Nature Cell Biology contents: August 2015 Volume 17 Number 8, pp 955 - 1088

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TABLE OF CONTENTS August 2015 Volume 17, Issue 8 Review News and Views Articles Resource Corrigendum Erratum Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Helmholtz Zentrum München and Nature Medicine are pleased to announce: THE 3RD ANNUAL HELMHOLTZ-NATURE MEDICINE DIABETES CONFERENCE September 19-21, 2015 | Munich, Germany  REGISTER NOW!    Review Top Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch   pp955 - 963 Lindsay B. Case and Clare M. Waterman doi:10.1038/ncb3191 Case and Waterman discuss how integrating extracellular-matrix-bound integrins and the actin cytoskeleton into a mechanosensitive molecular clutch transmits actin-cytoskeleton-generated forces to the extracellular matrix through focal adhesions. News and Views Top Condensing chromosome condensation   pp964 - 965 Jason C. Bell and Aaron F. Straight doi:10.1038/ncb3212 Mitotic chromosome condensation has fascinated biologists since Flemming's early illustrations of mitosis in the late nineteenth century. Now — 130 years later — chromatid condensation is reconstituted in vitro with the minimum components. The results are remarkably and beautifully simple, requiring only core histones, three histone chaperones, topoisomerase II and condensin I. See also: Article by Shintomi et al. Building stomach in a dish   pp966 - 967 Meritxell Huch doi:10.1038/ncb3211 Modelling organs in culture has great potential to improve our understanding of development, organogenesis and disease. While some endodermal derived organs have been modelled, the corpus region of the stomach, where acid-producing cells reside, remained an invincible target. A 60-day differentiation protocol now enables the generation of functional acid-producing cells in culture, conquering the challenge. See also: Article by Noguchi et al. RB-loss puts focus on Myc   pp968 - 969 Wayne O. Miles and Nicholas J. Dyson doi:10.1038/ncb3213 Activator E2Fs and Myc cooperate as master regulators of proliferation. A new study sheds light on one of the fundamental questions in cancer biology: how do oncogenic changes, such as Retinoblastoma (RB)-mutation, modify E2F and Myc activity? See also: Article by Liu et al. Cell Biology JOBS of the week Postdoctoral Position Studying B-Cell Biology University of Chicago Postdoctoral Position in Virology / Cell Biology Northwestern University Postdoctoral Position in Theoretical Immunology Icahn School of Medicine at Mount Sinai Post-doctoral Fellow Massachusetts General Hospital & Harvard Medical School Senior Scientist University of Helsinki More Science jobs from Cell Biology EVENT Single Cell Biology 08.03.16 Cambridge, UK More science events from Articles Top Hepatic progenitor cells of biliary origin with liver repopulation capacity   pp971 - 983 Wei-Yu Lu, Thomas G. Bird, Luke Boulter, Atsunori Tsuchiya, Alicia M. Cole et al. doi:10.1038/ncb3203 Forbes and colleagues report on a population of hepatic progenitor cells that regenerate the adult liver in a mouse model where more than 98% of all hepatocytes are irreversibly damaged. Generation of stomach tissue from mouse embryonic stem cells   pp984 - 993 Taka-aki K. Noguchi, Naoto Ninomiya, Mari Sekine, Shinji Komazaki, Pi-Chao Wang et al. doi:10.1038/ncb3200 Noguchi and colleagues report the generation of stomach-like tissue from mouse embryonic stem cells. They show that the tissue contains all stomach-specific cell types and secretes acid and digestive enzyme. See also: News and Views by Huch Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells   pp994 - 1003 Christoph Patsch, Ludivine Challet-Meylan, Eva C. Thoma, Eduard Urich, Tobias Heckel et al. doi:10.1038/ncb3205 Cowan and colleagues report a method to generate mature endothelial or vascular smooth muscle cells from human pluripotent stem cells with high efficiency and purity. NF-κB activation impairs somatic cell reprogramming in ageing   pp1004 - 1013 Clara Soria-Valles, Fernando G. Osorio, Ana Gutiérrez-Fernández, Alejandro De Los Angeles, Clara Bueno et al. doi:10.1038/ncb3207 Lopez-Otin and colleagues report that NF-κB signalling hyperactivation in progeria syndrome fibroblasts inhibits their reprogramming into iPS cells. Blockade of this pathway or the downstream factor DOTL1 rescues senescence-related phenotypes. Reconstitution of mitotic chromatids with a minimum set of purified factors   pp1014 - 1023 Keishi Shintomi, Tatsuro S. Takahashi and Tatsuya Hirano doi:10.1038/ncb3187 Hirano and colleagues have reconstituted mitotic chromatin condensation in cell-free extracts using six purified factors, including histone chaperones, topoisomerase II and condensin I. See also: News and Views by Bell & Straight PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2   pp1024 - 1035 Hiroshi Hanafusa, Shin Kedashiro, Motohiro Tezuka, Motoki Funatsu, Satoshi Usami et al. doi:10.1038/ncb3204 Hanafusa and Matsumato and colleagues find that LRRK1 is a substrate for PLK1 in mitosis. Phosphorylated LRRK1 in turn phosphorylates CDK5RAP2 to promote centrosomal microtubule nucleation and correct spindle orientation. Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles   pp1036 - 1048 Huayang Liu, Xing Tang, Arunima Srivastava, Thierry Pécot, Piotr Daniel et al. doi:10.1038/ncb3210 Leone and colleagues find that in intestinal crypt cells, Myc and E2F transcription factors control the transition into the G2 phase of the cell cycle, but in the absence of Rb, Myc and E2f3a drive S phase entry and ectopic proliferation in vivo. See also: News and Views by Miles & Dyson MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation   pp1049 - 1061 Remi-Martin Laberge, Yu Sun, Arturo V. Orjalo, Christopher K. Patil, Adam Freund et al. doi:10.1038/ncb3195 Campisi and colleagues show that the MTOR inhibitor rapamycin blocks the senescence-associated secretory phenotype (SASP) by inhibiting translation of IL1A, which prevents senescent fibroblasts from promoting tumour growth. Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth   pp1062 - 1073 Jonathan Lévy, Wulfran Cacheux, Medhi Ait Bara, Antoine L'Hermitte, Patricia Lepage et al. doi:10.1038/ncb3206 Romagnolo and colleagues report that Atg7 deficiency has a tumour-suppressive role in the intestinal epithelium, by inducing a microbiome-influenced immune response and inhibiting tumour growth through p53- and AMPK-related mechanisms. Advertisement An online-only, open access, multidisciplinary journal dedicated to publishing high-quality original research articles, reviews, editorials, commentaries, and hypothesis generating observations on all areas of breast cancer research. Part of the Nature Partner Journals series, published in partnership with the Breast Cancer Research Foundation. Now open for submissions.   Resource Top An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes   pp1074 - 1087 Gabrielle Wheway, Miriam Schmidts, Dorus A. Mans, Katarzyna Szymanska, Thanh-Minh T. Nguyen et al. doi:10.1038/ncb3201 In an effort by several research groups, a genome-wide RNAi-based screen presents a list of validated genes involved in cilia assembly and maintenance, and reveals previously unidentified ciliopathy factors. Corrigendum Top Corrigendum: Selective autophagy degrades DICER and AGO2 and regulates miRNA activity   p1088 Derrick Gibbings, Serge Mostowy, Florence Jay, Yannick Schwab, Pascale Cossart et al. doi:10.1038/ncb3208 Erratum Top Erratum: Proteostasis control by the unfolded protein response   p1088 Claudio Hetz, Eric Chevet and Scott A. Oakes doi:10.1038/ncb3221 Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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