Nature Communications - 28 January 2015

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Weekly Content Alert 28 January 2015  Featured image: Rahman et al. demonstrate broadband antireflectivity from a nanotextured block copolymer coating and use it to increase solar cell efficiency Latest content: Articles Corrigenda Erratum Advertisement Nature Communications is now fully open access All new submissions to Nature Communications, if accepted, will be published open access and an article processing charge will apply. For more information visit the website.  Many research funders and institutions make funds available to pay open access APCs: please consult our open access funding page to check if your funder or institution has funding available. For advice on whether you are eligible for APC funding and help in approaching funders and institutions please contact us at openaccess@nature.com Journal homepage Recommend to library Web feed   Advertisement Chronic Lymphocytic Leukemia: Recent advances in biology and therapy Access this new Collection from Leukemia available free online for six months. Produced with support from: Janssen Pharmaceuticals Companies of Johnson & Johnson     Latest Articles View all Articles     Intratumoral genome diversity parallels progression and predicts outcome in pediatric cancer Linda Holmquist Mengelbier, Jenny Karlsson, David Lindgren, Anders Valind, Henrik Lilljebjörn, Caroline Jansson, Daniel Bexell, Noémie Braekeveldt, Adam Ameur, Tord Jonson, Hanna Göransson Kultima, Anders Isaksson, Jurate Asmundsson, Rogier Versteeg, Marianne Rissler, Thoas Fioretos, Bengt Sandstedt, Anna Börjesson, Torbjörn Backman, Niklas Pal et al. Phenotypic and genetic heterogeneity of cells within a tumour is thought to mediate treatment resistance and contribute to cancer progression. Here the authors show that genetic diversity in pediatric cancers is common after chemotherapy and can be quantified to predict survival. 27 January 2015 | doi: 10.1038/ncomms7125 Biological Sciences  Cancer  Medical research  The oldest known snakes from the Middle Jurassic-Lower Cretaceous provide insights on snake evolution Michael W. Caldwell, Randall L. Nydam, Alessandro Palci and Sebastián Apesteguía The origin and evolution of snakes remain poorly understood. Here, the authors show that fossils previously described as anguimorph lizards are ancient snakes and demonstrate that they share features with snakes and lizards, which suggests great diversity of snakes by the Jurassic period. 27 January 2015 | doi: 10.1038/ncomms6996 Biological Sciences  Evolution  Palaeontology  The first archaic Homo from Taiwan OPEN Chun-Hsiang Chang, Yousuke Kaifu, Masanaru Takai, Reiko T. Kono, Rainer Grün, Shuji Matsu’ura, Les Kinsley and Liang-Kong Lin Growing evidence reveals great diversity of archaic Asian hominins. Here, Chang and colleagues describe a newly discovered archaic Homo mandible from Taiwan, which suggests the survival of multiple evolutionary lineages among archaic hominins before the arrival of modern humans to eastern Asia. 27 January 2015 | doi: 10.1038/ncomms7037 Biological Sciences  Evolution  Palaeontology  Herpes simplex virus enhances chemokine function through modulation of receptor trafficking and oligomerization Nadia Martinez-Martin, Abel Viejo-Borbolla, Rocío Martín, Soledad Blanco, Jeffrey L. Benovic, Marcus Thelen and Antonio Alcamí Herpes simplex viruses cause a variety of diseases, from cold sores to encephalitis. Here, Martinez-Martin et al. show that the viral protein gG binds to cell surface glycosaminoglycans and induces chemokine receptor clustering, enhancing chemokine function and thus modulating the immune response. 27 January 2015 | doi: 10.1038/ncomms7163 Biological Sciences  Cell biology  Immunology  Virology  Atomistic origin of an ordered superstructure induced superconductivity in layered chalcogenides R. Ang, Z. C. Wang, C. L. Chen, J. Tang, N. Liu, Y. Liu, W. J. Lu, Y. P. Sun, T. Mori and Y. Ikuhara The interplay between superconductivity, electron correlation and atomic ordering is at the heart of condensed-matter physics. Here, the authors demonstrate a link between superconductivity in the layered chalcogenide TaS2-x Se x and the ordering of the sulphur and selenium atoms 27 January 2015 | doi: 10.1038/ncomms7091 Physical Sciences  Condensed matter  Materials science  Coexistent ARID1A–PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling Ronald L. Chandler, Jeffrey S. Damrauer, Jesse R. Raab, Jonathan C. Schisler, Matthew D. Wilkerson, John P. Didion, Joshua Starmer, Daniel Serber, Della Yee, Jessie Xiong, David B. Darr, Fernando Pardo-Manuel de Villena, William Y. Kim and Terry Magnuson ARID1A is frequently mutated in ovarian clear-cell carcinoma. Here the authors show that ARID1A loss in mice cooperates with PI3K activation to recapitulate the human disease, and implicate IL-6 signalling as the underlying mechanism. 27 January 2015 | doi: 10.1038/ncomms7118 Biological Sciences  Cancer  Long-living terahertz magnons in ultrathin metallic ferromagnets H. J. Qin, Kh. Zakeri, A. Ernst, L. M. Sandratskii, P. Buczek, A. Marmodoro, T. -H. Chuang, Y. Zhang and J. Kirschner The technological application of ultrafast terahertz magnons in itinerant ferromagnetic nanostructures is currently limited by magnon relaxation due to Landau damping. Here, Qin et al. demonstrate suppressed Landau damping and enhanced magnon lifetimes in ultrathin films of Fe–Pd alloy. 27 January 2015 | doi: 10.1038/ncomms7126 Physical Sciences  Condensed matter  Materials science  Nanotechnology  The ligand binding mechanism to purine nucleoside phosphorylase elucidated via molecular dynamics and machine learning OPEN Sergio Decherchi, Anna Berteotti, Giovanni Bottegoni, Walter Rocchia and Andrea Cavalli Understanding the dynamics of enzyme-substrate complexation provides an insight into potential drugs, but intermediate states are difficult to observe experimentally. Here, the authors use simulations and machine learning to analyse the binding of transition state inhibitors to purine nucleoside phosphorylase. 27 January 2015 | doi: 10.1038/ncomms7155 Biological Sciences  Biochemistry  Single-photon sensitive light-in-fight imaging OPEN Genevieve Gariepy, Nikola Krstajic, Robert Henderson, Chunyong Li, Robert R. Thomson, Gerald S. Buller, Barmak Heshmat, Ramesh Raskar, Jonathan Leach and Daniele Faccio Ultrafast imaging schemes can enable a diverse range of applications but require long acquisition times or raster scanning. Here, Gariepy et al. demonstrate visualization and rapid characterization of light-in-flight and laser-induced plasma formation using single-photon detector arrays. 27 January 2015 | doi: 10.1038/ncomms7021 Physical Sciences  Optical physics  Redox response of actinide materials to highly ionizing radiation Cameron L. Tracy, Maik Lang, John M. Pray, Fuxiang Zhang, Dmitry Popov, Changyong Park, Christina Trautmann, Markus Bender, Daniel Severin, Vladimir A. Skuratov and Rodney C. Ewing Understanding the degradation of materials subject to energetic radiation is important for the development of technologies based on nuclear fission. Here, the authors show that redox reactions of actinide compounds play an important role in their response to energetic radiation and their radiation tolerance. 27 January 2015 | doi: 10.1038/ncomms7133 Physical Sciences  Materials science  Detecting noise with shot noise using on-chip photon detector Y. Jompol, P. Roulleau, T. Jullien, B. Roche, I. Farrer, D. A. Ritchie and D. C. Glattli The detection of high-frequency radiation emitted by a quantum conductor is promising but current approaches exhibit limited sensitivity. Here, Jompol et al. propose on-chip radiation detection based on photo-assisted shot noise and show the response to be independent of the nature and geometry of the quantum conductor. 27 January 2015 | doi: 10.1038/ncomms7130 Physical Sciences  Condensed matter  Nanotechnology  A dendrite-suppressing composite ion conductor from aramid nanofibres Siu-On Tung, Szushen Ho, Ming Yang, Ruilin Zhang and Nicholas A. Kotov Lithium dendrite growth is a serious hazard in battery operations. Here, the authors report an ion-conducting membrane based on aramid nanofibers, and demonstrate effective suppression of copper and lithium dendrites. 27 January 2015 | doi: 10.1038/ncomms7152 Chemical Sciences  Materials science  Nanotechnology  A quantitative model for charge carrier transport, trapping and recombination in nanocrystal-based solar cells OPEN Deniz Bozyigit, Weyde M. M. Lin, Nuri Yazdani, Olesya Yarema and Vanessa Wood Colloidal nanocrystals could help improve the performance of the next generation of solar cells, but a model that fully describes the electronic behaviour of such devices is missing. Bozyigit et al. now develop a quantitative model for charge transport in these solar cells. 27 January 2015 | doi: 10.1038/ncomms7180 Physical Sciences  Materials science  Optical physics  ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP Shuying Sun, Shuo-Chien Ling, Jinsong Qiu, Claudio P. Albuquerque, Yu Zhou, Seiya Tokunaga, Hairi Li, Haiyan Qiu, Anh Bui, Gene W. Yeo, Eric J. Huang, Kevin Eggan, Huilin Zhou, Xiang-Dong Fu, Clotilde Lagier-Tourenne and Don W. Cleveland Dominant mutations in the RNA-binding protein FUS/TLS cause amyotrophic lateral sclerosis (ALS), an adult-onset motor neuron degenerative disease. Here, the authors show that ALS-causative FUS/TLS mutations directly bind the SMN and U1-snRNP complexes, producing both loss and gain of function effects on RNA processing. 27 January 2015 | doi: 10.1038/ncomms7171 Biological Sciences  Bioinformatics  Cell biology  Molecular biology  A strong-field driver in the single-cycle regime based on self-compression in a kagome fibre OPEN T. Balciunas, C. Fourcade-Dutin, G. Fan, T. Witting, A. A. Voronin, A. M. Zheltikov, F. Gerome, G. G. Paulus, A. Baltuska and F. Benabid Single-cycle and sub-cycle field transients are typically generated by external pulse compression where a combination of nonlinear broadening followed up by dispersion compensation is used. Here, Balciunas et al. use self-compression in a Kagome fibre to generate phase-controlled single-cycle pulses. 27 January 2015 | doi: 10.1038/ncomms7117 Physical Sciences  Applied physics  Atomic and molecular physics  Optical physics  Multi-omics analysis defines core genomic alterations in pheochromocytomas and paragangliomas OPEN Luis Jaime Castro-Vega, Eric Letouzé, Nelly Burnichon, Alexandre Buffet, Pierre-Hélie Disderot, Emmanuel Khalifa, Céline Loriot, Nabila Elarouci, Aurélie Morin, Mélanie Menara, Charlotte Lepoutre-Lussey, Cécile Badoual, Mathilde Sibony, Bertrand Dousset, Rossella Libé, Franck Zinzindohoue, Pierre François Plouin, Jérôme Bertherat, Laurence Amar, Aurélien de Reyniès et al. Pheochromocytomas and paragangliomas (PCCs/PGLs) are rare neuroendocrine tumours with a significant genetic component. Here, the authors carry out a multi-omic integrative characterization of PCC/PGL and reveal potential genomic alterations and regulatory mechanisms involved in the disease. 27 January 2015 | doi: 10.1038/ncomms7044 Biological Sciences  Genetics  Observation of coherent quench dynamics in a metallic many-body state of fermionic atoms Sebastian Will, Deepak Iyer and Marcos Rigol In ultracold quantum gases, coherent nonequilibrium dynamics has been observed for bosons, but remained elusive in fermionic systems. Here, Will et al. demonstrate coherent quench dynamics in a hybrid quantum system composed of a metallic state of fermionic atoms and a Bose–Einstein condensate. 27 January 2015 | doi: 10.1038/ncomms7009 Physical Sciences  Atomic and molecular physics  Condensed matter  Probing failure susceptibilities of earthquake faults using small-quake tidal correlations Braden A.W. Brinkman, Michael LeBlanc, Yehuda Ben-Zion, Jonathan T. Uhl and Karin A. Dahmen Using tidal correlations as a predictive tool for earthquakes is controversial because of the size of the data set. This study examines correlations between small earthquakes and periodic fault stresses to build a simple predictive model for larger quakes that shows good agreement with observed trends. 27 January 2015 | doi: 10.1038/ncomms7157 Earth Sciences  Geology and geophysics  UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1a OPEN Yoko Goto, Lihua Zeng, Chan Joo Yeom, Yuxi Zhu, Akiyo Morinibu, Kazumi Shinomiya, Minoru Kobayashi, Kiichi Hirota, Satoshi Itasaka, Michio Yoshimura, Keiji Tanimoto, Masae Torii, Terumasa Sowa, Toshi Menju, Makoto Sonobe, Hideaki Kakeya, Masakazu Toi, Hiroshi Date, Ester M. Hammond, Masahiro Hiraoka et al. When stabilized, HIF-1 can activate adaptation to hypoxia and metastasis. Here the authors show that upregulation of Ubiquitin C-terminal hydrolase-L1 in human cancers promotes metastasis and correlates with poor prognosis because of its role in opposing ubiquitin-mediated degradation of HIF-1. 23 January 2015 | doi: 10.1038/ncomms7153 Biological Sciences  Cancer  Chromatin remodelling and autocrine TNFα are required for optimal interleukin-6 expression in activated human neutrophils Maili Zimmermann, Francisco Bianchetto Aguilera, Monica Castellucci, Marzia Rossato, Sara Costa, Claudio Lunardi, Renato Ostuni, Giampiero Girolomoni, Gioacchino Natoli, Flavia Bazzoni, Nicola Tamassia and Marco A. Cassatella How IL-6 expression is regulated in human neutrophils has remained unclear. Here the authors show, using highly purified neutrophils, that TLR8 or TLR4 signalling activates latent enhancers and cooperates with autocrine TNFα to induce IL-6 transcription. 23 January 2015 | doi: 10.1038/ncomms7061 Biological Sciences  Immunology  Site- and allele-specific polycomb dysregulation in T-cell leukaemia OPEN Jean-Marc Navarro, Aurore Touzart, Lydie C. Pradel, Marie Loosveld, Myriam Koubi, Romain Fenouil, Sandrine Le Noir, Muhammad Ahmad Maqbool, Ester Morgado, Claude Gregoire, Sebastien Jaeger, Emilie Mamessier, Charles Pignon, Salima Hacein-Bey-Abina, Bernard Malissen, Marta Gut, Ivo G. Gut, Hervé Dombret, Elizabeth A. Macintyre, Steven J. Howe et al. TAL1 is frequently deregulated in T-cell acute lymphoblastic leukaemias, but the mechanism remains largely unclear. Here the authors show that microinsertions upstream of TAL1 cause its epigenetic reactivation, and that the mode of TAL1 activation correlates with prognosis. 23 January 2015 | doi: 10.1038/ncomms7094 Biological Sciences  Cancer  Medical research  An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction Chen Zhu, Kaori Sakuishi, Sheng Xiao, Zhiyi Sun, Sarah Zaghouani, Guangxiang Gu, Chao Wang, Dewar J. Tan, Chuan Wu, Manu Rangachari, Thomas Pertel, Hyun-Tak Jin, Rafi Ahmed, Ana C. Anderson and Vijay K. Kuchroo Tim-3 is an inhibitory molecule that suppresses T-cell responses. Here the authors show that the cytokine IL-27, acting through the transcription factor NFIL3, induces Tim-3 in vivo, and that IL-27-conditioned Th1 cells have poor effector function. 23 January 2015 | doi: 10.1038/ncomms7072 Biological Sciences  Immunology  Evidence for a small hole pocket in the Fermi surface of underdoped YBa2Cu3Oy OPEN N. Doiron-Leyraud, S. Badoux, S. René de Cotret, S. Lepault, D. LeBoeuf, F. Laliberté, E. Hassinger, B. J. Ramshaw, D. A. Bonn, W. N. Hardy, R. Liang, J.-H.. Park, D. Vignolles, B. Vignolle, L. Taillefer and C. Proust Fully mapping the Fermi surface of a compound provides a clear picture of its fundamental properties. Through thermoelectric measurements of the underdoped cuprate YBa2Cu3O y , this study shows evidence for a second Fermi pocket, consistent with charge–density–wave Fermi surface reconstruction. 23 January 2015 | doi: 10.1038/ncomms7034 Physical Sciences  Condensed matter  Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus Michael R. Johnson, Jacques Behmoaras, Leonardo Bottolo, Michelle L. Krishnan, Katharina Pernhorst, Paola L. Meza Santoscoy, Tiziana Rossetti, Doug Speed, Prashant K. Srivastava, Marc Chadeau-Hyam, Nabil Hajji, Aleksandra Dabrowska, Maxime Rotival, Banafsheh Razzaghi, Stjepana Kovac, Klaus Wanisch, Federico W. Grillo, Anna Slaviero, Sarah R. Langley, Kirill Shkura et al. Neurological disorders such as temporal lobe epilepsy (TLE) are known to be regulated by gene networks. In this study, the authors describe a genome-wide approach that uses samples of hippocampal tissue from patients with TLE, to identify the gene Sestrin 3 (SESN3) as a positive regulator of the disease. 23 January 2015 | doi: 10.1038/ncomms7031 Biological Sciences  Genetics  Neuroscience  Dppa3 expression is critical for generation of fully reprogrammed iPS cells and maintenance of Dlk1-Dio3 imprinting OPEN Xingbo Xu, Lukasz Smorag, Toshinobu Nakamura, Tohru Kimura, Ralf Dressel, Antje Fitzner, Xiaoying Tan, Matthias Linke, Ulrich Zechner, Wolfgang Engel and D. V. Krishna Pantakani Reprogramming of mouse somatic cells into iPSCs often generates pre-iPSCs, low-grade iPSCs that show abnormal Dlk1-Dio3 imprinting, and fully reprogrammed, high-grade iPSCs. Here, the authors show that germ-cell marker Dppa3 enhances reprogramming kinetics, critical for the maintenance of Dlk1-Dio3 imprinting and generation of fully reprogrammed iPSCs. 23 January 2015 | doi: 10.1038/ncomms7008 Biological Sciences  Cell biology  Developmental biology  A number-form area in the blind OPEN Sami Abboud, Shachar Maidenbaum, Stanislas Dehaene and Amir Amedi The human visual cortex includes areas with preference for various object categories. Here, Abboud et al. demonstrate using visual-to-music substitution, that the congenitally blind show a similar preference for numerals in the right inferior temporal cortex as sighted individuals, despite having no visual experience. 23 January 2015 | doi: 10.1038/ncomms7026 Biological Sciences  Neuroscience  Predicting oculomotor behaviour from correlated populations of posterior parietal neurons Arnulf B. A. Graf and Richard A. Andersen Cortical brain signals are often studied by predicting sensory inputs and behaviours from ensembles of neurons, but the uncertainty of these predictions is poorly understood. Graf and Andersen show that the level of uncertainty is reduced when populations of cortical neurons exhibit correlated variability. 23 January 2015 | doi: 10.1038/ncomms7024 Biological Sciences  Neuroscience  Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179 OPEN Koji M. Nishiguchi, Livia S. Carvalho, Matteo Rizzi, Kate Powell, Sophia-Martha kleine Holthaus, Selina A. Azam, Yanai Duran, Joana Ribeiro, Ulrich F. O. Luhmann, James W. B. Bainbridge, Alexander J. Smith and Robin R. Ali The rd1 mouse is the most widely used model to study retinal degeneration. Here, the authors identify a wide-spread mutation in these mice that may explain the failure of previous gene therapeutic approaches and show that long-lasting restoration of vision is possible in rd1 mice without this mutation. 23 January 2015 | doi: 10.1038/ncomms7006 Biological Sciences  Medical research  Fumarate induces redox-dependent senescence by modifying glutathione metabolism OPEN Liang Zheng, Simone Cardaci, Livnat Jerby, Elaine D. MacKenzie, Marco Sciacovelli, T. Isaac Johnson, Edoardo Gaude, Ayala King, Joshua D. G. Leach, RuAngelie Edrada-Ebel, Ann Hedley, Nicholas A. Morrice, Gabriela Kalna, Karen Blyth, Eytan Ruppin, Christian Frezza and Eyal Gottlieb Fumarate hydratase (FH) mutations are associated with renal cancer. Here, Zheng et al. use metabolomic and analytical chemistry approaches to reveal that fumarate accumulated due to FH loss covalently modifies intracellular glutathione, leading to oxidative stress and senescence. 23 January 2015 | doi: 10.1038/ncomms7001 Biological Sciences  Cancer  Cell biology  Different forms of effective connectivity in primate frontotemporal pathways OPEN Christopher I. Petkov, Yukiko Kikuchi, Alice E. Milne, Mortimer Mishkin, Josef P. Rauschecker and Nikos K. Logothetis Neural pathways to frontal cortex areas of the brain enable communication, but their connectivity is unclear. Petkov et al. use electrical microstimulation and brain imaging to describe different forms of hierarchical effective connectivity that exist between the primate frontal and temporal cortex. 23 January 2015 | doi: 10.1038/ncomms7000 Biological Sciences  Neuroscience  DNA sequencing using polymerase substrate-binding kinetics OPEN Michael John Robert Previte, Chunhong Zhou, Matthew Kellinger, Rigo Pantoja, Cheng-Yao Chen, Jin Shi, BeiBei Wang, Amirali Kia, Sergey Etchin, John Vieceli, Ali Nikoomanzar, Erin Bomati, Christian Gloeckner, Mostafa Ronaghi and Molly Min He Next-generation sequencing technologies vary in performance, which is often measured by metrics such as sequencing speed, accuracy and read length. Here, the authors present a new sequencing by synthesis method that monitors polymerase binding to DNA, and suggest that this method has the potential to generate longer and faster reads. 23 January 2015 | doi: 10.1038/ncomms6936 Biological Sciences  Biotechnology  Genetics  Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor OPEN Ying Liu, Chunying Chen, Pengxu Qian, Xuefei Lu, Baoyun Sun, Xiao Zhang, Liming Wang, Xingfa Gao, Han Li, Zhiyun Chen, Jinglong Tang, Weijie Zhang, Jinquan Dong, Ru Bai, Peter E. Lobie, Qingfa Wu, Suling Liu, Huafeng Zhang, Feng Zhao, Max S. Wicha et al. A metallofullerenol nanomaterial, Gd@C82(OH)22, was shown to inhibit growth of several solid cancers in preclinical models and yet exhibit low toxicity. Herein the authors show that Gd@C82(OH)22 functions as an inhibitor of breast cancer stem cell function via blocking TGF-ß and HIF-1a signalling, while sparing normal tissue. 23 January 2015 | doi: 10.1038/ncomms6988 Biological Sciences  Cancer  A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting OPEN Adam Byron, Janet A. Askari, Jonathan D. Humphries, Guillaume Jacquemet, Ewa J. Koper, Stacey Warwood, Colin K. Choi, Matthew J. Stroud, Christopher S. Chen, David Knight and Martin J. Humphries Integrins are activated by many extracellular cues and respond by assembling diverse signalling complexes. Byron et al. use activation state-specific antibodies to proteomically characterize these complexes, and provide insight into integrin-dependent microtubule stabilization. 22 January 2015 | doi: 10.1038/ncomms7135 Biological Sciences  Cell biology  Systems biology  Osmotic pressure induced tensile forces in tendon collagen OPEN Admir Masic, Luca Bertinetti, Roman Schuetz, Shu-Wei Chang, Till Hartmut Metzger, Markus J. Buehler and Peter Fratzl Water is an important component of collagen in tendons, bone and extracellular matrix, but its role in the mechanical function of protein is poorly understood. Here, the authors study the effects of osmotic pressure on contraction in collagen, suggesting that collagen could function as a mechanical actuator. 22 January 2015 | doi: 10.1038/ncomms6942 Physical Sciences  Biophysics  Materials science  Structural analysis of herpes simplex virus by optical super-resolution imaging OPEN Romain F. Laine, Anna Albecka, Sebastian van de Linde, Eric J. Rees, Colin M. Crump and Clemens F. Kaminski Herpes simplex virus type-1 (HSV-1) is a widespread human pathogen, the structure of which is not yet fully characterized. Here, the authors apply dSTORM super-resolution microscopy in combination with advanced data analysis tools to locate the position of four key protein layers in HSV-1 with unprecedented precision. 22 January 2015 | doi: 10.1038/ncomms6980 Biological Sciences  Biophysics  Virology  Massive parallel sequencing uncovers actionable FGFR2–PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma Daniela Sia, Bojan Losic, Agrin Moeini, Laia Cabellos, Ke Hao, Kate Revill, Dennis Bonal, Oriana Miltiadous, Zhongyang Zhang, Yujin Hoshida, Helena Cornella, Mireia Castillo-Martin, Roser Pinyol, Yumi Kasai, Sasan Roayaie, Swan N. Thung, Josep Fuster, Myron E. Schwartz, Samuel Waxman, Carlos Cordon-Cardo et al. Intrahepatic cholangiocarcinoma is an aggressive cancer of the bile duct with few treatment options and a below 10% five-year survival rate. Here Sia et al. show a novel FGFR2–PPHLN1 fusion and ARAF mutations that may represent future potential therapeutic targets. 22 January 2015 | doi: 10.1038/ncomms7087 Biological Sciences  Cancer  Genetics  Interfering with stem cell-specific gatekeeper functions controls tumour initiation and malignant progression of skin tumours OPEN Monika Petersson, Karen Reuter, Heike Brylka, Andreas Kraus, Peter Schettina and Catherin Niemann The presence of multiple stem and progenitor cells in the skin has a major impact on the formation of different epidermal tumours. Here the authors identify bulge stem cells as the cells of origin of sebaceous tumours through genetic lineage tracing and molecular studies in a mouse model. 22 January 2015 | doi: 10.1038/ncomms6874 Biological Sciences  Cancer  Molecular biology  Proteasome assembly from 15S precursors involves major conformational changes and recycling of the Pba1–Pba2 chaperone Malte Kock, Maria M. Nunes, Matthias Hemann, Sebastian Kube, R. Jürgen Dohmen, Franz Herzog, Paula C. Ramos and Petra Wendler The barrel-shaped 20S proteasome core particle assembles via 15S intermediates through the action of Ump1 and Pba1–Pba2 chaperones. Using structural approaches, Kock et al. reveal conformational changes occurring upon formation of the nascent 20S particle leading to ejection of Pba1–Pba2. 22 January 2015 | doi: 10.1038/ncomms7123 Biological Sciences  Biochemistry  PD-L1hi B cells are critical regulators of humoral immunity Adnan R. Khan, Emily Hams, Achilleas Floudas, Tim Sparwasser, Casey T. Weaver and Padraic G. Fallon Follicular helper T cells promote antibody production by B cells, and regulatory B cells, in turn, can restrain T cell activation. Here, Khan et al. show that PD-L1 plays a critical role in regulatory B cell function, curbing excessive immune responses by engaging the PD-1 receptor on follicular helper T cells. 22 January 2015 | doi: 10.1038/ncomms6997 Biological Sciences  Immunology  Mechanics of epithelial closure over non-adherent environments OPEN Sri Ram Krishna Vedula, Grégoire Peyret, Ibrahim Cheddadi, Tianchi Chen, Agustí Brugués, Hiroaki Hirata, Horacio Lopez-Menendez, Yusuke Toyama, Luís Neves de Almeida, Xavier Trepat, Chwee Teck Lim and Benoit Ladoux Closure of epithelial gaps such as wounds is thought to involve contraction of an actomyosin ‘purse-string’. By creating non-adherent gaps to exclude contributions of adhesive protrusion, the authors find that large-scale tension, more than purse-string contraction, mediates closure. 22 January 2015 | doi: 10.1038/ncomms7111 Biological Sciences  Biophysics  Cell biology  Multi-channel electronic and vibrational dynamics in polyatomic resonant high-order harmonic generation OPEN A. Ferré, A. E. Boguslavskiy, M. Dagan, V. Blanchet, B. D. Bruner, F. Burgy, A. Camper, D. Descamps, B. Fabre, N. Fedorov, J. Gaudin, G. Geoffroy, J. Mikosch, S. Patchkovskii, S. Petit, T. Ruchon, H. Soifer, D. Staedter, I. Wilkinson, A. Stolow et al. Strong-field ionization in molecules is more complex than in atoms with multiple channel dynamics and a coherent superposition of electronic states. Here, Ferré et al. develop multi-modal spectroscopy to measure those dynamics and reveal a resonant to non-resonant high-harmonic generation transition. 22 January 2015 | doi: 10.1038/ncomms6952 Physical Sciences  Atomic and molecular physics  Optical physics  Structure and boosting activity of a starch-degrading lytic polysaccharide monooxygenase OPEN Leila Lo Leggio, Thomas J. Simmons, Jens-Christian N. Poulsen, Kristian E. H. Frandsen, Glyn R. Hemsworth, Mary A. Stringer, Pernille von Freiesleben, Morten Tovborg, Katja S. Johansen, Leonardo De Maria, Paul V. Harris, Chee-Leong Soong, Paul Dupree, Theodora Tryfona, Nicolas Lenfant, Bernard Henrissat, Gideon J. Davies and Paul H. Walton Lytic polysaccharide monooxygenases (LPMOs) are industrially important enzymes that oxidatively deconstruct polysaccharides. Here, Lo Leggio et al. report the activity, spectroscopy and three-dimensional structure of a LPMO of the new CAZy AA13 family active on recalcitrant-retrograded starch. 22 January 2015 | doi: 10.1038/ncomms6961 Biological Sciences  Biochemistry  Biotechnology  The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors Daniel Zingg, Julien Debbache, Simon M. Schaefer, Eylul Tuncer, Sandra C. Frommel, Phil Cheng, Natalia Arenas-Ramirez, Jessica Haeusel, Yudong Zhang, Mario Bonalli, Michael T. McCabe, Caretha L. Creasy, Mitchell P. Levesque, Onur Boyman, Raffaella Santoro, Olga Shakhova, Reinhard Dummer and Lukas Sommer The epigenetic modifier EZH2 is highly expressed in melanoma but its role in cancer initiation and progression is still unclear. Here the authors use mouse models and human cell lines to show that EZH2 has an essential role in melanoma progression and metastasis, thus highlighting its potential as a therapeutic target. 22 January 2015 | doi: 10.1038/ncomms7051 Biological Sciences  Cancer  Molecular biology  Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness Takashi Furusawa, Mark Rochman, Leila Taher, Emilios K. Dimitriadis, Kunio Nagashima, Stasia Anderson and Michael Bustin Whether heterochromatin affects the physical properties of the nucleus is not known. Here, Furusawa et al. show that chromatin decompaction decreases the sturdiness of the nucleus in cultured cells and leads to lamina disruption and cardiac abnormalities in adult mice, suggesting a structural, non-genetic function for heterochromatin. 22 January 2015 | doi: 10.1038/ncomms7138 Biological Sciences  Biophysics  Cell biology  Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci Regina C. Betz, Lynn Petukhova, Stephan Ripke, Hailiang Huang, Androniki Menelaou, Silke Redler, Tim Becker, Stefanie Heilmann, Tarek Yamany, Madeliene Duvic, Maria Hordinsky, David Norris, Vera H. Price, Julian Mackay-Wiggan, Annemieke de Jong, Gina M. DeStefano, Susanne Moebus, Markus Böhm, Ulrike Blume-Peytavi, Hans Wolff et al. Alopecia areata (AA) is a common autoimmune disease with a known genetic component. Here, the authors analyse 3,253 AA patients and 7,543 healthy controls, and identify two new risk loci and disrupted immune response pathways associated with the disease. 22 January 2015 | doi: 10.1038/ncomms6966 Biological Sciences  Genetics  Immunology  Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity Masashi Kanayama, Makoto Inoue, Keiko Danzaki, Gianna Hammer, You-Wen He and Mari L. Shinohara Immune activation must be carefully tuned to respond to infection and restrained to prevent tissue damage. Here the authors show that autophagy has a role in the immune response to Candida albicans, activating NFκB in macrophages by sequestering the NFκB inhibitor A20. 22 January 2015 | doi: 10.1038/ncomms6779 Biological Sciences  Immunology  Microbiology  Ferroelectrically driven spatial carrier density modulation in graphene Christoph Baeumer, Diomedes Saldana-Greco, John Mark P. Martirez, Andrew M. Rappe, Moonsub Shim and Lane W. Martin The non-volatile modulation of charge carriers in graphene could be useful for future electronic devices. Here, the authors demonstrate that fields arising from ferroelectric polarization in periodically poled LiNbO3 substrates can lead to a carrier modulation in adjacent graphene films. 22 January 2015 | doi: 10.1038/ncomms7136 Physical Sciences  Applied physics  Nanotechnology  Organization of the mitochondrial translation machinery studied in situ by cryoelectron tomography Stefan Pfeffer, Michael W. Woellhaf, Johannes M. Herrmann and Friedrich Förster While the cytosolic translation machinery is well characterized, the mitochondrial translation system remains largely elusive. Using cryo-electron tomography, Pfeffer et al. describe the ordered organization of mitochondrial polysomes in which each ribosome is tethered to the inner membrane by two defined contacts on the large subunit in situ. 22 January 2015 | doi: 10.1038/ncomms7019 Biological Sciences  Biochemistry  Climate variation explains a third of global crop yield variability OPEN Deepak K. Ray, James S. Gerber, Graham K. MacDonald and Paul C. West Agricultural crops are closely linked to the climate in which they grow, but the extent to which variability in weather influences yield is not well characterized. Here, Ray et al. find that climatic variation explains around a third of the variation in global crop yields, with important regional variations. 22 January 2015 | doi: 10.1038/ncomms6989 Biological Sciences  Climate science  Ecology  Plant sciences  MazF ribonucleases promote Mycobacterium tuberculosis drug tolerance and virulence in guinea pigs Prabhakar Tiwari, Garima Arora, Mamta Singh, Saqib Kidwai, Om Prakash Narayan and Ramandeep Singh Mycobacterium tuberculosis possesses several toxin–antitoxin systems of the MazEF family. Here, Tiwari et al. show that these systems contribute to stress adaptation, antibiotic tolerance and virulence. 22 January 2015 | doi: 10.1038/ncomms7059 Biological Sciences  Microbiology  Molecular biology  Mutual information reveals multiple structural relaxation mechanisms in a model glass former OPEN Andrew J. Dunleavy, Karoline Wiesner, Ryoichi Yamamoto and C. Patrick Royall One mystery of glass transition from supercooled liquid is the lack of apparent change in structure, which is in contrast to a large change in dynamics. Here Dunleavy et al. provide a possible solution to this discrepancy by simulating dynamic correlation using a mutual information approach. 22 January 2015 | doi: 10.1038/ncomms7089 Physical Sciences  Applied physics  Materials science  Evidence for an oxygen evolving iron–oxo–cerium intermediate in iron-catalysed water oxidation Zoel Codolà, Laura Gómez, Scott T. Kleespies, Lawrence Que Jr, Miquel Costas and Julio Lloret-Fillol Non-haeme iron complexes are known to be competent catalysts for chemically driven water oxidation. Here, the authors provide evidence for the formation of an inner-sphere iron(IV)- oxygen-cerium(IV) intermediate that may provide mechanistic insight into the naturally occurring oxygen evolving complex. 22 January 2015 | doi: 10.1038/ncomms6865 Chemical Sciences  Catalysis  Inorganic chemistry  Whole-exome sequencing reveals the mutational spectrum of testicular germ cell tumours Kevin Litchfield, Brenda Summersgill, Shawn Yost, Razvan Sultana, Karim Labreche, Darshna Dudakia, Anthony Renwick, Sheila Seal, Reem Al-Saadi, Peter Broderick, Nicholas C. Turner, Richard S. Houlston, Robert Huddart, Janet Shipley and Clare Turnbull Testicular germ cell tumour (TGCT) is the most common cancer in young men. Here, the authors sequence the whole exomes of 42 TGCTs, and characterize the mutational profile of this tumour type. 22 January 2015 | doi: 10.1038/ncomms6973 Biological Sciences  Cancer  Genetics  Tropical Atlantic temperature seasonality at the end of the last interglacial OPEN Thomas Felis, Cyril Giry, Denis Scholz, Gerrit Lohmann, Madlene Pfeiffer, Jürgen Pätzold, Martin Kölling and Sander R. Scheffers The last interglacial has been suggested as a test bed for models developed for future climate prediction, yet many climatic parameters remain unknown. Here, the authors present a precisely dated fossil coral and show that temperature seasonality in the southern Caribbean Sea 118 ka was similar to today. 22 January 2015 | doi: 10.1038/ncomms7159 Earth Sciences  Climate science  Oceanography  Discovery of optimal zeolites for challenging separations and chemical transformations using predictive materials modeling Peng Bai, Mi Young Jeon, Limin Ren, Chris Knight, Michael W. Deem, Michael Tsapatsis and J. Ilja Siepmann Zeolites are industrially important materials, functioning as separation media and catalyst supports. Here, the authors use a large-scale, multi-step computational screening process to identify promising zeolites for challenging separations, namely ethanol purification and alkane adsorption. 21 January 2015 | doi: 10.1038/ncomms6912 Chemical Sciences  Inorganic chemistry  Materials science  Physical chemistry  Northern-hemispheric differential warming is the key to understanding the discrepancies in the projected Sahel rainfall Jong-Yeon Park, Jürgen Bader and Daniela Matei Rainfall in the Sahel region has a decadal variability related to tropical sea-surface temperatures; however, models disagree regarding future changes in rainfall. Here the authors suggest that differential warming in the northern hemisphere is key to understanding this discrepancy. 21 January 2015 | doi: 10.1038/ncomms6985 Earth Sciences  Atmospheric science  Climate science  The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA Sarah D. Ackerman, Cynthia Garcia, Xianhua Piao, David H. Gutmann and Kelly R. Monk The adhesion class of G protein-coupled receptors (aGPCRs) is essential for peripheral nervous system myelination, but functions in central nervous system myelination are less understood. Here the authors show that the aGPCR Gpr56 plays a role in the development of myelinating oligodendrocytes and that this function is mediated by Gα12/13 proteins and Rho activation. 21 January 2015 | doi: 10.1038/ncomms7122 Biological Sciences  Developmental biology  Neuroscience  Selecting core-hole localization or delocalization in CS2 by photofragmentation dynamics R. Guillemin, P. Decleva, M. Stener, C. Bomme, T. Marin, L. Journel, T. Marchenko, R. K. Kushawaha, K. Jänkälä, N. Trcera, K. P. Bowen, D. W. Lindle, M. N. Piancastelli and M. Simon Molecular core levels are localized around a single atomic site, but for indistinguishable atoms, photoionised core-holes can either be seen as localized or delocalized. Using a prototypical symmetric system, CS2, Guillemin et al. show that these states can be disentangled by fragmentation dynamics. 21 January 2015 | doi: 10.1038/ncomms7166 Physical Sciences  Atomic and molecular physics  Physical chemistry  Synthesis of large single-crystal hexagonal boron nitride grains on Cu–Ni alloy Guangyuan Lu, Tianru Wu, Qinghong Yuan, Huishan Wang, Haomin Wang, Feng Ding, Xiaoming Xie and Mianheng Jiang High nucleation density has thus far limited the quality and grain size of CVD-grown hexagonal boron nitride. Here, by optimizing the Ni ratio in Cu–Ni substrates, the authors successfully reduce nucleation density and report single-crystal hexagonal boron nitride grains up to 7500?µm2. 21 January 2015 | doi: 10.1038/ncomms7160 Physical Sciences  Materials science  Nanotechnology  Internalization and vacuolar targeting of the brassinosteroid hormone receptor BRI1 are regulated by ubiquitination Sara Martins, Esther M. N. Dohmann, Anne Cayrel, Alexander Johnson, Wolfgang Fischer, Florence Pojer, Béatrice Satiat-Jeunemaître, Yvon Jaillais, Joanne Chory, Niko Geldner and Grégory Vert Ubiquitination of cargo proteins regulates endocytosis in yeast and mammalian cells, however the extent to which this applies to plants is less clear. Martins et al. show that both internalization and vacuolar targetting of the Arabidopsis brassinosteroid receptor BRI1 are regulated by ubiquitination. 21 January 2015 | doi: 10.1038/ncomms7151 Biological Sciences  Cell biology  Plant sciences  Interaction between emotional state and learning underlies mood instability Eran Eldar and Yael Niv Whether emotional state affects the perception of outcomes, and the possible consequences of this interaction remain unclear. Here the authors use behavioural tests and brain imaging to study the bidirectional interaction between emotional state and learning in humans and find that this interaction may play a role in mood instability. 21 January 2015 | doi: 10.1038/ncomms7149 Biological Sciences  Neuroscience  Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas Lauren Fishbein, Sanika Khare, Bradley Wubbenhorst, Daniel DeSloover, Kurt D’Andrea, Shana Merrill, Nam Woo Cho, Roger A. Greenberg, Tobias Else, Kathleen Montone, Virginia LiVolsi, Douglas Fraker, Robert Daber, Debbie L. Cohen and Katherine L. Nathanson Pheochromocytomas and paragangliomas (PCC/PGL) are tumours of the autonomic nervous system. Here, the authors identify ATRX mutations in PCC/PGL and suggest that ATRX loss is important for tumorigenesis in a subset of PCC/PGL. 21 January 2015 | doi: 10.1038/ncomms7140 Biological Sciences  Cancer  Genetics  IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis Bofeng Li, Prajwal Gurung, R. K. Subbarao Malireddi, Peter Vogel, Thirumala-Devi Kanneganti and Terrence L. Geiger The pro-inflammatory cytokine IL-1ß promotes the accumulation of pathologic Th17 lymphocytes that contribute to colitis. Here the authors show that the critical role of IL-10 in colitis suppression can be explained by its inhibition of IL-1ß production in macrophages. 21 January 2015 | doi: 10.1038/ncomms7131 Biological Sciences  Immunology  Imperceptible magnetoelectronics OPEN Michael Melzer, Martin Kaltenbrunner, Denys Makarov, Dmitriy Karnaushenko, Daniil Karnaushenko, Tsuyoshi Sekitani, Takao Someya and Oliver G. Schmidt Birds and many other animals can sense the Earth’s magnetic field, but not human beings. Here, Melzer et al. develop a type of artificial skin based on giant magnetoresistive sensor foils with micrometre thickness, which can be stretched up to >250% without sacrifices in device performance. 21 January 2015 | doi: 10.1038/ncomms7080 Physical Sciences  Applied physics  Materials science  Nanotechnology  The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development OPEN Stefanie Giera, Yiyu Deng, Rong Luo, Sarah D. Ackerman, Amit Mogha, Kelly R. Monk, Yanqin Ying, Sung-Jin Jeong, Manabu Makinodan, Allison R. Bialas, Bernard S. Chang, Beth Stevens, Gabriel Corfas and Xianhua Piao Mutations in GPR56, a member of the adhesion G protein-coupled receptor family, cause a specific human brain malformation and myelination defects but the cellular causes remain unclear. Here the authors show that loss of Gpr56 in mice leads to decreased oligodendrocyte precursor cell proliferation and diminished levels of active RhoA. 21 January 2015 | doi: 10.1038/ncomms7121 Biological Sciences  Developmental biology  Neuroscience  Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation OPEN Jiayi Yu, Xiaofei Zhou, Mikyoung Chang, Mako Nakaya, Jae-Hoon Chang, Yichuan Xiao, J. William Lindsey, Stephanie Dorta-Estremera, Wei Cao, Anna Zal, Tomasz Zal and Shao-Cong Sun T cells that are activated by self-antigens in the periphery can migrate into the brain causing neuroinflammatory disease. Here the authors show that TBK1 is necessary for activated T-cell egress from the lymph node, and blocking TBK1 ameliorates autoimmunity in a mouse model of multiple sclerosis. 21 January 2015 | doi: 10.1038/ncomms7074 Biological Sciences  Immunology  Interplay of weak interactions in the atom-by-atom condensation of xenon within quantum boxes OPEN Sylwia Nowakowska, Aneliia Wäckerlin, Shigeki Kawai, Toni Ivas, Jan Nowakowski, Shadi Fatayer, Christian Wäckerlin, Thomas Nijs, Ernst Meyer, Jonas Björk, Meike Stöhr, Lutz H. Gade and Thomas A. Jung Condensation in the regime of weakly interactions is of fundamental importance. Here, the authors study the condensation process one atom at a time, showing the forces driving the behaviour of xenon atoms as they condense into aggregate structures in nanoscale pores. 21 January 2015 | doi: 10.1038/ncomms7071 Chemical Sciences  Nanotechnology  Physical chemistry  The phase diagram of electron-doped La2-xCexCuO4-δ H. Saadaoui, Z. Salman, H. Luetkens, T. Prokscha, A. Suter, W. A. MacFarlane, Y. Jiang, K. Jin, R. L. Greene, E. Morenzoni and R. F. Kiefl The relationship between superconductivity and antiferromagnetism is an unresolved question in electron-doped high-T c superconductors. Saadaoui et al. perform low-energy muon spin relaxation measurements to study the phase diagram of La2-x Ce x CuO4-δ at the magnetic-superconducting transition region. 21 January 2015 | doi: 10.1038/ncomms7041 Physical Sciences  Condensed matter  The 40-residue insertion in Vibrio cholerae FadR facilitates binding of an additional fatty acyl-CoA ligand Wei Shi, Gabriela Kovacikova, Wei Lin, Ronald K. Taylor, Karen Skorupski and F. Jon Kull FadR is a regulator of fatty acid metabolism in bacteria, and contains a binding site for acyl-CoA. Here, Shi et al. present a structure of V. cholerae FadR and show that a unique C-terminal extension comprises a second acyl-CoA binding site, perhaps rendering V. cholerae FadR a more efficient regulator. 21 January 2015 | doi: 10.1038/ncomms7032 Biological Sciences  Biochemistry  Microbiology  An ultra-low-input native ChIP-seq protocol for genome-wide profiling of rare cell populations Julie Brind’Amour, Sheng Liu, Matthew Hudson, Carol Chen, Mohammad M. Karimi and Matthew C. Lorincz Standard ChIP-seq protocols require large numbers of cells for high-quality datasets, limiting the application of this technique on rare cell types. Here, Brind’Amour et al. introduce an ultra-low-input ChIP-seq protocol to generate maps of covalent histone marks from as few as 1,000 cells. 21 January 2015 | doi: 10.1038/ncomms7033 Biological Sciences  Biotechnology  Molecular biology  Self-assembly and electrostriction of arrays and chains of hopfion particles in chiral liquid crystals OPEN Paul J. Ackerman, Jao van de Lagemaat and Ivan I. Smalyukh Topological defects can be spontaneously generated to thermodynamically stabilize a variety of peculiar condensed matter phases for technological applications. Here, Ackerman et al. show electrically controllable self-assembly of knotted defects into periodic arrays in chiral liquid crystals. 21 January 2015 | doi: 10.1038/ncomms7012 Physical Sciences  Condensed matter  Materials science  Uncovering the spatial structure of mobility networks Thomas Louail, Maxime Lenormand, Miguel Picornell, Oliva García Cantú, Ricardo Herranz, Enrique Frias-Martinez, José J. Ramasco and Marc Barthelemy The availability of pervasive data has opened up possibilities for quantitative approaches to many phenomena, but extracting useful information from huge datasets is difficult. Here, Louail et al. propose a method to extract a coarse-grained signature of large weighted networks and apply it to mobility networks. 21 January 2015 | doi: 10.1038/ncomms7007 Physical Sciences  Theoretical physics  Upward electrical discharges observed above Tropical Depression Dorian OPEN Ningyu Liu, Nicholas Spiva, Joseph R. Dwyer, Hamid K. Rassoul, Dwayne Free and Steven A. Cummer Upward electrical discharges from thunderstorms were discovered recently, and only a very limited set of observations exist because they are rare and unpredictable. Here, the authors present recordings of different types of the discharge above a storm, which contradict current theories of their origins. 21 January 2015 | doi: 10.1038/ncomms6995 Earth Sciences  Planetary sciences  Sequencing of first-strand cDNA library reveals full-length transcriptomes Saurabh Agarwal, Todd S. Macfarlan, Maureen A. Sartor and Shigeki Iwase Strand-specific RNA-seq (ssRNA-seq) data often lack information on 5' and 3' ends of transcripts. Here the authors present a novel method for ssRNA-seq that enables the simultaneous profiling of gene expression, TSSs and polyadenylation sites at near-base resolution with a single library. 21 January 2015 | doi: 10.1038/ncomms7002 Biological Sciences  Bioinformatics  Molecular biology  Numerical chromosomal instability mediates susceptibility to radiation treatment Samuel F. Bakhoum, Lilian Kabeche, Matthew D. Wood, Christopher D. Laucius, Dian Qu, Ashley M. Laughney, Gloria E. Reynolds, Raymond J. Louie, Joanna Phillips, Denise A. Chan, Bassem I. Zaki, John P. Murnane, Claudia Petritsch and Duane A. Compton Ionizing radiations (IRs) cause widespread genomic damage and can, through unknown mechanisms, lead to changes in chromosome numbers by perturbing the cells undergoing mitosis. Here, the authors investigate the potential mechanism behind the increased susceptibility of mitotic cells to IRs. 21 January 2015 | doi: 10.1038/ncomms6990 Biological Sciences  Cancer  Sub-50-nm self-assembled nanotextures for enhanced broadband antireflection in silicon solar cells Atikur Rahman, Ahsan Ashraf, Huolin Xin, Xiao Tong, Peter Sutter, Matthew D. Eisaman and Charles T. Black Broadband light antireflection materials have numerous applications as highly transparent window, for broadband applications thin-film multilayers have been considered. Here, Rahman et al. demonstrate broadband antireflection enhancement in silicon solar cells using a self-assembled, nanostructured copolymer. 21 January 2015 | doi: 10.1038/ncomms6963 Physical Sciences  Materials science  Nanotechnology  An iron-based green approach to 1-h production of single-layer graphene oxide OPEN Li Peng, Zhen Xu, Zheng Liu, Yangyang Wei, Haiyan Sun, Zheng Li, Xiaoli Zhao and Chao Gao Oxidants currently used in the preparation of graphene oxide (GO) require long reaction times, relatively high temperatures and costly waste treatment. Here, the authors propose the use of a strong green oxidant, K2FeO4, establishing a fast, safe, toxicity-free route to GO production. 21 January 2015 | doi: 10.1038/ncomms6716 Chemical Sciences  Inorganic chemistry  Nanotechnology  A minimal physical model captures the shapes of crawling cells E. Tjhung, A. Tiribocchi, D. Marenduzzo and M. E. Cates How living cells move around is crucial for the understanding of their biological functions. Here, Tjhung et al. reproduce cellular motility via a minimal physical model, whereby a cell in three-dimensions is represented as a droplet of active polar fluid constrained by interfacial tension. 21 January 2015 | doi: 10.1038/ncomms6420 Physical Sciences  Biophysics  Theoretical physics    Nature Communications JOBS of the week Senior Research Fellow University of Portsmouth, UK Postdoctoral Researcher Lehigh University PhD studentship Centre National de la Recherche Scientifique (CNRS) Postdoc Position University of Sao Paulo (Brazil) PhD-student Georg-August-Universität Göttingen Clinical Trial Manager Institute of Cancer Research (ICR) Postdoctoral Associates Sanford Bunrham Medical Research Institute Bioinformatics Specialist II Massachusetts General Hospital Associate Research Fellow University of Exeter Postdoctoral Fellow Cleveland Clinic Lerner Research Institute More Science jobs from Nature Communications EVENT Novel Tools & Technologies for Studying Cells & Tissues 03.07.15 London, UK More science events from       Latest Corrigenda     Corrigendum: Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism Claire Piochon, Alexander D. Kloth, Giorgio Grasselli, Heather K. Titley, Hisako Nakayama, Kouichi Hashimoto, Vivian Wan, Dana H. Simmons, Tahra Eissa, Jin Nakatani, Adriana Cherskov, Taisuke Miyazaki, Masahiko Watanabe, Toru Takumi, Masanobu Kano, Samuel S.-H. Wang and Christian Hansel 27 January 2015 | doi: 10.1038/ncomms7014 Biological Sciences  Neuroscience      Corrigendum: Identifying signatures of photothermal current in a double-gated semiconducting nanotube G. Buchs, S. Bagiante and G. A. Steele 23 January 2015 | doi: 10.1038/ncomms6463 Physical Sciences  Applied physics  Nanotechnology      Corrigendum: The adipokine Retnla modulates cholesterol homeostasis in hyperlipidemic mice Mi-Ran Lee, Chae-ji Lim, You-Han Lee, Jong-Gil Park, Seong Keun Sonn, Mi-Ni Lee, In-Hyuk Jung, Se-Jin Jeong, Sejin Jeon, Myoungsook Lee, Ki Sook Oh, Young Yang, Jae Bum Kim, Hueng-Sik Choi, Woojin Jeong, Tae-Sook Jeong, Won Kee Yoon, Hyoung Chin Kim, Jae-Hoon Choi and Goo Taeg Oh et al. 21 January 2015 | doi: 10.1038/ncomms7076 Biological Sciences  Medical research        Latest Erratum     Erratum: Post-fusion structural changes and their roles in exocytosis and endocytosis of dense-core vesicles Hsueh-Cheng Chiang, Wonchul Shin, Wei-Dong Zhao, Edaeni Hamid, Jiansong Sheng, Maryna Baydyuk, Peter J. Wen, Albert Jin, Fanny Momboisse and Ling-Gang Wu 27 January 2015 | doi: 10.1038/ncomms7016 Biological Sciences  Biophysics  Cell biology      Advertisement Nature Reviews Clinical Oncology  FREE POSTER: BREAST CANCER INTRINSIC SUBTYPES This special Poster highlights recent achievements and development of our genetic understanding of the intrinsic subtypes of molecular breast cancer subtypes. Produced with support from:  NanoString® Technologies, Inc     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com  More Nature Events You have been sent this Table of Contents Alert because you have opted in to receive it. 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