Nature Communications - 18 March 2015

Advertisement   Avoid accidental plagiarism with this free white paper by an AJE editor & PhD.   Make sure you're citing correctly and thoroughly. Avoid common pitfalls (and the resulting embarrassment when a journal notices). Download "In Your Own Words: Best Practices for Avoiding Plagiarism."    AJE© provides publication services and resources for researchers. A division of Research Square©.       Weekly Content Alert 18 March 2015  Featured image: Shim et al. report a method giving a high degree of control over the three-dimensional shape of polymeric microstructures. Latest content: Articles Corrigendum Advertisement   "UltraMAB® is the only commercial monoclonal antibody validated by high density protein chips (>17,000 proteins) to ensure mono-specificity. Check Ultramab.com to see the full list of targets. Just Launched: A "universal" anti-LGR5 UltraMAB® antibody! The new clone provides the best results for both WB and FC applications, AND recognizes both human and mouse antigens." Journal homepage Recommend to library Web feed   Advertisement Nature Outlook Haemophilia Hopes are rising rapidly for people with the bleeding disorder haemophilia. The advent of longer-lasting blood-clotting factors is making treatment less onerous, and — on the horizon — gene therapy offers a potential cure.  Access the Outlook free online.  Produced with support from: Baxter Healthcare Corporation        Latest Articles View all Articles     Oscillation of the velvet worm slime jet by passive hydrodynamic instability OPEN Andrés Concha, Paula Mellado, Bernal Morera-Brenes, Cristiano Sampaio Costa, L Mahadevan and Julián Monge-Nájera The velvet worm emits a rapidly oscillating jet of proteinaceous slime to capture prey. Here, Concha et al. combine high-speed videography and a physical simulacrum to establish that this passive mechanism is the result of elastohydrodynamic instability during high-speed flow through the oral papillae. 17 March 2015 | doi: 10.1038/ncomms7292 Biological Sciences  Fluids and plasma physics  Zoology  Aqueous proton transfer across single-layer graphene OPEN Jennifer L. Achtyl, Raymond R. Unocic, Lijun Xu, Yu Cai, Muralikrishna Raju, Weiwei Zhang, Robert L. Sacci, Ivan V. Vlassiouk, Pasquale F. Fulvio, Panchapakesan Ganesh, David J. Wesolowski, Sheng Dai, Adri C. T. van Duin, Matthew Neurock and Franz M. Geiger Proton transfer across graphene is associated with large computed energy barriers and is thought to be generally unfavourable. Here, the authors observe aqueous proton transfer through graphene subjected to pH cycling, suggesting that it is due to transfer through rare, naturally occurring atomic defects. 17 March 2015 | doi: 10.1038/ncomms7539 Chemical Sciences  Materials science  Physical chemistry  Electrodeposition of hierarchically structured three-dimensional nickel–iron electrodes for efficient oxygen evolution at high current densities OPEN Xunyu Lu and Chuan Zhao Development of efficient and affordable oxygen evolution catalysts is essential for large-scale electrolytic water splitting. Here, the authors report mesoporous nickel–iron composite nanosheets loaded on macroporous nickel foam substrates, and evaluate their electrocatalytic oxygen evolution in basic media. 17 March 2015 | doi: 10.1038/ncomms7616 Chemical Sciences  Catalysis  Materials science  Physical chemistry  Ferroelectric domain wall motion induced by polarized light OPEN Fernando Rubio-Marcos, Adolfo Del Campo, Pascal Marchet and Jose F. Fernández Domain walls between ferroelectric domains are of interest for ferroelectric memory and to achieve a better control of the switching process. Here, the authors induce the motion of ferroelectric domains by light, creating a new possibility to control ferroelectrics. 17 March 2015 | doi: 10.1038/ncomms7594 Physical Sciences  Condensed matter  Materials science  Dynamically self-assembled silver nanoparticles as a thermally tunable metamaterial Wiktor Lewandowski, Martin Fruhnert, Józef Mieczkowski, Carsten Rockstuhl and Ewa Górecka Tunable metamaterials bring the promise of on-demand tailored optical properties, offering numerous device functionalities. Towards this aim, this study presents a tunable metamaterial based on dynamic self-assembly of nanoparticles coated with organic ligands, which also shows epsilon-near-zero behaviour. 17 March 2015 | doi: 10.1038/ncomms7590 Physical Sciences  Materials science  Nanotechnology  Optical physics  Impedance sensing device enables early detection of pressure ulcers in vivo Sarah L. Swisher, Monica C. Lin, Amy Liao, Elisabeth J. Leeflang, Yasser Khan, Felippe J. Pavinatto, Kaylee Mann, Agne Naujokas, David Young, Shuvo Roy, Michael R. Harrison, Ana Claudia Arias, Vivek Subramanian and Michel M. Maharbiz Sustained pressure on the skin reduces blood flow and causes wounds. Here the authors describe a flexible electronic ‘bandage’ that measures changes in tissue impedance spectra and detects early tissue damage in rats before it can be visualized, thus enabling possible prevention of pressure ulcers. 17 March 2015 | doi: 10.1038/ncomms7575 Biological Sciences  Medical research  High performing and stable supported nano-alloys for the catalytic hydrogenation of levulinic acid to γ-valerolactone OPEN Wenhao Luo, Meenakshisundaram Sankar, Andrew M. Beale, Qian He, Christopher J. Kiely, Pieter C. A. Bruijnincx and Bert M. Weckhuysen The hydrogenation of leuvinic acid to γ-valerolactone is an important step in the conversion of lignocellulose to high value chemicals. Here, the authors report that bimetallic alloys are active and stable catalysts for this reaction, and attribute this to geometric and electronic effects. 17 March 2015 | doi: 10.1038/ncomms7540 Chemical Sciences  Catalysis  Materials science  Physical chemistry  The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function Jessica K. Mountford, Claire Petitjean, Harun W. Kusuma Putra, Jonathan A. McCafferty, Natasha M. Setiabakti, Hannah Lee, Lotte L. Tønnesen, James D. McFadyen, Simone M. Schoenwaelder, Anita Eckly, Christian Gachet, Sarah Ellis, Anne K. Voss, Ross A. Dickins, Justin R. Hamilton and Shaun P. Jackson The lipid kinase PI3KC2α is essential for embryogenesis, yet its role in adult homeostasis is unknown. Here, the authors show that PI3KC2α regulates the structure of the internal membrane reserves of murine megakaryocytes and platelets, affecting the platelets’ adhesiveness and prothrombotic function. 17 March 2015 | doi: 10.1038/ncomms7535 Biological Sciences  Cell biology  Medical research  A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production Ueli Nachbur, Che A. Stafford, Aleksandra Bankovacki, Yifan Zhan, Lisa M. Lindqvist, Berthe K. Fiil, Yelena Khakham, Hyun-Ja Ko, Jarrod J. Sandow, Hendrik Falk, Jessica K. Holien, Diep Chau, Joanne Hildebrand, James E. Vince, Phillip P. Sharp, Andrew I. Webb, Katherine A. Jackman, Sabrina Mühlen, Catherine L. Kennedy, Kym N. Lowes et al. Receptor Interacting Protein Kinase 2 (RIPK2) mediates innate immune signalling in response to intracellular pathogens, but its aberrant activation contributes to autoimmune pathologies. Here Nachbur et al. describe a RIPK2 inhibitor that is effective in a mouse model of multiple sclerosis. 17 March 2015 | doi: 10.1038/ncomms7442 Biological Sciences  Immunology  Interdependence of specialization and biodiversity in Phanerozoic marine invertebrates Sabine Nürnberg and Martin Aberhan Biodiversity is thought to be bounded by upper limits, but less is known about what factors may influence these limits. Here, the authors find correlations between the global biodiversity of benthic marine invertebrates in the fossil record, and their degree of habitat specialization. 17 March 2015 | doi: 10.1038/ncomms7602 Biological Sciences  Ecology  Evolution  Palaeontology  Genetic structure characterization of Chileans reflects historical immigration patterns OPEN Susana Eyheramendy, Felipe I. Martinez, Federico Manevy, Cecilia Vial and Gabriela M. Repetto Chileans are genetically admixed. Here, the authors find that the average admixing time is around 10 generations ago and show the contribution of European men and Native-American women to the Chilean population. 17 March 2015 | doi: 10.1038/ncomms7472 Biological Sciences  Evolution  Genetics  Transformation of the intestinal epithelium by the MSI2 RNA-binding protein Shan Wang, Ning Li, Maryam Yousefi, Angela Nakauka-Ddamba, Fan Li, Kimberly Parada, Shilpa Rao, Gerard Minuesa, Yarden Katz, Brian D. Gregory, Michael G. Kharas, Zhengquan Yu and Christopher J. Lengner In mammals there are two Musashi proteins, MSI1 and MSI2, orthologues of the Drosophila protein, with roles in asymmetric stem cell division and cell fate determination. Here the authors report new functions for MSI2 in colorectal cancer using in vitro loss of function and in vivo ectopic overexpression. 16 March 2015 | doi: 10.1038/ncomms7517 Biological Sciences  Cancer  Molecular biology  Topological crystalline metal in orthorhombic perovskite iridates Yige Chen, Yuan-Ming Lu and Hae-Young Kee Topological insulators are insulators in the bulk, but can support conducting states on their surface. Here, Chen et al. predict orthorhombic perovskite iridates to be topological crystalline metals, exhibiting bulk metallic behaviour and surface states protected by certain crystal symmetries. 16 March 2015 | doi: 10.1038/ncomms7593 Physical Sciences  Condensed matter  Theoretical physics  Universal composition–structure–property maps for natural and biomimetic platelet–matrix composites and stacked heterostructures Navid Sakhavand and Rouzbeh Shahsavari Many layered composites exhibit a remarkable balance of strength, toughness and stiffness. Here, the authors construct a model to explain the synergy of key mechanical properties of layered composites by considering the elastic/plastic properties of the matrix and use 3D-printed samples to validate their predictions. 16 March 2015 | doi: 10.1038/ncomms7523 Physical Sciences  Materials science  Highly porous non-precious bimetallic electrocatalysts for efficient hydrogen evolution OPEN Qi Lu, Gregory S. Hutchings, Weiting Yu, Yang Zhou, Robert V. Forest, Runzhe Tao, Jonathan Rosen, Bryan T. Yonemoto, Zeyuan Cao, Haimei Zheng, John Q. Xiao, Feng Jiao and Jingguang G. Chen Investigations into non-precious metal catalysts for hydrogen evolution are ongoing. Here, the authors report a hierarchical, nanoporous copper-titanium electrocatalyst, and demonstrate that it catalyses hydrogen production at twice the over-all rate of commercial platinum-based catalysts. 16 March 2015 | doi: 10.1038/ncomms7567 Chemical Sciences  Catalysis  Materials science  Physical chemistry  Terahertz single conductance quantum and topological phase transitions in topological insulator Bi2Se3 ultrathin films Byung Cheol Park, Tae-Hyeon Kim, Kyung Ik Sim, Boyoun Kang, Jeong Won Kim, Beongki Cho, Kwang-Ho Jeong, Mann-Ho Cho and Jae Hoon Kim In ambient conditions, the detection of topological surface states in topological insulators is impaired by the presence of bulk and quantum well states. Here, Park et al. demonstrate how such topological states in epitaxial ultrathin Bi2Se3 may be isolated using terahertz time-domain spectroscopy. 16 March 2015 | doi: 10.1038/ncomms7552 Physical Sciences  Applied physics  Condensed matter  Nanotechnology  Sub-nanosecond signal propagation in anisotropy-engineered nanomagnetic logic chains OPEN Zheng Gu, Mark E. Nowakowski, David B. Carlton, Ralph Storz, Mi-Young Im, Jeongmin Hong, Weilun Chao, Brian Lambson, Patrick Bennett, Mohmmad T. Alam, Matthew A. Marcus, Andrew Doran, Anthony Young, Andreas Scholl, Peter Fischer and Jeffrey Bokor Closely-spaced anisotropically-engineered single-domain nanomagnets may be exploited to encode and transmit binary information. Here, Gu et al. use time-resolved X-ray microscopy to image signal propagation at the intrinsic nanomagnetic switching limit in permalloy nanomagnet chains. 16 March 2015 | doi: 10.1038/ncomms7466 Physical Sciences  Applied physics  Nanotechnology  Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development Baojun Chang, Kandice L. Tessneer, John McManus, Xiaolei Liu, Scott Hahn, Satish Pasula, Hao Wu, Hoogeun Song, Yiyuan Chen, Xiaofeng Cai, Yunzhou Dong, Megan L. Brophy, Ruby Rahman, Jian-Xing Ma, Lijun Xia and Hong Chen Wnt receptors and the cytoplasmic signalling adaptor, dishevelled (Dvl), are upregulated in cancer and result in elevated canonical Wnt signalling. Here the authors show that the adaptor protein Epsin acts as a chaperone that protects Dvl from degradation thereby contributing to excess Wnt signalling and colon cancer growth. 16 March 2015 | doi: 10.1038/ncomms7380 Biological Sciences  Cancer  Molecular biology  HEB associates with PRC2 and SMAD2/3 to regulate developmental fates Se-Jin Yoon, Joseph W. Foley and Julie C. Baker In embryonic stem cells, extracellular signals are required to derepress developmental promoters to drive lineage specification, but the proteins involved in this process remain unknown. Here the authors show that the protein HEB directly associates with the Polycomb repressive complex 2 at genes involved in mesoderm and endoderm specification. 16 March 2015 | doi: 10.1038/ncomms7546 Biological Sciences  Developmental biology  IRF8 directs stress-induced autophagy in macrophages and promotes clearance of Listeria monocytogenes Monica Gupta, Dong-Mi Shin, Lakshmi Ramakrishna, Dennis J. Goussetis, Leonidas C. Platanias, Huabao Xiong, Herbert C. Morse III and Keiko Ozato Autophagy is critical for pathogen clearance by innate immune cells. Here the authors show that IRF8 is activated in response to autophagy-inducing stimuli, promotes autophagic progression by driving transcription of autophagy genes and is critical for clearance of intracellular bacteria. 16 March 2015 | doi: 10.1038/ncomms7379 Biological Sciences  Immunology  Bound vortex dipoles generated at pinning centres by Meissner current Jun-Yi Ge, Joffre Gutierrez, Vladimir N. Gladilin, Jozef T. Devreese and Victor V. Moshchalkov A Meissner current is the resistance-free flow of charge induced by magnetic field in a superconductor. Here, the authors observe that Meissner currents flowing through an area containing a pinning centre generate two opposite-sense current half-loops that produce a bound vortex–antivortex pair. 16 March 2015 | doi: 10.1038/ncomms7573 Physical Sciences  Condensed matter  Materials science  ERK phosphorylation and miR-181a expression modulate activation of human memory TH17 cells Federico Mele, Camilla Basso, Cristina Leoni, Dominik Aschenbrenner, Simone Becattini, Daniela Latorre, Antonio Lanzavecchia, Federica Sallusto and Silvia Monticelli How the magnitude of the response is regulated in different T-cell memory subsets remains poorly understood. Here the authors show that miR-181 lowers the threshold of Th17 memory activation via sustained Erk phosphorylation, while Erk-dependent induction of ID3 limits Th17 activity at later time. 16 March 2015 | doi: 10.1038/ncomms7431 Biological Sciences  Immunology  Translational diffusion of hydration water correlates with functional motions in folded and intrinsically disordered proteins OPEN Giorgio Schirò, Yann Fichou, Francois-Xavier Gallat, Kathleen Wood, Frank Gabel, Martine Moulin, Michael Härtlein, Matthias Heyden, Jacques-Philippe Colletier, Andrea Orecchini, Alessandro Paciaroni, Joachim Wuttke, Douglas J. Tobias and Martin Weik Hydration water plasticizes protein structures and is essential for their biological functions, such as enzymatic catalysis. Here, the authors use neutron scattering and molecular dynamics simulations to study hydration water at the dynamical transition of folded and disordered proteins. 16 March 2015 | doi: 10.1038/ncomms7490 Biological Sciences  Biochemistry  Biophysics  Chemical biology  Structural and evolutionary versatility in protein complexes with uneven stoichiometry Joseph A. Marsh, Holly A. Rees, Sebastian E. Ahnert and Sarah A. Teichmann Although many heteromeric protein complexes exhibit 1:1 ratios between their components, a significant number feature uneven stoichiometry. Marsh et al. perform a global analysis of uneven stoichiometry, identifying structural mechanisms by which it is achieved, and explaining its differential conservation. 16 March 2015 | doi: 10.1038/ncomms7394 Biological Sciences  Biochemistry  Bioinformatics  Evolution  Genome-wide association study identifies a new susceptibility locus for cleft lip with or without a cleft palate Yimin Sun, Yongqing Huang, Aihua Yin, Yongchu Pan, Yirui Wang, Cheng Wang, Yong Du, Meilin Wang, Feifei Lan, Zhibin Hu, Guoqing Wang, Min Jiang, Junqing Ma, Xiaozhuang Zhang, Hongxia Ma, Jian Ma, Weibing Zhang, Qun Huang, Zhongwei Zhou, Lan Ma et al. Cleft lip is one of the most common congenital birth defects with substantial impairments to quality of life. Here, Sun et al. identify a new locus associated with cleft lip in diverse Chinese populations. 16 March 2015 | doi: 10.1038/ncomms7414 Biological Sciences  Genetics  Oriented cell division shapes carnivorous pitcher leaves of Sarracenia purpurea OPEN Kenji Fukushima, Hironori Fujita, Takahiro Yamaguchi, Masayoshi Kawaguchi, Hirokazu Tsukaya and Mitsuyasu Hasebe The pitcher-shaped leaf of the carnivorous plant Sarracenia purpurea acts as a pitfall trap to capture small animals. Here, Fukushima et al. analyse pitcher leaf development and propose that this unusual shape evolved from ancestral planar leaves through changes in the orientation of cell division. 16 March 2015 | doi: 10.1038/ncomms7450 Biological Sciences  Evolution  Plant sciences  Reversed oxygen sensing using colloidal quantum wells towards highly emissive photoresponsive varnishes OPEN Monica Lorenzon, Sotirios Christodoulou, Gianfranco Vaccaro, Jacopo Pedrini, Francesco Meinardi, Iwan Moreels and Sergio Brovelli Colloidal quantum wells have great potential as solution-processed light sources. Here, Lorenzon et al. demonstrate that such colloidal quantum wells can also be exploited as luminescent-sensing varnishes capable of detecting chemical agents through their reversible emission response. 16 March 2015 | doi: 10.1038/ncomms7434 Physical Sciences  Applied physics  Nanotechnology  Optical physics  Maturation of the proteasome core particle induces an affinity switch that controls regulatory particle association Prashant S. Wani, Michael A. Rowland, Alex Ondracek, Eric J. Deeds and Jeroen Roelofs Proteasome assembly requires the coordinated association of over sixty proteins and is dependent on chaperones. Wani et al. show that the core particle undergoes a maturation-associated decrease in its affinity for the chaperone Pba1-Pba2 that ensures timely association with the regulatory particle. 16 March 2015 | doi: 10.1038/ncomms7384 Biological Sciences  Biochemistry  Sensitive β-galactosidase-targeting fluorescence probe for visualizing small peritoneal metastatic tumours in vivo OPEN Daisuke Asanuma, Masayo Sakabe, Mako Kamiya, Kyoko Yamamoto, Jun Hiratake, Mikako Ogawa, Nobuyuki Kosaka, Peter L. Choyke, Tetsuo Nagano, Hisataka Kobayashi and Yasuteru Urano Surgical removal of the metastases remains a life-extending approach to ovarian cancer, but the nodules are difficult to detect. Here the authors show that a new cell-permeable probe for β-galactosidase can sensitively and specifically detect peritoneal metastases in mouse models of ovarian cancer. 13 March 2015 | doi: 10.1038/ncomms7463 Biological Sciences  Biotechnology  Cancer  Notch1–Dll4 signalling and mechanical force regulate leader cell formation during collective cell migration Reza Riahi, Jian Sun, Shue Wang, Min Long, Donna D. Zhang and Pak Kin Wong Many forms of collective cell migration are directed by specialized leader cells that have a distinct protrusive phenotype. Riahi et al. show that lateral inhibition mediated by Notch1–Dll4 signalling determines the stochastic emergence of leader cells in epithelial monolayers. 13 March 2015 | doi: 10.1038/ncomms7556 Biological Sciences  Cell biology  Dynamic designing of microstructures by chemical gradient-mediated growth OPEN Tae Soup Shim, Seung-Man Yang and Shin-Hyun Kim While microparticle shape can have significant influence on their properties, simple ways to control shape are difficult to achieve. Here, the authors report a method giving a high degree of control over the shape of such structures by generating gradients of oxygen concentration during photopolymerization. 13 March 2015 | doi: 10.1038/ncomms7584 Chemical Sciences  Materials science  Physical chemistry  Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic OPEN Sharon W. Way, Joseph R. Podojil, Benjamin L. Clayton, Anita Zaremba, Tassie L. Collins, Rejani B. Kunjamma, Andrew P. Robinson, Pedro Brugarolas, Robert H. Miller, Stephen D. Miller and Brian Popko Current multiple sclerosis treatments focus on prevention of immune attack on oligodendrocytes and myelin. Here the authors show a different strategy to ameliorate disease in several mouse models, protecting oligodendrocytes from inflammation-induced death with an FDA-approved drug, guanabenz. 13 March 2015 | doi: 10.1038/ncomms7532 Biological Sciences  Immunology  Neuroscience  Complete information acquisition in dynamic force microscopy Alexei Belianinov, Sergei V. Kalinin and Stephen Jesse An often overlooked component of scanning probe microscopy involves information transfer from the tip–surface junction to a macroscopic measurement system. Here, the authors present an information–theory-based approach that relies on capturing the response at a wide-frequency band, allowing a complete and unbiased look at probing interaction. 13 March 2015 | doi: 10.1038/ncomms7550 Physical Sciences  Applied physics  Nanotechnology  Physical chemistry  Surface modification-induced phase transformation of hexagonal close-packed gold square sheets Zhanxi Fan, Xiao Huang, Yu Han, Michel Bosman, Qingxiao Wang, Yihan Zhu, Qing Liu, Bing Li, Zhiyuan Zeng, Jumiati Wu, Wenxiong Shi, Shuzhou Li, Chee Lip Gan and Hua Zhang Phase transformations between different crystal structures in nanomaterials conventionally require extreme conditions, such as high pressure or high temperature. Here, the authors report the phase transformation of Au nanosheets by the exchange of surface ligands or coating of Ag at ambient conditions. 13 March 2015 | doi: 10.1038/ncomms7571 Chemical Sciences  Materials science  Nanotechnology  The interferon-related developmental regulator 1 is used by human papillomavirus to suppress NFκB activation OPEN Bart Tummers, Renske Goedemans, Laetitia P. L. Pelascini, Ekaterina S. Jordanova, Edith M. G. van Esch, Craig Meyers, Cornelis J. M. Melief, Judith M. Boer and Sjoerd H. van der Burg Human papillomavirus employs immune evasion strategies to establish a long-term infection. Here the authors show that the virus in the EGFR-dependent manner induces IFRD1, which blocks NFκB activating acetylation, and that this process can be suppressed by the EGFR inhibitor cetuximab. 13 March 2015 | doi: 10.1038/ncomms7537 Biological Sciences  Cancer  Immunology  Virology  Coherent quantum depletion of an interacting atom condensate OPEN M. Kira To overcome losses and thermalization, a quantum system requires strong interactions. Following recent experiments, Mackillo Kira shows that a BEC swept fast enough from weak to strong interactions exhibits coherent quantum-depletion dynamics dominated by particle clusters, resembling semiconductor excitations. 13 March 2015 | doi: 10.1038/ncomms7624 Physical Sciences  Atomic and molecular physics  Condensed matter  Theoretical physics  The a.c. Josephson effect without superconductivity OPEN Benoit Gaury, Joseph Weston and Xavier Waintal Most of the peculiar effects resulting from superconductivity have counterparts in nonsuperconducting nanoelectronic devices, but not yet in the a.c. Josephson effect. Here, the authors propose how to generate a transient version of this phenomenon in a normal conductor by abruptly changing the bias voltage. 13 March 2015 | doi: 10.1038/ncomms7524 Physical Sciences  Condensed matter  A clonotypic Vγ4Jγ1/Vδ5Dδ2Jδ1 innate γδ T-cell population restricted to the CCR6+CD27− subset Elham Kashani, Lisa Föhse, Solaiman Raha, Inga Sandrock, Linda Oberdörfer, Christian Koenecke, Sebastian Suerbaum, Siegfried Weiss and Immo Prinz Functional diversity of T cells expressing antigen receptors composed of γ and δ chains is just beginning to be appreciated. Here the authors show that within γδ T cells of highly diverse Vγ4+repertoire there is a population with germline rearranged, invariant TCR and a distinct phenotype. 13 March 2015 | doi: 10.1038/ncomms7477 Biological Sciences  Immunology  Sumoylation controls the timing of Tup1-mediated transcriptional deactivation Chong Han Ng, Akhi Akhter, Nathan Yurko, Justin M. Burgener, Emanuel Rosonina and James L. Manley Tup1 was identified as a transcriptional repressor; however the protein remains associated with promoters of target genes after activation. Ng et al. show that Tup1 is SUMOylated under stress conditions, and that SUMOylation is required for persistence of Tup1 at active promoters. 13 March 2015 | doi: 10.1038/ncomms7610 Biological Sciences  Molecular biology  Selective ingress of a Samoan plume component into the northern Lau backarc basin Oliver Nebel and Richard J. Arculus Ocean island basalts contain primordial and recycled crustal components, sourced from the deep mantle by plumes. Here, the authors examine Hf-Nd-He isotopes in ocean floor basalts south of Samoa and suggest that selective ingress of only the primordial component from the Samoan plume can occur. 12 March 2015 | doi: 10.1038/ncomms7554 Earth Sciences  Geology and geophysics  TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution Ronan Broderick, Jadwiga Nieminuszczy, Andrew N. Blackford, Alicja Winczura and Wojciech Niedzwiedz During chromosome segregation sister chromatids can be entangled, resulting in anaphase bridges that must be resolved. Here, the authors report that topoisomerase IIβ binding protein 1 recruits topoisomerase IIα to centromere-associated ultra-fine anaphase bridges to enable their efficient resolution. 12 March 2015 | doi: 10.1038/ncomms7572 Biological Sciences  Cell biology  Topological proximity effect in a topological insulator hybrid T. Shoman, A. Takayama, T. Sato, S. Souma, T. Takahashi, T. Oguchi, Kouji Segawa and Yoichi Ando A topologically protected state can exist at the interface between a topological insulator and an ordinary insulator. Here, the authors use photoemission spectroscopy to show that the topological Dirac-cone state migrates from the surface of the topological insulator TlBiSe2 to an attached bismuth film. 12 March 2015 | doi: 10.1038/ncomms7547 Physical Sciences  Condensed matter  Materials science  Nanotechnology  Local endocytosis triggers dendritic thinning and pruning in Drosophila sensory neurons Takahiro Kanamori, Jiro Yoshino, Kei-ichiro Yasunaga, Yusuke Dairyo and Kazuo Emoto During development, neurons prune their axons and dendrites to eliminate excessive or inappropriate connections initially formed but the mechanistic details of the pruning process are not completely understood. Here the authors visualize pruning events in dendritic branches in Drosophila and study the role of calcium transients and endocytosis in this process. 12 March 2015 | doi: 10.1038/ncomms7515 Biological Sciences  Developmental biology  Neuroscience  Mitochondrial SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity OPEN Ke Tan, Mitsuaki Fujimoto, Ryosuke Takii, Eiichi Takaki, Naoki Hayashida and Akira Nakai Heat shock induces proteotoxic stress, and the cellular response is mediated by heat-shock factor 1 (HSF1). Here, Tan et al. show that following heat shock, mitochondrial SSBP1 translocates to the nucleus and binds HSF1 to enhance the expression of chaperones and support the maintenance of mitochondrial function. 12 March 2015 | doi: 10.1038/ncomms7580 Biological Sciences  Cell biology  Structure of p15PAF–PCNA complex and implications for clamp sliding during DNA replication and repair Alfredo De Biasio, Alain Ibáñez de Opakua, Gulnahar B. Mortuza, Rafael Molina, Tiago N. Cordeiro, Francisco Castillo, Maider Villate, Nekane Merino, Sandra Delgado, David Gil-Cartón, Irene Luque, Tammo Diercks, Pau Bernadó, Guillermo Montoya and Francisco J. Blanco p15PAF regulates DNA replication and repair via interactions with the Proliferating Cell Nuclear Antigen (PCNA) sliding clamp. Here the authors present multi-faceted structural analyses of the p15-PCNA-DNA complex that suggests p15 regulates the sliding of PCNA along DNA during replication. 12 March 2015 | doi: 10.1038/ncomms7439 Biological Sciences  Biochemistry  Biophysics  Molecular biology  A high-mobility electronic system at an electrolyte-gated oxide surface OPEN Patrick Gallagher, Menyoung Lee, Trevor A. Petach, Sam W. Stanwyck, James R. Williams, Kenji Watanabe, Takashi Taniguchi and David Goldhaber-Gordon Electrolyte gating enables the accumulation of large carrier densities in two-dimensional electron systems. Here, the authors demonstrate that a few-atom thick layer of hexagonal boron nitride can dramatically improve carrier mobility in an electrolyte-gated system by limiting chemical reactions and disorder. 12 March 2015 | doi: 10.1038/ncomms7437 Physical Sciences  Condensed matter  Materials science  Tropical cyclone rainfall area controlled by relative sea surface temperature OPEN Yanluan Lin, Ming Zhao and Minghua Zhang The rainfall rate of tropical cyclones is expected to increase under a warmer climate, yet likely changes in rainfall area remain unknown. Here, the authors combine satellite data and model simulations and show that rainfall area is dependent on relative sea surface temperatures. 12 March 2015 | doi: 10.1038/ncomms7591 Earth Sciences  Atmospheric science  Climate science  Vimentin regulates activation of the NLRP3 inflammasome Gimena dos Santos, Micah R. Rogel, Margaret A. Baker, James R. Troken, Daniela Urich, Luisa Morales-Nebreda, Joseph A. Sennello, Mikhail A. Kutuzov, Albert Sitikov, Jennifer M. Davis, Anna P. Lam, Paul Cheresh, David Kamp, Dale K. Shumaker, G. R. Scott Budinger and Karen M. Ridge The mechanism of NLRP3 activation remains incompletely characterized. Here the authors show that it is dependent on vimentin, and that NLRP3-mediated lung injury and fibrosis induced by endotoxin, asbestos or bleomycin are reduced in vimentin-deficient mice. 12 March 2015 | doi: 10.1038/ncomms7574 Biological Sciences  Condensed matter  Immunology  Materials science  Surface transfer doping induced effective modulation on ambipolar characteristics of few-layer black phosphorus Du Xiang, Cheng Han, Jing Wu, Shu Zhong, Yiyang Liu, Jiadan Lin, Xue-Ao Zhang, Wen Ping Hu, Barbaros Özyilmaz, A. H. Castro Neto, Andrew Thye Shen Wee and Wei Chen Black phosphorus is a graphene-like material that can be harnessed for two-dimensional electronic devices. Here, Xiang et al. demonstrate that adding caesium carbonate or molybdenum trioxide can significantly enhance the electron or hole conduction, respectively, of this promising material. 12 March 2015 | doi: 10.1038/ncomms7485 Physical Sciences  Materials science  Micro-trace fossils reveal pervasive reworking of Pliocene sapropels by low-oxygen-adapted benthic meiofauna S.C. Löhr and M.J. Kennedy Meiofaunal burrowing is thought to produce sediment textures that appear devoid of animal activity, thus the record of meiofaunal activity remains unknown. Here, the authors apply a novel sampling and electron imaging approach to identify meiofaunal traces in Pliocene sapropels, a classic anoxic facies. 12 March 2015 | doi: 10.1038/ncomms7589 Earth Sciences  Geology and geophysics  Visualization of nanocrystal breathing modes at extreme strains Erzsi Szilagyi, Joshua S. Wittenberg, Timothy A. Miller, Katie Lutker, Florian Quirin, Henrik Lemke, Diling Zhu, Matthieu Chollet, Joseph Robinson, Haidan Wen, Klaus Sokolowski-Tinten and Aaron M. Lindenberg Nanoscale dimensions can lead to unique functional properties, often achieved via large-amplitude strains. Here, the authors use femtosecond X-rays to visualize light-induced strains in semiconductor nanocrystals, showing that they correspond to anisotropic ‘breathing modes’, which collapse after straining. 12 March 2015 | doi: 10.1038/ncomms7577 Physical Sciences  Materials science  Spin-dependent charge transfer state design rules in organic photovoltaics Wendi Chang, Daniel N. Congreve, Eric Hontz, Matthias E. Bahlke, David P. McMahon, Sebastian Reineke, Tony C. Wu, Vladimir Bulović, Troy Van Voorhis and Marc A. Baldo An important source of loss in solar cells is the recombination of the photogenerated charge carriers before they are extracted from the device. Chang et al. now show that such recombination can be reduced in organic solar cells by increasing the separation between donors and acceptors. 12 March 2015 | doi: 10.1038/ncomms7415 Physical Sciences  Materials science  Optical physics  IL-23-mediated mononuclear phagocyte crosstalk protects mice from Citrobacter rodentium-induced colon immunopathology OPEN Tegest Aychek, Alexander Mildner, Simon Yona, Ki-Wook Kim, Nardy Lampl, Shlomit Reich-Zeliger, Louis Boon, Nir Yogev, Ari Waisman, Daniel J. Cua and Steffen Jung Macrophages and dendritic cells contribute to gut homeostasis and mucosal immune defense. Here, Aychek et al. describe an IL-23-based crosstalk between these cells that prevents lethal immunopathology during Citrobacter rodentium infection. 12 March 2015 | doi: 10.1038/ncomms7525 Biological Sciences  Immunology  Microbiology  Targeting bacteria via iminoboronate chemistry of amine-presenting lipids Anupam Bandyopadhyay, Kelly A. McCarthy, Michael A. Kelly and Jianmin Gao The analysis of cell membrane biology, and in particular the constituent lipid content, can yield important information on cell function. Here, the authors present a method to selectively and covalently label amine-presenting lipids in bacterial cell membranes. 12 March 2015 | doi: 10.1038/ncomms7561 Biological Sciences  Cell biology  Chemical biology  Organic chemistry  Immunotoxin targeting glypican-3 regresses liver cancer via dual inhibition of Wnt signalling and protein synthesis Wei Gao, Zhewei Tang, Yi-Fan Zhang, Mingqian Feng, Min Qian, Dimiter S. Dimitrov and Mitchell Ho Tumour-targeted antibodies can kill cancer cells by blocking pro-survival signalling or by delivering a toxin. Here the authors show that glypican-3 antibody fused to a bacterial toxin suppresses tumour growth more efficiently if designed to block Wnt signalling downstream of glypican-3. 11 March 2015 | doi: 10.1038/ncomms7536 Biological Sciences  Biotechnology  Cancer  Artificial human Met agonists based on macrocycle scaffolds OPEN Kenichiro Ito, Katsuya Sakai, Yoshinori Suzuki, Naoya Ozawa, Tomohisa Hatta, Tohru Natsume, Kunio Matsumoto and Hiroaki Suga Activation of the Met receptor by hepatocyte growth factor requires Met receptor dimerization. Here, the authors identify Met-binding peptide macrocycles that, in a dimeric form as a result of chemical crosslinking, induce Met receptor dimerization and activation in cultured human cells. 11 March 2015 | doi: 10.1038/ncomms7373 Biological Sciences  Chemical biology  Organelles maintain spindle position in plant meiosis Lynette Brownfield, Jun Yi, Hua Jiang, Elena A. Minina, David Twell and Claudia Köhler In many plants, male meiosis involves two rounds of chromosome separation without cell division, resulting in two spindles in a single cell. Here Brownfield et al. show that an organelle band acts as a physical barrier between the spindles to ensure accurate chromosome segregation. 11 March 2015 | doi: 10.1038/ncomms7492 Biological Sciences  Cell biology  Developmental biology  Plant sciences  Porous molybdenum carbide nano-octahedrons synthesized via confined carburization in metal-organic frameworks for efficient hydrogen production OPEN Hao Bin Wu, Bao Yu Xia, Le Yu, Xin-Yao Yu and Xiong Wen (David) Lou There is extensive research into non-platinum electrocatalysts for hydrogen evolution. Here, the authors report a molybdenum carbide catalyst, prepared via the carburization of a copper metal-organic framework host/molybdenum-based polyoxometalates guest system, and demonstrate its catalytic activity. 11 March 2015 | doi: 10.1038/ncomms7512 Chemical Sciences  Inorganic chemistry  Materials science  Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota OPEN Lucie Geurts, Amandine Everard, Matthias Van Hul, Ahmed Essaghir, Thibaut Duparc, Sébastien Matamoros, Hubert Plovier, Julien Castel, Raphael G. P. Denis, Marie Bergiers, Céline Druart, Mireille Alhouayek, Nathalie M. Delzenne, Giulio G. Muccioli, Jean-Baptiste Demoulin, Serge Luquet and Patrice D. Cani Endocannabinoids are bioactive lipid molecules produced in the body. Here, Geurts et al. create mice lacking the endocannabinoid-producing enzyme NAPE-PLD in adipocytes and report defects in adipose-induced browning, which are mediated by alterations in the gut microbiome. 11 March 2015 | doi: 10.1038/ncomms7495 Biological Sciences  Medical research  Red blood cell as an adaptive optofluidic microlens L. Miccio, P. Memmolo, F. Merola, P. A. Netti and P. Ferraro The shape of red blood cells is highly sensitive to surrounding liquid environment. Here, Miccio et al. make red blood cells into optofluidic lenses with fully controllable focal length at the microscale, which can be used for imaging and optical magnification in addition to blood diseases detection. 11 March 2015 | doi: 10.1038/ncomms7502 Physical Sciences  Biophysics  Fluids and plasma physics  Optical physics  Total synthesis of clostrubin OPEN Ming Yang, Jian Li and Ang Li Due to rising resistance, efficient routes to new antibiotics is a vital task for human health. Here, the authors report a short, convergent and elegant synthesis of a very recently reported antibiotic, successfully giving access to this material on scale. 11 March 2015 | doi: 10.1038/ncomms7445 Chemical Sciences  Medicinal chemistry  Organic chemistry  Multiple-length-scale deformation analysis in a thermoplastic polyurethane OPEN Tan Sui, Nikolaos Baimpas, Igor P. Dolbnya, Cristina Prisacariu and Alexander M. Korsunsky Thermoplastic polyurethane elastomers are of interest in many applications, but their structure–property relations are not well understood. Here, the authors perform a multiple-length-scale deformation analysis on a thermoplastic polyurethane and shed light on morphological changes during the deformation. 11 March 2015 | doi: 10.1038/ncomms7583 Physical Sciences  Applied physics  Materials science  Silane-catalysed fast growth of large single-crystalline graphene on hexagonal boron nitride OPEN Shujie Tang, Haomin Wang, Hui Shan Wang, Qiujuan Sun, Xiuyun Zhang, Chunxiao Cong, Hong Xie, Xiaoyu Liu, Xiaohao Zhou, Fuqiang Huang, Xiaoshuang Chen, Ting Yu, Feng Ding, Xiaoming Xie and Mianheng Jiang The growth of high-quality graphene directly on to dielectric substrates is of key importance for future electronic and optoelectronic applications. Here, the authors use silane-catalysed chemical vapour deposition to fabricate large graphene sheets, up to 20 μm in size, on hexagonal boron nitride. 11 March 2015 | doi: 10.1038/ncomms7499 Physical Sciences  Applied physics  Materials science  Nanotechnology  Choice-correlated activity fluctuations underlie learning of neuronal category representation OPEN Tatiana A. Engel, Warasinee Chaisangmongkon, David J. Freedman and Xiao-Jing Wang The ability to categorize stimuli into discrete behaviourally relevant groups is an essential cognitive function. Here, the authors demonstrate a critical role for choice-correlated activity fluctuations in the emergence of stable cortical category representations. 11 March 2015 | doi: 10.1038/ncomms7454 Biological Sciences  Neuroscience  Epigenetic variation in the Egfr gene generates quantitative variation in a complex trait in ants Sebastian Alvarado, Rajendhran Rajakumar, Ehab Abouheif and Moshe Szyf Variation in complex traits is generated by the interaction of genetic and environmental factors. Here, the authors show that genome-wide DNA methylation indirectly regulates quantitative methylation of the Egfr gene to generate continuous size variation of larvae workers in the carpenter ant. 11 March 2015 | doi: 10.1038/ncomms7513 Biological Sciences  Evolution  Genetics  A molecular catalyst for water oxidation that binds to metal oxide surfaces OPEN Stafford W. Sheehan, Julianne M. Thomsen, Ulrich Hintermair, Robert H. Crabtree, Gary W. Brudvig and Charles A. Schmuttenmaer Molecular catalysts can exhibit high activity, but their practical application may be limited by solubility and stability issues. Here, the authors report stable, direct binding of an iridium molecular catalyst to conductive oxide surfaces and demonstrate its activity for electrochemical water oxidation. 11 March 2015 | doi: 10.1038/ncomms7469 Chemical Sciences  Catalysis  Inorganic chemistry  Physical chemistry  RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer OPEN Matthew J. Niederst, Lecia V. Sequist, John T. Poirier, Craig H. Mermel, Elizabeth L. Lockerman, Angel R. Garcia, Ryohei Katayama, Carlotta Costa, Kenneth N. Ross, Teresa Moran, Emily Howe, Linnea E. Fulton, Hillary E. Mulvey, Lindsay A. Bernardo, Farhiya Mohamoud, Norikatsu Miyoshi, Paul A. VanderLaan, Daniel B. Costa, Pasi A. Jänne, Darrell R. Borger et al. Resistance to tyrosine kinase inhibitors occurs in treatments of non-small-cell lung cancers (NSCLCs) with EGFR mutations but the mechanisms underlying this acquired resistance are unknown. Here the authors examine the molecular changes that occur in resistant cancers that transition from NSCLC to small-cell lung cancer phenotype and implicate loss of retinoblastoma in this process. 11 March 2015 | doi: 10.1038/ncomms7377 Biological Sciences  Cancer  Medical research  Berry phases and the intrinsic thermal Hall effect in high-temperature cuprate superconductors Vladimir Cvetkovic and Oskar Vafek A fully quantum mechanical description of the thermal Hall effect in high-temperature cuprate superconductors remains elusive. Here, by connecting it to momentum space Berry phases, the authors calculate the dependence of the intrinsic thermal Hall conductivity on temperature, external field and pairing gap. 11 March 2015 | doi: 10.1038/ncomms7518 Physical Sciences  Condensed matter  The insulin and IGF1 receptor kinase domains are functional dimers in the activated state M. Zulema Cabail, Shiqing Li, Eric Lemmon, Mark E. Bowen, Stevan R. Hubbard and W. Todd Miller In contrast to most receptor tyrosine kinases, the insulin and insulin-like growth factor-1 receptors are preformed, disulfide-linked dimers. Here the authors show that, after the two kinase domains of IR and IGF1R undergo autophosphorylation, they form a specific dimer to phosphorylate downstream substrates. 11 March 2015 | doi: 10.1038/ncomms7406 Biological Sciences  Biochemistry  Biophysics  Gut microbiome development along the colorectal adenoma–carcinoma sequence Qiang Feng, Suisha Liang, Huijue Jia, Andreas Stadlmayr, Longqing Tang, Zhou Lan, Dongya Zhang, Huihua Xia, Xiaoying Xu, Zhuye Jie, Lili Su, Xiaoping Li, Xin Li, Junhua Li, Liang Xiao, Ursula Huber-Schönauer, David Niederseer, Xun Xu, Jumana Yousuf Al-Aama, Huanming Yang et al. The gut microbiota is involved in the development of colorectal cancer. Here, the authors analyse the faecal microbiomes of healthy subjects and of patients with colorectal cancer or benign adenoma, revealing microbial genes, strains and functions enriched in each group. 11 March 2015 | doi: 10.1038/ncomms7528 Biological Sciences  Cancer  Medical research  Microbiology  Plastid establishment did not require a chlamydial partner OPEN Daryl Domman, Matthias Horn, T. Martin Embley and Tom A. Williams Primary plastids descend from an endosymbiosis involving cyanobacteria, an ancient eukaryotic host and, possibly, a chlamydial pathogen. Here, Domman and colleagues use sophisticated phylogenetic methods to show that Chlamydiae did not play a role in establishing the primary plastid endosymbiosis. 11 March 2015 | doi: 10.1038/ncomms7421 Biological Sciences  Evolution  Exploitation of desilylation chemistry in tailor-made functionalization on diverse surfaces OPEN Yongchun Fu, Songjie Chen, Akiyoshi Kuzume, Alexander Rudnev, Cancan Huang, Veerabhadrarao Kaliginedi, Masoud Baghernejad, Wenjing Hong, Thomas Wandlowski, Silvio Decurtins and Shi-Xia Liu Formation of stable and uniform self-assembled monolayers on surfaces is a prerequisite for bottom-up fabrication of many organic molecular devices. Here, the authors present a fabrication approach based on desilylation chemistry for modification and functionalization on various metal and carbon surfaces. 11 March 2015 | doi: 10.1038/ncomms7403 Chemical Sciences  Materials science  Nanotechnology    Nature Communications JOBS of the week Post-doctoral Fellowship Cornell University Postdoctoral Scientist Medical Research Council PhD Position Otto-Von-Guericke University Magdeburg Professor / Reader in Advanced Textiles Nottingham Trent University P / D Research Fellow University of Leeds Postdoctoral Research Associate Princeton University Post-doctoral Researcher University of Miami Postdoctoral Scientist Medical Research Council - Toxicology Unit Postdoctoral Research Associate Grade 7 University of Liverpool More Science jobs from Nature Communications EVENT Single Cell Analysis USA Congress 27.10.15 Boston, USA More science events from       Latest Corrigendum     Corrigendum: The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis Roberto Lande, Elisabetta Botti, Camilla Jandus, Danijel Dojcinovic, Giorgia Fanelli, Curdin Conrad, Georgios Chamilos, Laurence Feldmeyer, Barbara Marinari, Susan Chon, Luis Vence, Valeria Riccieri, Phillippe Guillaume, Alex A. Navarini, Pedro Romero, Antonio Costanzo, Enza Piccolella, Michel Gilliet and Loredana Frasca 11 March 2015 | doi: 10.1038/ncomms7595 Biological Sciences  Immunology  Medical research      Advertisement Nature Communications is now fully open access All new submissions if accepted, will be published open access and an article processing charge will apply. For more information visit the website. Visit our open access funding page or contact  openaccess@nature.com to learn more on APC funding.     Advertisement Don't let your data go to waste...  Scientific Data helps researchers make the most of their data, offering publication in a peer reviewed open access journal. We welcome data of all sizes, from all areas of science. What's unique? 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