Nature Reviews Immunology Contents June 2015 Volume 15 Number 6 pp 331-400

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TABLE OF CONTENTS
June 2015 Volume 15 Number 6		Advertisement
Impact Factor 33.836 *	In this issue Research Highlights Reviews Also this month  Featured article: Fever and the thermal regulation of immunity: the immune system feels the heat Sharon S. Evans, Elizabeth A. Repasky & Daniel T. Fisher	Determine the Metabolic Phenotype of Your Cells The XFp Cell Energy Phenotype Test Kit from Seahorse Bioscience. Using as few as 15,000 cells and an XFp Analyzer, the XF Cell Energy Phenotype Test identifies your cells' metabolic phenotype as well as their metabolic potential — the relative utilization of mitochondrial respiration and glycolysis.  http://bit.ly/1Caw9Eq
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RESEARCH HIGHLIGHTS Top T cell memory: New insight on old-timers p331 | doi:10.1038/nri3866 Interleukin-7 supports metabolic activity in memory CD8+ T cells, and should our paradigms of memory subsets be revised? PDF T cell responses: B cells control T cell traffic p332 | doi:10.1038/nri3860 A newly discovered B cell-derived peptide inhibits T cell migration during inflammatory responses. PDF T cells: Role reversal p332 | doi:10.1038/nri3864 T helper 17 (TH17) cells transdifferentiate into T regulatory type 1 (TR1) cells and contribute to the resolution of inflammation in mice. PDF Granulocytes: Eosinophils enable the antitumour T cell response p333 | doi:10.1038/nri3861 Tumour-associated eosinophils support CD8+ T cell-mediated rejection through chemoattraction and vascular normalization. PDF T cells: LEM keeps the wheels turning p334 | doi:10.1038/nri3870 A newly identified protein, LEM, promotes CD8+ T cell proliferation and memory formation. PDF IN BRIEF Inflammation: Interferon-λ2 limits neutrophil migration | Parasite immunity: Commensals regulate the schistosome response | Gene regulation: Seasonal genes explain the winter blues PDF Immunology JOBS of the week Medical Oncologist & Clinical Investigator in Cancer Immunotherapy Institut Curie Postdoctoral Fellow Positions Openings UCLA David Geffen School of Medicine - Obstetrics and Gynecology Post-doctoral position in virus-host interactions and liver disease Inserm Unit 1110 Postdoctoral Researcher University of Maryland Baltimore Postdoctoral Researcher in Vascular Biology Uppsala University More Science jobs from Immunology EVENT AAI Advanced Course in Immunology 02.08.15 Boston, USA More science events from
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REVIEWS		Top
Fever and the thermal regulation of immunity: the immune system feels the heat Sharon S. Evans, Elizabeth A. Repasky & Daniel T. Fisher p335 | doi:10.1038/nri3843 This Review considers the impact of host temperature on the immune system. In particular, the authors focus on how the thermal element of the fever response can shape both innate and adaptive immune responses. Abstract | Full Text | PDF
Lymph node fibroblastic reticular cells in health and disease Anne L. Fletcher, Sophie E. Acton & Konstantin Knoblich p350 | doi:10.1038/nri3846 Fibroblastic reticular cells — which are immunologically specialized myofibroblasts of mesenchymal origin — create a network within lymph nodes that is essential for immunological health through interactions with B cells, T cells, dendritic cells and high endothelial venules. Abstract | Full Text | PDF
Regulation of tumour necrosis factor signalling: live or let die Dirk Brenner, Heiko Blaser & Tak W. Mak p362 | doi:10.1038/nri3834 In this Review, the authors describe how tumour necrosis factor (TNF) signals via its receptors. They explain how TNF is able to promote cell survival or cell death in different contexts and discuss the consequences of deregulated TNF receptor signalling for chronic human diseases. Finally, they discuss new strategies for targeting TNF in the clinic. Abstract | Full Text | PDF
Immune modulation by bacterial outer membrane vesicles Maria Kaparakis-Liaskos & Richard L. Ferrero p375 | doi:10.1038/nri3837 Outer membrane vesicles (OMVs) are produced by bacteria and can interact with leukocytes and other host cells to shape the immune response during infection. OMVs can have both pro-inflammatory and anti-inflammatory effects; in this Review, the authors discuss how they may contribute to human diseases and also their potential as vaccine adjuvants. Abstract | Full Text | PDF
Perforin and granzymes: function, dysfunction and human pathology Ilia Voskoboinik, James C. Whisstock & Joseph A. Trapani p388 | doi:10.1038/nri3839 Cytotoxic lymphocytes recognize virus-infected and transformed cells and kill them by apoptosis. Recent studies on the structural and cellular biology of the key mediators of this cytotoxicity — perforin and granzymes — have advanced our understanding of their mechanisms of action, their regulation and the pathophysiological consequences of impaired cytotoxicity. Abstract | Full Text | PDF
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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