Scientific Reports Biology Table of Contents e-alert: 24 March 2015

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24 March 2015      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports               Biological Sciences               Identification of domestication-related loci associated with flowering time and seed size in soybean with the RAD-seq genotyping method ▶     Ling Zhou, Shi-Bo Wang, Jianbo Jian et al.     Flowering time and seed size are traits related to domestication. However, identification of domestication-related loci/genes of controlling the traits in soybean is rarely …             Congruent tactile stimulation reduces the strength of visual suppression during binocular rivalry ▶     Claudia Lunghi, David Alais     Presenting different images to each eye triggers ‘binocular rivalry’ in which one image is visible and the other suppressed, with the visible image alternating every second or …             Module organization and variance in protein-protein interaction networks ▶     Chun-Yu Lin, Tsai-Ling Lee, Yi-Yuan Chiu et al.     A module is a group of closely related proteins that act in concert to perform specific biological functions through protein–protein interactions (PPIs) that occur in time and …             Assembly of forest communities across East Asia – insights from phylogenetic community structure and species pool scaling ▶     Gang Feng, Xiangcheng Mi, Wolf L. Eiserhardt et al.     Local communities are assembled from larger-scale species pools via dispersal, environmental filtering, biotic interactions, and local stochastic demographic processes. The …             Design of a PDZbody, a bivalent binder of the E6 protein from human papillomavirus ▶     O. Andreas Karlsson, Juan Ramirez, Daniel Öberg et al.     Chronic infection by high risk human papillomavirus (HPV) strains may lead to cancer. Expression of the two viral oncoproteins E6 and E7 is largely responsible for …             Characterization of a novel N-acetylneuraminic acid lyase favoring N-acetylneuraminic acid synthesis ▶     Wenyan Ji, Wujin Sun, Jinmei Feng et al.     N-Acetylneuraminic acid lyase (NAL, E.C. number 4.1.3.3) is a Class I aldolase that catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (Neu5Ac) from pyruvate and N…             The Association of GSTM1 Deletion Polymorphism with Lung Cancer Risk in Chinese Population: Evidence from an Updated Meta-analysis ▶     Haiyan Yang, Siyu Yang, Jing Liu et al.     Previous studies have reported the association of glutathione S-transferase M1 (GSTM1) deletion polymorphism with genetic susceptibility of lung cancer in Chinese population. …             Integrating Clinical Indexes into Four-Diagnostic Information Contributes to the Traditional Chinese Medicine (TCM) Syndrome Diagnosis of Chronic Hepatitis B ▶     Hong Kang, Yu Zhao, Chao Li et al.     Traditional Chinese Medicine (TCM) treatment has been commonly used to treat Chronic Hepatitis B (CHB) in Asian countries based on TCM syndrome diagnosis, also called “ZHENG”. …             Fibronectin localization and fibrillization are affected by the presence of serum in culture media ▶     Alessandro Siani, Rong R. Khaw, Oliver W. G. Manley et al.     In vitro models of fibrotic phenomena are often based on the fibroblast-myofibroblast transition as the contraction-triggering cellular event. There are, however, multiple …             Titration of biologically active amyloid–β seeds in a transgenic mouse model of Alzheimer's disease ▶     Rodrigo Morales, Javiera Bravo-Alegria, Claudia Duran-Aniotz et al.     Experimental evidence in animal models suggests that misfolded Amyloid-β (Aβ) spreads in disease following a prion-like mechanism. Several properties characteristics of …             Reduction of nutrients, microbes, and personal care products in domestic wastewater by a benchtop electrocoagulation unit ▶     E. M. Symonds, M. M. Cook, S. M. McQuaig et al.     To preserve environmental and human health, improved treatment processes are needed to reduce nutrients, microbes, and emerging chemical contaminants from domestic wastewater …             Spatial evolutionary public goods game on complete graph and dense complex networks ▶     Jinho Kim, Huiseung Chae, Soon-Hyung Yook et al.     We study the spatial evolutionary public goods game (SEPGG) with voluntary or optional participation on a complete graph (CG) and on dense networks. Based on analyses of the …             Effects of waterlogging on carbon assimilate partitioning in the Zoigê alpine wetlands revealed by 13CO2 pulse labeling ▶     Jun-Qin Gao, Ju-Juan Gao, Xue-Wen Zhang et al.     Waterlogging has been suggested to affect carbon (C) turnover in wetlands, but how it affects C allocation and stocks remains unclear in alpine wetlands. Using in situ 13CO2 …             The relationship between coagulation abnormality and mortality in ICU patients: a prospective, observational study ▶     Aihua Fei, Qiang Lin, Jiafu Liu et al.     We conducted a prospective, observational study to assess the prognostic value of hemostasis-related parameters in unselected IC patients. We collected baseline characteristics …             Modulation of expression of genes involved in glycosaminoglycan metabolism and lysosome biogenesis by flavonoids ▶     Marta Moskot, Joanna Jakóbkiewicz-Banecka, Anna Kloska et al.     Flavonoids were found previously to modulate efficiency of synthesis of glycosaminoglycans (GAGs), compounds which are accumulated in cells of patients suffering from …             Leptin ameliorates ischemic necrosis of the femoral head in rats with obesity induced by a high-fat diet ▶     Lu Zhou, Kyu Yun Jang, Young Jae Moon et al.     Obesity is a risk factor for ischemic necrosis of the femoral head (INFH). The purpose of this study was to determine if leptin treatment of INFH stimulates new bone formation to …             Altered autophagic flux enhances inflammatory responses during inflammation-induced preterm labor ▶     Varkha Agrawal, Mukesh K. Jaiswal, Timothy Mallers et al.     Cellular organelles and proteins are degraded and recycled through autophagy, a process during which vesicles known as autophagosomes fuse with lysosomes. Altered autophagy …             Quantifying Nucleoporin Stoichiometry Inside Single Nuclear Pore Complexes In vivo ▶     Lan Mi, Alexander Goryaynov, Andre Lindquist et al.     The nuclear pore complex (NPC) is one of the largest supramolecular structures in eukaryotic cells. Its octagonal ring-scaffold perforates the nuclear envelope and features a …             In vitro γ-ray-induced inflammatory response is dominated by culturing conditions rather than radiation exposures ▶     G. Babini, J. Morini, G. Baiocco et al.     The inflammatory pathway has a pivotal role in regulating the fate and functions of cells after a wide range of stimuli, including ionizing radiation. However, the molecular …             Synergy between intention recognition and commitments in cooperation dilemmas ▶     The Anh Han, Francisco C. Santos, Tom Lenaerts et al.     Commitments have been shown to promote cooperation if, on the one hand, they can be sufficiently enforced, and on the other hand, the cost of arranging them is justified with …             MicroRNA-derived Fragment Length Polymorphism Assay ▶     Xiaoping Xie, Fang Tang, Zhao Yang et al.     MicroRNA (miRNA) studies are experiencing a transition from basic research applications to clinical applications. However, the lack of reliable and sensitive miRNA detection …             Transcriptome comparison of the sex pheromone glands from two sibling Helicoverpa species with opposite sex pheromone components ▶     Zhao-Qun Li, Shuai Zhang, Jun-Yu Luo et al.     Differences in sex pheromone component can lead to reproductive isolation. The sibling noctuid species, Helicoverpa armigera and Helicoverpa assulta, share the same two sex …             C6-ceramide nanoliposome suppresses tumor metastasis by eliciting PI3K and PKCζ tumor-suppressive activities and regulating integrin affinity modulation ▶     Pu Zhang, Changliang Fu, Yijuan Hu et al.     Nanoliposomal formulation of C6-ceramide, a proapoptotic sphingolipid metabolite, presents an effective way to treat malignant tumor. Here, we provide evidence that acute …             Transgenerational effects from early developmental exposures to bisphenol A or 17α-ethinylestradiol in medaka, Oryzias latipes ▶     Ramji K. Bhandari, Frederick S. vom Saal, Donald E. Tillitt     The transgenerational consequences of environmental contaminant exposures of aquatic vertebrates have the potential for broad ecological impacts, yet are largely uninvestigated. …             The mealybug Phenacoccus solenopsis suppresses plant defense responses by manipulating JA-SA crosstalk ▶     Peng-Jun Zhang, Fang Huang, Jin-Ming Zhang et al.     Induced plant defenses against herbivores are modulated by jasmonic acid-, salicylic acid-, and ethylene-signaling pathways. Although there is evidence that some pathogens …             Enhanced photocurrent production by bio-dyes of photosynthetic macromolecules on designed TiO2 film ▶     Daoyong Yu, Mengfei Wang, Guoliang Zhu et al.     The macromolecular pigment-protein complex has the merit of high efficiency for light-energy capture and transfer after long-term photosynthetic evolution. Here bio-dyes of A. …             Contest experience enhances aggressive behaviour in a fly: when losers learn to win ▶     Giovanni Benelli, Nicolas Desneux, Donato Romano et al.     In several animal species, aggressive experience influences the characteristics and outcomes of subsequent conflicts, such that winners are more likely to win again (the winner …             Molecular origins of synaptotagmin 1 activities on vesicle docking and fusion pore opening ▶     Ying Lai, Xiaochu Lou, Jiajie Diao et al.     Synaptotagmin 1 (Syt1), a major Ca2 sensor in neuroexocytosis, utilizes SNARE- and membrane-binding to regulate vesicle fusion, a required process for neurotransmitter release at …             Complex trait architecture: the pleiotropic model revisited ▶     T.-L. North, M. A. Beaumont     There is currently much debate about how much the genetic heritability of complex traits is due to very rare alleles. This issue is important because it determines sampling …             Hypergravity exposure during gestation modifies the TCRβ repertoire of newborn mice ▶     Stéphanie Ghislin, Nassima Ouzren-Zarhloul, Sandra Kaminski et al.     During spaceflight, organisms are subjected to mechanical force changes (gravity (G) changes) that affect the immune system. However, gravitational effects on lymphopoiesis have …             Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 “Therapeutic Window” ▶     Yingmin Zhu, Haijun Chen, Stephen Boulton et al.     The cAMP signaling cascade is one of the most frequently targeted pathways for the development of pharmaceutics. A plethora of recent genetic and pharmacological studies suggest …             The Relationship Between Lower Limb Bone and Muscle in Military Recruits, Response to Physical Training, and Influence of Smoking Status ▶     Zudin Puthucheary, Mehdi Kordi, Jai Rawal et al.     The relationship between bone and skeletal muscle mass may be affected by physical training. No studies have prospectively examined the bone and skeletal muscle responses to a …             Clustered Distribution of Natural Product Leads of Drugs in the Chemical Space as Influenced by the Privileged Target-Sites ▶     Lin Tao, Feng Zhu, Chu Qin et al.     Some natural product leads of drugs (NPLDs) have been found to congregate in the chemical space. The extent, detailed patterns, and mechanisms of this congregation phenomenon …             The bacterial communities associated with fecal types and body weight of rex rabbits ▶     Bo Zeng, Shushu Han, Ping Wang et al.     Rex rabbit is an important small herbivore for fur and meat production. However, little is known about the gut microbiota in rex rabbit, especially regarding their relationship …             Oligomerized, filamentous surface presentation of RANTES/CCL5 on vascular endothelial cells ▶     Inger Øynebråten, Nicolas Barois, Trygve Bergeland et al.     Vascular endothelial cells present luminal chemokines that arrest rolling leukocytes by activating integrins. It appears that several chemokines must form higher-order oligomers …             Functional Diversification and Specialization of Cytosolic 70-kDa Heat Shock Proteins ▶     Chelsea McCallister, Matthew C. Siracusa, Farzaneh Shirazi et al.     A fundamental question in molecular evolution is how protein functional differentiation alters the ability of cells and organisms to cope with stress and survive. To answer this …             Isolation of high-purity myenteric plexus from adult human and mouse gastrointestinal tract ▶     David Grundmann, Markus Klotz, Holger Rabe et al.     The enteric nervous system (ENS) orchestrates a broad range of important gastrointestinal functions such as intestinal motility and gastric secretion. The ENS can be affected by …             Distinct type I and type II toxin-antitoxin modules control Salmonella lifestyle inside eukaryotic cells ▶     Damián Lobato-Márquez, Inmaculada Moreno-Córdoba, Virginia Figueroa et al.     Toxin-antitoxin (TA) modules contribute to the generation of non-growing cells in response to stress. These modules abound in bacterial pathogens although the bases for this …             Inferring Cuisine - Drug Interactions Using the Linked Data Approach ▶     Milos Jovanovik, Aleksandra Bogojeska, Dimitar Trajanov et al.     Food - drug interactions are well studied, however much less is known about cuisine - drug interactions. Non-native cuisines are becoming increasingly more popular as they are …             NHE8 Is Essential for RPE Cell Polarity and Photoreceptor Survival ▶     Chun-hong Xia, Haiquan Liu, Debra Cheung et al.     A new N-ethyl-N-nitrosourea (ENU)-induced mouse recessive mutation, identified by fundus examination of the eye, develops depigmented patches, indicating retinal disorder. …             Elevated CO2 shifts the functional structure and metabolic potentials of soil microbial communities in a C4 agroecosystem ▶     Jinbo Xiong, Zhili He, Shengjing Shi et al.     Atmospheric CO2 concentration is continuously increasing, and previous studies have shown that elevated CO2 (eCO2) significantly impacts C3 plants and their soil microbial …             Calcium, ARMS2 Genotype, and Chlamydia Pneumoniae Infection in Early Age-Related Macular Degeneration: a Multivariate Analysis from the Nagahama Study ▶     Isao Nakata, Kenji Yamashiro, Takahisa Kawaguchi et al.     Although various risk factors have been identified for the development of age-related macular degeneration (AMD), risk factors of early AMD have been relatively under studied. We …             Liquid chromatography-mass spectrometry platform for both small neurotransmitters and neuropeptides in blood, with automatic and robust solid phase extraction ▶     Elin Johnsen, Siri Leknes, Steven Ray Wilson et al.     Neurons communicate via chemical signals called neurotransmitters (NTs). The numerous identified NTs can have very different physiochemical properties (solubility, charge, size …             Urinary candidate biomarker discovery in a rat unilateral ureteral obstruction model ▶     Yuan Yuan, Fanshuang Zhang, Jianqiang Wu et al.     Urine has the potential to become a better source of biomarkers. Urinary proteins are affected by many factors; therefore, differentiating between the variables associated with …             Gene Expression Mapping of Histone Deacetylases and Co-factors, and Correlation with Survival Time and 1H-HRMAS Metabolomic Profile in Human Gliomas ▶     Nassim Dali-Youcef, Sébastien Froelich, François-Marie Moussallieh et al.     Primary brain tumors are presently classified based on imaging and histopathological techniques, which remains unsatisfaying. We profiled here by quantitative real time PCR …             Down-regulation of miR-206 is associated with Hirschsprung disease and suppresses cell migration and proliferation in cell models ▶     Ankur Sharan, Hairong Zhu, Hua Xie et al.     Hirschsprung disease (HSCR) is a well-known congenital digestive disease that originates due to the developmental disorder of neural crest cells. MiR-206 is kown to have a …             Association Between Patatin-Like Phospholipase Domain Containing 3 Gene (PNPLA3) Polymorphisms and Nonalcoholic Fatty Liver Disease: A HuGE Review and Meta-Analysis ▶     Renfan Xu, Anyu Tao, Shasha Zhang et al.     We conducted a meta-analysis to assess the association between patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 polymorphism and nonalcoholic fatty liver disease …             Generation mechanism of hydroxyl radical species and its lifetime prediction during the plasma-initiated ultraviolet (UV) photolysis ▶     Pankaj Attri, Yong Hee Kim, Dae Hoon Park et al.     Through this work, we have elucidated the mechanism of hydroxyl radicals (OH•) generation and its life time measurements in biosolution. We observed that plasma-initiated …             p53-dependent expression of CXCR5 chemokine receptor in MCF-7 breast cancer cells ▶     Nikita A. Mitkin, Christina D. Hook, Anton M. Schwartz et al.     Elevated expression of chemokine receptors in tumors has been reported in many instances and is related to a number of survival advantages for tumor cells including abnormal …             A combination of targeted enrichment methodologies for whole-exome sequencing reveals novel pathogenic mutations ▶     Fuyuki Miya, Mitsuhiro Kato, Tadashi Shiohama et al.     Whole-exome sequencing (WES) is a useful method to identify disease-causing mutations, however, often no candidate mutations are identified using commonly available targeted …             In Vitro Epithelial Organoid Generation Induced by Substrate Nanotopography ▶     Yusheng Shen, Youmin Hou, Shuhuai Yao et al.     The extracellular matrix (ECM) exhibits tissue-specific topography and composition and plays a crucial role in initiating the biochemical and biomechanical signaling required for …             Understanding the effect of alternative splicing in the folding and function of the second PDZ from Protein Tyrosine Phosphatase-BL ▶     Eva Di Silvio, Angelo Toto, Daniela Bonetti et al.     PDZ domains are the most prominent biological structural domains involved in protein-protein interactions in the human cell. The second PDZ domain of the protein tyrosine …             ZNF32 inhibits autophagy through the mTOR pathway and protects MCF-7 cells from stimulus-induced cell death ▶     Yanyan Li, Le Zhang, Kai Li et al.     ZNF32 is a recently identified zinc finger protein and its functions remain largely unknown. Autophagy has been shown to affect cell proliferation and survival. Here, we …             Indole diketopiperazines from endophytic Chaetomium sp 88194 induce breast cancer cell apoptotic death ▶     Fu-qian Wang, Qing-yi Tong, Hao-ran Ma et al.     Diketopiperazines are important secondary metabolites of the fungi with variety bioactivities. Several species belonging to genus Chaetomium produce compounds of this class, such …             Palladium-Mediated Dealkylation of N-Propargyl-Floxuridine as a Bioorthogonal Oxygen-Independent Prodrug Strategy ▶     Jason T. Weiss, Neil O. Carragher, Asier Unciti-Broceta     Herein we report the development and biological screening of a bioorthogonal palladium-labile prodrug of the nucleoside analogue floxuridine, a potent antineoplastic drug used in …             Early crocodylomorph increases top tier predator diversity during rise of dinosaurs ▶     Lindsay E. Zanno, Susan Drymala, Sterling J. Nesbitt et al.     Triassic predatory guild evolution reflects a period of ecological flux spurred by the catastrophic end-Permian mass extinction and terminating with the global ecological …             High survival of mouse oocytes/embryos after vitrification without permeating cryoprotectants followed by ultra-rapid warming with an IR laser pulse ▶     Bo Jin, Peter Mazur     Vitrification is now the main route to the cryopreservation of human and animal oocytes and preimplantation embryos. A central belief is that for success, the cells must be …             The Impact of Concomitant Genomic Alterations on Treatment Outcome for Trastuzumab Therapy in HER2-Positive Gastric Cancer ▶     Ji Yun Lee, Mineui Hong, Seung Tae Kim et al.     Clinical benefit from trastuzumab and other anti-human epidermal growth factor receptor-2 (HER2) therapies in patients with HER2-positive gastric cancer (GC) remains limited by …             A combinatorial approach of comprehensive QTL-based comparative genome mapping and transcript profiling identified a seed weight-regulating candidate gene in chickpea ▶     Deepak Bajaj, Hari D. Upadhyaya, Yusuf Khan et al.     High experimental validation/genotyping success rate (94–96%) and intra-specific polymorphic potential (82–96%) of 1536 SNP and 472 SSR markers showing in silico polymorphism …             Single cell visualization of transcription kinetics variance of highly mobile identical genes using 3D nanoimaging ▶     Paolo Annibale, Enrico Gratton     Multi-cell biochemical assays and single cell fluorescence measurements revealed that the elongation rate of Polymerase II (PolII) in eukaryotes varies largely across different …             Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health ▶     Usman Ahmed, Attia Anwar, Richard S. Savage et al.     There is currently no biochemical test for detection of early-stage osteoarthritis (eOA). Tests for early-stage rheumatoid arthritis (eRA) such as rheumatoid factor (RF) and …             Circulating Peptidome to Indicate the Tumor-resident Proteolysis ▶     Zaian Deng, Yaojun Li, Jia Fan et al.     Tumor-resident proteases (TRPs) are regarded as informative biomarkers for staging cancer progression and evaluating therapeutic efficacy. Currently in the clinic, measurement of …             bFGF regulates autophagy and ubiquitinated protein accumulation induced by myocardial ischemia/reperfusion via the activation of the PI3K/Akt/mTOR pathway ▶     Zhou-Guang Wang, Yue Wang, Yan Huang et al.     Autophagy is involved in the development and/or progression of many diseases, including myocardial ischemia/reperfusion (I/R). In this study, we hypothesized a protective role of …             Role of liposome and peptide in the synergistic enhancement of transfection with a lipopolyplex vector ▶     Mustafa M. Munye, Jascindra Ravi, Aristides D. Tagalakis et al.     Lipopolyplexes are of widespread interest for gene therapy due to their multifunctionality and high transfection efficiencies. Here we compared the biological and biophysical …             Divalent cations and molecular crowding buffers stabilize G-triplex at physiologically relevant temperatures ▶     Hong-Xin Jiang, Yunxi Cui, Ting Zhao et al.     G-triplexes are non-canonical DNA structures formed by G-rich sequences with three G-tracts. Putative G-triplex-forming sequences are expected to be more prevalent than putative …             Probing Immobilization Mechanism of alpha-chymotrypsin onto Carbon Nanotube in Organic Media by Molecular Dynamics Simulation ▶     Liyun Zhang, Xiuchan Xiao, Yuan Yuan et al.     The enzyme immobilization has been adopted to enhance the activity and stability of enzymes in non-aqueous enzymatic catalysis. However, the activation and stabilization …             Mechanochemical regulations of RPA's binding to ssDNA ▶     Jin Chen, Shimin Le, Anindita Basu et al.     Replication protein A (RPA) is a ubiquitous eukaryotic single-stranded DNA (ssDNA) binding protein that serves to protect ssDNA from degradation and annealing, and as a template …             Deciphering deterioration mechanisms of complex diseases based on the construction of dynamic networks and systems analysis ▶     Yuanyuan Li, Suoqin Jin, Lei Lei et al.     The early diagnosis and investigation of the pathogenic mechanisms of complex diseases are the most challenging problems in the fields of biology and medicine. Network-based …             Sensitization of Gram-negative bacteria to rifampin and OAK combinations ▶     Joanna Jammal, Fadia Zaknoon, Galoz Kaneti et al.     While individually inefficient against Gram-negative bacteria, in-vitro combinations of rifampin and OAK were mutually synergistic since sub-minimal inhibitory concentrations of …             Distribution and heritability of diurnal preference (chronotype) in a rural Brazilian family-based cohort, the Baependi study ▶     Malcolm von Schantz, Tamara P. Taporoski, Andréa R. V. R. Horimoto et al.     Diurnal preference (chronotype) is a useful instrument for studying circadian biology in humans. It harbours trait-like dimensions relating to circadian period and sleep …             Global mapping transcriptional start sites revealed both transcriptional and post-transcriptional regulation of cold adaptation in the methanogenic archaeon Methanolobus psychrophilus ▶     Jie Li, Lei Qi, Yang Guo et al.     Psychrophilic methanogenic Archaea contribute significantly to global methane emissions, but archaeal cold adaptation mechanisms remain poorly understood. Hinted by that mRNA …             The Secretion Process of Liquid Silk with Nanopillar Structures from Stenopsyche marmorata (Trichoptera: Stenopsychidae) ▶     Tomohiro Hatano, Takayuki Nagashima     Stenopsyche marmorata larvae spin underwater adhesive silk for constructing nests and capture nets. The silk can be divided into fiber and adhesive regions, according to their …             Effect of Electric Field Gradient on Sub-nanometer Spatial Resolution of Tip-enhanced Raman Spectroscopy ▶     Lingyan Meng, Zhilin Yang, Jianing Chen et al.     Tip-enhanced Raman spectroscopy (TERS) with sub-nanometer spatial resolution has been recently demonstrated experimentally. However, the physical mechanism underlying is still …             Differentiation of human induced pluripotent stem cells to mature functional Purkinje neurons ▶     Shuyan Wang, Bin Wang, Na Pan et al.     It remains a challenge to differentiate human induced pluripotent stem cells (iPSCs) or embryonic stem (ES) cells to Purkinje cells. In this study, we derived iPSCs from human …             Si-CSP9 regulates the integument and moulting process of larvae in the red imported fire ant, Solenopsis invicta ▶     Daifeng Cheng, Yongyue Lu, Ling Zeng et al.     Chemosensory proteins (CSPs) have been predicted to be involved in development; however, direct evidence for their involvement is lacking, and genetic basis is largely unknown. …             CASP7 variants modify susceptibility to cervical cancer in Chinese women ▶     Ting-Yan Shi, Jing He, Meng-Yun Wang et al.     Polymorphisms in Caspase-7 (CASP7) may modulate the programmed cell death and thus contribute to cervical cancer risk. In this case-control study of 1,486 cervical cancer cases …             Breeding scheme and maternal small RNAs affect the efficiency of transgenerational inheritance of a paramutation in mice ▶     Shuiqiao Yuan, Daniel Oliver, Andrew Schuster et al.     Paramutations result from interactions between two alleles at a single locus, whereby one induces a heritable change in the other. Although common in plants, paramutations are …             Analysis of the metabolome of Anopheles gambiae mosquito after exposure to Mycobacterium ulcerans ▶     J. Charles Hoxmeier, Brice D. Thompson, Corey D. Broeckling et al.     Infection with Mycobacterium ulcerans causes Buruli Ulcer, a neglected tropical disease. Mosquito vectors are suspected to participate in the transmission and environmental …             Reduced MCMV Δm157 viral clearance in the absence of TSAd ▶     P. Moussa, G. Abrahamsen, N. Fodil et al.     The T cell specific adapter protein (TSAd) is expressed in activated T cells and NK cells. While TSAd is beginning to emerge as a critical regulator of Lck and Itk activity in T …             Overexpression of DHX32 contributes to the growth and metastasis of colorectal cancer ▶     Huayue Lin, Wenjuan Liu, Zanxi Fang et al.     Our previous work demonstrates that DHX32 is upregulated in colorectal cancer (CRC) compared to its adjacent normal tissues. However, how overexpressed DHX32 contributes to CRC …             Synergetic Action of Domain II and IV Underlies Persistent Current Generation in Nav1.3 as revealed by a tarantula toxin ▶     Cheng Tang, Xi Zhou, Yunxiao Zhang et al.     The persistent current (INaP) through voltage-gated sodium channels enhances neuronal excitability by causing prolonged depolarization of membranes. Nav1.3 intrinsically …             Supervised exercise training reduces oxidative stress and cardiometabolic risk in adults with type 2 diabetes: a randomized controlled trial ▶     Giovanni Vinetti, Chiara Mozzini, Paolo Desenzani et al.     To evaluate the effects of supervised exercise training (SET) on cardiometabolic risk, cardiorespiratory fitness and oxidative stress status in 2 diabetes mellitus (T2DM), twenty …             Network-based proteomic approaches reveal the neurodegenerative, neuroprotective and pain-related mechanisms involved after retrograde axonal damage ▶     Caty Casas, Laura Isus, Mireia Herrando-Grabulosa et al.     Neurodegenerative processes are preceded by neuronal dysfunction and synaptic disconnection. Disconnection between spinal motoneuron (MN) soma and synaptic target leads either to …             Structure based aggregation studies reveal the presence of helix-rich intermediate during α-Synuclein aggregation ▶     Dhiman Ghosh, Pradeep K. Singh, Shruti Sahay et al.     Mechanistic understanding of nucleation dependent polymerization by α-synuclein (α-Syn) into toxic oligomers and amyloids is important for the drug development against …             Isotopic Resonance Hypothesis: Experimental Verification by Escherichia coli Growth Measurements ▶     Xueshu Xie, Roman A. Zubarev     Isotopic composition of reactants affects the rates of chemical and biochemical reactions. As a rule, enrichment of heavy stable isotopes leads to progressively slower reactions. …             Using size-selected gold clusters on graphene oxide films to aid cryo-transmission electron tomography alignment ▶     Kenton P. Arkill, Judith M. Mantell, Simon R. Plant et al.     A three-dimensional reconstruction of a nano-scale aqueous object can be achieved by taking a series of transmission electron micrographs tilted at different angles in vitreous …             IP-10 measured by Dry Plasma Spots as biomarker for therapy responses in Mycobacterium Tuberculosis infection ▶     Kristian Tonby, Morten Ruhwald, Dag Kvale et al.     Tuberculosis (TB) has huge impact on human morbidity and mortality and biomarkers to support rapid TB diagnosis and ensure treatment initiation and cure are needed, especially in …             A novel composite conductive microfiltration membrane and its anti-fouling performance with an external electric field in membrane bioreactors ▶     Jian Huang, Zhiwei Wang, Junyao Zhang et al.     Membrane fouling remains an obstacle to wide-spread applications of membrane bioreactors (MBRs) for wastewater treatment and reclamation. Herein, we report a simple method to …             Genetic variations in sites of affinity between FVIII and LRP1 are not associated with high FVIII levels in venous thromboembolism ▶     Luis F. Bittar, Lucia H. Siqueira, Fernanda A. Orsi et al.     Increased factor VIII (FVIII) levels are a prevalent and independent risk factor for venous thromboembolism (VTE). The low density lipoprotein receptor-related protein 1 (LRP1) …             Macaques Exhibit a Naturally-Occurring Depression Similar to Humans ▶     Fan Xu, Qingyuan Wu, Liang Xie et al.     Rodent models have dominated preclinical investigations into the mechanisms of depression. However, these models-which rely on subjecting individual rodents to physical stressors …             Role of Ran-regulated nuclear-cytoplasmic trafficking of pVHL in the regulation of microtubular stability-mediated HIF-1α in hypoxic cardiomyocytes ▶     Xupin Jiang, Dongxia Zhang, Hengshu Zhang et al.     Our previous study suggested that microtubule network alteration affects the process of glycolysis in cardiomyocytes (CMs) via the regulation of hypoxia-inducible factor (HIF)-1α …             The juxtamembrane regions of human receptor tyrosine kinases exhibit conserved interaction sites with anionic lipids ▶     George Hedger, Mark S. P. Sansom, Heidi Koldsø     Receptor tyrosine kinases (RTKs) play a critical role in diverse cellular processes and their activity is regulated by lipids in the surrounding membrane, including PIP2 …             Imbalanced functional link between executive control network and reward network explain the online-game seeking behaviors in Internet gaming disorder ▶     Guangheng Dong, Xiao Lin, Yanbo Hu et al.     Literatures have shown that Internet gaming disorder (IGD) subjects show impaired executive control and enhanced reward sensitivities than healthy controls. However, how these …             Requirement of CHROMOMETHYLASE3 for somatic inheritance of the spontaneous tomato epimutation Colourless non-ripening ▶     Weiwei Chen, Junhua Kong, Cheng Qin et al.     Naturally-occurring epimutants are rare and have mainly been described in plants. However how these mutants maintain their epigenetic marks and how they are inherited remain …             The multikinase inhibitor Sorafenib enhances glycolysis and synergizes with glycolysis blockade for cancer cell killing ▶     Valentina Tesori, Anna Chiara Piscaglia, Daniela Samengo et al.     Although the only effective drug against primary hepatocarcinoma, the multikinase inhibitor Sorafenib (SFB) usually fails to eradicate liver cancer. Since SFB targets …             A Nomogram for Predicting the Benefit of Adjuvant Cytokine-Induced Killer Cell Immunotherapy in Patients with Hepatocellular Carcinoma ▶     Qiu-Zhong Pan, Qi-Jing Wang, Jia-Qiang Dan et al.     The benefits of adjuvant cytokine-induced killer (CIK) cell immunotherapy for hepatocellular carcinoma (HCC) remain mixed among patients. Here, we constructed a prognostic …             Major decline in marine and terrestrial animal consumption by brown bears (Ursus arctos) ▶     Jun Matsubayashi, Junko O. Morimoto, Ichiro Tayasu et al.     Human activities have had the strongest impacts on natural ecosystems since the last glacial period, including the alteration of interspecific relationships such as food webs. In …             A platform for rapid generation of single and multiplexed reporters in human iPSC lines ▶     Ying Pei, Guadalupe Sierra, Renuka Sivapatham et al.     Induced pluripotent stem cells (iPSC) are important tools for drug discovery assays and toxicology screens. In this manuscript, we design high efficiency TALEN and ZFN to target …             Structural conservation among the rhodopsin-like and other G protein-coupled receptors ▶     Mikitaka Kinoshita, Tetsuji Okada     Intramolecular remote coupling within the polypeptide backbones of membrane proteins is difficult to analyze owing to the limited structural information available at the atomic …             Does left-handedness confer resistance to spatial bias? ▶     Corinne A. Bareham, Tristan A. Bekinschtein, Sophie K. Scott et al.     We recently demonstrated that drowsiness, indexed using EEG, was associated with left-inattention in a group of 26 healthy right-handers. This has been linked to …             Unexpected behavioural consequences of preterm newborns' clothing ▶     Virginie Durier, Séverine Henry, Emmanuelle Martin et al.     Restrictions of preterm newborns' movements could have consequences ranging from stress enhancement to impairment of their motor development. Therefore, ability to freely express …             Characterization of macrophage - cancer cell crosstalk in estrogen receptor positive and triple-negative breast cancer ▶     Maija Hollmén, Filip Roudnicky, Sinem Karaman et al.     Tumor heterogeneity may broadly influence the activation of tumor-associated macrophages. We aimed to dissect how breast cancer cells of different molecular characteristics …             Rsite: a computational method to identify the functional sites of noncoding RNAs ▶     Pan Zeng, Jianwei Li, Wei Ma et al.     There is an increasing demand for identifying the functional sites of noncoding RNAs (ncRNAs). Here we introduce a tertiary-structure based computational approach, Rsite, which …             miRNA in situ hybridization in circulating tumor cells - MishCTC ▶     Francisco G. Ortega, Jose A. Lorente, Jose L. Garcia Puche et al.     Circulating tumor cells (CTCs) must be phenotypically and genetically characterized before they can be utilized in clinical applications. Here, we present the first protocol for …             Pushing the limit: Examining factors that affect anoxia tolerance in a single genotype of adult D. melanogaster ▶     Raquel Benasayag-Meszaros, Monica G. Risley, Priscilla Hernandez et al.     Drosophila melanogaster is a promiscuous species that inhabits a large range of harsh environments including flooded habitats and varying temperature changes. To survive these …             Identification of genetic variations associated with epsilon-poly-lysine biosynthesis in Streptomyces albulus ZPM by genome sequencing ▶     Lin Wang, Chunhui Gao, Nan Tang et al.     The biosynthesis of the antibiotic epsilon-poly-lysine (ε-PL) in Streptomyces albulus is performed by polylysine synthase (pls); however, the regulatory mechanism of this process …             Topological analysis of the Escherichia coli WcaJ protein reveals a new conserved configuration for the polyisoprenyl-phosphate hexose-1-phosphate transferase family ▶     Sarah E. Furlong, Amy Ford, Lorena Albarnez-Rodriguez et al.     WcaJ is an Escherichia coli membrane enzyme catalysing the biosynthesis of undecaprenyl-diphosphate-glucose, the first step in the assembly of colanic acid exopolysaccharide. …             Sex differences in skeletal muscle Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) levels: A cross-sectional study ▶     M. Constantine Samaan, Sonia S. Anand, Arya M. Sharma et al.     Women have higher adiposity but maintain insulin sensitivity when compared to men. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibits insulin signaling, but …             Intergenerational continuity of cell shape dynamics in Caulobacter crescentus ▶     Charles S. Wright, Shiladitya Banerjee, Srividya Iyer-Biswas et al.     We investigate the intergenerational shape dynamics of single Caulobacter crescentus cells using a novel combination of imaging techniques and theoretical modeling. We determine …             The Glycan Role in the Glycopeptide Immunogenicity Revealed by Atomistic Simulations and Spectroscopic Experiments on the Multiple Sclerosis Biomarker CSF114(Glc) ▶     Agostino Bruno, Mario Scrima, Ettore Novellino et al.     Glycoproteins are often recognized as not-self molecules by antibodies triggering the onset of severe autoimmune diseases such as Multiple Sclerosis (MS). Thus, the development …             A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging ▶     Haruki Eguchi, Masanari Umemura, Reiko Kurotani et al.     Research on controlled drug delivery for cancer chemotherapy has focused mainly on ways to deliver existing anti-cancer drug compounds to specified targets, e.g., by conjugating …             Flagellar Kinematics and Swimming of Algal Cells in Viscoelastic Fluids ▶     B. Qin, A. Gopinath, J. Yang et al.     The motility of microorganisms is influenced greatly by their hydrodynamic interactions with the fluidic environment they inhabit. We show by direct experimental observation of …             CORRIGENDUM: Landscape cultivation alters δ30Si signature in terrestrial ecosystems ▶     Floor I. Vandevenne, Claire Delvaux, Harold J. Hughes et al.                 Transient contribution of left posterior parietal cortex to cognitive restructuring ▶     Chihiro Sutoh, Daisuke Matsuzawa, Yoshiyuki Hirano et al.     Cognitive restructuring is a fundamental method within cognitive behavioural therapy of changing dysfunctional beliefs into flexible beliefs and learning to react appropriately …             Ruthenium Polypyridyl Complex Inhibits Growth and Metastasis of Breast Cancer Cells by Suppressing FAK signaling with Enhancement of TRAIL-induced Apoptosis ▶     Wenqiang Cao, Wenjie Zheng, Tianfeng Chen     Ruthenium-based complexes have emerged as promising antitumor and antimetastatic agents during the past decades. However, the limited understanding of the antimetastatic …             Detection of single ion channel activity with carbon nanotubes ▶     Weiwei Zhou, Yung Yu Wang, Tae-Sun Lim et al.     Many processes in life are based on ion currents and membrane voltages controlled by a sophisticated and diverse family of membrane proteins (ion channels), which are comparable …             Collisions of deformable cells lead to collective migration ▶     Jakob Löber, Falko Ziebert, Igor S. Aranson     Collective migration of eukaryotic cells plays a fundamental role in tissue growth, wound healing and immune response. The motion, arising spontaneously or in response to …             Trek1 contributes to maintaining nasal epithelial barrier integrity ▶     Jing Jiang, Jiang-Qi Liu, Jing Li et al.     Epithelial barrier integrity is critical to maintain the homeostasis in the body. The regulatory mechanism of the epithelial barrier function has not been fully understood. This …             Error-based Extraction of States and Energy Landscapes from Experimental Single-Molecule Time-Series ▶     J. Nicholas Taylor, Chun-Biu Li, David R. Cooper et al.     Characterization of states, the essential components of the underlying energy landscapes, is one of the most intriguing subjects in single-molecule (SM) experiments due to the …             Quo vadis? Microbial profiling revealed strong effects of cleanroom maintenance and routes of contamination in indoor environments ▶     Christine Moissl-Eichinger, Anna K. Auerbach, Alexander J. Probst et al.     Space agencies maintain highly controlled cleanrooms to ensure the demands of planetary protection. 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