Nature Reviews Genetics Contents April 2015 Volume 16 Number 4 pp 193-251

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TABLE OF CONTENTS
April 2015 Volume 16 Number 4
Impact Factor 39.794 *	In this issue Research Highlights Reviews Also this month  Featured article: The role of regulatory variation in complex traits and disease Frank W. Albert & Leonid Kruglyak
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The 2015 IMB Conference on DNA Repair and Genome Stability in a Chromatin Environment will explore local chromatin events and their implications for genome stability, such as the emerging roles of chromatin remodellers and posttranslational modifications in a variety of DNA repair and damage signalling pathways. Keynote speakers will be Susan Gasser and Titia Sixma.
RESEARCH HIGHLIGHTS Top Tumorigenesis: Order matters p193 | doi:10.1038/nrg3923 PDF Metagenomics: Urban microbiome p194 | doi:10.1038/nrg3921 PDF Cancer genetics: CRISPR screens go in vivo p194 | doi:10.1038/nrg3924 PDF Technology: Bead capture for single-cell transcriptomics p195 | doi:10.1038/nrg3919 PDF Evolution: Polyploid gains p196 | doi:10.1038/nrg3925 PDF Biotechnology: Making a meal of RNA p196 | doi:10.1038/nrg3926 PDF IN BRIEF Genetic testing: Genetic risk and statin preventative therapy | Pathogen genetics: S. aureus multi-host tropism | Genomics: Benchmarking genome analysis pipelines PDF Genetics JOBS of the week Leverhulme Trust Doctoral Scholarships In Evolutionary Genomics University of Huddersfield Tenure-Track / Tenured Faculty Position University of Rochester School of Medicine & Dentistry Post doc IGBMC, Institute of Genetics and Molecular and Cellular Biology Post-Doctoral Fellow (4 Posts) The University of Hong Kong Research Associate University College London (UCL) More Science jobs from Genetics EVENT Yeast Genetics & Genomics 21.07.15 Cold Spring Harbour, USA More science events from
REVIEWS		Top
The role of regulatory variation in complex traits and disease Frank W. Albert & Leonid Kruglyak p197 | doi:10.1038/nrg3891 Genetic variation in gene expression among individuals is an important contributor to differences in organismal phenotypes. This Review describes key concepts of such variation and provides an update on recent research on the effects of regulatory variants on the transcriptome, proteome and complex traits, including human disease risk. Abstract | Full Text | PDF
The effects of chromatin organization on variation in mutation rates in the genome Kateryna D. Makova & Ross C. Hardison p213 | doi:10.1038/nrg3890 The evolution of genes is influenced by regional variation in mutation rates (RViMR). Chromatin organization affects RViMR, although the correlation between chromatin state and mutation types and rates is complex. This Review describes recent research on RViMR and chromatin organization, and the emerging findings from investigations of both germline and somatic mutations. Abstract | Full Text | PDF
Evolutionary insights into host–pathogen interactions from mammalian sequence data Manuela Sironi, Rachele Cagliani, Diego Forni & Mario Clerici p224 | doi:10.1038/nrg3905 Host–pathogen interactions influence genetic diversity, and comparative genomic analyses are beginning to dissect genetic determinants involved in this process. This Review describes examples of such host–pathogen interactions and outline evolutionary approaches that are useful for identifying genomic regions associated with susceptibility to infection in mammals. Abstract | Full Text | PDF | Supplementary information
Genetic mechanisms of abiotic stress tolerance that translate to crop yield stability Michael V. Mickelbart, Paul M. Hasegawa & Julia Bailey-Serres p237 | doi:10.1038/nrg3901 The rising human population and climate instability are putting unprecedented pressure on global agricultural practices. This Review describes the diverse mechanisms by which plants tolerate various stresses, such as flooding, drought, toxins, salinity and temperature extremes. The authors focus on how the genetic loci that underlie these survival and tolerance traits can be introgressed into current crops to improve yield stability. Abstract | Full Text | PDF | Supplementary information
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