to make new medicines Jeffrey C. Barrett, Ian Dunham & Ewan Birney p561 | doi:10.1038/nrg3998 Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Genomics: Adding another dimension to gene regulation p563 | doi:10.1038/nrg4007 PDF Genetic screens: CombiGEM — high-throughput identification of combinatorial gene effects p564 | doi:10.1038/nrg4008 PDF Cancer genetics: The interloper p564 | doi:10.1038/nrg4009 PDF Evolutionary genetics: From phenotype to genotype p566 | doi:10.1038/nrg4010 PDF Evolutionary genetics: Red Queen dynamics in fruit fly sex p566 | doi:10.1038/nrg4011 PDF IN BRIEF Synthetic biology: Post-transcriptional synthetic circuits | Cancer genetics: Improved prediction of relapse in breast cancer | Evolutionary genetics: Alternative splicing shapes vertebrate evolution PDF Genetics JOBS of the week Postdoctoral Positions in Stem Cell, Developmental, and Cancer Biology Columbia University Medical Center Research Scientist Institute of Molecular Biology (IMB) Mainz Tenure-Track Faculty Positions Brandeis University Advanced Research Assistant - Cellular Phenotyping Wellcome Trust Sanger Institute Call for Translational Research Team Leaders Institut Curie More Science jobs from Genetics EVENT Plant Genetics and Breeding Technologies II 01.02.16 Vienna, Austria More science events from
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REVIEWS		Top
Article series: Applications of next-generation sequencing Elucidating the molecular architecture of adaptation via evolve and resequence experiments Anthony Long, Gianni Liti, Andrej Luptak & Olivier Tenaillon p567 | doi:10.1038/nrg3937 Combining experimental evolution with next-generation sequencing, the evolve and resequence (E&R) approach is a powerful method for dissecting the genomic changes underlying the adaptation of populations of laboratory organisms or molecules. This Review describes the E&R results from diverse systems and discusses the extent to which various features, including population genetics, experimental setups and reproduction modes, account for the distinct observed outcomes. Abstract | Full Text | PDF | Supplementary information
R loops: new modulators of genome dynamics and function José M. Santos-Pereira & Andrés Aguilera p583 | doi:10.1038/nrg3961 R loops form when a transcript hybridizes to a complementary DNA locus to result in an RNA-DNA hybrid and a displaced single DNA strand. Such structures can have detrimental cellular roles by causing genome instability. However, recent studies have provided detailed views of genome-wide R-loop occurrences and uncovered various apparently beneficial roles in gene regulation. This Review discusses our latest understanding of the contrasting functions of R loops and the implications for genome regulation and various diseases. Abstract | Full Text | PDF
Integrating circadian dynamics with physiological processes in plants Kathleen Greenham & C. Robertson McClung p598 | doi:10.1038/nrg3976 The plant circadian clock regulates many physiological processes, such as growth, flowering time, abiotic and biotic stress responses, and metabolism. In turn, many of these responses feed back to control the circadian clock. This Review describes the integration of circadian dynamics into the study of plant physiological processes and highlights the importance of incorporating circadian, spatial and temporal information into predictive models to improve crop breeding. Abstract | Full Text | PDF
Eco-Evo-Devo: developmental symbiosis and developmental plasticity as evolutionary agents Scott F. Gilbert, Thomas C. G. Bosch & Cristina Ledón-Rettig p611 | doi:10.1038/nrg3982 Ecological evolutionary developmental biology (Eco-Evo-Devo) is a relatively new field that integrates developmental biology and ecology into evolutionary theory. The authors review new research in this field relating to the roles of developmental plasticity and developmental symbiosis in evolution. Abstract | Full Text | PDF
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Celebrating 15 years of high-quality Reviews October 2015 marks the 15th anniversary of the launch of Nature Reviews Genetics, Nature Reviews Neuroscience, and Nature Reviews Molecular Cell Biology. See what each journal is publishing in 2015. Visit the current issues to see what each journal is publishing in 2015. Nature Reviews Genetics, Nature Reviews Neuroscience and Nature Reviews Molecular Cell Biology.
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