The EDGE

Therapy of older persons with acute myeloid leukemia

R P Gale and A Hochhaus

Leukemia 2015 29: 759; advance online publication, January 23, 2015; 10.1038/leu.2014.337

Reviews

Novel drugs for older patients with acute myeloid leukemia

G Montalban-Bravo and G Garcia-Manero

Leukemia 2015 29: 760-769; advance online publication, August 21, 2014; 10.1038/leu.2014.244

Management of older or unfit patients with acute myeloid leukemia

R B Walter and E H Estey

Leukemia 2015 29: 770-775; advance online publication, July 9, 2014; 10.1038/leu.2014.216

A novel view of the adult bone marrow stem cell hierarchy and stem cell trafficking OPEN

M Z Ratajczak

Leukemia 2015 29: 776-782; advance online publication, December 9, 2014; 10.1038/leu.2014.346

Original Articles

THERAPY

Ibrutinib inhibits collagen-mediated but not ADP-mediated platelet aggregation

S Kamel, L Horton, L Ysebaert, M Levade, K Burbury, S Tan, M Cole-Sinclair, J Reynolds, R Filshie, S Schischka, A Khot, S Sandhu, M J Keating, H Nandurkar and C S Tam

Leukemia 2015 29: 783-787; advance online publication, August 20, 2014; 10.1038/leu.2014.247

ACUTE LEUKEMIAS

Cytotoxicity of CD56-positive lymphocytes against autologous B-cell precursor acute lymphoblastic leukemia cells

F Fei, M Lim, A A George, J Kirzner, D Lee, R Seeger, J Groffen, H Abdel-Azim and N Heisterkamp

Leukemia 2015 29: 788-797; advance online publication, August 19, 2014; 10.1038/leu.2014.246

MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia

E Mets, J Van der Meulen, G Van Peer, M Boice, P Mestdagh, I Van de Walle, T Lammens, S Goossens, B De Moerloose, Y Benoit, N Van Roy, E Clappier, B Poppe, J Vandesompele, H-G Wendel, T Taghon, P Rondou, J Soulier, P Van Vlierberghe and F Speleman

Leukemia 2015 29: 798-806; advance online publication, September 18, 2014; 10.1038/leu.2014.276

A regimen combining the Wee1 inhibitor AZD1775 with HDAC inhibitors targets human acute myeloid leukemia cells harboring various genetic mutations

L Zhou, Y Zhang, S Chen, M Kmieciak, Y Leng, H Lin, K A Rizzo, C I Dumur, A Ferreira-Gonzalez, Y Dai and S Grant

Leukemia 2015 29: 807-818; advance online publication, October 6, 2014; 10.1038/leu.2014.296

Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias

M L Tursky, D Beck, J A I Thoms, Y Huang, A Kumari, A Unnikrishnan, K Knezevic, K Evans, L A Richards, E Lee, J Morris, L Goldberg, S Izraeli, J W H Wong, J Olivier, R B Lock, K L MacKenzie and J E Pimanda

Leukemia 2015 29: 819-827; advance online publication, October 13, 2014; 10.1038/leu.2014.299

Dual PI3K/mTOR inhibition shows antileukemic activity in MLL-rearranged acute myeloid leukemia

N Sandhöfer, K H Metzeler, M Rothenberg, T Herold, S Tiedt, V Groiß, M Carlet, G Walter, T Hinrichsen, O Wachter, M Grunert, S Schneider, M Subklewe, A Dufour, S Fröhling, H-G Klein, W Hiddemann, I Jeremias and K Spiekermann

Leukemia 2015 29: 828-838; advance online publication, October 17, 2014; 10.1038/leu.2014.305

Clonal origins of ETV6-RUNX1⁺ acute lymphoblastic leukemia: studies in monozygotic twins

D Alpar, D Wren, L Ermini, M B Mansur, F W van Delft, C M Bateman, I Titley, L Kearney, T Szczepanski, D Gonzalez, A M Ford, N E Potter and M Greaves

Leukemia 2015 29: 839-846; advance online publication, November 12, 2014; 10.1038/leu.2014.322

MYELODYSPLASIAS

SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS

D Inoue, J Kitaura, H Matsui, H-A Hou, W-C Chou, A Nagamachi, K C Kawabata, K Togami, R Nagase, S Horikawa, M Saika, J-B Micol, Y Hayashi, Y Harada, H Harada, T Inaba, H-F Tien, O Abdel-Wahab and T Kitamura

Leukemia 2015 29: 847-857; advance online publication, October 13, 2014; 10.1038/leu.2014.301

CHRONIC MYELOPROLIFERATIVE NEOPLASIAS

Grb10 is involved in BCR-ABL-positive leukemia in mice

A L Illert, C Albers, S Kreutmair, H Leischner, C Peschel, C Miething and J Duyster

Leukemia 2015 29: 858-868; advance online publication, September 24, 2014; 10.1038/leu.2014.283

Clonal evolution revealed by whole genome sequencing in a case of primary myelofibrosis transformed to secondary acute myeloid leukemia

E K Engle, D A C Fisher, C A Miller, M D McLellan, R S Fulton, D M Moore, R K Wilson, T J Ley and S T Oh

Leukemia 2015 29: 869-876; advance online publication, September 25, 2014; 10.1038/leu.2014.289

CHRONIC LYMPHOCYTIC LEUKEMIA

Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia OPEN

J Malcikova, K Stano-Kozubik, B Tichy, B Kantorova, S Pavlova, N Tom, L Radova, J Smardova, F Pardy, M Doubek, Y Brychtova, M Mraz, K Plevova, E Diviskova, A Oltova, J Mayer, S Pospisilova and M Trbusek

Leukemia 2015 29: 877-885; advance online publication, October 28, 2014; 10.1038/leu.2014.297

IMMUNOLOGY

Immunosuppressive therapy of LGL leukemia: prospective multicenter phase II study by the Eastern Cooperative Oncology Group (E5998)

T P Loughran, Jr, L Zickl, T L Olson, V Wang, D Zhang, H L M Rajala, Z Hasanali, J M Bennett, H M Lazarus, M R Litzow, A M Evens, S Mustjoki and M S Tallman

Leukemia 2015 29: 886-894; advance online publication, September 13, 2014; 10.1038/leu.2014.298

SENSITIVITY AND RESISTANCE TO THERAPY

Functional characterization of BTK^C481S mutation that confers ibrutinib resistance: exploration of alternative kinase inhibitors

S Cheng, A Guo, P Lu, J Ma, M Coleman and Y L Wang

Leukemia 2015 29: 895-900; advance online publication, September 5, 2014; 10.1038/leu.2014.263

ONCOGENES, FUSION GENES AND TUMOR SUPPRESSOR GENES

Insulin-like growth factor 1 is a direct HOXA9 target important for hematopoietic transformation

J Steger, E Füller, M-P Garcia-Cuellar, K Hetzner and R K Slany

Leukemia 2015 29: 901-908; advance online publication, September 25, 2014; 10.1038/leu.2014.287

U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing

T Okeyo-Owuor, B S White, R Chatrikhi, D R Mohan, S Kim, M Griffith, L Ding, S Ketkar-Kulkarni, J Hundal, K M Laird, C L Kielkopf, T J Ley, M J Walter and T A Graubert

Leukemia 2015 29: 909-917; advance online publication, October 14, 2014; 10.1038/leu.2014.303

TRANSCRIPTIONAL CONTROL AND SIGNAL TRANSDUCTION

The role of TLR8 signaling in acute myeloid leukemia differentiation

J J Ignatz-Hoover, H Wang, S A Moreton, A Chakrabarti, M K Agarwal, K Sun, K Gupta and D N Wald

Leukemia 2015 29: 918-926; advance online publication, October 6, 2014; 10.1038/leu.2014.293

ANIMAL MODELS

Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice

B J Shields, R Alserihi, C Nasa, C Bogue, W S Alexander and M P McCormack

Leukemia 2015 29: 927-938; advance online publication, October 6, 2014; 10.1038/leu.2014.292

IL-35 mitigates murine acute graft-versus-host disease with retention of graft-versus-leukemia effects

Y Liu, Y Wu, Y Wang, Y Cai, B Hu, G Bao, H Fang, L Zhao, S Ma, Q Cheng, Y Song, Y Liu, Z Zhu, H Chang, X Yu, A Sun, Y Zhang, D A A Vignali, D Wu and H Liu

Leukemia 2015 29: 939-946; advance online publication, November 3, 2014; 10.1038/leu.2014.310

LYMPHOMA

Anti-CD20 therapy induces a memory Th1 response through the IFN-γ/IL-12 axis and prevents protumor regulatory T-cell expansion in mice

C Deligne, A Metidji, W-H Fridman and J-L Teillaud

Leukemia 2015 29: 947-957; advance online publication, September 18, 2014; 10.1038/leu.2014.275

The interleukin (IL)-31/IL-31R axis contributes to tumor growth in human follicular lymphoma

E Ferretti, C Tripodo, G Pagnan, C Guarnotta, D Marimpietri, M V Corrias, D Ribatti, S Zupo, G Fraternali-Orcioni, J L Ravetti, V Pistoia and A Corcione

Leukemia 2015 29: 958-967; advance online publication, October 6, 2014; 10.1038/leu.2014.291

A microRNA-mediated regulatory loop modulates NOTCH and MYC oncogenic signals in B- and T-cell malignancies

M Ortega, H Bhatnagar, A-P Lin, L Wang, J C Aster, H Sill and R C T Aguiar

Leukemia 2015 29: 968-976; advance online publication, October 14, 2014; 10.1038/leu.2014.302

Letters To The Editor

Rapid childhood T-ALL growth in xenograft models correlates with mature phenotype and NF-κB pathway activation but not with poor prognosis

S Poglio, X Cahu, B Uzan, C Besnard-Guérin, H Lapillonne, T Leblanc, A Baruchel, J Landman-Parker, A Petit, F Baleydier, S Amsellem, V Baud, P Ballerini and F Pflumio

Leukemia 2015 29: 977-980; advance online publication, November 5, 2014; 10.1038/leu.2014.317

Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia

M F Huelsemann, M Patz, L Beckmann, K Brinkmann, T Otto, J Fandrey, H J Becker, S Theurich, M von Bergwelt-Baildon, C P Pallasch, R P Zahedi, H Kashkar, H C Reinhardt, M Hallek, C M Wendtner and L P Frenzel

Leukemia 2015 29: 981-984; advance online publication, November 7, 2014; 10.1038/leu.2014.320

Epigenetic aging upon allogeneic transplantation: the hematopoietic niche does not affect age-associated DNA methylation

C I Weidner, P Ziegler, M Hahn, T H Brümmendorf, A D Ho, P Dreger and W Wagner

Leukemia 2015 29: 985-988; advance online publication, November 12, 2014; 10.1038/leu.2014.323

Prognostic value of monitoring a candidate immunophenotypic leukaemic stem/progenitor cell population in patients allografted for acute myeloid leukaemia

C Bradbury, A E Houlton, S Akiki, R Gregg, M Rindl, J Khan, J Ward, N Khan, M Griffiths, S Nagra, R Hills, A Burnett, N Russell, P Vyas, D Grimwade, C Craddock and S D Freeman

Leukemia 2015 29: 988-991; advance online publication, November 26, 2014; 10.1038/leu.2014.327

The rate of transformation from JAK2-mutated ET to PV is influenced by an accurate WHO-defined clinico-morphological diagnosis

T Barbui, J Thiele, A Carobbio, A M Vannucchi and A Tefferi

Leukemia 2015 29: 992-993; advance online publication, November 26, 2014; 10.1038/leu.2014.328

Constitutive phosphorylation of the active Notch1 intracellular domain in chronic lymphocytic leukemia cells with NOTCH1 mutation

F De Falco, R Sabatini, F Falzetti, M Di Ianni, P Sportoletti, S Baldoni, B Del Papa, I Screpanti, P Marconi and E Rosati

Leukemia 2015 29: 994-998; advance online publication, November 26, 2014; 10.1038/leu.2014.329