Scientific Reports Biology Table of Contents e-alert: 17 March 2015

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17 March 2015      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports         nature.com webcasts Nature Publishing Group presents a custom webcast on: Using cellular reprogramming and live cell identification to advance cardiac disease modelling   Wednesday 18 March, 8AM PDT, 11AM EDT, 3PM GMT, 4PM CET Register for the webcast and live Q & A session    Sponsored by: EMD Millipore           Biological Sciences               An Unprecedented alteration in mode of action of IsCT resulting its translocation into bacterial cytoplasm and inhibition of macromolecular syntheses ▶     Jitendra K. Tripathi, Manoj Kathuria, Amit Kumar et al.     IsCT, a 13-residue, non-cell-selective antimicrobial peptide is comprised of mostly hydrophobic residues and lesser cationic residues. Assuming that placement of an additional …             Canine helper-dependent vectors production: implications of Cre activity and co-infection on adenovirus propagation ▶     Paulo Fernandes, Ana I. Almeida, Eric J. Kremer et al.     The importance of Cre recombinase to minimize helper vector (HV) contamination during helper-dependent adenovirus vectors (HDVs) production is well documented. However, Cre …             Enhancer-promoter interaction facilitated by transiently forming G-quadruplexes ▶     Hedi Hegyi     G-quadruplexes are guanine-rich nucleic acid sequences capable of forming a four-stranded structure through Hoogsteen hydrogen bonding. G-quadruplexes are highly concentrated …             Determination of Base Binding Strength and Base Stacking Interaction of DNA Duplex Using Atomic Force Microscope ▶     Tian-biao Zhang, Chang-lin Zhang, Zai-li Dong et al.     As one of the most crucial properties of DNA, the structural stability and the mechanical strength are attracting a great attention. Here, we take advantage of high force …             Oseltamivir Expands Quasispecies of Influenza Virus through Cell-to-cell Transmission ▶     Kotaro Mori, Kensaku Murano, Ryosuke L. Ohniwa et al.     The population of influenza virus consists of a huge variety of variants, called quasispecies, due to error-prone replication. Previously, we reported that progeny virions of …             Plant community composition determines the strength of top-down control in a soil food web motif ▶     Madhav Prakash Thakur, Nico Eisenhauer     Top-down control of prey by predators are magnified in productive ecosystems due to higher sustenance of prey communities. In soil micro-arthropod food webs, plant communities …             Contact Bubble Bilayers with Flush Drainage ▶     Masayuki Iwamoto, Shigetoshi Oiki     Planar lipid bilayers have been used to form stable bilayers into which membrane proteins are reconstituted for measurements of their function under an applied membrane …             Nr0b1 is a negative regulator of Zscan4c in mouse embryonic stem cells ▶     Setsuko Fujii, Satomi Nishikawa-Torikai, Yoko Futatsugi et al.     Nuclear receptor subfamily 0, group B, member 1 (Nr0b1, also known as Dax1) is regarded as an important component of the transcription factor network that governs pluripotency in …             Hyperpolarized 15N-pyridine Derivatives as pH-Sensitive MRI Agents ▶     Weina Jiang, Lloyd Lumata, Wei Chen et al.     Highly sensitive MR imaging agents that can accurately and rapidly monitor changes in pH would have diagnostic and prognostic value for many diseases. Here, we report an …             7-Ketocholesterol Increases Retinal Microglial Migration, Activation, and Angiogenicity: A Potential Pathogenic Mechanism Underlying Age-related Macular Degeneration ▶     Maanasa Indaram, Wenxin Ma, Lian Zhao et al.     Age-related macular degeneration (AMD) has been associated with both accumulation of lipid and lipid oxidative products, as well as increased neuroinflammatory changes and …             Rational stabilization of complex proteins: a divide and combine approach ▶     Emilio Lamazares, Isabel Clemente, Marta Bueno et al.     Increasing the thermostability of proteins is often crucial for their successful use as analytic, synthetic or therapeutic tools. Most rational thermostabilization strategies …             Progranulin Knockout Accelerates Intervertebral Disc Degeneration in Aging Mice ▶     Yun-peng Zhao, Qing-yun Tian, Ben Liu et al.     Intervertebral disc (IVD) degeneration is a common degenerative disease, yet much is unknown about the mechanisms during its pathogenesis. Herein we investigated whether …             Highly efficient cell-type-specific gene inactivation reveals a key function for the DrosophilaFUS homolog cabeza in neurons ▶     Marie Frickenhaus, Marina Wagner, Moushami Mallik et al.     To expand the rich genetic toolkit of Drosophila melanogaster, we evaluated whether introducing FRT or LoxP sites in endogenous genes could allow for cell-type-specific gene …             New Insights into the Mechanisms of Gene Electrotransfer – Experimental and Theoretical Analysis ▶     Mojca Pavlin, Maša Kandušer     Gene electrotransfer is a promising non-viral method of gene delivery. In our in vitro study we addressed open questions about this multistep process: how electropermeabilization …             Metagenomic sequencing reveals altered metabolic pathways in the oral microbiota of sailors during a long sea voyage ▶     Weiwei Zheng, Ze Zhang, Cuihua Liu et al.     Seafaring is a difficult occupation, and sailors face higher health risks than individuals on land. Commensal microbiota participates in the host immune system and metabolism, …             Novel Type II and Monomeric NAD+ Specific Isocitrate Dehydrogenases: Phylogenetic Affinity, Enzymatic Characterization, and Evolutionary Implication ▶     Peng Wang, Changqi Lv, Guoping Zhu     NAD use is an ancestral trait of isocitrate dehydrogenase (IDH), and the NADP phenotype arose through evolution as an ancient adaptation event. However, no NAD-specific IDHs have …             Amide-controlled, one-pot synthesis of tri-substituted purines generates structural diversity and analogues with trypanocidal activity ▶     Maria J. Pineda de las Infantas y Villatoro, Juan D. Unciti-Broceta, Rafael Contreras-Montoya et al.     A novel one-pot synthesis of tri-substituted purines and the discovery of purine analogues with trypanocidal activity are reported. The reaction is initiated by a metal-free …             Bisphenol-A Affects Male Fertility via Fertility-related Proteins in Spermatozoa ▶     Md Saidur Rahman, Woo-Sung Kwon, June-Sub Lee et al.     The xenoestrogen bisphenol-A (BPA) is a widespread environmental contaminant that has been studied for its impact on male fertility in several species of animals and humans. …             Mitochondrial superoxide in osteocytes perturbs canalicular networks in the setting of age-related osteoporosis ▶     Keiji Kobayashi, Hidetoshi Nojiri, Yoshitomo Saita et al.     Osteocytes are major bone cells that play a crucial role in maintaining the quality of and healing damage to bone tissue. The number of living osteocytes and canalicular networks …             Combination of Electroacupuncture and Grafted Mesenchymal Stem Cells Overexpressing TrkC Improves Remyelination and Function in Demyelinated Spinal Cord of Rats ▶     Ying Ding, Rong-Yi Zhang, Bing He et al.     This study attempted to graft neurotrophin-3 (NT-3) receptor (TrkC) gene modified mesenchymal stem cells (TrkC-MSCs) into the demyelinated spinal cord and to investigate whether …             The effects of Rho-associated kinase inhibitor Y-27632 on primary human corneal endothelial cells propagated using a dual media approach ▶     Gary S. L. Peh, Khadijah Adnan, Benjamin L. George et al.     The global shortage of donor corneas has garnered extensive interest in the development of graft alternatives suitable for endothelial keratoplasty using cultivated primary human …             Hardy-Weinberg equilibrium revisited for inferences on genotypes featuring allele and copy-number variations ▶     Andreas Recke, Klaus-Günther Recke, Saleh Ibrahim et al.     Copy number variations represent a substantial source of genetic variation and are associated with a plethora of physiological and pathophysiological conditions. Joint copy …             Late-responding normal tissue cells benefit from high-precision radiotherapy with prolonged fraction delivery times via enhanced autophagy ▶     Qiwei Yao, Rong Zheng, Guozhu Xie et al.     High-precision radiotherapy (HPR) has established its important role in the treatment of tumors due to its precise dose distribution. Given its more complicated delivery process, …             Genomic analysis of LPS-stimulated myeloid cells identifies a common pro-inflammatory response but divergent IL-10 anti-inflammatory responses ▶     Andrew Paul Hutchins, Yoshiko Takahashi, Diego Miranda-Saavedra     Inflammation is an essential physiological response to infection and injury that must be kept within strict bounds. The IL-10/STAT3 anti-inflammatory response (AIR) is …             Different autosomes evolved into sex chromosomes in the sister genera of Salix and Populus ▶     Jing Hou, Ning Ye, Defang Zhang et al.     Willows (Salix) and poplars (Populus) are dioecious plants in Salicaceae family. Sex chromosome in poplar genome was consistently reported to be associated with chromosome XIX. …             How insurance affects altruistic provision in threshold public goods games ▶     Jianlei Zhang, Chunyan Zhang, Ming Cao     The occurrence and maintenance of cooperative behaviors in public goods systems have attracted great research attention across multiple disciplines. A threshold public goods game …             SOAX: A software for quantification of 3D biopolymer networks ▶     Ting Xu, Dimitrios Vavylonis, Feng-Ching Tsai et al.     Filamentous biopolymer networks in cells and tissues are routinely imaged by confocal microscopy. Image analysis methods enable quantitative study of the properties of these …             Protective effect of botulinum toxin A after cutaneous ischemia-reperfusion injury ▶     Akihiko Uchiyama, Kazuya Yamada, Buddhini Perera et al.     Botulinum toxin A (BTX-A) blocks the release of acetylcholine vesicles into the synaptic space, and has been clinically used for aesthetic indications, neuromuscular disorders …             Rapid genome resequencing of an atoxigenic strain of Aspergillus carbonarius ▶     F. Javier Cabañes, Walter Sanseverino, Gemma Castellá et al.     In microorganisms, Ion Torrent sequencing technology has been proved to be useful in whole-genome sequencing of bacterial genomes (5 Mbp). In our study, for the first time we …             Correcting positional correlations in Affymetrix® Genome Chips ▶     Dirar Homouz, Gang Chen, Andrzej S. Kudlicki     We report and model a previously undescribed systematic error causing spurious excess correlations that depend on the distance between probes on Affymetrix® microarrays. The …             Biosynthesis of soluble carotenoid holoproteins in Escherichia coli ▶     Céline Bourcier de Carbon, Adrien Thurotte, Adjélé Wilson et al.     Carotenoids are widely distributed natural pigments that are excellent antioxidants acting in photoprotection. They are typically solubilized in membranes or attached to …             Apoptotic effect of novel Schiff Based CdCl2(C14H21N3O2) complex is mediated via activation of the mitochondrial pathway in colon cancer cells ▶     Maryam Hajrezaie, Mohammadjavad Paydar, Chung Yeng Looi et al.     The development of metal-based agents has had a tremendous role in the present progress in cancer chemotherapy. One well-known example of metal-based agents is Schiff based metal …             Asymmetric warming significantly affects net primary production, but not ecosystem carbon balances of forest and grassland ecosystems in northern China ▶     Hongxin Su, Jinchao Feng, Jan C. Axmacher et al.     We combine the process-based ecosystem model (Biome-BGC) with climate change-scenarios based on both RegCM3 model outputs and historic observed trends to quantify differential …             Association of FPGS genetic polymorphisms with primary retroperitoneal liposarcoma ▶     Chengli Miao, Ding Liu, Feng Zhang et al.     Primary retroperitoneal liposarcoma is generally regarded as a genetic disorder. We have retrospectively genotyped 8 single nucleotide polymorphisms (SNPs) in 6 candidate genes (…             Blood cell transcriptomic-based early biomarkers of adverse programming effects of gestational calorie restriction and their reversibility by leptin supplementation ▶     Jadwiga Konieczna, Juana Sánchez, Mariona Palou et al.     The challenge of preventing major chronic diseases requires reliable, early biomarkers. Gestational mild undernutrition in rats is enough to program the offspring to develop …             Transport of organic anions and cations in murine embryonic kidney development and in serially-reaggregated engineered kidneys ▶     Melanie L. Lawrence, C-Hong Chang, Jamie A. Davies     Recent advances in renal tissue engineering have shown that dissociated, early renogenic tissue from the developing embryo can self-assemble into morphologically accurate …             Monitoring Disease Trends using Hospital Traffic Data from High Resolution Satellite Imagery: A Feasibility Study ▶     Elaine O. Nsoesie, Patrick Butler, Naren Ramakrishnan et al.     Challenges with alternative data sources for disease surveillance include differentiating the signal from the noise, and obtaining information from data constrained settings. For …             Shot-noise Limited Faraday Rotation Spectroscopy for Detection of Nitric Oxide Isotopes in Breath, Urine, and Blood ▶     Yin Wang, Michal Nikodem, Eric Zhang et al.     Measurement of NO and/or its metabolites in the various body compartments has transformed our understanding of biology. The inability of the current NO measurement methods to …             Suppressed rate of carcinogenesis and decreases in tumour volume and lung metastasis in CXCL14/BRAK transgenic mice ▶     Ryu-Ichiro Hata, Kazuhito Izukuri, Yasumasa Kato et al.     Cancer progression involves carcinogenesis, an increase in tumour size, and metastasis. Here, we investigated the effect of overexpressed CXC chemokine ligand 14 (CXCL14) on …             MitoCeption as a new tool to assess the effects of mesenchymal stem/stromal cell mitochondria on cancer cell metabolism and function ▶     Andrés Caicedo, Vanessa Fritz, Jean-Marc Brondello et al.     Mitochondrial activity is central to tissue homeostasis. Mitochondria dysfunction constitutes a hallmark of many genetic diseases and plays a key role in tumor progression. The …             Tissue- and time-dependent transcription in Ixodes ricinus salivary glands and midguts when blood feeding on the vertebrate host ▶     Michalis Kotsyfakis, Alexandra Schwarz, Jan Erhart et al.     Ixodes ricinus is a tick that transmits the pathogens of Lyme and several arboviral diseases. Pathogens invade the tick midgut, disseminate through the hemolymph, and are …             Unified model of hyperthermia via hysteresis heating in systems of interacting magnetic nanoparticles ▶     S. Ruta, R. Chantrell, O. Hovorka     We present a general study of the frequency and magnetic field dependence of the specific heat power produced during field-driven hysteresis cycles in magnetic nanoparticles with …             Lipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers ▶     Hiu Yee Kwan, Xuyan Niu, Wenlin Dai et al.     Schisandrin B (SchB) is one of the most abundant bioactive dibenzocyclooctadiene derivatives found in the fruit of Schisandra chinensis. Here, we investigated the potential …             Feature Integration in the Mapping of Multi-Attribute Visual Stimuli to Responses ▶     Takuya Ishizaki, Hiromi Morita, Masahiko Morita     In the human visual system, different attributes of an object, such as shape and color, are separately processed in different modules and then integrated to elicit a specific …             The location and translocation of ndh genes of chloroplast origin in the Orchidaceae family ▶     Choun-Sea Lin, Jeremy J. W. Chen, Yao-Ting Huang et al.     The NAD(P)H dehydrogenase complex is encoded by 11 ndh genes in plant chloroplast (cp) genomes. However, ndh genes are truncated or deleted in some autotrophic Epidendroideae …             A Filifactor alocis-centered co-occurrence group associates with periodontitis across different oral habitats ▶     Hui Chen, Ying Liu, Menghui Zhang et al.     Periodontitis is a highly prevalent polymicrobial disease worldwide, yet the synergistic pattern of the multiple oral pathogens involved is still poorly characterized. Here, …             Learning-related brain hemispheric dominance in sleeping songbirds ▶     Sanne Moorman, Sharon M. H. Gobes, Ferdinand C. van de Kamp et al.     There are striking behavioural and neural parallels between the acquisition of speech in humans and song learning in songbirds. In humans, language-related brain activation is …             Now you see it, now you don't: flushing hosts prior to experimentation can predict their responses to brood parasitism ▶     Daniel Hanley, Peter Samaš, Josef Heryán et al.     Brood parasitic birds lay their eggs in other birds' nests, leaving hosts to raise their offspring. To understand parasite-host coevolutionary arms races, many studies have …             Protein Traffic Disorders: an Effective High-Throughput Fluorescence Microscopy Pipeline for Drug Discovery ▶     Hugo M. Botelho, Inna Uliyakina, Nikhil T. Awatade et al.     Plasma membrane proteins are essential molecules in the cell which mediate interactions with the exterior milieu, thus representing key drug targets for present pharma. Not …             ERRATUM: Tet1-mediated DNA demethylation regulates neuronal cell death induced by oxidative stress ▶     Yong-Juan Xin, Bo Yuan, Bin Yu et al.                 Structure, Function and Inhibition of the Phosphoethanolamine Methyltransferases of the Human Malaria Parasites Plasmodium vivax and Plasmodium knowlesi ▶     Aprajita Garg, Tiit Lukk, Vidya Kumar et al.     Phosphoethanolamine methyltransferases (PMTs) catalyze the three-step methylation of phosphoethanolamine to form phosphocholine, a critical step in the synthesis of …             CORRIGENDUM: Peripheral blood miRNAs as a biomarker for chronic cardiovascular diseases ▶     Yong Jiang, Hui-yan Wang, Yan Li et al.                 Presynaptic c-Jun N-terminal Kinase 2 regulates NMDA receptor-dependent glutamate release ▶     Robert Nisticò, Fulvio Florenzano, Dalila Mango et al.     Activation of c-Jun N-terminal kinase (JNK) signaling pathway is a critical step for neuronal death occurring in several neurological conditions. JNKs can be activated via …             Brassinosteroids play a critical role in the regulation of pesticide metabolism in crop plants ▶     Yanhong Zhou, Xiaojian Xia, Gaobo Yu et al.     Pesticide residues in agricultural produce pose a threat to human health worldwide. Although the detoxification mechanisms for xenobiotics have been extensively studied in …             Four-dimensional in vivo X-ray microscopy with projection-guided gating ▶     Rajmund Mokso, Daniel A. Schwyn, Simon M. Walker et al.     Visualizing fast micrometer scale internal movements of small animals is a key challenge for functional anatomy, physiology and biomechanics. We combine phase contrast …             Rightward-biased hemodynamic response of the parahippocampal system during virtual navigation ▶     Travis E. Baker, Akina Umemoto, Adam Krawitz et al.     Phase reset of parahippocampal electrophysiological oscillations in the theta frequency range is said to contribute to item encoding and retrieval during spatial navigation. …             The transmembrane transporter domain of glutamate transporters is a process tip localizer ▶     Mariko Kato Hayashi, Masato Yasui     Glutamate transporters in the central nervous system remove glutamate released from neurons to terminate the signal. These transporters localize to astrocyte process tips …             Production of diacetyl by metabolically engineered Enterobacter cloacae ▶     Lijie Zhang, Yingxin Zhang, Qiuyuan Liu et al.     Diacetyl, a high value product that can be extensively used as a food ingredient, could be produced from the non-enzymatic oxidative decarboxylation of α-acetolactate during …             Genome wide expression profiling of p53 regulated miRNAs in neuroblastoma ▶     Ali Rihani, Alan Van Goethem, Maté Ongenaert et al.     Restoration of the antitumor activity of p53 could offer a promising approach for the treatment of neuroblastoma. MicroRNAs (miRNAs) are important mediators of p53 activity, but …             Kirenol Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Differentiation of Th1 and Th17 Cells and Inducing Apoptosis of Effector T Cells ▶     Juan Xiao, Rongbing Yang, Lin Yang et al.     Experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS), is characterized by CNS demyelination mediated by autoreactive T cells. Kirenol, a …             An adenosine A3 receptor agonist inhibits DSS-induced colitis in mice through modulation of the NF-κB signaling pathway ▶     Tianhua Ren, Ting Tian, Xiao Feng et al.     The role of the adenosine A3 receptor (A3AR) in experimental colitis is controversial. The A3AR agonist N6-(3-iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA) has been shown …             The Effect of Direct and Indirect Monitoring on Generosity Among Preschoolers ▶     Takayuki Fujii, Haruto Takagishi, Michiko Koizumi et al.     The purpose of this study is to examine the effect of direct and indirect monitoring on generosity among five-year-old preschoolers and to reveal the primary motivation for their …             The Nuclear Receptor Nr4a1 Controls CD8 T Cell Development Through Transcriptional Suppression of Runx3 ▶     Heba N. Nowyhed, Tridu R. Huynh, Amy Blatchley et al.     The NR4A nuclear receptor family member Nr4a1 is strongly induced in thymocytes undergoing selection, and has been shown to control the development of Treg cells; however the …             Physicochemical Evolution and Molecular Adaptation of the Cetacean Osmoregulation-related Gene UT-A2 and Implications for Functional Studies ▶     Jingzhen Wang, Xueying Yu, Bo Hu et al.     Cetaceans have an enigmatic evolutionary history of re-invading aquatic habitats. One of their essential adaptabilities that has enabled this process is their homeostatic …             Characterization of the MCM homohexamer from the thermoacidophilic euryarchaeon Picrophilus torridus ▶     Kasturi Goswami, Jasmine Arora, Swati Saha     The typical archaeal MCM exhibits helicase activity independently in vitro. This study characterizes MCM from the euryarchaeon Picrophilus torridus. While PtMCM hydrolyzes ATP in …             Primate immune responses to HIV-1 Env formulated in the saponin-based adjuvant AbISCO-100 in the presence or absence of TLR9 co-stimulation ▶     Paola Martinez, Christopher Sundling, Sijy O'Dell et al.     Protein-based vaccines require adjuvants to achieve optimal responses. Toll-like receptor (TLR) 9 agonists were previously shown to improve responses to protein-based vaccines, …             Multiple strategies of oxygen supply in Drosophila malignancies identify tracheogenesis as a novel cancer hallmark ▶     Daniela Grifoni, Manuela Sollazzo, Elisabetta Fontana et al.     Angiogenesis is the term used to describe all the alterations in blood vessel growth induced by a tumour mass following hypoxic stress. The occurrence of multiple strategies of …             Ubiquitous distribution of salts and proteins in spider glue enhances spider silk adhesion ▶     Gaurav Amarpuri, Vishal Chaurasia, Dharamdeep Jain et al.     Modern orb-weaving spiders use micron-sized glue droplets on their viscid silk to retain prey in webs. A combination of low molecular weight salts and proteins makes the glue …             Growth of a deep-water, predatory fish is influenced by the productivity of a boundary current system ▶     Hoang Minh Nguyen, Adam N. Rountrey, Jessica J. Meeuwig et al.     The effects of climate change on predatory fishes in deep shelf areas are difficult to predict because complex processes may govern food availability and temperature at depth. We …             Repair of spinal cord injury by implantation of bFGF-incorporated HEMA-MOETACL hydrogel in rats ▶     Bo Chen, Jianyu He, Hao Yang et al.     There is no effective strategy for the treatment of spinal cord injury (SCI). An appropriate combination of hydrogel materials and neurotrophic factor therapy is currently …             Lrrk2 R1628P variant is a risk factor for essential tremor ▶     Yin Xia Chao, Ebonne Yulin Ng, Louis Tan et al.     Essential tremor (ET) and Parkinson's disease (PD) are two of the most common adult onset movement disorders with overlapping clinical features. PD patients with leucine-rich …             TALEN mediated targeted editing of GM2/GD2-synthase gene modulates anchorage independent growth by reducing anoikis resistance in mouse tumor cells ▶     Barun Mahata, Avisek Banerjee, Manjari Kundu et al.     Complex ganglioside expression is highly deregulated in several tumors which is further dependent on specific ganglioside synthase genes. Here, we designed and constructed a pair …             Construction of stable packaging cell lines for clinical lentiviral vector production ▶     Khaled S. Sanber, Sean B. Knight, Sam L. Stephen et al.     Lentiviral vectors are useful experimental tools for stable gene delivery and have been used to treat human inherited genetic disorders and hematologic malignancies with …             Allostery through protein-induced DNA bubbles ▶     Joseph J. Traverso, Valipuram S. Manoranjan, A. R. Bishop et al.     Allostery through DNA is increasingly recognized as an important modulator of DNA functions. Here, we show that the coalescence of protein-induced DNA bubbles can mediate …             The cholesterol biosynthesis enzyme oxidosqualene cyclase is a new target to impair tumour angiogenesis and metastasis dissemination ▶     Federica Maione, Simonetta Oliaro-Bosso, Claudia Meda et al.     Aberrant cholesterol homeostasis and biosynthesis has been observed in different tumour types. This paper investigates the role of the post-squalenic enzyme of cholesterol …             Coffee consumption and bladder cancer: a meta-analysis of observational studies ▶     Weixiang Wu, Yeqing Tong, Qiang Zhao et al.     Controversial results of the association between coffee consumption and bladder cancer (BC) risk were reported among epidemiological studies. Therefore, we conducted this …             Magnetic Resonance Imaging with Superparamagnetic Iron Oxide Fails to Track the Long-term Fate of Mesenchymal Stem Cells Transplanted into Heart ▶     Ning Ma, Huaibing Cheng, Minjie Lu et al.     MRI for in vivo stem cell tracking remains controversial. Here we tested the hypothesis that MRI can track the long-term fate of the superparamagnetic iron oxide (SPIO) …             New Anti-angiogenic Leading Structure Discovered in the Fruit of Cimicifuga yunnanensis ▶     Yin Nian, Jing Yang, Tong-Yang Liu et al.     Cimyunnins A–C (1–3), characterized with an unusual fused cyclopentenone ring G, together with cimyunnin D (4), possessing a highly rearranged γ-lactone ring F, were …             PERK silence inhibits glioma cell growth under low glucose stress by blockage of p-AKT and subsequent HK2's mitochondria translocation ▶     Xu Hou, Yaohua Liu, Huailei Liu et al.     Glioma relies on glycolysis to obtain energy and sustain its survival under low glucose microenvironment in vivo. The mechanisms on glioma cell glycolysis regulation are still …             Revealing the cellular localization of STAT1 during the cell cycle by super-resolution imaging ▶     Jing Gao, Feng Wang, Yanhou Liu et al.     Signal transducers and activators of transcription (STATs) can transduce cytokine signals and regulate gene expression. The cellular localization and nuclear trafficking of …             Loss of muscleblind-like 1 results in cardiac pathology and persistence of embryonic splice isoforms ▶     Donald M. Dixon, Jongkyu Choi, Ayea El-Ghazali et al.     Cardiac dysfunction is a prominent cause of mortality in myotonic dystrophy I (DM1), a disease where expanded CUG repeats bind and disable the muscleblind-like family of splice …             A monomer-trimer model supports intermittent glucagon fibril growth ▶     Andrej Košmrlj, Pia Cordsen, Anders Kyrsting et al.     We investigate in vitro fibrillation kinetics of the hormone peptide glucagon at various concentrations using confocal microscopy and determine the glucagon fibril persistence …             Tim-3 protects decidual stromal cells from toll-like receptor-mediated apoptosis and inflammatory reactions and promotes Th2 bias at the maternal-fetal interface ▶     SongCun Wang, ChunMei Cao, HaiLan Piao et al.     Toll-like receptors (TLRs) are important in mediating immune responses against various pathogens during pregnancy. However, uncontrolled TLR-triggered inflammation will endanger …             Chondroitin sulfate-E mediates estrogen-induced osteoanabolism ▶     Toshiyasu Koike, Tadahisa Mikami, Miharu Shida et al.     Osteoporosis is an age-related disorder of bone remodeling in which bone resorption outstrips bone matrix deposition. Although anticatabolic agents are frequently used as …             STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavior ▶     Eryan Kong, Sonja Sucic, Francisco J. Monje et al.     Experimental evidence suggests a role for the immune system in the pathophysiology of depression. A specific involvement of the proinflammatory cytokine interleukin 6 (IL6) in …             Effective use of high CO2 efflux at the soil surface in a tropical understory plant ▶     Atsushi Ishida, Takashi Nakano, Minaco Adachi et al.     Many terrestrial plants are C3 plants that evolved in the Mesozoic Era when atmospheric CO2 concentrations ([CO2]) were high. Given current conditions, C3 plants can no longer …             Segmentation of biological multivariate time-series data ▶     Nooshin Omranian, Bernd Mueller-Roeber, Zoran Nikoloski     Time-series data from multicomponent systems capture the dynamics of the ongoing processes and reflect the interactions between the components. The progression of processes in …             The coelacanth rostral organ is a unique low-resolution electro-detector that facilitates the feeding strike ▶     Rachel M. Berquist, Vitaly L. Galinsky, Stephen M. Kajiura et al.     The cartilaginous and non-neopterygian bony fishes have an electric sense typically comprised of hundreds or thousands of sensory canals distributed in broad clusters over the …             Molecular-based approaches to characterize coastal microbial community and their potential relation to the trophic state of Red Sea ▶     Mohd Ikram Ansari, Moustapha Harb, Burton Jones et al.     Molecular-based approaches were used to characterize the coastal microbiota and to elucidate the trophic state of Red Sea. Nutrient content and enterococci numbers were …             Dissection of keratin network formation, turnover and reorganization in living murine embryos ▶     Nicole Schwarz, Reinhard Windoffer, Thomas M. Magin et al.     Epithelial functions are fundamentally determined by cytoskeletal keratin network organization. However, our understanding of keratin network plasticity is only based on analyses …             Interferon-α inducible protein 6 impairs EGFR activation by CD81 and inhibits hepatitis C virus infection ▶     Keith Meyer, Young-Chan Kwon, Shuanghu Liu et al.     Viral entry requires co-operative interactions of several host cell factors. Interferon (IFN) and the IFN-stimulated genes (ISGs) play a central role in antiviral responses …             Causal evidence between monsoon and evolution of rhizomyine rodents ▶     Raquel López-Antoñanzas, Fabien Knoll, Shiming Wan et al.     The modern Asian monsoonal systems are currently believed to have originated around the end of the Oligocene following a crucial step of uplift of the Tibetan-Himalayan …             Mobile dune fixation by a fast-growing clonal plant: a full life-cycle analysis ▶     Shou-Li Li, Fei-Hai Yu, Marinus J. A. Werger et al.     Desertification is a global environmental problem, and arid dunes with sparse vegetation are especially vulnerable to desertification. One way to combat desertification is to …             Sumoylation of CCAAT/enhancer-binding protein α is implicated in hematopoietic stem/progenitor cell development through regulating runx1 in zebrafish ▶     Hao Yuan, Tao Zhang, Xiaohui Liu et al.     The small ubiquitin-related modifier (SUMO) participates in various cellular processes, including maintenance of genome integrity, nuclear transport, transcription and signal …             PIK3R1 negatively regulates the epithelial-mesenchymal transition and stem-like phenotype of renal cancer cells through the AKT/GSK3β/CTNNB1 signaling pathway ▶     Youcheng Lin, Zhao Yang, Abai Xu et al.     The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway has been identified as an important pathway in renal cell carcinoma (RCC). We have reported a nonsense …             In vivo CaspaseTracker biosensor system for detecting anastasis and non-apoptotic caspase activity ▶     Ho Lam Tang, Ho Man Tang, Ming Chiu Fung et al.     The discovery that mammalian cells can survive late-stage apoptosis challenges the general assumption that active caspases are markers of impending death. However, tools have not …             Biologically inspired band-edge laser action from semiconductor with dipole-forbidden band-gap transition ▶     Cih-Su Wang, Chi-Shung Liau, Tzu-Ming Sun et al.     A new approach is proposed to light up band-edge stimulated emission arising from a semiconductor with dipole-forbidden band-gap transition. To illustrate our working principle, …             Bilberry extract (Antho 50) selectively induces redox-sensitive caspase 3-related apoptosis in chronic lymphocytic leukemia cells by targeting the Bcl-2/Bad pathway ▶     Mahmoud Alhosin, Antonio J. León-González, Israa Dandache et al.     Defect in apoptosis has been implicated as a major cause of resistance to chemotherapy observed in B cell chronic lymphocytic leukaemia (B CLL). This study evaluated the …             Highly selective fluorescent and colorimetric probe for live-cell monitoring of sulphide based on bioorthogonal reaction ▶     Fang-Jun Huo, Jin Kang, Caixia Yin et al.     H2S is the third endogenously generated gaseous signaling compound and has also been known to involve a variety of physiological processes. To better understand its physiological …             Prevention of exercised induced cardiomyopathy following Pip-PMO treatment in dystrophic mdx mice ▶     Corinne A. Betts, Amer F. Saleh, Carolyn A. Carr et al.     Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disorder caused by mutations in the Dmd gene. In addition to skeletal muscle wasting, DMD patients develop …             The vaginal microbiome during pregnancy and the postpartum period in a European population ▶     David A. MacIntyre, Manju Chandiramani, Yun S. Lee et al.     The composition and structure of the pregnancy vaginal microbiome may influence susceptibility to adverse pregnancy outcomes. Studies on the pregnant vaginal microbiome have …             Angiostatic treatment prior to chemo- or photodynamic therapy improves anti-tumor efficacy ▶     Andrea Weiss, Débora Bonvin, Robert H. Berndsen et al.     Tumor vasculature is known to be poorly organized leading to increased leakage of molecules to the extravascular space. This process can potentially increase interstitial fluid …             A weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma ▶     Weijian Zhang, Lina Zhou, Peiyuan Yin et al.     Dynamic metabolomics studies can provide a systematic view of the metabolic trajectory during disease development and drug treatment and reveal the nature of biological processes …             Lysosomal Targeting with Stable and Sensitive Fluorescent Probes (Superior LysoProbes): Applications for Lysosome Labeling and Tracking during Apoptosis ▶     Xin Chen, Yue Bi, Tianyang Wang et al.     Intracellular pH plays an important role in the response to cancer invasion. We have designed and synthesized a series of new fluorescent probes (Superior LysoProbes) with the …             Microstructural Abnormalities in Children with Post-traumatic Stress Disorder: A Diffusion Tensor Imaging Study at 3.0T ▶     Du Lei, Lingjiang Li, Lei Li et al.     Posttraumatic stress disorder (PTSD) is a severe anxiety disorder characterized by re-experiencing, avoidance and hyperarousal. Brain microstructure abnormalities in PTSD, …             Metabolomics integrated elementary flux mode analysis in large metabolic networks ▶     Matthias P. Gerstl, David E. Ruckerbauer, Diethard Mattanovich et al.     Elementary flux modes (EFMs) are non-decomposable steady-state pathways in metabolic networks. They characterize phenotypes, quantify robustness or identify engineering targets. …             Voluntary rewards mediate the evolution of pool punishment for maintaining public goods in large populations ▶     Tatsuya Sasaki, Satoshi Uchida, Xiaojie Chen     Punishment is a popular tool when governing commons in situations where free riders would otherwise take over. It is well known that sanctioning systems, such as the police and …             Epigenetic Biomarker to Support Classification into Pluripotent and Non-Pluripotent Cells ▶     Michael Lenz, Roman Goetzke, Arne Schenk et al.     Quality control of human induced pluripotent stem cells (iPSCs) can be performed by several methods. These methods are usually relatively labor-intensive, difficult to …             Paliperidone and aripiprazole differentially affect the strength of calcium-secretion coupling in female pituitary lactotrophs ▶     Marek Kucka, Melanija Tomić, Ivana Bjelobaba et al.     Hyperprolactinemia is a common adverse in vivo effect of antipsychotic medications that are used in the treatment of patients with schizophrenia. Here, we compared the effects of …             Extensive phenotypic plasticity of a Red Sea coral over a strong latitudinal temperature gradient suggests limited acclimatization potential to warming ▶     Yvonne Sawall, Abdulmoshin Al-Sofyani, Sönke Hohn et al.     Global warming was reported to cause growth reductions in tropical shallow water corals in both, cooler and warmer, regions of the coral species range. This suggests regional …             The nucleolar protein nucleophosmin is essential for autophagy induced by inhibiting Pol I transcription ▶     Naohiro Katagiri, Takao Kuroda, Hiroyuki Kishimoto et al.     Various cellular stresses activate autophagy, which is involved in lysosomal degradation of cytoplasmic materials for maintaining nutrient homeostasis and eliminating harmful …             Critical evidence for the prediction error theory in associative learning ▶     Kanta Terao, Yukihisa Matsumoto, Makoto Mizunami     In associative learning in mammals, it is widely accepted that the discrepancy, or error, between actual and predicted reward determines whether learning occurs. Complete …             p53 Suppresses Tetraploid Development in Mice ▶     Takuro Horii, Masamichi Yamamoto, Sumiyo Morita et al.     Mammalian tetraploid embryos die in early development because of defects in the epiblast. Experiments with diploid/tetraploid chimeric mice, obtained via the aggregation of …             Meta-analyses of gene methylation and smoking behavior in non-small cell lung cancer patients ▶     Tao Huang, Xiaoying Chen, Qingxiao Hong et al.     Aberrant DNA methylation can be a potential genetic mechanism in non-small cell lung cancer (NSCLC). However, inconsistent findings existed among the recent association studies …             “Roar” of blaNDM-1 and “silence” of blaOXA-58 co-exist in Acinetobacter pittii ▶     Shuru Zhou, Xin Chen, Xiaobin Meng et al.     Acinetobacter pittii 44551 was recovered from a patient with gout combined with tuberculosis and was found to harbor the carbapenemase genes blaNDM-1 and blaOXA-58 on two …             Characterization and expression of the cytochrome P450 gene family in diamondback moth, Plutella xylostella (L.) ▶     Liying Yu, Weiqi Tang, Weiyi He et al.     Cytochrome P450 monooxygenases are present in almost all organisms and can play vital roles in hormone regulation, metabolism of xenobiotics and in biosynthesis or inactivation …             Novel genetic variants in differentiated thyroid cancer and assessment of the cumulative risk ▶     Gisella Figlioli, Bowang Chen, Rossella Elisei et al.     A genome-wide association study (GWAS) performed on a high-incidence Italian population followed by replications on low-incidence cohorts suggested a strong association of …             Systematic identification and characterization of long intergenic non-coding RNAs in fetal porcine skeletal muscle development ▶     Weimin Zhao, Yulian Mu, Lei Ma et al.     Long intergenic non-coding RNAs (lincRNAs) play important roles in many cellular processes. Here, we present the first systematic identification and characterization of lincRNAs …             Comparison between single-molecule and X-ray crystallography data on yeast F1-ATPase ▶     Bradley C. Steel, Ashley L. Nord, Yamin Wang et al.     Single molecule studies in recent decades have elucidated the full chemo-mechanical cycle of F1-ATPase, mostly based on F1 from thermophilic bacteria. In contrast, …             Conditional-ready mouse embryonic stem cell derived macrophages enable the study of essential genes in macrophage function ▶     A. T. Y. Yeung, C. Hale, J. Xia et al.     The ability to differentiate genetically modified mouse embryonic stem (ES) cells into functional macrophages provides a potentially attractive resource to study host-pathogen …             Bioinspired Tuning of Hydrogel Permeability-Rigidity Dependency for 3D Cell Culture ▶     Min Kyung Lee, Max H. Rich, Kwanghyun Baek et al.     Hydrogels are being extensively used for three-dimensional immobilization and culture of cells in fundamental biological studies, biochemical processes, and clinical treatments. …             Nicotinic Acid is a Common Regulator of Heat-Sensing TRPV1-4 Ion Channels ▶     Linlin Ma, Bo Hyun Lee, Heather Clifton et al.     Nicotinic acid (NA, a.k.a. vitamin B3 or niacin) can reduce blood cholesterol and low-density lipoproteins whereas increase high-density lipoproteins. However, when NA is used to …             Tuning IL-2 signaling by ADP-ribosylation of CD25 ▶     Sophie Teege, Alexander Hann, Maria Miksiewicz et al.     Control of immunologic tolerance and homeostasis rely on Foxp3CD4CD25 regulatory T cells (Tregs) that constitutively express the high affinity receptor for Interleukin-2, CD25. …             Lack of stress responses to long-term effects of corticosterone in Caps2 knockout mice ▶     Yuriko Mishima, Yo Shinoda, Tetsushi Sadakata et al.     Chronic stress is associated with anxiety and depressive disorders, and can cause weight gain. Ca2-dependent activator protein for secretion 2 (CAPS2) is involved in insulin …             Diminished appetitive startle modulation following targeted inhibition of prefrontal cortex ▶     René Hurlemann, Stephan Arndt, Thomas E. Schlaepfer et al.     From an evolutionary perspective the startle eye-blink response forms an integral part of the human avoidance behavioral repertoire and is typically diminished by pleasant …             Visualization of synaptic domains in the Drosophila brain by magnetic resonance microscopy at 10 micron isotropic resolution ▶     Choong H. Lee, Stephen J. Blackband, Pedro Fernandez-Funez     Understanding the complex architecture, connectivity, and pathology of the human brain is a major application of magnetic resonance imaging (MRI). However, the cellular basis of …             The Role of Receptor for Advanced Glycation End Products in Airway Inflammation in CF and CF related Diabetes ▶     Siobhain Mulrennan, Svetlana Baltic, Shashi Aggarwal et al.     Cystic Fibrosis (CF) is often accompanied by diabetes leading to worsening lung function, the reason for which is unclear. The receptor for advanced-glycation-end-products (RAGE) …             How mobile are protons in the structure of dental glass ionomer cements? ▶     Ana R. Benetti, Johan Jacobsen, Benedict Lehnhoff et al.     The development of dental materials with improved properties and increased longevity can save costs and minimize discomfort for patients. Due to their good biocompatibility, …             Lunge feeding in early marine reptiles and fast evolution of marine tetrapod feeding guilds ▶     Ryosuke Motani, Xiao-hong Chen, Da-yong Jiang et al.     Traditional wisdom holds that biotic recovery from the end-Permian extinction was slow and gradual, and was not complete until the Middle Triassic. Here, we report that the …             Photothermal cellular stimulation in functional bio-polymer interfaces ▶     Nicola Martino, Paul Feyen, Matteo Porro et al.     Hybrid interfaces between organic semiconductors and living tissues represent a new tool for in-vitro and in-vivo applications, bearing a huge potential, from basic researches to …             Targeted Next-generation Sequencing Reveals Novel EYS Mutations in Chinese Families with Autosomal Recessive Retinitis Pigmentosa ▶     Xue Chen, Xiaoxing Liu, Xunlun Sheng et al.     EYS mutations demonstrate great genotypic and phenotypic varieties, and are one of the major causes for patients with autosomal recessive retinitis pigmentosa (ARRP). Here, we …             Epidemiological and Etiological Characteristics of Hand, Foot, and Mouth Disease in Henan, China, 2008–2013 ▶     Xueyong Huang, Haiyan Wei, Shuyu Wu et al.     Hand, foot, and mouth disease (HFMD) is a common childhood illness caused by enteroviruses. HFMD outbreaks and reported cases have sharply increased in China since 2008. …                 Introducing HGV Database The HGV Database is a fully searchable online database of genome variations published in peer-reviewed Data Reports in Human Genome Variation   Search and filter by specific disease, gene, region, population. 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