Nature Cell Biology contents: April 2015 Volume 17 Number 4, pp 351-532

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TABLE OF CONTENTS April 2015 Volume 17, Issue 4 Review News and Views Articles Letter Retraction Errata Corrigenda Subscribe   Facebook   RSS   Recommend to library   Twitter   Review Top Metabolic pathways promoting cancer cell survival and growth   pp351 - 359 Lindsey K. Boroughs and Ralph J. DeBerardinis doi:10.1038/ncb3124 Burroughs and DeBerardinis discuss the metabolic pathways that tumour cells employ to promote their survival and proliferation, and present the current approaches to study cancer metabolism in an in vivo setting. News and Views Top Two paths to fat   pp360 - 361 Evan D. Rosen doi:10.1038/ncb3133 Excess caloric intake leads to both the growth of existing fat cells and the generation of new adipocytes. New findings show that PI3K-Akt2 signalling is involved in the differentiation of adult adipose precursor cells — a pathway not required for adipogenesis in the embryo. See also: Article by Jeffery et al. Energy stress tames the Hippo pathway   pp362 - 363 Iswar K. Hariharan doi:10.1038/ncb3141 The kinase AMPK, a sensor of cellular energy stress, has been shown to oppose the growth-promoting activity of YAP, the transcriptional co-activator downstream of the Hippo signalling pathway. This finding may help to explain why the antidiabetic drug metformin, for which AMPK is a key effector, is linked to cancer-protective activity. See also: Article by Mo et al. | Article by Wang et al. Cell Biology JOBS of the week Postdoctoral Fellow: Gene Regulation in Breast Cancer / Stem Cell Biology UC College of Medicine Postdoctoral Fellow in bioinformatics and stem cell biology The University of Texas Medical School At Houston PhD Student Positions in Regenerative Medicine / Stem Cell Biology University Hospital Tubingen PhD student A*STAR Institute of Molecular and Cell Biology (IMCB) More Science jobs from Cell Biology EVENT 3rd Advances in Stem Cell Biology Course 29.06.15 Paris, France More science events from Advertisement Sort Smarter with the S3e™ Cell Sorter. Maximize the sorting capacity of your flow cytometry core with the S3e, an automated benchtop instrument that does not require a dedicated operator. From software-driven setup and real-time sort monitoring to an intuitive interface and small footprint, the S3e makes 1- to 4-color sorts simple and efficient. It's time to start sorting smarter. Learn more.   Articles Top EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival   pp365 - 375 Nai Yang Fu, Anne C. Rios, Bhupinder Pal, Rina Soetanto, Aaron T. L. Lun et al. doi:10.1038/ncb3117 Visvader and colleagues report that in the mouse mammary gland, EGF and mTOR signalling induce expression of the anti-apoptotic Bcl2 family member Mcl-1 and show that this is required for the survival of milk-producing mammary epithelial cells. Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity   pp376 - 385 Elise Jeffery, Christopher D. Church, Brandon Holtrup, Laura Colman and Matthew S. Rodeheffer doi:10.1038/ncb3122 Rodeheffer and colleagues show that a high-fat diet in mice activates Akt2 signalling in adipocyte precursors within white adipose tissue deposits, leading to their proliferation and differentiation into adipocytes, and to obesity. See also: News and Views by Rosen The suture provides a niche for mesenchymal stem cells of craniofacial bones   pp386 - 396 Hu Zhao, Jifan Feng, Thach-Vu Ho, Weston Grimes, Mark Urata et al. doi:10.1038/ncb3139 Chai and colleagues report that Gli1-expressing cells within the mouse cranial suture mesenchyme contribute to all cranial bones, and their ablation leads to impaired skull injury repair, skull growth arrest and osteoporosis. Myosin-II-mediated cell shape changes and cell intercalation contribute to primitive streak formation   pp397 - 408 Emil Rozbicki, Manli Chuai, Antti I. Karjalainen, Feifei Song, Helen M. Sang et al. doi:10.1038/ncb3138 Using light-sheet microscopy to image tissue flows, Weijer and colleagues demonstrate that myosin-II-driven changes in cell shape and cell intercalation contribute to primitive streak formation in chick embryos. Control of cell–cell forces and collective cell dynamics by the intercellular adhesome   pp409 - 420 Elsa Bazellières, Vito Conte, Alberto Elosegui-Artola, Xavier Serra-Picamal, María Bintanel-Morcillo et al. doi:10.1038/ncb3135 Trepat and colleagues conduct a systematic analysis of how key cell–cell adhesion molecules affect intercellular forces and epithelial monolayer dynamics. Kinetochore–microtubule error correction is driven by differentially regulated interaction modes   pp421 - 433 Maria Kalantzaki, Etsushi Kitamura, Tongli Zhang, Akihisa Mino, Béla Novák et al. doi:10.1038/ncb3128 Tanaka and colleagues find that aurora B regulates end-on versus lateral kinetochore–microtubule attachments differently to ensure that chromosomes orient correctly for segregation in mitosis. Ppm1b negatively regulates necroptosis through dephosphorylating Rip3   pp434 - 444 Wanze Chen, Jianfeng Wu, Lisheng Li, Zhengmao Zhang, Junming Ren et al. doi:10.1038/ncb3120 Han and colleagues reveal that the phosphatase Ppm1b dephosphorylates the kinase Rip3 to negatively regulate necroptosis in vitro and in vivo. Cellular chirality arising from the self-organization of the actin cytoskeleton   pp445 - 457 Yee Han Tee, Tom Shemesh, Visalatchi Thiagarajan, Rizal Fajar Hariadi, Karen L. Anderson et al. doi:10.1038/ncb3137 Bershadsky and colleagues show that cells confined to circular adhesive patterns exhibit defined and dynamic self-assembly of their actin cytoskeleton into a chiral pattern with defined handedness, potentially informing left–right cell asymmetry. The telomere bouquet regulates meiotic centromere assembly   pp458 - 469 Michael Klutstein, Alex Fennell, Alfonso Fernández-Álvarez and Julia Promisel Cooper doi:10.1038/ncb3132 Studying spindle formation in fission yeast, Cooper and colleagues discover a role for the meiotic telomere bouquet in supporting centromere assembly. Active diffusion positions the nucleus in mouse oocytes   pp470 - 479 Maria Almonacid, Wylie W. Ahmed, Matthias Bussonnier, Philippe Mailly, Timo Betz et al. doi:10.1038/ncb3131 By live imaging of mouse oocytes, Verlhac and colleagues demonstrate that actin-coated vesicles together with myosin Vb participate in centring of the nucleus by creating a gradient of cytoplasmic forces. Cell-sized spherical confinement induces the spontaneous formation of contractile actomyosin rings in vitro   pp480 - 489 Makito Miyazaki, Masataka Chiba, Hiroki Eguchi, Takashi Ohki and Shin’ichi Ishiwata doi:10.1038/ncb3142 Ishiwata and colleagues demonstrate that actin and myosin II can spontaneously form a contractile ring structure when constrained in a cell-size droplet and that this is regulated by myosin concentration and oligomerization state. AMPK modulates Hippo pathway activity to regulate energy homeostasis   pp490 - 499 Wenqi Wang, Zhen-Dong Xiao, Xu Li, Kathryn E. Aziz, Boyi Gan et al. doi:10.1038/ncb3113 In two related papers, Chen and colleagues and Guan and colleagues report a crucial role for the AMPK and Hippo pathways in glucose homeostasis. Starvation triggers AMPK-mediated phosphorylation and inactivation of YAP. See also: Article by Mo et al. | News and Views by Hariharan Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway   pp500 - 510 Jung-Soon Mo, Zhipeng Meng, Young Chul Kim, Hyun Woo Park, Carsten Gram Hansen et al. doi:10.1038/ncb3111 In two related papers, Chen and colleagues and Guan and colleagues report a crucial role for the AMPK and Hippo pathways in glucose homeostasis. Starvation triggers AMPK-mediated phosphorylation and inactivation of YAP. See also: Article by Wang et al. | News and Views by Hariharan Hypoxia-inducible TAp73 supports tumorigenesis by regulating the angiogenic transcriptome   pp511 - 523 Iqbal Dulloo, Beng Hooi Phang, Rashidah Othman, Soo Yong Tan, Aadhitthya Vijayaraghavan et al. doi:10.1038/ncb3130 Sabapathy and colleagues report that under hypoxic conditions, HIF-1α-mediated repression of the Siah1 ubiquitin ligases leads to stabilization of TAp73, which in turn promotes tumour angiogenesis. Letter Top Force transmission during adhesion-independent migration   pp524 - 529 Martin Bergert, Anna Erzberger, Ravi A. Desai, Irene M. Aspalter, Andrew C. Oates et al. doi:10.1038/ncb3134 Bergert et al. use theoretical modelling and cell-based experiments to show that adhesion-independent cell migration is powered by nonspecific substrate friction, with smaller forces exerted compared with those of focal-adhesion-dependent movement. Retraction Top Retraction: Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels   p530 Igor Dzhura, Yuejin Wu, Roger J. Colbran, Jeffrey R. Balser and Mark E. Anderson doi:10.1038/ncb3151 Errata Top Erratum: Kinetochore-microtubule error correction is driven by differentially regulated interaction modes   p530 Maria Kalantzaki, Etsushi Kitamura, Tongli Zhang, Akihisa Mino, Bela Novak et al. doi:10.1038/ncb3153 Erratum: RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2   p531 Dafni-Eleftheria Pefani, Robert Latusek, Isabel Pires, Anna M. Grawenda, Karen S. Yee et al. doi:10.1038/ncb3152 Erratum: Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation   p531 Quanlong Lu, Christine Insinna, Carolyn Ott, Jimmy Stauffer, Petra A. Pintado et al. doi:10.1038/ncb3155 Corrigenda Top Corrigendum: Ascl1a regulates Muller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway   p532 Rajesh Ramachandran, Blake V. Fausett and Daniel Goldman doi:10.1038/ncb3144 Corrigendum: Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model   p532 Yifeng Xia, Narayana Yeddula, Mathias Leblanc, Eugene Ke, Yonghui Zhang et al. doi:10.1038/ncb3145 Top Advertisement Epigenome Roadmap Nature Publishing Group presents an online portal - the Epigenome Roadmap - which collects key research papers from The NIH Roadmap Epigenomics Program, complemented by thematical 'threads' to help the readers mine the wealth of available information. 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