Nature Reviews Cancer contents April 2015 Volume 15 Number 4 pp195-254

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TABLE OF CONTENTS
April 2015 Volume 15 Number 4
Impact Factor 37.912 *	In this issue Research Highlights Reviews Perspectives Correspondence Perspectives Also this month  Featured article: Haematological malignancies: at the forefront of immunotherapeutic innovation Pavan Bachireddy, Ute E. Burkhardt, Mohini Rajasagi & Catherine J. Wu
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Nature Outlook Liver Cancer Liver cancer is one of the most lethal forms of the disease. But if researchers can understand why some people with unhealthy livers develop cancer but others do not, they may be able to more effectively treat the disease — or even prevent it.  Access the Outlook free online. Produced with support from:  Tongji Hospital
RESEARCH HIGHLIGHTS Top Tumour microenvironment: Driving relapse p195 | doi:10.1038/nrc3935 Two papers in Nature Genetics report on the role of stromal cells, especially cancer-associated fibroblasts, in poor-prognosis colorectal cancer. PDF Tumorigenesis: Order matters p196 | doi:10.1038/nrc3926 Ortmann and Kent et al. show that the order of acquisition of Janus kinase 2 (JAK2) mutations and tet methylcytosine dioxygenase 2 (TET2) mutations in myeloproliferative neoplasms can affect tumour cell biology and clinical phenotypes. PDF Epigenetics: Chromatin marks the spot p196 | doi:10.1038/nrc3934 Polak et al. have found that the mutation profile of a given cancer can be predicted from the epigenomic signature of the cell type from which that cancer was most likely to have originated. PDF Inflammation: An innate response p197 | doi:10.1038/nrc3927 Alberto Mantovani and colleagues have found that loss of a regulator of the complement cascade, penatraxin 3 (PTX3), accelerates tumour development in mice owing to a complement- and macrophage-mediated immune response. PDF Heterogeneity: Explosive beginnings p198 | doi:10.1038/nrc3928 Sottoriva et al. propose a model by which colorectal tumours evolve, which generates different types of spatial intratumoural heterogeneity. PDF Genomic instability: Building bridges p198 | doi:10.1038/nrc3933 Marzec et al. have described a new telomere-dependent mechanism by which genomic instability and chromosomal translocations can be induced in cancer cells that use alternative lengthening of telomeres for telomere maintenance. PDF IN BRIEF Non-coding RNA: Editing suppresses melanoma progression | Heterogeneity: Cooperative crosstalk | Leukaemia: Putting leukaemia genes in context | Metabolism: Diabetes treatment and intestinal tumorigenesis | Tumour microenvironment: Clearing the air for T cells | Circulating tumour cells: Breaking free | Tumour immunology: If the mountain will not come to Muhammad... | Treatment response: Stay warm PDF Cancer JOBS of the week Faculty Position in Cancer Genomics Northwestern University Postdoctoral Research Fellow in Cancer Systems Biology Cincinnati Children's Hospital Medical Center PhD in Cancer and Genetics Cardiff University Postdoctoral position to study the role of epigenetics in the pathogenesis of cancer Cold Spring Harbor Laboratory (CSHL) Postdoctoral - Vivo Cancer Imaging - California Institute of Quantitative Biosciences University of California, Berkeley More Science jobs from Cancer EVENT Metabolism in Cancer and Stromal Cells 08.09.15 Leuven, Belgium More science events from
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REVIEWS		Top
Haematological malignancies: at the forefront of immunotherapeutic innovation Pavan Bachireddy, Ute E. Burkhardt, Mohini Rajasagi & Catherine J. Wu p201 | doi:10.1038/nrc3907 Haematological malignancies have provided both initial proofs of concept and an informative testing ground for various immune-based cancer therapeutics. The immune-cell origin of many of the blood malignancies provides a unique opportunity both to understand the mechanisms of cancer immune responsiveness and immune evasion, and to exploit the unique therapeutic opportunities they provide. Abstract | Full Text | PDF
Targeting liver X receptors in cancer therapeutics Chin-Yo Lin & Jan-Ake Gustafsson p216 | doi:10.1038/nrc3912 This Review discusses the roles of liver X receptors (LXRs) in cancer and the possibilities for targeting them. Abstract | Full Text | PDF
Caveolae and signalling in cancer Ubaldo E. Martinez-Outschoorn, Federica Sotgia & Michael P. Lisanti p225 | doi:10.1038/nrc3915 Caveolar lipid rafts are distinct regions of the cell membrane that can mediate diverse signalling events, including the regulation of autophagy, responses to oxidative stress and metabolism. What are the implications of caveolae in cancer cells and associated stromal cells? Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Metastasis prevention by targeting the dormant niche Cyrus M. Ghajar p238 | doi:10.1038/nrc3910 This Opinion article advocates therapeutically targeting the niches that harbour dormant disseminated tumour cells in order to make them susceptible to cytotoxic agents. Similar strategies have sensitized leukaemic cells and latent HIV to therapy, and such an approach might delay or even prevent metastasis. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Correspondence: The role of academic health centres to inform evidence-based integrative oncology practice Jun J. Mao, Robert B. Saper & Margaret A. Chesney p247 | doi:10.1038/nrc3822-c3 Full Text | PDF
REPLY		Top
Reply: The role of academic health centres to inform evidence-based integrative oncology practice David H. Gorski p247 | doi:10.1038/nrc3822-c4 Full Text | PDF
Corrigendum: Non-small-cell lung cancers: a heterogeneous set of diseases Zhao Chen, Christine M. Fillmore, Peter S. Hammerman, Carla F. Kim & Kwok-Kin Wong p247 | doi:10.1038/nrc3931 Full Text | PDF
PERSPECTIVES		Top
OPINION Triple-negative breast cancer in African-American women: disparities versus biology Eric C. Dietze, Christopher Sistrunk, Gustavo Miranda-Carboni, Ruth O'Regan & Victoria L. Seewaldt p248 | doi:10.1038/nrc3896 There is evidence that African-American women with triple-negative breast cancer (TNBC) have worse clinical outcomes than women of European descent with TNBC. However, it is unclear whether survival differences persist after adjusting for health disparities. Understanding the relative contributions of biology and disparities is crucial for improving the poor survival of African-American women with TNBC. Abstract | Full Text | PDF
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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