Nature Communications - 15 April 2015

Advertisement Nature Communications is now fully open access All new submissions if accepted, will be published open access and an article processing charge will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more on APC funding.       Weekly Content Alert Nature Communications is now fully open access. Read more. 15 April 2015  Featured image: Runting et al. show that coordinated planning would allow the island of Borneo to meet both economic and conservation goals. Latest content: Articles Corrigendum Erratum Advertisement Ready for a glimpse of tomorrow? Visit KAUST Discovery today KAUST Discovery highlights the cutting-edge research, technologies and innovations emerging from the King Abdullah University of Science and Technology.   http://discovery.kaust.edu.sa Journal homepage Recommend to library Web feed   Advertisement The Naturejobs Career Expo is returning to Boston! May 20, 2015 This career fair offers young, talented researchers an excellent opportunity to meet a diverse selection of national and international employers from academic institutions and scientific industries, such as pharmaceutical organisations, digital technology companies, science publishing and more.  Register for FREE today!           Nature Communications - now fully open access All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Articles View all Articles     Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3 Vinodkumar B. Pillai, Sadhana Samant, Nagalingam R. Sundaresan, Hariharasundaram Raghuraman, Gene Kim, Michael Y. Bonner, Jack L. Arbiser, Douglas I. Walker, Dean P. Jones, David Gius and Mahesh P. Gupta The chemical honokiol is found in the bark of magnolia trees, which are used for traditional medicine in Asian countries. Here, Pillai et al, show honokiol protects the heart from hypertrophic remodelling in mice, and even reverses established cardiac hypertrophy, by activating the deacetylase Sirt3. 14 April 2015 | doi: 10.1038/ncomms7656 Biological Sciences  Medical research  Alternative futures for Borneo show the value of integrating economic and conservation targets across borders OPEN Rebecca K. Runting, Erik Meijaard, Nicola K. Abram, Jessie A. Wells, David L.A. Gaveau, Marc Ancrenaz, Hugh P. Posssingham, Serge A. Wich, Fitrian Ardiansyah, Melvin T. Gumal, Laurentius N. Ambu and Kerrie A. Wilson Balancing biological conservation with economic development is a challenge for policymakers. Analysing a range of possible future scenarios, Runting et al, show that coordinated planning would allow the island of Borneo to simultaneously retain forested land, protect species and meet economic goals. 14 April 2015 | doi: 10.1038/ncomms7819 Biological Sciences  Ecology  Control of response reliability by parvalbumin-expressing interneurons in visual cortex Yingjie Zhu, Wenhui Qiao, Kefei Liu, Huiyuan Zhong and Haishan Yao Natural stimuli evoke temporally reliable responses from visual cortical neurons, yet the underlying mechanisms are not well understood. Here, the authors demonstrate a critical role for parvalbumin- but not somatostatin-positive inhibitory interneurons in regulating visual cortical response reliability. 14 April 2015 | doi: 10.1038/ncomms7802 Biological Sciences  Neuroscience  Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells OPEN Katrina L. Adams, David L. Rousso, Joy A. Umbach and Bennett G. Novitch The differentiation of spinal motor neurons (MNs) from mouse and human embryonic stem cells provides opportunities to model MN development and disease, but most protocols produce only a subset of the MN subtypes found in vivo. Here the authors show that limb projecting lateral motor column MNs can be efficiently generated though the expression of Foxp1. 14 April 2015 | doi: 10.1038/ncomms7778 Biological Sciences  Developmental biology  Neuroscience  Molecular development of chondrichthyan claspers and the evolution of copulatory organs OPEN Katherine L. O’Shaughnessy, Randall D. Dahn and Martin J. Cohn Claspers are copulatory organs found in male cartilaginous fishes. Here, the authors show that androgen receptor signalling maintains the Shh pathway to promote clasper development in male skates and suggest the importance of hormonal regulation in the evolution of male copulatory organs. 14 April 2015 | doi: 10.1038/ncomms7698 Biological Sciences  Developmental biology  Evolution  Genetics  Zoology  Quantum Hall effect on top and bottom surface states of topological insulator (Bi1−xSbx)2Te3 films R. Yoshimi, A. Tsukazaki, Y. Kozuka, J. Falson, K.S. Takahashi, J.G. Checkelsky, N. Nagaosa, M. Kawasaki and Y. Tokura Three-dimensional topological insulators are materials that are nonmagnetic insulators in the bulk but exhibit metallic surface states. Yoshimi et al, now identify a signature of such two-dimensional states, the quantum Hall effect, in bismuth-based chalcogenide topological insulators. 14 April 2015 | doi: 10.1038/ncomms7627 Physical Sciences  Applied physics  Condensed matter  Probing long-range carrier-pair spin–spin interactions in a conjugated polymer by detuning of electrically detected spin beating OPEN Kipp J. van Schooten, Douglas L. Baird, Mark E. Limes, John M. Lupton and Christoph Boehme Interactions between weakly coupled pairs of electron spins are thought to play a role in biological magnetoreception and spin-dependent carrier dynamics in semiconductors. Here, the authors investigate such intrapair dipolar and exchange interactions in a polymer using electrically detected magnetic resonance experiments. 14 April 2015 | doi: 10.1038/ncomms7688 Physical Sciences  Materials science  Temperature-triggered chemical switching growth of in-plane and vertically stacked graphene-boron nitride heterostructures OPEN Teng Gao, Xiuju Song, Huiwen Du, Yufeng Nie, Yubin Chen, Qingqing Ji, Jingyu Sun, Yanlian Yang, Yanfeng Zhang and Zhongfan Liu Targeted synthesis of vertically stacked graphene (G) and hexagonal boron nitride (h-BN) heterostructures remains a challenge. Here, the authors achieve the selective, CVD growth of h-BN-G and G/h-BN through a temperature-triggered switching reaction. 14 April 2015 | doi: 10.1038/ncomms7835 Physical Sciences  Materials science  Nanotechnology  Polarization control at spin-driven ferroelectric domain walls Naëmi Leo, Anders Bergman, Andres Cano, Narayan Poudel, Bernd Lorenz, Manfred Fiebig and Dennis Meier Domain walls in ferroelectrics can lead to phenomena different from the bulk. Here the authors achieve polarization control of charged domain walls in improper ferroelectrics by magnetic fields that convert neutral into charged domain walls. 14 April 2015 | doi: 10.1038/ncomms7661 Physical Sciences  Condensed matter  Interaction-free measurements by quantum Zeno stabilization of ultracold atoms OPEN J. Peise, B. Lücke, L. Pezzé, F. Deuretzbacher, W. Ertmer, J. Arlt, A. Smerzi, L. Santos and C. Klempt The inherent strangeness of quantum mechanics means it is possible to detect objects using single-quantum particles even if they do not interact directly. Peise et al. realize such an ‘interaction-free measurement’ by exploiting the quantum Zeno effect in a BEC, obviating the need for single-particle sources. 14 April 2015 | doi: 10.1038/ncomms7811 Physical Sciences  Atomic and molecular physics  Regulation of systemic energy homeostasis by serotonin in adipose tissues OPEN Chang-Myung Oh, Jun Namkung, Younghoon Go, Ko Eun Shong, Kyuho Kim, Hyeongseok Kim, Bo-Yoon Park, Ho Won Lee, Yong Hyun Jeon, Junghan Song, Minho Shong, Vijay K. Yadav, Gerard Karsenty, Shingo Kajimura, In-Kyu Lee, Sangkyu Park and Hail Kim The neurotransmitter serotonin has both central and peripheral effects. Here, the authors show that adipocyte-derived serotonin regulates organismal energy homeostasis in mice by acting on adipocyte serotonin receptors on fat cells, which regulates lipolysis and thermogenesis in white and brown fat tissue. 13 April 2015 | doi: 10.1038/ncomms7794 Biological Sciences  Medical research  EphB4 forward signalling regulates lymphatic valve development OPEN Gu Zhang, John Brady, Wei-Ching Liang, Yan Wu, Mark Henkemeyer and Minhong Yan The bidirectional Eph-ephrin signalling regulates a myriad of developmental programmes. Zhang et al. show that EphB4 forward signalling is crucial for lymphatic valve development, providing new insight into this important developmental process previously thought to be regulated by ephrinB2-dependent reverse signalling. 13 April 2015 | doi: 10.1038/ncomms7625 Biological Sciences  Cell biology  Plasticity of Hopx+ type I alveolar cells to regenerate type II cells in the lung Rajan Jain, Christina E. Barkauskas, Norifumi Takeda, Emily J. Bowie, Haig Aghajanian, Qiaohong Wang, Arun Padmanabhan, Lauren J. Manderfield, Mudit Gupta, Deqiang Li, Li Li, Chinmay M. Trivedi, Brigid L. M. Hogan and Jonathan A. Epstein Alveoli are the lung’s functional units composed of two major epithelial cell types, type I and type II. Type II cells are adult lung stem cells, but this study shows that differentiated Type I cells can also self-renew and give rise to Type II cells, revealing a bidirectional relationship between lung epithelial cell types. 13 April 2015 | doi: 10.1038/ncomms7727 Biological Sciences  Cell biology  Developmental biology  The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60 Hongmei Cui, Mingxiong Guo, Dong Xu, Zhi-Chun Ding, Gang Zhou, Han-Fei Ding, Junran Zhang, Yi Tang and Chunhong Yan ATF3, a stress mediator, regulates the activities of key cancer-associated proteins by altering their interactions with DNA or other proteins. Here, the authors report that ATF3 also regulates Tip60, a protein acetyltransferase, by promoting its enzymatic activity and increasing its protein stability. 13 April 2015 | doi: 10.1038/ncomms7752 Biological Sciences  Cell biology  Molecular biology  G-CSF supports long-term muscle regeneration in mouse models of muscular dystrophy Nozomi Hayashiji, Shinsuke Yuasa, Yuko Miyagoe-Suzuki, Mie Hara, Naoki Ito, Hisayuki Hashimoto, Dai Kusumoto, Tomohisa Seki, Shugo Tohyama, Masaki Kodaira, Akira Kunitomi, Shin Kashimura, Makoto Takei, Yuki Saito, Shinichiro Okata, Toru Egashira, Jin Endo, Toshikuni Sasaoka, Shin’ichi Takeda and Keiichi Fukuda. In response to injury, satellite cells (SCs) asymmetrically divide to self-renew and repair muscle. Here the authors show that a cytokine G-CSF is crucial for long-term expansion of activated SCs and muscle regeneration in mice, suggesting that G-CSF treatment may have beneficial effect in Duchenne muscular dystrophy. 13 April 2015 | doi: 10.1038/ncomms7745 Biological Sciences  Medical research  Dynamic imaging of the growth plate cartilage reveals multiple contributors to skeletal morphogenesis OPEN Yuwei Li, Vikas Trivedi, Thai V. Truong, David S. Koos, Rusty Lansford, Cheng-Ming Chuong, David Warburton, Rex A. Moats and Scott E. Fraser It is largely unknown how individual cell behaviours translate into collective cell action that underlies bone morphogenesis. Here the authors perform quantitative imaging of the long bone cartilage growth plate and identify the key cellular mechanisms of cartilage morphogenesis. 13 April 2015 | doi: 10.1038/ncomms7798 Biological Sciences  Cell biology  Developmental biology  A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses OPEN Jianning Lu, Ceng Luo, Kiran Kumar Bali, Rou-Gang Xie, Richard E. Mains, Betty A. Eipper and Rohini Kuner The development of chronic inflammatory pain is linked with functional and structural modifications in nociceptive synapses. Here the authors demonstrate that Kalrinin-7 forms an essential link between synaptic receptors and cytoskeletal elements to functionally modify spinal nociceptive synapses. 13 April 2015 | doi: 10.1038/ncomms7820 Biological Sciences  Cell biology  Molecular biology  Neuroscience  A fungal protease allergen provokes airway hyper-responsiveness in asthma Nariman A. Balenga, Michael Klichinsky, Zhihui Xie, Eunice C. Chan, Ming Zhao, Joseph Jude, Michel Laviolette, Reynold A. Panettieri and Kirk M. Druey Airway hyper-responsiveness, a hallmark of asthma, is often associated with sensitization to fungi. Here, the authors show that a fungal protease allergen Asp f13/Alp1 from Aspergillus fumigatus can promote airway hyper-responsiveness in asthma via its effect on the airway smooth muscle cells. 13 April 2015 | doi: 10.1038/ncomms7763 Biological Sciences  Immunology  Microbiology  Ultra-sensitive all-fibre photothermal spectroscopy with large dynamic range OPEN Wei Jin, Yingchun Cao, Fan Yang and Hoi Lut Ho Photothermal interferometry systems using free-space optics have limits in terms of light–matter interaction efficiency, size, optical alignment and integration. Here, Jin et al. use a gas-filled hollow-core photonic bandgap fibre to demonstrate an all-fibre gas sensor with ultrahigh sensitivity and dynamic range. 13 April 2015 | doi: 10.1038/ncomms7767 Physical Sciences  Applied physics  Optical physics  Energy transfer pathways in semiconducting carbon nanotubes revealed using two-dimensional white-light spectroscopy Randy D. Mehlenbacher, Thomas J. McDonough, Maksim Grechko, Meng-Yin Wu, Michael S. Arnold and Martin T. Zanni Thin films of carbon nanotubes are been considered for energy harvesting and optoelectronic devices but their energy transfer pathways are largely unknown. Here, Mehlenbacher et al. use two-dimensional white-light spectroscopy to investigate the ultrafast energy redistribution in carbon nanotube films. 13 April 2015 | doi: 10.1038/ncomms7732 Physical Sciences  Applied physics  Materials science  Optical physics  Distinct metabolomic signatures are associated with longevity in humans Susan Cheng, Martin G. Larson, Elizabeth L. McCabe, Joanne M. Murabito, Eugene P. Rhee, Jennifer E. Ho, Paul F. Jacques, Anahita Ghorbani, Martin Magnusson, Amanda L. Souza, Amy A. Deik, Kerry A. Pierce, Kevin Bullock, Christopher J. O’Donnell, Olle Melander, Clary B. Clish, Ramachandran S. Vasan, Robert E. Gerszten and Thomas J. Wang Metabolomic profiling provides clues at alterations in cellular biochemistry. Here, the authors perform metabolomics analyses on samples from the Framingham Heart Study, and a Danish validation cohort, to identify small-molecule biomarkers prospectively associated with longevity or ageing. 13 April 2015 | doi: 10.1038/ncomms7791 Biological Sciences  Medical research  CDK1 structures reveal conserved and unique features of the essential cell cycle CDK OPEN Nicholas R. Brown, Svitlana Korolchuk, Mathew P. Martin, Will A. Stanley, Rouslan Moukhametzianov, Martin E. M. Noble and Jane A. Endicott Cyclin-dependent kinases are the principal drivers of cell cycle progression. Here the authors present several crystal structures of Cdk1 in complex with cyclin B and/or the assembly factors Cks1/2 and a small molecule inhibitor to reveal key features of this essential mitotic kinase. 13 April 2015 | doi: 10.1038/ncomms7769 Biological Sciences  Biochemistry  Biophysics  Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype OPEN William T. Ralvenius, Dietmar Benke, Mario A. Acuña, Uwe Rudolph and Hanns Ulrich Zeilhofer Benzodiazepines (BDZs) target GABAA receptors to alleviate pain but these also cause side effects. Here the authors use mice in which only one GABAA receptor is BDZ-sensitive at a time to identify α2GABAA as the receptor that provides maximal analgesic activity but minimal side-effects in response to BDZs. 13 April 2015 | doi: 10.1038/ncomms7803 Biological Sciences  Medical research  Hall effect of triplons in a dimerized quantum magnet Judit Romhányi, Karlo Penc and R. Ganesh The spins in quantum magnets couple to each other through an exchange interaction. Here, the authors show that a weak coupling between neighbouring spins called the Dzyaloshinskii–Moriya interaction can give rise to topological behaviour in the archetypal quantum magnet strontium copper borate. 13 April 2015 | doi: 10.1038/ncomms7805 Physical Sciences  Condensed matter  Theoretical physics  Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain Margaret M. P. Pearce, Ellen J. Spartz, Weizhe Hong, Liqun Luo and Ron R. Kopito Phagocytic glia can internalize protein aggregates in vitro. Here Pearce et al. show in Drosophila that glia clear mutant huntingtin (Htt) aggregates in a scavenger receptor Draper-dependent manner in vivo, and that internalized Htt aggregates induce the prion-like conversion of wild-type Htt expressed in the glial cytoplasm. 13 April 2015 | doi: 10.1038/ncomms7768 Biological Sciences  Cell biology  Locating and classifying fluorescent tags behind turbid layers using time-resolved inversion Guy Satat, Barmak Heshmat, Christopher Barsi, Dan Raviv, Ou Chen, Moungi G. Bawendi and Ramesh Raskar Fluorescent patches can be localized in 3D and identified behind a diffusive layer by use of streak images taken from one horizontal line on the diffusive barrier. Satat et al. show that the time-resolved inversion along with sparse prior can be used to perform this with deeper recovery range. 13 April 2015 | doi: 10.1038/ncomms7796 Physical Sciences  Applied physics  Materials science  Optical physics  Logging cuts the functional importance of invertebrates in tropical rainforest OPEN Robert M. Ewers, Michael J. W. Boyle, Rosalind A. Gleave, Nichola S. Plowman, Suzan Benedick, Henry Bernard, Tom R. Bishop, Effendi Y. Bakhtiar, Vun Khen Chey, Arthur Y. C. Chung, Richard G. Davies, David P. Edwards, Paul Eggleton, Tom M. Fayle, Stephen R. Hardwick, Rahman Homathevi, Roger L. Kitching, Min Sheng Khoo, Sarah H. Luke, Joshua J. March et al. Invertebrates are key components in the ecological functioning of tropical forests. Here, Ewers et al. show that, compared to primary forest, logging halves the contribution of invertebrate species to several key ecosystem processes, including litter decomposition. 13 April 2015 | doi: 10.1038/ncomms7836 Biological Sciences  Ecology  The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF Anthony J. Sadler, Bandar A. Suliman, Liang Yu, Xiangliang Yuan, Die Wang, Aaron T. Irving, Soroush T. Sarvestani, Ashish Banerjee, Ashley S. Mansell, Jun-Ping Liu, Steve Gerondakis, Bryan R. G. Williams and Dakang Xu The importance of the post-translational modification by acetylation in regulating protein function is not fully understood. Here, the authors show that acetylation of the transcriptional factor PLZF promotes the assembly of a repressor complex that limits the inflammatory response mediated by NF-κB. 13 April 2015 | doi: 10.1038/ncomms7795 Biological Sciences  Immunology  Direct electron injection into an oxide insulator using a cathode buffer layer OPEN Eungkyu Lee, Jinwon Lee, Ji-Hoon Kim, Keon-Hee Lim, Jun Seok Byun, Jieun Ko, Young Dong Kim, Yongsup Park and Youn Sang Kim Carrier injection from a metallic electrode into an oxide insulator component is made difficult by the large energy level offset between the two. Here, the authors show that an intermediary zinc-oxide layer enables an Ohmic electrical contact between a metal and an oxide insulator layer. 13 April 2015 | doi: 10.1038/ncomms7785 Physical Sciences  Applied physics  Materials science  Self-templated chemically stable hollow spherical covalent organic framework Sharath Kandambeth, V. Venkatesh, Digambar B. Shinde, Sushma Kumari, Arjun Halder, Sandeep Verma and Rahul Banerjee Hollow, spherical nano/microstructures are potentially useful for energy and drug delivery applications. Here, the authors show that these structures can be fabricated from covalent organic frameworks, and exploit their chemical stability and mesoporous structures for enzyme encapsulation. 10 April 2015 | doi: 10.1038/ncomms7786 Chemical Sciences  Materials science  Radiation-mode optical microscopy on the growth of graphene Tomo-o Terasawa and Koichiro Saiki Real-time observation of graphene growth is likely to result in a greater understanding of growth mechanisms and ultimately enable improved growth control. Here, the authors propose a new technique for observing CVD grown graphene, which they term ‘radiation-mode optical microscopy’. 10 April 2015 | doi: 10.1038/ncomms7834 Physical Sciences  Materials science  Nanotechnology  Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing OPEN Ryan R. White, Brandon Milholland, Alain de Bruin, Samuel Curran, Remi-Martin Laberge, Harry van Steeg, Judith Campisi, Alexander Y. Maslov and Jan Vijg Accumulation of DNA damage is a hallmark of cellular ageing but cause and effect are unclear. Here White et al. induce clean DNA double-strand breaks in the liver of mice using a modified restriction enzyme and demonstrate that DNA damage alone is sufficient to recapitulate some aspects of tissue ageing. 10 April 2015 | doi: 10.1038/ncomms7790 Biological Sciences  Medical research  miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement OPEN Qin-Hua Gu, Danni Yu, Zhonghua Hu, Xing Liu, Yanqin Yang, Yan Luo, Jun Zhu and Zheng Li Long-term potentiation (LTP) is a form of synaptic plasticity that results in enhanced synaptic strength. Here, the authors demonstrate that miR-26a and miR-384-5p affect the maintenance, but not induction, of LTP as well as spine enlargement by regulating the expression of RSK3. 10 April 2015 | doi: 10.1038/ncomms7789 Biological Sciences  Molecular biology  Neuroscience  Liquid crystals for organic thin-film transistors OPEN Hiroaki Iino, Takayuki Usui and Jun-ichi Hanna Polycrystalline thin films of small molecules hold promise for organic thin-film transistors because of their large charge mobility, but are currently limited by poor film homogeneity and thermal durability. Here, Iino et al. design an ordered liquid crystal phase to overcome these two problems. 10 April 2015 | doi: 10.1038/ncomms7828 Physical Sciences  Applied physics  Materials science  Neutrino and cosmic-ray emission from multiple internal shocks in gamma-ray bursts Mauricio Bustamante, Philipp Baerwald, Kohta Murase and Walter Winter Gamma-ray bursts are short-lived luminous explosions at cosmological distances caused by jets from the deaths of massive stars. Bustamante et al. study neutrino, gamma-ray and cosmic-ray production by internal shocks, and find that multi-messenger observations are crucial to understand the evolving outflows. 10 April 2015 | doi: 10.1038/ncomms7783 Physical Sciences  Astronomy  Particle physics  Pontin functions as an essential coactivator for Oct4-dependent lincRNA expression in mouse embryonic stem cells OPEN Kyungjin Boo, Jinhyuk Bhin, Yoon Jeon, Joomyung Kim, Hi-Jai R. Shin, Jong-Eun Park, Kyeongkyu Kim, Chang Rok Kim, Hyonchol Jang, In-Hoo Kim, V. Narry Kim, Daehee Hwang, Ho Lee and Sung Hee Baek Long non-coding RNAs or lincRNAs identified in embryonic stem (ES) cells have been shown to regulate ES cell states; however, how these lincRNAs are regulated remains unclear. Here the authors show that the transcriptional coactivator Pontin regulates the expression of lincRNAs involved in ES cell maintenance in an Oct4-dependent manner. 10 April 2015 | doi: 10.1038/ncomms7810 Biological Sciences  Cell biology  Developmental biology  Enhancing grain boundary ionic conductivity in mixed ionic–electronic conductors OPEN Ye Lin, Shumin Fang, Dong Su, Kyle S Brinkman and Fanglin Chen The performance of mixed ionic–electronic conductors used in energy conversion and storage devices can be restricted by their high grain boundary resistance. Here, the authors present the formation of an emergent phase to alleviate dopant segregation at the grain boundary and enhance ionic conductivity. 10 April 2015 | doi: 10.1038/ncomms7824 Chemical Sciences  Inorganic chemistry  Materials science  Plant macrofossil evidence for an early onset of the Holocene summer thermal maximum in northernmost Europe OPEN M. Väliranta, J. S. Salonen, M. Heikkilä, L. Amon, K. Helmens, A. Klimaschewski, P. Kuhry, S. Kultti, A. Poska, S. Shala, S. Veski and H. H. Birks A geographical disequilibrium between climate and tree populations may bias northern European pollen-based temperature reconstructions for the early Holocene. Here, the authors compare pollen- and macrofossil-based temperature reconstructions, showing that macrofossils reveal warmer July temperatures. 10 April 2015 | doi: 10.1038/ncomms7809 Earth Sciences  Climate science  Plant sciences  MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease OPEN Neal L. Millar, Derek S. Gilchrist, Moeed Akbar, James H. Reilly, Shauna C. Kerr, Abigail L. Campbell, George A. C. Murrell, Foo Y. Liew, Mariola Kurowska-Stolarska and Iain B. McInnes Collagen 3 is increased during tendon repair, but is then replaced by Collagen 1 that has superior biomechanical properties. Here the authors show that IL-33 is induced by tendon damage and regulates miR-29a, which controls Collagen 3 production and feeds back on IL-33, orchestrating tendon repair. 10 April 2015 | doi: 10.1038/ncomms7774 Biological Sciences  Immunology  Medical research  APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p Kun Wang, Cui-Yun Liu, Lu-Yu Zhou, Jian-Xun Wang, Man Wang, Bing Zhao, Wen-Ke Zhao, Shi-Jun Xu, Li-Hua Fan, Xiao-Jie Zhang, Chang Feng, Chao-Qun Wang, Yan-Fang Zhao and Pei-Feng Li ATG7 promotes cardiomyocyte autophagy but the molecular mechanism of its regulation is unknown. Here, Wang et al. identify a long non-coding RNA dubbed autophagy promoting factor (APF) that binds and inhibits miR-188-3p, which in turn acts on ATG7, to regulate cardiac autophagy. 10 April 2015 | doi: 10.1038/ncomms7779 Biological Sciences  Cell biology  Medical research  Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction Sherin J. Rouhani, Jacob D. Eccles, Priscila Riccardi, J. David Peske, Eric F. Tewalt, Jarish N. Cohen, Roland Liblau, Taija Mäkinen and Victor H. Engelhard Lymphatic endothelial cells (LECs) induce peripheral tolerance of CD8 T cells. Here the authors show that LECs cannot directly tolerize CD4 T cells as they lack the machinery for loading the antigenic peptide to MHC-II; instead, LECs pass these antigens to dendritic cells that induce CD4 tolerance. 10 April 2015 | doi: 10.1038/ncomms7771 Biological Sciences  Immunology  Long distance spin communication in chemical vapour deposited graphene M. Venkata Kamalakar, Christiaan Groenveld, André Dankert and Saroj P. Dash Although graphene promises long spin coherence lengths in spintronic devices, state-of-the-art performance has been limited to exfoliated flakes, limiting industrial scalability. Here, Kumalakar et al. demonstrate long-distance spin transport in large-scale chemical vapour-deposited graphene. 10 April 2015 | doi: 10.1038/ncomms7766 Physical Sciences  Applied physics  Condensed matter  Nanotechnology  Multinuclear metal-binding ability of a carotene OPEN Shinnosuke Horiuchi, Yuki Tachibana, Mitsuki Yamashita, Koji Yamamoto, Kohei Masai, Kohei Takase, Teruo Matsutani, Shiori Kawamata, Yuki Kurashige, Takeshi Yanai and Tetsuro Murahashi Carotenes are naturally abundant, widely studied unsaturated hydrocarbon pigments but their metal-binding ability has been virtually unexplored. Here, the authors demonstrate that they can be used to reversibly assemble and align homo- and hetero-metallic decanuclear chain complexes. 10 April 2015 | doi: 10.1038/ncomms7742 Chemical Sciences  Inorganic chemistry  Mitochondrial function provides instructive signals for activation-induced B-cell fates OPEN Kyoung-Jin Jang, Hiroto Mano, Koji Aoki, Tatsunari Hayashi, Akihiko Muto, Yukiko Nambu, Katsu Takahashi, Katsuhiko Itoh, Shigeru Taketani, Stephen L. Nutt, Kazuhiko Igarashi, Akira Shimizu and Manabu Sugai Cell fate choices are often based on amplification of noise. Here the authors show that small initial differences in mitochondrial reactive oxygen species lead to bigger changes in mitochondrial mass and membrane potential, which then determine plasma cell fate choice of activated B cells. 10 April 2015 | doi: 10.1038/ncomms7750 Biological Sciences  Immunology  RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock Constantinos M. Mikelis, May Simaan, Koji Ando, Shigetomo Fukuhara, Atsuko Sakurai, Panomwat Amornphimoltham, Andrius Masedunskas, Roberto Weigert, Triantafyllos Chavakis, Ralf H. Adams, Stefan Offermanns, Naoki Mochizuki, Yi Zheng and J. Silvio Gutkind Histamine causes vascular leakage by a direct and yet mechanistically poorly defined effect on endothelium. Here, the authors show that histamine elicits endothelial RhoA/Rock signaling and that inhibition of this pathway preserves the vascular barrier, thereby identifying novel pharmacological targets for histamine-mediated diseases. 10 April 2015 | doi: 10.1038/ncomms7725 Biological Sciences  Cell biology  Medical research  Autoprocessing of neutrophil elastase near its active site reduces the efficiency of natural and synthetic elastase inhibitors T. Dau, R. S. J. Sarker, A. O. Yildirim, O. Eickelberg and D. E. Jenne Elastase secreted by immune cells contributes to various lung diseases; however, elastase inhibitors have mostly failed in the clinic. Here, the authors discover a second, truncated form of elastase, which is the result of autocatalytic cleavage and is not well targeted by current synthetic elastase inhibitors. 10 April 2015 | doi: 10.1038/ncomms7722 Biological Sciences  Biochemistry  Medical research  Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy OPEN Giulia Milan, Vanina Romanello, Francesca Pescatore, Andrea Armani, Ji-Hye Paik, Laura Frasson, Anke Seydel, Jinghui Zhao, Reimar Abraham, Alfred L. Goldberg, Bert Blaauw, Ronald A. DePinho and Marco Sandri FoxO transcription factors promote muscle atrophy in response to stresses such as low nutrient availability. By generating muscle-specific FoxO triple-knockout mice, Milan et al. identify mechanisms by which the FoxO transcriptional network coordinates autophagic and proteasomal protein degradation. 10 April 2015 | doi: 10.1038/ncomms7670 Biological Sciences  Cell biology  Medical research  Arabidopsis uses two gluconeogenic gateways for organic acids to fuel seedling establishment OPEN Peter J. Eastmond, Holly M. Astley, Kate Parsley, Sylvain Aubry, Ben P. Williams, Guillaume N. Menard, Christian P. Craddock, Adriano Nunes-Nesi, Alisdair R. Fernie and Julian M. Hibberd During seed germination plants use gluconeogenesis to mobilize noncarbohydrate energy reserves. Here Eastmond et al. show that plants, unlike other eukaryotes, do not solely rely on a gluconeogenic pathway via the enzyme PCK but also use a second pathway relying on PPDK. 10 April 2015 | doi: 10.1038/ncomms7659 Biological Sciences  Plant sciences  Transport properties of pristine few-layer black phosphorus by van der Waals passivation in an inert atmosphere Rostislav A. Doganov, Eoin C. T. O’Farrell, Steven P. Koenig, Yuting Yeo, Angelo Ziletti, Alexandra Carvalho, David K. Campbell, David F. Coker, Kenji Watanabe, Takashi Taniguchi, Antonio H. Castro Neto and Barbaros Özyilmaz Ultrathin black phosphorus is a two-dimensional semiconductor with a finite band gap, unlike graphene, but it is known to degrade upon exposure to air. Here, the authors show that passivating few-layer samples of this material in an inert gas environment greatly improves the n-type charge transport. 10 April 2015 | doi: 10.1038/ncomms7647 Physical Sciences  Materials science  Crystal preferred orientation of an amphibole experimentally deformed by simple shear OPEN Byeongkwan Ko and Haemyeong Jung Seismic anisotropy has been widely observed in the crust and mantle due to the crystal preferred orientation (CPO) of highly anisotropic minerals such as amphibole, though it is poorly constrained. Here, the authors present an experimental study showing that three CPOs exist depending on temperature and stress. 10 April 2015 | doi: 10.1038/ncomms7586 Earth Sciences  Geology and geophysics  Changing cell behaviours during beetle embryogenesis correlates with slowing of segmentation A. Nakamoto, S. D. Hester, S. J. Constantinou, W. G. Blaine, A. B. Tewksbury, M. T. Matei, L. M. Nagy and T. A. Williams Sequential segmentation in development is best described in vertebrates, where it relies on cell proliferation and shows regular periodicity. Here, the authors show that in the flour beetle segments are added with irregular rate and their elongation during periods of fast growth relies mostly on cell movements. 10 April 2015 | doi: 10.1038/ncomms7635 Biological Sciences  Developmental biology  Analysis of immunoglobulin transcripts and hypermutation following SHIVAD8 infection and protein-plus-adjuvant immunization OPEN Joseph R. Francica, Zizhang Sheng, Zhenhai Zhang, Yoshiaki Nishimura, Masashi Shingai, Akshaya Ramesh, Brandon F. Keele, Stephen D. Schmidt, Barbara J. Flynn, Sam Darko, Rebecca M. Lynch, Takuya Yamamoto, Rodrigo Matus-Nicodemos, David Wolinsky, null null, Betty Barnabas, Robert Blakesley, Gerry Bouffard, Shelise Brooks, Holly Coleman et al. HIV vaccine development will be facilitated by having animal models that are predictive for translation to humans. Here, the authors use two nonhuman primate models to compare the effects of natural infection and different adjuvants on antigen persistence, diversity and humoral immunity. 10 April 2015 | doi: 10.1038/ncomms7565 Biological Sciences  Immunology  Microbiology  Virology  Borealin dimerization mediates optimal CPC checkpoint function by enhancing localization to centromeres and kinetochores Michael E. Bekier, Travis Mazur, Maisha S. Rashid and William R. Taylor Borealin is a subunit of the chromosomal passenger complex that prevents premature mitosis before spindle assembly is complete. Bekier et al. show that Borealin mediates recruitment of this complex to both kinetochores and centromeres via distinct mechanisms, both of which depend on Borealin dimerization. 09 April 2015 | doi: 10.1038/ncomms7775 Biological Sciences  Cell biology  Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state OPEN Annelien Verfaillie, Hana Imrichova, Zeynep Kalender Atak, Michael Dewaele, Florian Rambow, Gert Hulselmans, Valerie Christiaens, Dmitry Svetlichnyy, Flavie Luciani, Laura Van den Mooter, Sofie Claerhout, Mark Fiers, Fabrice Journe, Ghanem-Elias Ghanem, Carl Herrmann, Georg Halder, Jean-Christophe Marine and Stein Aerts The key regulators that allow transition from proliferative to invasive phenotype in melanoma cells have not been identified yet. The authors perform chromatin and transcriptome profiling followed by comprehensive bioinformatics analysis identifying new candidate regulators for two distinct cell states of melanoma. 09 April 2015 | doi: 10.1038/ncomms7683 Biological Sciences  Bioinformatics  Cancer  Visible light-driven efficient overall water splitting using p-type metal-nitride nanowire arrays M. G. Kibria, F. A. Chowdhury, S. Zhao, B. AlOtaibi, M. L. Trudeau, H. Guo and Z. Mi Solar water splitting for hydrogen generation may be a future source of renewable energy. Here, the authors demonstrate that controlled p-type doping of metal-nitride nanowires can eradicate surface potential barriers and promotes stable stoichiometric dissociation of water under visible light. 09 April 2015 | doi: 10.1038/ncomms7797 Chemical Sciences  Catalysis  Materials science  Processing of visually evoked innate fear by a non-canonical thalamic pathway OPEN Pengfei Wei, Nan Liu, Zhijian Zhang, Xuemei Liu, Yongqiang Tang, Xiaobin He, Bifeng Wu, Zheng Zhou, Yaohan Liu, Juan Li, Yi Zhang, Xuanyi Zhou, Lin Xu, Lin Chen, Guoqiang Bi, Xintian Hu, Fuqiang Xu and Liping Wang The ability of animals to respond to life-threatening stimuli is critical for survival, yet the neural circuits mediating innate defensive behaviors are not well understood. Here, the authors reveal a novel collicular–thalamic–amygdala circuit critical for innate defensive responses to visual threats. 09 April 2015 | doi: 10.1038/ncomms7756 Biological Sciences  Neuroscience  Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets OPEN Agnieszka K. Witkiewicz, Elizabeth A. McMillan, Uthra Balaji, GuemHee Baek, Wan-Chi Lin, John Mansour, Mehri Mollaee, Kay-Uwe Wagner, Prasad Koduru, Adam Yopp, Michael A. Choti, Charles J. Yeo, Peter McCue, Michael A. White and Erik S. Knudsen Diagnosis of pancreatic ductal adenocarcinoma (PDA) has poor long-term survival rates with limited therapy options. Here Witkiewicz et al. use microdissection and whole-exome sequencing to identify novel recurrent PDA mutations, highlighting the genetic diversity of this aggressive cancer. 09 April 2015 | doi: 10.1038/ncomms7744 Biological Sciences  Cancer  Genetics  Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system OPEN Paul S. Baxter, Karen F.S. Bell, Philip Hasel, Angela M. Kaindl, Michael Fricker, Derek Thomson, Sean P. Cregan, Thomas H. Gillingwater and Giles E. Hardingham How the brain’s antioxidant defenses adapt to changing demand is not well understood. Here the authors demonstrate that synaptic activity is coupled to transcriptional control of the glutathione antioxidant system via NMDA receptors, enabling neurons to tune their antioxidant defenses. 09 April 2015 | doi: 10.1038/ncomms7761 Biological Sciences  Biochemistry  Molecular biology  Neuroscience  New basal cell carcinoma susceptibility loci OPEN Simon N. Stacey, Hannes Helgason, Sigurjon A. Gudjonsson, Gudmar Thorleifsson, Florian Zink, Asgeir Sigurdsson, Birte Kehr, Julius Gudmundsson, Patrick Sulem, Bardur Sigurgeirsson, Kristrun R. Benediktsdottir, Kristin Thorisdottir, Rafn Ragnarsson, Victoria Fuentelsaz, Cristina Corredera, Yolanda Gilaberte, Matilde Grasa, Dolores Planelles, Onofre Sanmartin, Peter Rudnai et al. Basal cell carcinoma is a common cancer among people of European ancestry, with associated high economic costs to monitor and treat. Here Stacey et al. conduct a genome-wide association study on Icelandic and other European populations, identifying four novel loci associated with cancer susceptibility. 09 April 2015 | doi: 10.1038/ncomms7825 Biological Sciences  Cancer  Genetics  Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis OPEN Xianbo Zuo, Liangdan Sun, Xianyong Yin, Jinping Gao, Yujun Sheng, Jinhua Xu, Jianzhong Zhang, Chundi He, Ying Qiu, Guangdong Wen, Hongqing Tian, Xiaodong Zheng, Shengxiu Liu, Wenjun Wang, Weiran Li, Yuyan Cheng, Longdan Liu, Yan Chang, Zaixing Wang, Zenggang Li et al. Psoriasis is a chronic inflammatory disease affecting up to 3% of the population. Here, Zuo et al. perform exome array analysis, identify single-nucleotide polymorphisms at 15 new loci, implicating several biological pathways in psoriasis risk and disease heritability. 09 April 2015 | doi: 10.1038/ncomms7793 Biological Sciences  Genetics  A versatile nano display platform from bacterial spore coat proteins OPEN I-Lin Wu, Kedar Narayan, Jean-Philippe Castaing, Fang Tian, Sriram Subramaniam and Kumaran S. Ramamurthi The densely crosslinked protein coats of bacterial spores are among the most durable static structures in biology. Wu et al. reconstitute the basement layer of a bacterial spore coat on membrane-coated beads, and generate covalently-modified spore-like particles with therapeutic potential. 09 April 2015 | doi: 10.1038/ncomms7777 Biological Sciences  Biotechnology  Microbiology  Sensitivity of nonlinear photoionization to resonance substructure in collective excitation OPEN T. Mazza, A. Karamatskou, M. Ilchen, S. Bakhtiarzadeh, A. J. Rafipoor, P. O’Keeffe, T. J. Kelly, N. Walsh, J. T. Costello, M. Meyer and R. Santra Electrons in atoms exhibit many-body collective behaviours that can be studied by highbrightness X-rays from FELs. Here, the authors examine two-photon above threshold ionization of xenon and find that nonlinearities in the response uncover that more than one state underpins the 4d giant resonance. 09 April 2015 | doi: 10.1038/ncomms7799 Physical Sciences  Atomic and molecular physics  Emergent long-range synchronization of oscillating ecological populations without external forcing described by Ising universality OPEN Andrew E. Noble, Jonathan Machta and Alan Hastings Long-range synchronization of ecological populations separated by distances greater than their dispersal range is thought only to occur via environmental correlations. Here, Noble et al. show that synchronization can also occur beyond these distances, and is described by the Ising universality class. 08 April 2015 | doi: 10.1038/ncomms7664 Biological Sciences  Ecology  Theoretical physics  Rio1 promotes rDNA stability and downregulates RNA polymerase I to ensure rDNA segregation Maria G. Iacovella, Cristina Golfieri, Lucia F. Massari, Sara Busnelli, Cinzia Pagliuca, Marianna Dal Maschio, Valentina Infantino, Rosella Visintin, Karl Mechtler, Sébastien Ferreira-Cerca and Peter De Wulf The protein kinase Rio1 is known to promote 40S ribosome formation in the cytoplasm. Using budding yeast, the authors here show that Rio1 also acts in the nucleus, downregulates rDNA transcription by Pol I, and activates the processing of its transcripts to ensure rDNA stability and segregation. 08 April 2015 | doi: 10.1038/ncomms7643 Biological Sciences  Biochemistry  Cell biology  A cohesin–OCT4 complex mediates Sox enhancers to prime an early embryonic lineage Nesrine Abboud, Thomas Moore- Morris, Emilye Hiriart, Henry Yang, Hudson Bezerra, Maria-Giovanna Gualazzi, Sonia Stefanovic, Anne-Claire Guénantin, Sylvia M. Evans and Michel Pucéat Higher order chromatin structures affect gene transcription, but how they determine cell fate is unclear. Here, the authors show that OCT4 and SALL4 alter the higher-order chromatin structure and mediate cell fate switching in embryonic cells by targeting cohesin and polycomb complexes, respectively. 08 April 2015 | doi: 10.1038/ncomms7749 Biological Sciences  Cell biology  Molecular biology  Mammalian adaptation of influenza A(H7N9) virus is limited by a narrow genetic bottleneck OPEN Hassan Zaraket, Tatiana Baranovich, Bryan S. Kaplan, Robert Carter, Min-Suk Song, James C. Paulson, Jerold E. Rehg, Justin Bahl, Jeri C. Crumpton, Jon Seiler, Michael Edmonson, Gang Wu, Erik Karlsson, Thomas Fabrizio, Huachen Zhu, Yi Guan, Matloob Husain, Stacey Schultz-Cherry, Scott Krauss, Ryan McBride et al. H7N9 bird flu viruses cause mild disease in poultry but can occasionally infect humans with fatal consequences. Here, the authors show that viral genetic diversification is low in ferrets and high in chickens, suggesting that a genetic bottleneck limits H7N9 adaptation to mammals 08 April 2015 | doi: 10.1038/ncomms7553 Biological Sciences  Evolution  Microbiology  Virology  The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling Atanu Chakraborty, Markus E. Diefenbacher, Anastasia Mylona, Olivier Kassel and Axel Behrens Ras signalling activates the transcription factor c-Jun/AP-1, but the mechanism was unclear. Here, Chakraborty et al. describe a phosphorylation–ubiquitination cascade involving MSK1 and the E3 ubiquitin ligases Trim7 and RACO-1, which mediates c-Jun activation in Ras-driven lung tumorigenesis. 08 April 2015 | doi: 10.1038/ncomms7782 Biological Sciences  Cancer  Cell biology  Making water-soluble integral membrane proteins in vivo using an amphipathic protein fusion strategy OPEN Dario Mizrachi, Yujie Chen, Jiayan Liu, Hwei-Ming Peng, Ailong Ke, Lois Pollack, Raymond J. Turner, Richard J. Auchus and Matthew P. DeLisa The study of integral membrane proteins (IMPs) is hampered by yields and the difficulty in retaining activity once they have been solubilized. Here Mizrachi et al. develop a strategy for in vivo expression and solubilization of IMPs in functionally relevant states by fusing them to truncated apolipoprotein A-I. 08 April 2015 | doi: 10.1038/ncomms7826 Biological Sciences  Biochemistry  Biotechnology  Interplay between chemotaxis and contact inhibition of locomotion determines exploratory cell migration Benjamin Lin, Taofei Yin, Yi I. Wu, Takanari Inoue and Andre Levchenko It remains unclear how conflicting guidance cues are reconciled during cell motility. Lin et al. show that cell repulsion normally provoked by cell–cell contact can be suppressed during attraction to a growth factor, highlighting a cell’s ability to prioritize cues by evaluating input strengths. 08 April 2015 | doi: 10.1038/ncomms7619 Biological Sciences  Cell biology  Transcriptional refractoriness is dependent on core promoter architecture François Cesbron, Michael Oehler, Nati Ha, Gencer Sancar and Michael Brunner Genes are often transcribed in random bursts followed by long periods of inactivity. Here the authors show, by a light-inducible transcription system in Neurospora, that refractory promoters carry a physical memory of their previous transcription history. 08 April 2015 | doi: 10.1038/ncomms7753 Biological Sciences  Cell biology  Molecular biology  A causal role of the right inferior frontal cortex in implementing strategies for multi-component behaviour Gabriel Dippel and Christian Beste Complex behaviours, such as driving a car, require the organization and processing of several individual actions. Here, the authors use transcranial magnetic stimulation to demonstrate that the right inferior frontal gyrus determines the strategy used to sequence actions during complex behaviours. 08 April 2015 | doi: 10.1038/ncomms7587 Biological Sciences  Neuroscience  RECQ5-dependent SUMOylation of DNA topoisomerase I prevents transcription-associated genome instability Min Li, Subhash Pokharel, Jiin-Tarng Wang, Xiaohua Xu and Yilun Liu DNA topoisomerase I (TOP1) maintains DNA topology by relaxing supercoiled DNA during transcription. Here, the authors show that SUMOylation of TOP1 is necessary for its association with transcriptionally active RNA polymerase II and can reduce R-loops, preventing TOP1-induced DNA damage. 08 April 2015 | doi: 10.1038/ncomms7720 Biological Sciences  Cell biology  Molecular biology  Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules OPEN Alina Röhl, Daniela Wengler, Tobias Madl, Stephan Lagleder, Franziska Tippel, Monika Herrmann, Jelle Hendrix, Klaus Richter, Gordon Hack, Andreas B. Schmid, Horst Kessler, Don C. Lamb and Johannes Buchner The chaperones Hsp70 and Hsp90 are physically linked via the cochaperone Sti1/Hop, that has two binding sites for Hsp70. Here, Röhl et al. show that binding of Hsp90 changes the conformation of Sti1/Hop and determines to which site Hsp70 binds, perhaps facilitating transfer of client proteins from Hsp70 to Hsp90. 08 April 2015 | doi: 10.1038/ncomms7655 Biological Sciences  Biochemistry    Nature Communications JOBS of the week Postdoctoral Scientist Texas Biomedical Research Institute Clinical Research Fellow University of Oxford Senior Scientist - Tenure Track Paul Scherrer Institut (PSI) Research Associate University of Cambridge Postdoc and PhD studentship CEITEC - Central European Institute of Technology Postdoctoral Research Fellow – Postdoc Universität Innsbruck Postdoctoral Fellow San Diego Biomedical Research Institute Senior Scientist National Institutes of Health (NIH) Ph.D. Studentship The Roskamp Institute Bioinformatician University of Edinburgh More Science jobs from Nature Communications EVENT Alzheimer's Association International Conference 2015 18.07.15 Washington, USA More science events from       Latest Corrigendum     Corrigendum: Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes Nicholas E. Ilott, James A. Heward, Benoit Roux, Eleni Tsitsiou, Peter S. Fenwick, Luca Lenzi, Ian Goodhead, Christiane Hertz-Fowler, Andreas Heger, Neil Hall, Louise E. Donnelly, David Sims and Mark A. Lindsay 09 April 2015 | doi: 10.1038/ncomms7814 Biological Sciences  Immunology        Latest Erratum     Erratum: A vlincRNA participates in senescence maintenance by relieving H2AZ-mediated repression at the INK4 locus Sandra Lazorthes, Céline Vallot, Sébastien Briois, Marion Aguirrebengoa, Jean-Yves Thuret, Georges St. Laurent, Claire Rougeulle, Philipp Kapranov, Carl Mann, Didier Trouche and Estelle Nicolas 08 April 2015 | doi: 10.1038/ncomms7918 Biological Sciences  Cell biology  Molecular biology      Advertisement Nature Genetics: Genomes of Icelanders The largest-ever set of human genomes from a single population and the consequent insights into mutation, evolution, gene function and disease predisposition are reported in four linked papers.  Access the Web Focus free online. 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