The EMBO Journal Table of Contents for 1 April 2015; Vol. 34, No. 7

1 April 2015 | Volume 34, Number 7 Submit Table of Contents Have you seen? Reviews Articles Volume 34, Number 7 Have you seen? SIGNing a symbiotic treaty with gut microbiota Mouse C‐type lectin SIGNR3 and Lactobacillus acidophilus surface layer protein A interactions mediate the immune benefits of this food‐grade bacterium. Geanncarlo Lugo‐Villarino and Olivier Neyrolles Published online 03.03.2015 In‐TOX‐icating neurogenesis The HMG‐box transcription factor Tox regulates neural stem cell expansion, fate decisions and neuronal differentiation during early cortical development. Marisa Karow and Benedikt Berninger Published online 17.02.2015 Metabolic remodeling: a pyruvate transport affair A new study in yeast links metabolic changes to the expression of alternative mitochondrial pyruvate carriers (MPCs) displaying different activities, adding to recent studies in cancer cells that associated MPC function to metabolic reprogramming and cell fate. Heike Rampelt and Martin van der Laan Published online 27.02.2015 The BAFFling function of Syk in B‐cell homeostasis The BAFFR/CD19 pathway promotes B‐cell survival in parallel with canonical Syk‐dependent homeostatic NF‐κB/AKT activation. Sebastian Königsberger and Friedemann Kiefer Published online 20.02.2015 Reviews Focus: Induced Pluripotency & Cellular Reprogramming: Toward beta cell replacement for diabetes Dieter Egli & colleagues provide a stem cell perspective on pancreatic beta‐cells for diabetes therapies and disease modeling. Bjarki Johannesson, Lina Sui, Donald O Freytes, Remi J Creusot, and Dieter Egli Published online 01.03.2015 Autophagy in malignant transformation and cancer progression Autophagy has been described to have tumor‐suppressive as well as tumor‐promoting functions. This review discusses how stage and context alters the role for autophagy in cancer, and argues for further research prior to targeting autophagy in cancer therapy. Lorenzo Galluzzi, Federico Pietrocola, José Manuel Bravo‐San Pedro, Ravi K Amaravadi, Eric H Baehrecke, Francesco Cecconi, Patrice Codogno, Jayanta Debnath, David A Gewirtz, Vassiliki Karantza, Alec Kimmelman, Sharad Kumar, Beth Levine, Maria Chiara Maiuri, Seamus J Martin, Josef Penninger, Mauro Piacentini, David C Rubinsztein, Hans‐Uwe Simon, Anne Simonsen, Andrew M Thorburn, Guillermo Velasco, Kevin M Ryan, and Guido Kroemer Published online 23.02.2015 Articles SIGNR3‐dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis C‐lectin binding of the L. acidophilus surface layer glycoprotein SlpA protects against experimental colitis in mice by preventing mucosal inflammation, microbial dysbiosis, and barrier dysfunction. Yaíma L Lightfoot, Kurt Selle, Tao Yang, Yong Jun Goh, Bikash Sahay, Mojgan Zadeh, Jennifer L Owen, Natacha Colliou, Eric Li, Timo Johannssen, Bernd Lepenies, Todd R Klaenhammer, and Mansour Mohamadzadeh Published online 09.02.2015 Tox: a multifunctional transcription factor and novel regulator of mammalian corticogenesis A novel neuronal transcription factor promotes renewal in neural stem cells and neurite outgrowth in newborn neurons, but is transiently downregulated while neural stem cells switch to neurogenic divisions. Benedetta Artegiani, Antonio M de Jesus Domingues, Sara Bragado Alonso, Elisabeth Brandl, Simone Massalini, Andreas Dahl, and Federico Calegari Published online 19.12.2014 Regulation of mitochondrial pyruvate uptake by alternative pyruvate carrier complexes Different growth conditions trigger the expression of alternative mitochondrial pyruvate carriers (MPCs) with distinct transport activities, allowing yeast cells to adapt cellular metabolism to nutrient availability. Tom Bender, Gabrielle Pena, and Jean‐Claude Martinou Published online 11.02.2015 CD19 and BAFF‐R can signal to promote B‐cell survival in the absence of Syk Syk‐deficient B cells require BAFF receptor and CD19/PI3K signaling for their long‐term survival and maintenance. Elias Hobeika, Ella Levit‐Zerdoun, Vasiliki Anastasopoulou, Roland Pohlmeyer, Simon Altmeier, Ameera Alsadeq, Marc‐Werner Dobenecker, Roberta Pelanda, and Michael Reth Published online 28.01.2015 The Spectrin cytoskeleton regulates the Hippo signalling pathway In Drosophila, both the apical and the basolateral Spectrin cytoskeleton are able to activate the Hippo signaling pathway in a tissue‐dependent manner. In cultured human cells this depends on cell density, suggesting a role for Spectrins in mechanosensing. Georgina C Fletcher, Ahmed Elbediwy, Ichha Khanal, Paulo S Ribeiro, Nic Tapon, and Barry J Thompson Published online 23.02.2015 PI3P binding by Atg21 organises Atg8 lipidation Atg21 binds to PI3P at the preautophagosomal structure, recruits ubiquitin‐like Atg8 and the E3 ligase complex Atg12~Atg5/Atg16 and arranges them for efficient lipidation of Atg8. Lisa Juris, Marco Montino, Peter Rube, Petra Schlotterhose, Michael Thumm, and Roswitha Krick Published online 17.02.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.